StarFunc result for job id P29374

User Input

>input (1257 residues)
MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQDNTTQLVQDDQVKGPL
RVGAIVETRTSDGSFQEAIISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETL
DQLPLTNPEHFGTPVIAKKTNRGRRSSLPVTEDEKEEESSEEEDEDKRRLNDELLGKVVS
VVSATERTEWYPALVISPSCNDDITVKKDQCLVRSFIDSKFYSIARKDIKEVDILNLPES
ELSTKPGLQKASIFLKTRVVPDNWKMDISEILESSSSDDEDGPAEENDEEKEKEAKKTEE
EVPEEELDPEERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGCDNID
SGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTVHHHEPKVKEE
KKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRIARDVNSI
KKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQEDSDK
DSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIYEASIKSTE
IDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEKDEKRDEE
RQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSCSSDSETEDALEKNLINEELSLKDE
LEKNENLNDDKLDEENPKISAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTE
EVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSS
ATEDEIDQCVKEKKLKRKILGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNF
EQHFERENEGMPSLIAESNQCIQQLTSERFDSPAEETVNIPLKEDEDAMPLIGPETLVCH
EVDLDDLDEKDKTSIEDVAVESSESNSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVK
SESDITIEVDSIAEESQEGLCERESANGFETNVASGTCSIIVQERESREKGQKRPSDGNS
GLMAKKQKRTPKRTSAAAKNEKNGTGQSSDSEDLPVLDNSSKCTPVKHLNVSKPQKLARS
PARISPHIKDGEKDKHREKHPNSSPRTYKWSFQLNELDNMNSTERISFLQEKLQEIRKYY
MSLKSEVATIDRRRKRLKKKDREVSHAGASMSSASSDTGMSPSSSSPPQNVLAVECR

