StarFunc result for job id P30085

User Input

>input (196 residues)
MKPLVVFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNPDSQYGELIEKYIKEG
KIVPVEITISLLKREMDQTMAANAQKNKFLIDGFPRNQDNLQGWNKTMDGKADVSFVLFF
DCNNEICIERCLERGKSSGRSDDNRESLEKRIQTYLQSTKPIIDLYEEMGKVKKIDASKS
VDEVFDEVVQIFDKEG

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P30085	1.000	1.000	2.058E-39	196	1.000	1.000	P30085.pdb.gz	KCY_HUMAN UMP-CMP kinase OS=Homo sapiens OX=9606 GN=CMPK1 PE=1 SV=3
2	PDB:1tevA	0.841	0.849	8.884E-31	194	0.990	1.000	1tevA.pdb.gz
3	AFDB:Q8IGD0	0.910	0.595	1.121E-27	304	0.587	0.378	Q8IGD0.pdb.gz	Q8IGD0_DROME RH52725p (Fragment) OS=Drosophila melanogaster OX=7227 GN=Cmpk PE=2 SV=1
4	AFDB:P20425	0.946	0.951	6.140E-26	195	0.500	0.503	P20425.pdb.gz	KCY_DICDI UMP-CMP kinase OS=Dictyostelium discoideum OX=44689 GN=pyrK PE=1 SV=2
5	AFDB:O17622	0.924	0.948	1.320E-25	191	0.541	0.555	O17622.pdb.gz	KCY1_CAEEL UMP-CMP kinase 1 OS=Caenorhabditis elegans OX=6239 GN=C29F7.3 PE=1 SV=1
6	AFDB:Q20230	0.925	0.949	3.010E-25	191	0.561	0.576	Q20230.pdb.gz	KCY2_CAEEL UMP-CMP kinase 2 OS=Caenorhabditis elegans OX=6239 GN=F40F8.1 PE=1 SV=1
7	AFDB:P15700	0.948	0.911	7.279E-25	204	0.474	0.456	P15700.pdb.gz	KCY_YEAST Uridylate kinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=URA6 PE=1 SV=1
8	AFDB:A0A494BXC7	0.678	0.741	1.158E-23	179	0.750	0.821	A0A494BXC7.pdb.gz	A0A494BXC7_HUMAN nucleoside-diphosphate kinase OS=Homo sapiens OX=9606 GN=CMPK1 PE=1 SV=1
9	PDB:1qf9A	0.930	0.940	3.487E-23	194	0.505	0.510	1qf9A.pdb.gz	pH influences fluoride coordination number of the AlFx phosphoryl transfer transition state analog.
10	AFDB:O59771	0.926	0.950	5.047E-23	191	0.459	0.471	O59771.pdb.gz	KCY_SCHPO Uridylate kinase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPCC1795.05c PE=3 SV=1
11	PDB:1ukyA	0.935	0.935	8.433E-23	196	0.474	0.474	1ukyA.pdb.gz	Substrate specificity and assembly of the catalytic center derived from two structures of ligated uridylate kinase.
12	AFDB:O04905	0.885	0.859	2.624E-22	202	0.515	0.500	O04905.pdb.gz	KCY3_ARATH UMP-CMP kinase 3 OS=Arabidopsis thaliana OX=3702 GN=UMK3 PE=1 SV=1
13	AFDB:Q8VY84	0.913	0.878	5.604E-21	204	0.480	0.461	Q8VY84.pdb.gz	KCY1_ARATH Probable UMP-CMP kinase 1 OS=Arabidopsis thaliana OX=3702 GN=UMK1 PE=2 SV=1
14	PDB:2c95A	0.875	0.879	8.324E-21	195	0.403	0.405	2c95A.pdb.gz	Structure of Adenylate Kinase 1 in Complex with P1, P4-Di(Adenosine)Tetraphosphate
15	PDB:2cdnA	0.838	0.880	3.511E-15	186	0.296	0.312	2cdnA.pdb.gz	The Crystal Structure of Mycobacterium Tuberculosis Adenylate Kinase in Complex with Two Molecules of Adp and Mg2+ Supports an Associative Mechanism for Phosphoryl Transfer.
16	PDB:3tlxB	0.837	0.691	2.164E-13	240	0.301	0.246	3tlxB.pdb.gz	Crystal Structure of PF10_0086, adenylate kinase from plasmodium falciparum
17	PDB:1akeA	0.798	0.734	3.268E-13	214	0.352	0.322	1akeA.pdb.gz	Structure of the complex between adenylate kinase from Escherichia coli and the inhibitor Ap5A refined at 1.9 A resolution. A model for a catalytic transition state.
18	PDB:2c9yA	0.705	0.643	1.000E-12	218	0.332	0.298	2c9yA.pdb.gz	Structure of Human Adenylate Kinase 2
