StarFunc result for job id P29803

User Input

>input (388 residues)
MLAAFISRVLRRVAQKSARRVLVASRNSSNDATFEIKKCDLYLLEEGPPVTTVLTRAEGL
KYYRMMLTVRRMELKADQLYKQKFIRGFCHLCDGQEACCVGLEAGINPSDHVITSYRAHG
VCYTRGLSVRSILAELTGRRGGCAKGKGGSMHMYTKNFYGGNGIVGAQGPLGAGIALACK
YKGNDEICLTLYGDGAANQGQIAEAFNMAALWKLPCVFICENNLYGMGTSTERAAASPDY
YKRGNFIPGLKVDGMDVLCVREATKFAANYCRSGKGPILMELQTYRYHGHSMSDPGVSYR
TREEIQEVRSKRDPIIILQDRMVNSKLATVEELKEIGAEVRKEIDDAAQFATTDPEPHLE
ELGHHIYSSDSSFEVRGANPWIKFKSVS

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P29803	1.000	1.000	3.155E-76	388	1.000	1.000	P29803.pdb.gz	ODPAT_HUMAN Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial OS=Homo sapiens OX=9606 GN=PDHA2 PE=1 SV=1
2	AFDB:P35487	0.950	0.942	3.145E-65	391	0.729	0.724	P35487.pdb.gz	ODPAT_MOUSE Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial OS=Mus musculus OX=10090 GN=Pdha2 PE=1 SV=1
3	PDB:3exeA	0.932	0.996	1.587E-63	363	0.809	0.865	3exeA.pdb.gz	Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops.
4	PDB:6cerA	0.871	0.988	2.464E-57	342	0.758	0.860	6cerA.pdb.gz	Pyruvate dehydrogenase complex deficiency is linked to regulatory loop disorder in the alpha V138M variant of human pyruvate dehydrogenase.
5	AFDB:Q8I111	0.921	0.864	6.807E-53	414	0.557	0.522	Q8I111.pdb.gz	Q8I111_CAEEL Pyruvate dehydrogenase E1 component subunit alpha OS=Caenorhabditis elegans OX=6239 GN=pdha-1 PE=1 SV=1
6	AFDB:Q54C70	0.886	0.912	1.262E-48	377	0.479	0.493	Q54C70.pdb.gz	ODPA_DICDI Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial OS=Dictyostelium discoideum OX=44689 GN=pdhA PE=1 SV=1
7	AFDB:Q7KVX1	0.898	0.788	6.731E-48	443	0.526	0.460	Q7KVX1.pdb.gz	Q7KVX1_DROME Pyruvate dehydrogenase E1 component subunit alpha OS=Drosophila melanogaster OX=7227 GN=Pdha PE=1 SV=1
8	AFDB:P16387	0.889	0.822	1.982E-47	420	0.474	0.438	P16387.pdb.gz	ODPA_YEAST Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=PDA1 PE=1 SV=2
9	AFDB:Q8H1Y0	0.902	0.891	3.053E-47	393	0.474	0.468	Q8H1Y0.pdb.gz	ODPA2_ARATH Pyruvate dehydrogenase E1 component subunit alpha-2, mitochondrial OS=Arabidopsis thaliana OX=3702 GN=IAR4 PE=1 SV=2
10	AFDB:P52901	0.894	0.892	5.836E-47	389	0.466	0.465	P52901.pdb.gz	ODPA1_ARATH Pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial OS=Arabidopsis thaliana OX=3702 GN=E1 ALPHA PE=1 SV=2
11	AFDB:Q9ZQY0	0.898	0.889	5.341E-46	392	0.482	0.477	Q9ZQY0.pdb.gz	Q9ZQY0_MAIZE Pyruvate dehydrogenase E1 component subunit alpha OS=Zea mays OX=4577 PE=4 SV=1
12	AFDB:Q10489	0.889	0.844	2.060E-45	409	0.482	0.457	Q10489.pdb.gz	ODPA_SCHPO Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=pda1 PE=1 SV=1
13	PDB:2bffA	0.767	0.760	4.665E-24	392	0.232	0.230	2bffA.pdb.gz	A Versatile Conformational Switch Regulates Reactivity in Human Branched-Chain Alpha-Ketoacid Dehydrogenase.
14	PDB:1umbA	0.783	0.837	4.924E-24	362	0.245	0.262	1umbA.pdb.gz	Ligand-induced Conformational Changes and a Reaction Intermediate in Branched-chain 2-Oxo Acid Dehydrogenase (E1) from Thermus thermophilus HB8, as Revealed by X-ray Crystallography
15	PDB:3dufA	0.733	0.777	7.077E-22	365	0.229	0.244	3dufA.pdb.gz	Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multienzyme complex
16	PDB:1um9C	0.703	0.809	2.938E-20	335	0.224	0.260	1um9C.pdb.gz
17	PDB:1v1mA	0.715	0.745	4.776E-20	372	0.206	0.215	1v1mA.pdb.gz	Cross-Talk between Thiamin Diphosphate Binding and Phosphorylation Loop Conformation in Human Branched-Chain Alpha-Keto Acid Decarboxylase/Dehydrogenase.
18	PDB:3dv0E	0.678	0.761	2.413E-19	344	0.206	0.233	3dv0E.pdb.gz	Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multienzyme complex
19	PDB:6u3jA	0.600	0.287	3.249E-12	876	0.178	0.079	6u3jA.pdb.gz	Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex.
20	PDB:6vefA	0.572	0.282	7.333E-9	844	0.162	0.075	6vefA.pdb.gz	Cryo-EM Structure of Escherichia coli 2-oxoglutarate dehydrogenase E1 component sucA

