StarFunc result for job id P30043

User Input

>input (206 residues)
MAVKKIAIFGATGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPRPAHVVVGDVLQAAD
VDKTVAGQDAVIVLLGTRNDLSPTTVMSEGARNIVAAMKAHGVDKVVACTSAFLLWDPTK
VPPRLQAVTDDHIRMHKVLRESGLKYVAVMPPHIGDQPLTGAYTVTLDGRGPSRVISKHD
LGHFMLRCLTTDEYDGHSTYPSHQYQ

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	PDB:7er7A	0.993	0.989	2.617E-42	207	1.000	0.995	7er7A.pdb.gz	Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IX beta Reductase B as a Novel Thrombocytopenia Therapeutic Target.
2	AFDB:B5DF65	0.993	0.993	7.040E-41	206	0.937	0.937	B5DF65.pdb.gz
3	AFDB:A0A2R8YEP4	0.858	0.723	2.491E-31	245	0.874	0.735	A0A2R8YEP4.pdb.gz	A0A2R8YEP4_HUMAN Biliverdin reductase B OS=Homo sapiens OX=9606 GN=BLVRB PE=1 SV=1
4	AFDB:Q8SWZ8	0.936	0.945	9.622E-21	204	0.350	0.353	Q8SWZ8.pdb.gz	Q8SWZ8_DROME RH49505p OS=Drosophila melanogaster OX=7227 GN=CG9471 PE=2 SV=1
5	AFDB:Q12437	0.765	0.571	2.252E-13	285	0.248	0.179	Q12437.pdb.gz	AFLI_ASPPU Averufin oxidase A OS=Aspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1) OX=1403190 GN=aflI PE=2 SV=2
6	AFDB:Q8H124	0.774	0.583	6.600E-13	280	0.248	0.182	Q8H124.pdb.gz	Y2446_ARATH Uncharacterized protein At2g34460, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=At2g34460 PE=1 SV=1
7	AFDB:Q94EG6	0.806	0.667	7.896E-13	253	0.180	0.146	Q94EG6.pdb.gz	Y5224_ARATH Uncharacterized protein At5g02240 OS=Arabidopsis thaliana OX=3702 GN=At5g02240 PE=1 SV=1
8	AFDB:F4JSP1	0.762	0.488	1.617E-12	338	0.243	0.148	F4JSP1.pdb.gz	F4JSP1_ARATH NAD(P)-binding Rossmann-fold superfamily protein OS=Arabidopsis thaliana OX=3702 GN=ROQH PE=1 SV=1
9	AFDB:C8VQ62	0.816	0.647	1.935E-12	265	0.233	0.181	C8VQ62.pdb.gz	MDPK_EMENI Oxidoreductase mdpK OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=mdpK PE=3 SV=1
10	AFDB:Q6UEF2	0.790	0.625	3.963E-12	266	0.204	0.158	Q6UEF2.pdb.gz	AFLX_ASPPU Oxidoreductase aflX OS=Aspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1) OX=1403190 GN=aflX PE=3 SV=1
11	AFDB:O80934	0.756	0.497	4.466E-12	325	0.204	0.129	O80934.pdb.gz	Y2766_ARATH Uncharacterized protein At2g37660, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=At2g37660 PE=1 SV=2
12	PDB:2q46A	0.758	0.630	6.933E-11	253	0.189	0.154	2q46A.pdb.gz	Ensemble refinement of protein crystal structures: validation and application.
13	PDB:4r1sA	0.717	0.477	1.507E-10	319	0.170	0.110	4r1sA.pdb.gz	Structural Studies of Cinnamoyl-CoA Reductase and Cinnamyl-Alcohol Dehydrogenase, Key Enzymes of Monolignol Biosynthesis.
14	PDB:3rftA	0.669	0.532	2.908E-10	266	0.214	0.165	3rftA.pdb.gz
15	PDB:4r1uB	0.649	0.445	4.980E-10	309	0.180	0.120	4r1uB.pdb.gz
16	PDB:7qskP	0.671	0.421	2.089E-9	342	0.180	0.108	7qskP.pdb.gz	Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy.
17	PDB:2c59A	0.715	0.422	3.797E-9	364	0.155	0.088	2c59A.pdb.gz	Structure and Function of Gdp-Mannose-3',5'-Epimerase: An Enzyme which Performs Three Chemical Reactions at the Same Active Site.
18	PDB:5b6kA	0.693	0.446	5.119E-9	336	0.160	0.098	5b6kA.pdb.gz
19	PDB:7aqrP	0.687	0.444	6.124E-9	332	0.175	0.108	7aqrP.pdb.gz	A ferredoxin bridge connects the two arms of plant mitochondrial complex I.
20	PDB:7b93P	0.690	0.432	9.304E-9	342	0.204	0.123	7b93P.pdb.gz	Cork-in-bottle mechanism of inhibitor binding to mammalian complex I.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P30043	1.66e-151	420	206	1.000	1.000	BLVRB_HUMAN Flavin reductase (NADPH) OS=Homo sapiens OX=9606 GN=BLVRB PE=1 SV=3