19	PDB:6zjbD	0.821	0.743	2.721E-12	218	0.260	0.234	6zjbD.pdb.gz	Structural Basis for GTP versus ATP Selectivity in the NMP Kinase AK3.
20	PDB:1dvrA	0.707	0.638	1.118E-11	220	0.270	0.241	1dvrA.pdb.gz	Structure of a mutant adenylate kinase ligated with an ATP-analogue showing domain closure over ATP.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P30085	3.21e-145	403	196	1.000	1.000	KCY_HUMAN UMP-CMP kinase OS=Homo sapiens OX=9606 GN=CMPK1 PE=1 SV=3
2	Q4KM73	3.98e-141	393	196	0.969	0.969	KCY_RAT UMP-CMP kinase OS=Rattus norvegicus OX=10116 GN=Cmpk1 PE=1 SV=2
3	A0A494BXC7	1.84e-97	282	179	0.750	0.821	A0A494BXC7_HUMAN nucleoside-diphosphate kinase OS=Homo sapiens OX=9606 GN=CMPK1 PE=1 SV=1
4	Q9VBI2	2.09e-80	241	253	0.592	0.458	Q9VBI2_DROME UMP-CMP kinase OS=Drosophila melanogaster OX=7227 GN=Cmpk PE=1 SV=1
5	Q8IGD0	7.15e-79	239	304	0.587	0.378	Q8IGD0_DROME RH52725p (Fragment) OS=Drosophila melanogaster OX=7227 GN=Cmpk PE=2 SV=1
6	Q9TW62	7.04e-73	220	196	0.587	0.587	Q9TW62_DROME UMP-CMP kinase OS=Drosophila melanogaster OX=7227 GN=Cmpk PE=2 SV=1
7	Q20230	2.22e-72	219	191	0.556	0.571	KCY2_CAEEL UMP-CMP kinase 2 OS=Caenorhabditis elegans OX=6239 GN=F40F8.1 PE=1 SV=1
8	O17622	4.32e-72	218	191	0.536	0.550	KCY1_CAEEL UMP-CMP kinase 1 OS=Caenorhabditis elegans OX=6239 GN=C29F7.3 PE=1 SV=1
9	O04905	2.29e-62	194	202	0.515	0.500	KCY3_ARATH UMP-CMP kinase 3 OS=Arabidopsis thaliana OX=3702 GN=UMK3 PE=1 SV=1
10	P15700	1.78e-61	191	204	0.474	0.456	KCY_YEAST Uridylate kinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=URA6 PE=1 SV=1
11	P20425	3.12e-58	183	195	0.520	0.523	KCY_DICDI UMP-CMP kinase OS=Dictyostelium discoideum OX=44689 GN=pyrK PE=1 SV=2
12	O59771	1.11e-57	181	191	0.454	0.466	KCY_SCHPO Uridylate kinase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPCC1795.05c PE=3 SV=1
13	Q8VY84	2.38e-56	178	204	0.474	0.456	KCY1_ARATH Probable UMP-CMP kinase 1 OS=Arabidopsis thaliana OX=3702 GN=UMK1 PE=2 SV=1
14	P39069	1.22e-50	164	194	0.403	0.407	KAD1_RAT Adenylate kinase isoenzyme 1 OS=Rattus norvegicus OX=10116 GN=Ak1 PE=1 SV=3
15	Q6NMK6	4.80e-50	164	259	0.423	0.320	KCY2_ARATH Probable UMP-CMP kinase 2 OS=Arabidopsis thaliana OX=3702 GN=UMK2 PE=2 SV=2
16	P05081	7.30e-49	159	194	0.393	0.397	KAD1_CHICK Adenylate kinase isoenzyme 1 OS=Gallus gallus OX=9031 GN=AK1 PE=1 SV=1
17	P00571	9.37e-49	159	194	0.398	0.402	KAD1_PIG Adenylate kinase isoenzyme 1 OS=Sus scrofa OX=9823 GN=AK1 PE=1 SV=1
18	P00568	2.81e-48	157	194	0.398	0.402	KAD1_HUMAN Adenylate kinase isoenzyme 1 OS=Homo sapiens OX=9606 GN=AK1 PE=1 SV=3
19	Q6FGX9	2.81e-48	157	194	0.398	0.402	Q6FGX9_HUMAN Adenylate kinase isoenzyme 1 OS=Homo sapiens OX=9606 GN=AK1 PE=2 SV=1
20	Q9R0Y5	3.10e-48	157	194	0.393	0.397	KAD1_MOUSE Adenylate kinase isoenzyme 1 OS=Mus musculus OX=10090 GN=Ak1 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF13207 AAA_17	4.7e-34	129.2	AAA domain
2	PF13238 AAA_18	0.00011	34.2	AAA domain
3	PF13671 AAA_33	0.092	24.4	AAA domain
4	PF00406 ADK	2.5e-41	152.7	Adenylate kinase
5	PF02224 Cytidylate_kin	25	16.0	Cytidylate kinase
6	PF01712 dNK	1.8e+02	13.4	Deoxynucleoside kinase
7	PF02223 Thymidylate_kin	4.6e-05	34.7	Thymidylate kinase
8	PF06414 Zeta_toxin	0.051	24.5	Zeta toxin