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P08559	0.0	670	390	0.858	0.854	ODPA_HUMAN Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial OS=Homo sapiens OX=9606 GN=PDHA1 PE=1 SV=3
2	P26284	0.0	696	390	0.858	0.854	ODPA_RAT Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial OS=Rattus norvegicus OX=10116 GN=Pdha1 PE=1 SV=2
3	P29803	0.0	809	388	1.000	1.000	ODPAT_HUMAN Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial OS=Homo sapiens OX=9606 GN=PDHA2 PE=1 SV=1
4	P35486	0.0	699	390	0.863	0.859	ODPA_MOUSE Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial OS=Mus musculus OX=10090 GN=Pdha1 PE=1 SV=1
5	P35487	0.0	603	391	0.747	0.742	ODPAT_MOUSE Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial OS=Mus musculus OX=10090 GN=Pdha2 PE=1 SV=1
6	Q06437	0.0	605	391	0.753	0.747	ODPAT_RAT Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial OS=Rattus norvegicus OX=10116 GN=Pdha2 PE=1 SV=1
7	Q5JPU2	0.0	657	418	0.832	0.773	Q5JPU2_HUMAN Pyruvate dehydrogenase E1 component subunit alpha OS=Homo sapiens OX=9606 GN=PDHA1 PE=1 SV=2
8	P52899	6.17e-158	451	397	0.559	0.547	ODPA_CAEEL Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial OS=Caenorhabditis elegans OX=6239 GN=T05H10.6 PE=3 SV=1
9	Q8I111	8.45e-158	452	414	0.559	0.524	Q8I111_CAEEL Pyruvate dehydrogenase E1 component subunit alpha OS=Caenorhabditis elegans OX=6239 GN=pdha-1 PE=1 SV=1
10	Q9W4H6	1.02e-150	433	399	0.528	0.514	Q9W4H6_DROME Pyruvate dehydrogenase E1 component subunit alpha OS=Drosophila melanogaster OX=7227 GN=Pdha PE=1 SV=2
11	Q7KVX1	5.86e-149	430	443	0.531	0.465	Q7KVX1_DROME Pyruvate dehydrogenase E1 component subunit alpha OS=Drosophila melanogaster OX=7227 GN=Pdha PE=1 SV=1
12	Q7YU05	9.02e-140	403	328	0.490	0.579	Q7YU05_DROME Pyruvate dehydrogenase E1 component subunit alpha OS=Drosophila melanogaster OX=7227 GN=Pdha PE=1 SV=1
13	Q54C70	5.44e-136	395	377	0.492	0.507	ODPA_DICDI Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial OS=Dictyostelium discoideum OX=44689 GN=pdhA PE=1 SV=1
14	P16387	7.72e-128	376	420	0.469	0.433	ODPA_YEAST Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=PDA1 PE=1 SV=2
15	Q9ZQY0	3.98e-126	370	392	0.495	0.490	Q9ZQY0_MAIZE Pyruvate dehydrogenase E1 component subunit alpha OS=Zea mays OX=4577 PE=4 SV=1
16	P52901	4.38e-126	370	389	0.459	0.458	ODPA1_ARATH Pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial OS=Arabidopsis thaliana OX=3702 GN=E1 ALPHA PE=1 SV=2
17	Q10489	7.90e-125	368	409	0.464	0.440	ODPA_SCHPO Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=pda1 PE=1 SV=1
18	Q8H1Y0	2.52e-124	366	393	0.459	0.453	ODPA2_ARATH Pyruvate dehydrogenase E1 component subunit alpha-2, mitochondrial OS=Arabidopsis thaliana OX=3702 GN=IAR4 PE=1 SV=2
19	Q5B2R8	2.66e-122	361	405	0.464	0.444	Q5B2R8_EMENI Pyruvate dehydrogenase E1 component subunit alpha OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=ANIA_05162 PE=4 SV=1
20	Q388X3	2.14e-105	317	378	0.443	0.455	Q388X3_TRYB2 Pyruvate dehydrogenase E1 component alpha subunit, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb10.389.0890 PE=4 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF13292 DXP_synthase_N	1.3e+02	13.2	1-deoxy-D-xylulose-5-phosphate synthase
2	PF00676 E1_dh	7.2e-116	397.9	Dehydrogenase E1 component
3	PF02775 TPP_enzyme_C	29	15.9	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000295266

