StarFunc result for job id P30556

User Input

>input (359 residues)
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:O35210	0.833	0.833	3.803E-41	359	0.930	0.930	O35210.pdb.gz	AGTR1_MERUN Type-1 angiotensin II receptor OS=Meriones unguiculatus OX=10047 GN=AGTR1 PE=2 SV=1
2	AFDB:P35373	0.884	0.875	1.327E-34	363	0.604	0.598	P35373.pdb.gz	AGTRB_XENLA Type-1 angiotensin II receptor B OS=Xenopus laevis OX=8355 GN=agtr1-b PE=2 SV=1
3	AFDB:P32303	0.869	0.862	2.872E-33	362	0.593	0.588	P32303.pdb.gz	AGTRA_XENLA Type-1 angiotensin II receptor A OS=Xenopus laevis OX=8355 GN=agtr1-a PE=2 SV=2
4	AFDB:A0T2N3	0.809	0.809	1.042E-21	359	0.331	0.331	A0T2N3.pdb.gz	APJB_DANRE Apelin receptor B OS=Danio rerio OX=7955 GN=aplnrb PE=1 SV=1
5	AFDB:Q7SZP9	0.779	0.773	2.991E-21	362	0.318	0.315	Q7SZP9.pdb.gz	APJA_DANRE Apelin receptor A OS=Danio rerio OX=7955 GN=aplnra PE=1 SV=2
6	AFDB:G3V7C3	0.791	0.789	5.066E-21	360	0.326	0.325	G3V7C3.pdb.gz	G3V7C3_RAT C-C motif chemokine receptor 4 OS=Rattus norvegicus OX=10116 GN=Ccr4 PE=3 SV=1
7	AFDB:Q2TAD5	0.797	0.789	7.522E-21	363	0.295	0.292	Q2TAD5.pdb.gz	APJB_XENLA Apelin receptor B OS=Xenopus laevis OX=8355 GN=aplnr-b PE=2 SV=1
8	AFDB:A0N0Q1	0.779	0.777	4.973E-20	360	0.329	0.328	A0N0Q1.pdb.gz	A0N0Q1_HUMAN Chemokine (C-C motif) receptor 4 OS=Homo sapiens OX=9606 GN=CCR4 PE=2 SV=1
9	AFDB:O88410	0.759	0.743	8.802E-20	367	0.292	0.286	O88410.pdb.gz	CXCR3_MOUSE C-X-C chemokine receptor type 3 OS=Mus musculus OX=10090 GN=Cxcr3 PE=1 SV=2
10	AFDB:P35351	0.776	0.768	1.197E-19	363	0.312	0.309	P35351.pdb.gz	AGTR2_RAT Type-2 angiotensin II receptor OS=Rattus norvegicus OX=10116 GN=Agtr2 PE=1 SV=1
11	PDB:6lw5A	0.718	0.611	7.472E-17	427	0.262	0.220	6lw5A.pdb.gz	Structural basis of ligand binding modes at the human formyl peptide receptor 2.
12	PDB:7vl9R	0.731	0.862	1.799E-16	302	0.279	0.331	7vl9R.pdb.gz	Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1.
13	PDB:7f1qR	0.703	0.689	1.879E-16	367	0.262	0.256	7f1qR.pdb.gz
14	PDB:7f1tA	0.743	0.635	1.879E-16	423	0.267	0.227	7f1tA.pdb.gz	Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5.
15	PDB:7f6hA	0.760	0.888	5.635E-16	305	0.281	0.331	7f6hA.pdb.gz	Cryo-EM structures of human bradykinin receptor-G q proteins complexes.
16	PDB:7eibA	0.736	0.888	7.019E-16	295	0.265	0.322	7eibA.pdb.gz	Molecular basis for kinin selectivity and activation of the human bradykinin receptors.
17	PDB:7sk8A	0.734	0.853	1.042E-15	306	0.267	0.314	7sk8A.pdb.gz	Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.
18	PDB:7wicR	0.704	0.868	1.356E-15	288	0.248	0.309	7wicR.pdb.gz	Structures of the endogenous peptide- and selective non-peptide agonist-bound SSTR2 signaling complexes.
19	PDB:8ef5M	0.688	0.847	7.860E-15	288	0.256	0.319	8ef5M.pdb.gz	Molecular recognition of morphine and fentanyl by the human mu-opioid receptor.