2	V9HWI1	1.66e-151	420	206	1.000	1.000	V9HWI1_HUMAN Epididymis secretory protein Li 10 OS=Homo sapiens OX=9606 GN=HEL-S-10 PE=2 SV=1
3	A0A8I5ZUN1	5.43e-140	391	216	0.932	0.889	A0A8I5ZUN1_RAT Biliverdin reductase B OS=Rattus norvegicus OX=10116 GN=Blvrb PE=1 SV=1
4	A0A2R8YEP4	1.72e-120	343	245	0.883	0.743	A0A2R8YEP4_HUMAN Biliverdin reductase B OS=Homo sapiens OX=9606 GN=BLVRB PE=1 SV=1
5	A0A8I6AHQ8	2.09e-109	315	247	0.816	0.680	A0A8I6AHQ8_RAT Biliverdin reductase B OS=Rattus norvegicus OX=10116 GN=Blvrb PE=1 SV=1
6	A0A8I5ZND2	1.21e-80	238	120	0.539	0.925	A0A8I5ZND2_RAT Biliverdin reductase B OS=Rattus norvegicus OX=10116 GN=Blvrb PE=4 SV=1
7	Q9VH72	7.64e-40	137	204	0.359	0.363	Q9VH72_DROME TA01656p1 OS=Drosophila melanogaster OX=7227 GN=BVR PE=1 SV=1
8	Q8SWZ8	1.64e-39	136	204	0.354	0.358	Q8SWZ8_DROME RH49505p OS=Drosophila melanogaster OX=7227 GN=CG9471 PE=2 SV=1
9	Q8H124	1.30e-08	55.8	280	0.252	0.186	Y2446_ARATH Uncharacterized protein At2g34460, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=At2g34460 PE=1 SV=1
10	Q8X7P7	9.03e-07	50.4	331	0.165	0.103	GNU_ECO57 N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-epimerase OS=Escherichia coli O157:H7 OX=83334 GN=gnu PE=1 SV=1
11	P9WIH5	0.002	40.4	854	0.180	0.043	Y2047_MYCTU Uncharacterized protein Rv2047c OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=Rv2047c PE=1 SV=1
12	O65502	0.006	39.3	395	0.272	0.142	HC244_ARATH Protein HIGH CHLOROPHYLL FLUORESCENCE PHENOTYPE 244, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=HCF244 PE=1 SV=1
13	Q72EM3	0.007	38.9	312	0.180	0.119	Q72EM3_DESVH NAD-dependent epimerase/dehydratase family protein OS=Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough) OX=882 GN=DVU_0554 PE=1 SV=1
14	Q12177	0.020	37.4	298	0.184	0.128	YL056_YEAST Uncharacterized protein YLL056C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=YLL056C PE=2 SV=1
15	W7LL82	0.032	37.0	369	0.199	0.111	FUM13_GIBM7 NAD-dependent epimerase/dehydratase FUM13 OS=Gibberella moniliformis (strain M3125 / FGSC 7600) OX=334819 GN=FUM13 PE=1 SV=1
16	G4NE58	0.060	36.2	321	0.170	0.109	G4NE58_MAGO7 NmrA-like domain-containing protein OS=Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) OX=242507 GN=MGG_00156 PE=4 SV=1
17	P39315	0.15	34.7	286	0.194	0.140	QOR2_ECOLI Quinone oxidoreductase 2 OS=Escherichia coli (strain K12) OX=83333 GN=qorB PE=1 SV=1
18	E9PI87	0.44	33.1	196	0.150	0.158	E9PI87_HUMAN HIV-1 Tat interactive protein 2 OS=Homo sapiens OX=9606 GN=HTATIP2 PE=1 SV=1
19	Q9BUP3	0.82	32.3	242	0.107	0.091	HTAI2_HUMAN Oxidoreductase HTATIP2 OS=Homo sapiens OX=9606 GN=HTATIP2 PE=1 SV=2
20	F4JSP1	1.2	32.0	338	0.160	0.098	F4JSP1_ARATH NAD(P)-binding Rossmann-fold superfamily protein OS=Arabidopsis thaliana OX=3702 GN=ROQH PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF01073 3Beta_HSD	0.59	20.7	3-beta hydroxysteroid dehydrogenase/isomerase family
2	PF01370 Epimerase	2.8e-06	38.6	NAD dependent epimerase/dehydratase family
3	PF16363 GDP_Man_Dehyd	3.2e+02	12.2	GDP-mannose 4,6 dehydratase
4	PF13460 NAD_binding_10	5.5e-34	129.2	NAD(P)H-binding
5	PF05368 NmrA	7.2e-07	40.5	NmrA-like family
6	PF09754 PAC2	3.3e+02	12.7	PAC2 family
7	PF01118 Semialdhyde_dh	1.7e+02	14.0	Semialdehyde dehydrogenase, NAD binding domain
8	PF02254 TrkA_N	2e+02	13.6	TrkA-N domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000263368

