StarFunc result for job id P28330

User Input

>input (430 residues)
MAARLLRGSLRVLGGHRAPRQLPAARCSHSGGEERLETPSAKKLTDIGIRRIFSPEHDIF
RKSVRKFFQEEVIPHHSEWEKAGEVSREVWEKAGKQGLLGVNIAEHLGGIGGDLYSAAIV
WEEQAYSNCSGPGFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGAGSD
LQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGISLFLVENGMK
GFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQERLLIADVAI
SASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVDNCLQLHEAKRL
DSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKE
LIAREIVFDK

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P28330	1.000	1.000	3.173E-69	430	1.000	1.000	P28330.pdb.gz	ACADL_HUMAN Long-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADL PE=1 SV=2
2	AFDB:P15650	0.942	0.942	1.467E-60	430	0.853	0.853	P15650.pdb.gz	ACADL_RAT Long-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Rattus norvegicus OX=10116 GN=Acadl PE=1 SV=1
3	AFDB:Q9I3H8	0.843	0.946	1.401E-32	382	0.337	0.380	Q9I3H8.pdb.gz	Q9I3H8_PSEAE Probable acyl-CoA dehydrogenase OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964 GN=PA1535 PE=3 SV=1
4	PDB:1ivhA	0.848	0.940	2.845E-32	387	0.302	0.336	1ivhA.pdb.gz	Structure of human isovaleryl-CoA dehydrogenase at 2.6 A resolution: structural basis for substrate specificity,.
5	AFDB:P26440	0.855	0.862	7.735E-32	426	0.312	0.315	P26440.pdb.gz	IVD_HUMAN Isovaleryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=IVD PE=1 SV=2
6	AFDB:H6LGM6	0.830	0.939	9.744E-32	379	0.307	0.348	H6LGM6.pdb.gz	CARC_ACEWD Caffeyl-CoA reductase-Etf complex subunit CarC OS=Acetobacterium woodii (strain ATCC 29683 / DSM 1030 / JCM 2381 / KCTC 1655 / WB1) OX=931626 GN=carC PE=1 SV=1
7	AFDB:P12007	0.851	0.863	1.227E-31	424	0.298	0.302	P12007.pdb.gz	IVD_RAT Isovaleryl-CoA dehydrogenase, mitochondrial OS=Rattus norvegicus OX=10116 GN=Ivd PE=1 SV=2
8	AFDB:Q9SWG0	0.846	0.888	1.477E-31	409	0.284	0.298	Q9SWG0.pdb.gz	IVD_ARATH Isovaleryl-CoA dehydrogenase, mitochondrial OS=Arabidopsis thaliana OX=3702 GN=IVD PE=1 SV=2
9	AFDB:Q9HZV8	0.845	0.939	1.696E-31	386	0.295	0.329	Q9HZV8.pdb.gz	Q9HZV8_PSEAE Citronellyl-CoA dehydrogenase involved in catabolism of citronellol OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964 GN=atuD PE=3 SV=1
10	AFDB:Q9VSA3	0.836	0.857	3.091E-31	419	0.300	0.308	Q9VSA3.pdb.gz	ACADM_DROME Medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Drosophila melanogaster OX=7227 GN=Mcad PE=1 SV=1
11	AFDB:A0A0S2Z366	0.817	0.834	4.906E-31	421	0.295	0.302	A0A0S2Z366.pdb.gz	A0A0S2Z366_HUMAN Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (Fragment) OS=Homo sapiens OX=9606 GN=ACADM PE=2 SV=1
12	PDB:1jqiA	0.832	0.929	5.018E-30	384	0.286	0.320	1jqiA.pdb.gz	Crystal structure of rat short chain acyl-CoA dehydrogenase complexed with acetoacetyl-CoA: comparison with other acyl-CoA dehydrogenases.
13	PDB:6fahC	0.847	0.958	7.964E-30	379	0.307	0.348	6fahC.pdb.gz	Molecular basis of the flavin-based electron-bifurcating caffeyl-CoA reductase reaction.
14	PDB:2a1tC	0.833	0.919	2.304E-29	388	0.286	0.317	2a1tC.pdb.gz	Stabilization of Non-productive Conformations Underpins Rapid Electron Transfer to Electron-transferring Flavoprotein
15	PDB:1rx0A	0.830	0.926	2.902E-29	384	0.286	0.320	1rx0A.pdb.gz	Structures of Isobutyryl-CoA Dehydrogenase and Enzyme-Product Complex: COMPARISON WITH ISOVALERYL- AND SHORT-CHAIN ACYL-COA DEHYDROGENASES.
16	PDB:7s7gA	0.797	0.607	7.407E-27	571	0.256	0.193	7s7gA.pdb.gz	Crystal Structure Analysis of Human VLCAD
17	PDB:2ix6A	0.813	0.840	1.122E-26	416	0.242	0.250	2ix6A.pdb.gz	Controlling Electron Transfer in Acyl-Coa Oxidases and Dehydrogenases: A Structural View.
18	PDB:2r0mA	0.823	0.905	4.284E-26	390	0.228	0.251	2r0mA.pdb.gz	The effect of a Glu370Asp mutation in glutaryl-CoA dehydrogenase on proton transfer to the dienolate intermediate.