20	PDB:7wvuR	0.719	0.858	1.274E-14	298	0.251	0.302	7wvuR.pdb.gz	Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	O35210	0.0	699	359	0.930	0.930	AGTR1_MERUN Type-1 angiotensin II receptor OS=Meriones unguiculatus OX=10047 GN=AGTR1 PE=2 SV=1
2	P25095	0.0	704	359	0.947	0.947	AGTRA_RAT Type-1 angiotensin II receptor A OS=Rattus norvegicus OX=10116 GN=Agtr1 PE=1 SV=1
3	P25104	0.0	707	359	0.953	0.953	AGTR1_BOVIN Type-1 angiotensin II receptor OS=Bos taurus OX=9913 GN=AGTR1 PE=2 SV=1
4	P29089	0.0	679	359	0.942	0.942	AGTRB_RAT Type-1 angiotensin II receptor B OS=Rattus norvegicus OX=10116 GN=Agtr1b PE=2 SV=1
5	P29754	0.0	702	359	0.944	0.944	AGTRA_MOUSE Type-1 angiotensin II receptor A OS=Mus musculus OX=10090 GN=Agtr1a PE=1 SV=1
6	P29755	0.0	694	359	0.930	0.930	AGTRB_MOUSE Type-1 angiotensin II receptor B OS=Mus musculus OX=10090 GN=Agtr1b PE=3 SV=1
7	P30555	0.0	708	359	0.964	0.964	AGTR1_PIG Type-1 angiotensin II receptor OS=Sus scrofa OX=9823 GN=AGTR1 PE=2 SV=1
8	P30556	0.0	731	359	1.000	1.000	AGTR1_HUMAN Type-1 angiotensin II receptor OS=Homo sapiens OX=9606 GN=AGTR1 PE=1 SV=1
9	P43240	0.0	697	359	0.947	0.947	AGTR1_CANLF Type-1 angiotensin II receptor OS=Canis lupus familiaris OX=9615 GN=AGTR1 PE=2 SV=1
10	Q6NUP5	0.0	729	359	0.997	0.997	Q6NUP5_HUMAN Type-1 angiotensin II receptor OS=Homo sapiens OX=9606 GN=AGTR1 PE=1 SV=1
11	P35373	5.72e-169	477	363	0.621	0.614	AGTRB_XENLA Type-1 angiotensin II receptor B OS=Xenopus laevis OX=8355 GN=agtr1-b PE=2 SV=1
12	P32303	2.18e-163	462	362	0.610	0.605	AGTRA_XENLA Type-1 angiotensin II receptor A OS=Xenopus laevis OX=8355 GN=agtr1-a PE=2 SV=2
13	A0T2N3	4.63e-67	217	359	0.345	0.345	APJB_DANRE Apelin receptor B OS=Danio rerio OX=7955 GN=aplnrb PE=1 SV=1
14	Q7SZP9	3.93e-65	212	362	0.348	0.345	APJA_DANRE Apelin receptor A OS=Danio rerio OX=7955 GN=aplnra PE=1 SV=2
15	P51680	4.65e-65	212	360	0.340	0.339	CCR4_MOUSE C-C chemokine receptor type 4 OS=Mus musculus OX=10090 GN=Ccr4 PE=2 SV=2
16	Q91ZH4	8.97e-64	209	360	0.323	0.322	Q91ZH4_RAT C-C chemokine receptor 4 OS=Rattus norvegicus OX=10116 GN=Ccr4 PE=2 SV=2
17	G3V7C3	2.11e-63	207	360	0.315	0.314	G3V7C3_RAT C-C motif chemokine receptor 4 OS=Rattus norvegicus OX=10116 GN=Ccr4 PE=3 SV=1
18	A0N0Q1	4.72e-62	204	360	0.318	0.317	A0N0Q1_HUMAN Chemokine (C-C motif) receptor 4 OS=Homo sapiens OX=9606 GN=CCR4 PE=2 SV=1
19	P51679	4.72e-62	204	360	0.318	0.317	CCR4_HUMAN C-C chemokine receptor type 4 OS=Homo sapiens OX=9606 GN=CCR4 PE=1 SV=1
20	Q2TAD5	5.38e-59	196	363	0.315	0.311	APJB_XENLA Apelin receptor B OS=Xenopus laevis OX=8355 GN=aplnr-b PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00001 7tm_1	8.8e-53	190.8	7 transmembrane receptor (rhodopsin family)
2	PF10320 7TM_GPCR_Srsx	9.3e-05	33.5	Serpentine type 7TM GPCR chemoreceptor Srsx
3	PF10328 7TM_GPCR_Srx	23	16.0	Serpentine type 7TM GPCR chemoreceptor Srx