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000477572	0.971	Heme oxygenase 2
2	9606.ENSP00000216117	0.963	Heme oxygenase 1
3	9606.ENSP00000385757	0.963	Biliverdin reductase A
4	9606.ENSP00000365926	0.911	Riboflavin kinase
5	9606.ENSP00000468767	0.904	Tartrate-resistant acid phosphatase type 5
6	9606.ENSP00000256997	0.900	Acid phosphatase 2, lysosomal
7	9606.ENSP00000383178	0.764	Protein diaphanous homolog 3
8	9606.ENSP00000229447	0.720	Iodotyrosine deiodinase 1
9	9606.ENSP00000304845	0.712	UDP-glucuronosyltransferase 1-1
10	9606.ENSP00000362549	0.712	UDP-glucuronosyltransferase 1-8
11	9606.ENSP00000303174	0.704	UDP-glucuronosyltransferase 1-6
12	9606.ENSP00000475028	0.703	UDP glucuronosyltransferase 2 family, polypeptide A2
13	9606.ENSP00000387683	0.694	UDP-glucuronosyltransferase 2B11
14	9606.ENSP00000334276	0.693	UDP-glucuronosyltransferase 2B28
15	9606.ENSP00000362513	0.690	UDP-glucuronosyltransferase 1-5
16	9606.ENSP00000251566	0.689	UDP-glucuronosyltransferase 2A3
17	9606.ENSP00000265403	0.683	UDP-glucuronosyltransferase 2B10
18	9606.ENSP00000343838	0.677	UDP-glucuronosyltransferase 1-10
19	9606.ENSP00000362525	0.676	UDP-glucuronosyltransferase 1-7
20	9606.ENSP00000362508	0.675	UDP-glucuronosyltransferase 1-4

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0016646	0.995	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
GO:0016628	0.990	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0044237	0.997	cellular metabolic process
GO:0071704	0.995	organic substance metabolic process
GO:0046483	0.987	heterocycle metabolic process
GO:0006725	0.987	cellular aromatic compound metabolic process
GO:0034641	0.987	cellular nitrogen compound metabolic process
GO:1901360	0.985	organic cyclic compound metabolic process
GO:0042168	0.982	heme metabolic process
GO:0044248	0.957	cellular catabolic process
GO:1901575	0.947	organic substance catabolic process
GO:0019439	0.947	aromatic compound catabolic process
GO:0044270	0.945	cellular nitrogen compound catabolic process
GO:1901361	0.941	organic cyclic compound catabolic process
GO:0046700	0.936	heterocycle catabolic process
GO:1901565	0.912	organonitrogen compound catabolic process
GO:0044238	0.417	primary metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005737	0.999	cytoplasm
GO:0043231	0.999	intracellular membrane-bounded organelle
GO:0070013	0.994	intracellular organelle lumen
GO:0016020	0.988	membrane
GO:0005634	0.987	nucleus
GO:0005829	0.986	cytosol
GO:0031981	0.978	nuclear lumen
GO:0005576	0.947	extracellular region
GO:0005654	0.933	nucleoplasm
GO:0071944	0.928	cell periphery
GO:0031982	0.908	vesicle
GO:0005615	0.904	extracellular space
GO:0005886	0.843	plasma membrane
GO:0070062	0.775	extracellular exosome
GO:0030054	0.424	cell junction
GO:0042995	0.400	cell projection
GO:0120025	0.364	plasma membrane bounded cell projection
GO:0045202	0.334	synapse

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:1.5.1.-	0.995	With NAD(+) or NADP(+) as acceptor.
EC:1.3.1.-	0.990	With NAD(+) or NADP(+) as acceptor.

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