19	PDB:6af6A	0.806	0.901	8.621E-25	383	0.228	0.256	6af6A.pdb.gz	Crystal Structure of PigA: A Prolyl Thioester-Oxidizing Enzyme in Prodigiosin Biosynthesis.
20	PDB:4xvxB	0.775	0.887	1.386E-22	373	0.207	0.239	4xvxB.pdb.gz	A covalent adduct of MbtN, an acyl-ACP dehydrogenase from Mycobacterium tuberculosis, reveals an unusual acyl-binding pocket.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P15650	0.0	758	430	0.826	0.826	ACADL_RAT Long-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Rattus norvegicus OX=10116 GN=Acadl PE=1 SV=1
2	P28330	0.0	893	430	1.000	1.000	ACADL_HUMAN Long-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADL PE=1 SV=2
3	P51174	0.0	767	430	0.863	0.863	ACADL_MOUSE Long-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Acadl PE=1 SV=2
4	Q9I3H8	2.83e-80	254	382	0.344	0.387	Q9I3H8_PSEAE Probable acyl-CoA dehydrogenase OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964 GN=PA1535 PE=3 SV=1
5	A0A0A0MT83	6.70e-76	244	423	0.302	0.307	A0A0A0MT83_HUMAN Isovaleryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=IVD PE=1 SV=2
6	P26440	8.63e-76	244	426	0.302	0.305	IVD_HUMAN Isovaleryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=IVD PE=1 SV=2
7	Q9HZV8	1.53e-73	237	386	0.300	0.334	Q9HZV8_PSEAE Citronellyl-CoA dehydrogenase involved in catabolism of citronellol OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964 GN=atuD PE=3 SV=1
8	Q9JHI5	3.88e-72	234	424	0.288	0.292	IVD_MOUSE Isovaleryl-CoA dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Ivd PE=1 SV=1
9	P12007	8.18e-72	234	424	0.284	0.288	IVD_RAT Isovaleryl-CoA dehydrogenase, mitochondrial OS=Rattus norvegicus OX=10116 GN=Ivd PE=1 SV=2
10	H6LGM6	4.14e-70	228	379	0.312	0.354	CARC_ACEWD Caffeyl-CoA reductase-Etf complex subunit CarC OS=Acetobacterium woodii (strain ATCC 29683 / DSM 1030 / JCM 2381 / KCTC 1655 / WB1) OX=931626 GN=carC PE=1 SV=1
11	G3KIM8	9.53e-70	228	394	0.321	0.350	ACRC_ANAPI Acryloyl-CoA reductase (NADH) OS=Anaerotignum propionicum OX=28446 GN=acrC PE=1 SV=1
12	Q9I296	5.22e-68	223	387	0.284	0.315	Q9I296_PSEAE Isovaleryl-CoA dehydrogenase OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964 GN=liuA PE=3 SV=1
13	P70584	8.39e-68	223	432	0.288	0.287	ACDSB_RAT Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial OS=Rattus norvegicus OX=10116 GN=Acadsb PE=1 SV=1
14	A0A0S2Z3P9	1.80e-65	218	432	0.291	0.289	A0A0S2Z3P9_HUMAN Acyl-CoA dehydrogenase short/branched chain isoform 1 (Fragment) OS=Homo sapiens OX=9606 GN=ACADSB PE=2 SV=1
15	P45954	1.80e-65	218	432	0.291	0.289	ACDSB_HUMAN Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADSB PE=1 SV=1
16	Q9DBL1	2.34e-65	217	432	0.286	0.285	ACDSB_MOUSE Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Acadsb PE=1 SV=1
17	Q9VSA3	6.82e-65	216	419	0.288	0.296	ACADM_DROME Medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Drosophila melanogaster OX=7227 GN=Mcad PE=1 SV=1
18	G5EEH6	1.77e-64	214	419	0.284	0.291	G5EEH6_CAEEL Isovaleryl-CoA dehydrogenase, mitochondrial OS=Caenorhabditis elegans OX=6239 GN=ivd-1 PE=1 SV=1
19	Q9FS88	2.08e-64	214	412	0.274	0.286	MBCD_SOLTU 2-methylacyl-CoA dehydrogenase, mitochondrial OS=Solanum tuberosum OX=4113 GN=2MBCD PE=1 SV=2
20	P15651	3.97e-64	213	412	0.291	0.303	ACADS_RAT Short-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Rattus norvegicus OX=10116 GN=Acads PE=1 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00441 Acyl-CoA_dh_1	4.5e-38	142.3	Acyl-CoA dehydrogenase, C-terminal domain
2	PF08028 Acyl-CoA_dh_2	8.7e-05	34.2	Acyl-CoA dehydrogenase, C-terminal domain
3	PF02770 Acyl-CoA_dh_M	6e-23	92.2	Acyl-CoA dehydrogenase, middle domain
4	PF02771 Acyl-CoA_dh_N	2.8e-27	107.0	Acyl-CoA dehydrogenase, N-terminal domain
5	PF14749 Acyl-CoA_ox_N	44	16.0	Acyl-coenzyme A oxidase N-terminal