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A0A024R657	0.217	0.217	0.000	1257	1.000	1.000	A0A024R657.pdb.gz
2	AFDB:F8VPQ2	0.290	0.290	0.000	1261	0.858	0.856	F8VPQ2.pdb.gz	ARI4A_MOUSE AT-rich interactive domain-containing protein 4A OS=Mus musculus OX=10090 GN=Arid4a PE=1 SV=1
3	AFDB:A2CG63	0.198	0.190	1.116E-78	1314	0.432	0.413	A2CG63.pdb.gz	ARI4B_MOUSE AT-rich interactive domain-containing protein 4B OS=Mus musculus OX=10090 GN=Arid4b PE=1 SV=1
4	AFDB:Q4LE39	0.204	0.199	8.616E-78	1312	0.436	0.418	Q4LE39.pdb.gz	ARI4B_HUMAN AT-rich interactive domain-containing protein 4B OS=Homo sapiens OX=9606 GN=ARID4B PE=1 SV=2
5	AFDB:Q9VWP5	0.116	0.066	1.432E-38	2486	0.243	0.123	Q9VWP5.pdb.gz	Q9VWP5_DROME Hat-trick, isoform D OS=Drosophila melanogaster OX=7227 GN=htk PE=1 SV=4
6	AFDB:Q8BM75	0.082	0.087	2.929E-5	1188	0.118	0.125	Q8BM75.pdb.gz	ARI5B_MOUSE AT-rich interactive domain-containing protein 5B OS=Mus musculus OX=10090 GN=Arid5b PE=1 SV=3
7	AFDB:Q14865	0.082	0.087	9.563E-5	1188	0.113	0.120	Q14865.pdb.gz	ARI5B_HUMAN AT-rich interactive domain-containing protein 5B OS=Homo sapiens OX=9606 GN=ARID5B PE=1 SV=3
8	PDB:6hiwDB	0.057	0.062	2.208E-4	1111	0.020	0.023	6hiwDB.pdb.gz	Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes.
9	AFDB:O13736	0.056	0.053	2.411E-3	1420	0.106	0.094	O13736.pdb.gz	SLA1_SCHPO Actin cytoskeleton-regulatory complex protein sla1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=sla1 PE=1 SV=1
10	AFDB:Q5ALV2	0.043	0.043	2.544E-3	1257	0.102	0.102	Q5ALV2.pdb.gz	SLA1_CANAL Actin cytoskeleton-regulatory complex protein SLA1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=SLA1 PE=1 SV=1
11	AFDB:Q9VUQ9	0.037	0.026	2.308E-2	2139	0.095	0.056	Q9VUQ9.pdb.gz	Q9VUQ9_DROME non-specific serine/threonine protein kinase OS=Drosophila melanogaster OX=7227 GN=dop PE=1 SV=1
12	PDB:7okyZ	0.044	0.121	3.285E-2	374	0.029	0.099	7okyZ.pdb.gz	Allosteric transcription stimulation by RNA polymerase II super elongation complex.
13	PDB:2lqnA	0.035	0.121	4.787E-2	303	0.020	0.083	2lqnA.pdb.gz
14	PDB:2ns2A	0.032	0.174	5.051E-2	201	0.023	0.144	2ns2A.pdb.gz	Structure of human spindlin1. Tandem tudor-like domains for cell cycle regulation
15	PDB:6tedZ	0.040	0.091	6.264E-2	510	0.025	0.061	6tedZ.pdb.gz	Structure of complete Pol II-DSIF-PAF-SPT6 transcription complex reveals RTF1 allosteric activation.
16	PDB:7abi7	0.041	0.192	9.127E-2	236	0.010	0.051	7abi7.pdb.gz	Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation.
17	PDB:7e29A	0.054	0.131	1.073E-1	496	0.011	0.028	7e29A.pdb.gz	H3K36 methylation and DNA-binding both promote Ioc4 recruitment and Isw1b remodeler function.
18	PDB:7w3ax	0.038	0.071	2.536E-1	494	0.014	0.034	7w3ax.pdb.gz	USP14-regulated allostery of the human proteasome by time-resolved cryo-EM.
19	PDB:7un3A	0.056	0.102	2.824E-1	649	0.019	0.037	7un3A.pdb.gz
20	PDB:5ikjA	0.049	0.121	3.145E-1	448	0.022	0.062	5ikjA.pdb.gz	SHREC Silences Heterochromatin via Distinct Remodeling and Deacetylation Modules.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	F8VPQ2	0.0	1833	1261	0.858	0.856	ARI4A_MOUSE AT-rich interactive domain-containing protein 4A OS=Mus musculus OX=10090 GN=Arid4a PE=1 SV=1
2	P29374	0.0	2557	1257	1.000	1.000	ARI4A_HUMAN AT-rich interactive domain-containing protein 4A OS=Homo sapiens OX=9606 GN=ARID4A PE=1 SV=3
3	A2CG63	8.98e-160	514	1314	0.232	0.221	ARI4B_MOUSE AT-rich interactive domain-containing protein 4B OS=Mus musculus OX=10090 GN=Arid4b PE=1 SV=1
4	Q4LE39	1.67e-158	511	1312	0.209	0.200	ARI4B_HUMAN AT-rich interactive domain-containing protein 4B OS=Homo sapiens OX=9606 GN=ARID4B PE=1 SV=2
5	Q9VWP5	1.31e-80	295	2486	0.137	0.069	Q9VWP5_DROME Hat-trick, isoform D OS=Drosophila melanogaster OX=7227 GN=htk PE=1 SV=4
6	A0A0K3AXH1	2.48e-28	126	1648	0.057	0.044	ARID1_CAEEL AT-rich interactive domain-containing protein arid-1 OS=Caenorhabditis elegans OX=6239 GN=arid-1 PE=3 SV=1
7	Q8IVW6	3.87e-17	89.0	561	0.049	0.111	ARI3B_HUMAN AT-rich interactive domain-containing protein 3B OS=Homo sapiens OX=9606 GN=ARID3B PE=1 SV=2
8	Q9Z1N7	4.11e-16	85.5	568	0.034	0.076	ARI3B_MOUSE AT-rich interactive domain-containing protein 3B OS=Mus musculus OX=10090 GN=Arid3b PE=1 SV=1
9	Q62431	1.73e-14	80.5	601	0.031	0.065	ARI3A_MOUSE AT-rich interactive domain-containing protein 3A OS=Mus musculus OX=10090 GN=Arid3a PE=1 SV=1
10	A6NKF2	3.15e-14	78.6	412	0.029	0.090	ARI3C_HUMAN AT-rich interactive domain-containing protein 3C OS=Homo sapiens OX=9606 GN=ARID3C PE=1 SV=1
11	Q99856	4.70e-14	79.3	593	0.027	0.057	ARI3A_HUMAN AT-rich interactive domain-containing protein 3A OS=Homo sapiens OX=9606 GN=ARID3A PE=1 SV=2
12	A6PWV5	9.51e-14	77.0	409	0.029	0.090	ARI3C_MOUSE AT-rich interactive domain-containing protein 3C OS=Mus musculus OX=10090 GN=Arid3c PE=2 SV=2
13	B7ZP08	9.86e-14	77.0	379	0.029	0.098	B7ZP08_MOUSE AT-rich interactive domain-containing protein 3 OS=Mus musculus OX=10090 GN=Arid3c PE=2 SV=1
14	Q24573	1.05e-13	78.6	911	0.029	0.040	DRI_DROME Protein dead ringer OS=Drosophila melanogaster OX=7227 GN=retn PE=1 SV=2
15	O02326	1.20e-10	67.8	467	0.029	0.079	CFI1_CAEEL AT-rich interactive domain-containing protein cfi-1 OS=Caenorhabditis elegans OX=6239 GN=cfi-1 PE=1 SV=3
16	Q8BM75	4.67e-10	66.6	1188	0.028	0.029	ARI5B_MOUSE AT-rich interactive domain-containing protein 5B OS=Mus musculus OX=10090 GN=Arid5b PE=1 SV=3
17	Q14865	6.77e-10	66.2	1188	0.028	0.029	ARI5B_HUMAN AT-rich interactive domain-containing protein 5B OS=Homo sapiens OX=9606 GN=ARID5B PE=1 SV=3
18	Q3U108	8.47e-09	62.4	590	0.028	0.059	ARI5A_MOUSE AT-rich interactive domain-containing protein 5A OS=Mus musculus OX=10090 GN=Arid5a PE=1 SV=1
19	A0A669KBH0	1.30e-08	60.5	327	0.023	0.089	A0A669KBH0_HUMAN AT-rich interaction domain 5A OS=Homo sapiens OX=9606 GN=ARID5A PE=1 SV=1
20	Q03989	3.21e-08	60.5	594	0.023	0.049	ARI5A_HUMAN AT-rich interactive domain-containing protein 5A OS=Homo sapiens OX=9606 GN=ARID5A PE=1 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF01388 ARID	2.3e-16	71.6	ARID/BRIGHT DNA binding domain
2	PF00855 PWWP	8.4e+02	11.9	PWWP domain
3	PF08169 RBB1NT	6.7e-32	120.8	RBB1NT (NUC162) domain
4	PF11717 Tudor-knot	2.7e-05	35.3	RNA binding activity-knot of a chromodomain
5	PF18104 Tudor_2	2.1	19.4	Jumonji domain-containing protein 2A Tudor domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000347602