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000360939

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000286648	0.970	Deoxycytidine kinase
2	9606.ENSP00000219479	0.967	Nucleoside diphosphate kinase, mitochondrial
3	9606.ENSP00000232607	0.963	Uridine 5'-monophosphate synthase
4	9606.ENSP00000337060	0.950	Nucleoside diphosphate kinase A
5	9606.ENSP00000300738	0.946	Ribonucleoside-diphosphate reductase large subunit
6	9606.ENSP00000416658	0.942	Nucleoside diphosphate kinase 6
7	9606.ENSP00000251810	0.936	Ribonucleoside-diphosphate reductase subunit M2 B
8	9606.ENSP00000356785	0.931	Nucleoside diphosphate kinase 7
9	9606.ENSP00000353770	0.929	Ribonucleoside-diphosphate reductase subunit M2
10	9606.ENSP00000219302	0.927	Nucleoside diphosphate kinase 3
11	9606.ENSP00000304802	0.926	Thymidylate kinase
12	9606.ENSP00000265191	0.921	Nucleoside diphosphate kinase homolog 5
13	9606.ENSP00000425809	0.868	Phosphoacetylglucosamine mutase
14	9606.ENSP00000256722	0.844	UMP-CMP kinase 2, mitochondrial
15	9606.ENSP00000346155	0.753	Uridine-cytidine kinase-like 1
16	9606.ENSP00000364212	0.741	Cytidine deaminase
17	9606.ENSP00000324842	0.737	Acetoacetyl-CoA synthetase
18	9606.ENSP00000335246	0.733	Ectonucleoside triphosphate diphosphohydrolase 5
19	9606.ENSP00000325548	0.732	Cytosolic non-specific dipeptidase
20	9606.ENSP00000301825	0.726	Ectonucleoside triphosphate diphosphohydrolase 3

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0050145	0.998	nucleoside monophosphate kinase activity
GO:0005488	0.983	binding
GO:0009041	0.838	uridylate kinase activity
GO:0004017	0.817	adenylate kinase activity
GO:0019206	0.767	nucleoside kinase activity
GO:0005515	0.728	protein binding
GO:0033862	0.452	UMP kinase activity
GO:0004550	0.413	nucleoside diphosphate kinase activity
GO:1901363	0.325	heterocyclic compound binding
GO:0097159	0.325	organic cyclic compound binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:1901293	0.995	nucleoside phosphate biosynthetic process
GO:0009165	0.994	nucleotide biosynthetic process
GO:0009259	0.988	ribonucleotide metabolic process
GO:1901137	0.984	carbohydrate derivative biosynthetic process
GO:0009132	0.983	nucleoside diphosphate metabolic process
GO:0006220	0.976	pyrimidine nucleotide metabolic process
GO:0046390	0.945	ribose phosphate biosynthetic process
GO:0072528	0.944	pyrimidine-containing compound biosynthetic process
GO:0009260	0.942	ribonucleotide biosynthetic process
GO:0009185	0.927	ribonucleoside diphosphate metabolic process
GO:0006221	0.865	pyrimidine nucleotide biosynthetic process
GO:0009218	0.818	pyrimidine ribonucleotide metabolic process
GO:0009220	0.359	pyrimidine ribonucleotide biosynthetic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005737	1.000	cytoplasm
GO:0043231	1.000	intracellular membrane-bounded organelle
GO:0070013	0.982	intracellular organelle lumen
GO:0031981	0.974	nuclear lumen
GO:0005576	0.965	extracellular region
GO:0005829	0.958	cytosol
GO:1903561	0.958	extracellular vesicle
GO:0005615	0.948	extracellular space
GO:0070062	0.944	extracellular exosome
GO:0005654	0.933	nucleoplasm
GO:0043232	0.862	intracellular non-membrane-bounded organelle
GO:0005730	0.448	nucleolus

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:24036	0.998	a ribonucleoside 5'-phosphate + ATP = a ribonucleoside 5'-diphosphate + ADP
EC:2.7.4.4	0.998	nucleoside-phosphate kinase.
EC:2.7.4.22	0.838	UMP kinase.
RHEA:12973	0.817	AMP + ATP = 2 ADP
EC:2.7.4.3	0.817	adenylate kinase.
RHEA:24400	0.452	ATP + UMP = ADP + UDP
EC:2.7.4.6	0.413	nucleoside-diphosphate kinase.

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