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000233710

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000360541	0.983	Carnitine O-palmitoyltransferase 2, mitochondrial
2	9606.ENSP00000325136	0.982	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
3	9606.ENSP00000370023	0.981	Trifunctional enzyme subunit alpha, mitochondrial
4	9606.ENSP00000285093	0.978	3-ketoacyl-CoA thiolase, mitochondrial
5	9606.ENSP00000422607	0.971	Long-chain-fatty-acid--CoA ligase 1
6	9606.ENSP00000231887	0.970	Peroxisomal bifunctional enzyme
7	9606.ENSP00000357535	0.967	Enoyl-CoA hydratase, mitochondrial
8	9606.ENSP00000350012	0.958	Long-chain-fatty-acid--CoA ligase 3
9	9606.ENSP00000333664	0.957	3-ketoacyl-CoA thiolase, peroxisomal
10	9606.ENSP00000348429	0.953	Long-chain-fatty-acid--CoA ligase 5
11	9606.ENSP00000267842	0.950	Very long-chain acyl-CoA synthetase
12	9606.ENSP00000465589	0.949	Long-chain-fatty-acid--CoA ligase ACSBG2
13	9606.ENSP00000339787	0.947	Long-chain-fatty-acid--CoA ligase 4
14	9606.ENSP00000258873	0.941	Long-chain-fatty-acid--CoA ligase ACSBG1
15	9606.ENSP00000368566	0.940	Long-chain-fatty-acid--CoA ligase 6
16	9606.ENSP00000293217	0.936	Peroxisomal acyl-coenzyme A oxidase 1
17	9606.ENSP00000438689	0.922	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
18	9606.ENSP00000242592	0.912	Short-chain specific acyl-CoA dehydrogenase, mitochondrial
19	9606.ENSP00000348775	0.888	Peroxisomal acyl-coenzyme A oxidase 3
20	9606.ENSP00000357873	0.886	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005488	0.996	binding
GO:0003995	0.996	acyl-CoA dehydrogenase activity
GO:0005515	0.987	protein binding
GO:1901363	0.841	heterocyclic compound binding
GO:0036094	0.832	small molecule binding
GO:0097159	0.830	organic cyclic compound binding
GO:0000166	0.810	nucleotide binding
GO:0043168	0.796	anion binding
GO:0050660	0.654	flavin adenine dinucleotide binding
GO:0004466	0.465	long-chain-acyl-CoA dehydrogenase activity
GO:0042802	0.427	identical protein binding
GO:0008289	0.317	lipid binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0044238	0.999	primary metabolic process
GO:0019752	0.997	carboxylic acid metabolic process
GO:0006631	0.990	fatty acid metabolic process
GO:0044282	0.985	small molecule catabolic process
GO:0019395	0.981	fatty acid oxidation
GO:0044242	0.979	cellular lipid catabolic process
GO:0046395	0.977	carboxylic acid catabolic process
GO:0009062	0.971	fatty acid catabolic process
GO:0006635	0.942	fatty acid beta-oxidation
GO:0006807	0.408	nitrogen compound metabolic process
GO:1901564	0.364	organonitrogen compound metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005739	0.999	mitochondrion
GO:0070013	0.997	intracellular organelle lumen
GO:0016020	0.803	membrane
GO:0005759	0.776	mitochondrial matrix
GO:0005740	0.400	mitochondrial envelope
GO:0031090	0.369	organelle membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:1.3.-.-	0.996	Acting on the CH-CH group of donors.
RHEA:17721	0.465	a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]
EC:1.3.8.8	0.465	long-chain-acyl-CoA dehydrogenase.

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