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000307241	0.999	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
2	9606.ENSP00000280346	0.998	Dihydrolipoamide S-acetyltransferase
3	9606.ENSP00000205402	0.988	Dihydrolipoyl dehydrogenase, mitochondrial
4	9606.ENSP00000227868	0.986	Pyruvate dehydrogenase protein X component, mitochondrial
5	9606.ENSP00000318351	0.958	2-oxoisovalerate dehydrogenase subunit beta, mitochondrial
6	9606.ENSP00000309548	0.954	[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial
7	9606.ENSP00000379503	0.951	[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
8	9606.ENSP00000387536	0.938	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial
9	9606.ENSP00000320171	0.935	Pyruvate kinase PKM
10	9606.ENSP00000339933	0.935	Pyruvate kinase PKLR
11	9606.ENSP00000377532	0.932	Pyruvate carboxylase, mitochondrial
12	9606.ENSP00000376352	0.928	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
13	9606.ENSP00000288050	0.925	Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial
14	9606.ENSP00000005178	0.923	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial
15	9606.ENSP00000321070	0.922	NAD-dependent malic enzyme, mitochondrial
16	9606.ENSP00000358719	0.922	Malic enzyme 1
17	9606.ENSP00000440246	0.922	NADP-dependent malic enzyme, mitochondrial
18	9606.ENSP00000420927	0.921	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
19	9606.ENSP00000319531	0.912	Glycine cleavage system H protein, mitochondrial
20	9606.ENSP00000377115	0.908	Lipoyltransferase 1, mitochondrial

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0016624	1.000	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0004738	1.000	pyruvate dehydrogenase activity
GO:0005515	0.998	protein binding
GO:0004739	0.921	pyruvate dehydrogenase (acetyl-transferring) activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071704	0.997	organic substance metabolic process
GO:0044238	0.997	primary metabolic process
GO:0044237	0.997	cellular metabolic process
GO:0006807	0.996	nitrogen compound metabolic process
GO:0006085	0.991	acetyl-CoA biosynthetic process
GO:0006090	0.986	pyruvate metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005739	1.000	mitochondrion
GO:0070013	0.997	intracellular organelle lumen
GO:0031981	0.976	nuclear lumen
GO:0043232	0.950	intracellular non-membrane-bounded organelle
GO:0005759	0.840	mitochondrial matrix
GO:0032991	0.797	protein-containing complex
GO:1902494	0.552	catalytic complex
GO:1990204	0.425	oxidoreductase complex
GO:0098798	0.358	mitochondrial protein-containing complex

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:1.2.4.-	1.000	With a disulfide as acceptor.
RHEA:19189	0.921	(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2
EC:1.2.4.1	0.921	pyruvate dehydrogenase (acetyl-transferring).

[back to server]