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000396052	0.996	Breast cancer metastasis-suppressor 1
2	9606.ENSP00000362649	0.971	Histone deacetylase 1
3	9606.ENSP00000378402	0.957	Paired amphipathic helix protein Sin3a
4	9606.ENSP00000296504	0.949	Histone deacetylase complex subunit SAP30
5	9606.ENSP00000443988	0.942	Sin3 histone deacetylase corepressor complex component SDS3
6	9606.ENSP00000369424	0.920	Histone-binding protein RBBP7
7	9606.ENSP00000297012	0.915	Histone H2A type 1-A
8	9606.ENSP00000328484	0.915	Histone H2A type 1-J
9	9606.ENSP00000332194	0.915	Histone H2A type 2-C
10	9606.ENSP00000332790	0.915	Histone H2A type 2-B
11	9606.ENSP00000341094	0.915	Histone H2A type 1-D
12	9606.ENSP00000355656	0.915	Histone H2A type 3
13	9606.ENSP00000366679	0.915	Histone H2A type 1-H
14	9606.ENSP00000367022	0.915	Histone H2A type 1-C
15	9606.ENSP00000358151	0.914	Histone H2B type 2-E
16	9606.ENSP00000274764	0.913	Histone H2B type 1-A
17	9606.ENSP00000289316	0.913	Histone H2B type 1-D
18	9606.ENSP00000349430	0.913	Histone H2B type 1-K
19	9606.ENSP00000366618	0.913	Histone H2B type 1-L
20	9606.ENSP00000445831	0.913	Histone H2B type 2-F

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.999	protein binding
GO:0003677	0.999	DNA binding
GO:0003682	0.300	chromatin binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0050794	0.995	regulation of cellular process
GO:0060255	0.989	regulation of macromolecule metabolic process
GO:0031323	0.988	regulation of cellular metabolic process
GO:0080090	0.987	regulation of primary metabolic process
GO:0051171	0.987	regulation of nitrogen compound metabolic process
GO:0048519	0.985	negative regulation of biological process
GO:0048523	0.983	negative regulation of cellular process
GO:0010468	0.983	regulation of gene expression
GO:0019219	0.980	regulation of nucleobase-containing compound metabolic process
GO:0010605	0.968	negative regulation of macromolecule metabolic process
GO:0031324	0.968	negative regulation of cellular metabolic process
GO:0051253	0.960	negative regulation of RNA metabolic process
GO:0045892	0.946	negative regulation of DNA-templated transcription
GO:0009987	0.865	cellular process
GO:0048518	0.716	positive regulation of biological process
GO:0071704	0.673	organic substance metabolic process
GO:0044238	0.673	primary metabolic process
GO:0043170	0.664	macromolecule metabolic process
GO:0048522	0.648	positive regulation of cellular process
GO:0006807	0.636	nitrogen compound metabolic process
GO:0010604	0.635	positive regulation of macromolecule metabolic process
GO:0006357	0.633	regulation of transcription by RNA polymerase II
GO:0051173	0.603	positive regulation of nitrogen compound metabolic process
GO:0031325	0.597	positive regulation of cellular metabolic process
GO:0071840	0.591	cellular component organization or biogenesis
GO:0016043	0.569	cellular component organization
GO:1901564	0.566	organonitrogen compound metabolic process
GO:0019538	0.558	protein metabolic process
GO:0043412	0.545	macromolecule modification
GO:0006325	0.516	chromatin organization
GO:0036211	0.511	protein modification process
GO:0045935	0.494	positive regulation of nucleobase-containing compound metabolic process
GO:0045893	0.387	positive regulation of DNA-templated transcription

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005886	1.000	plasma membrane
GO:0005829	1.000	cytosol
GO:0005654	1.000	nucleoplasm
GO:0032991	0.950	protein-containing complex
GO:0043232	0.573	intracellular non-membrane-bounded organelle

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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