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000419422

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000286548	0.999	Guanine nucleotide-binding protein G(q) subunit alpha
2	9606.ENSP00000355627	0.993	Angiotensinogen
3	9606.ENSP00000403701	0.993	Beta-arrestin-2
4	9606.ENSP00000265023	0.988	Kininogen-1
5	9606.ENSP00000319713	0.985	Type-1 angiotensin II receptor-associated protein
6	9606.ENSP00000386444	0.979	S-arrestin
7	9606.ENSP00000409581	0.979	Beta-arrestin-1
8	9606.ENSP00000244007	0.976	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
9	9606.ENSP00000371067	0.973	Tyrosine-protein kinase JAK2
10	9606.ENSP00000339191	0.971	Caveolin-1
11	9606.ENSP00000387760	0.949	Angiotensin-converting enzyme
12	9606.ENSP00000272190	0.943	Renin
13	9606.ENSP00000290866	0.924	Angiotensin-converting enzyme
14	9606.ENSP00000223095	0.911	Plasminogen activator inhibitor 1
15	9606.ENSP00000298316	0.911	ADP-ribosylation factor 6
16	9606.ENSP00000297494	0.906	Nitric oxide synthase, endothelial
17	9606.ENSP00000345195	0.901	Ubiquilin-2
18	9606.ENSP00000389326	0.868	Angiotensin-converting enzyme 2
19	9606.ENSP00000078429	0.853	Guanine nucleotide-binding protein subunit alpha-11
20	9606.ENSP00000308541	0.837	Prothrombin

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0008528	1.000	G protein-coupled peptide receptor activity
GO:0005488	0.995	binding
GO:0005515	0.994	protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0032501	0.996	multicellular organismal process
GO:0065008	0.996	regulation of biological quality
GO:0050896	0.993	response to stimulus
GO:0009987	0.988	cellular process
GO:0003008	0.988	system process
GO:0050789	0.986	regulation of biological process
GO:0050794	0.983	regulation of cellular process
GO:0050886	0.982	endocrine process
GO:0003044	0.982	regulation of systemic arterial blood pressure mediated by a chemical signal
GO:0051716	0.967	cellular response to stimulus
GO:0023052	0.923	signaling
GO:0007154	0.923	cell communication
GO:0001990	0.915	regulation of systemic arterial blood pressure by hormone
GO:0007165	0.879	signal transduction
GO:0003014	0.855	renal system process
GO:0003018	0.804	vascular process in circulatory system
GO:0097746	0.777	blood vessel diameter maintenance
GO:0048518	0.761	positive regulation of biological process
GO:0048522	0.700	positive regulation of cellular process
GO:0008152	0.633	metabolic process
GO:0071704	0.530	organic substance metabolic process
GO:0051239	0.528	regulation of multicellular organismal process
GO:0007186	0.524	G protein-coupled receptor signaling pathway
GO:0032502	0.512	developmental process
GO:0048583	0.504	regulation of response to stimulus
GO:0044237	0.486	cellular metabolic process
GO:0023051	0.479	regulation of signaling
GO:0010646	0.479	regulation of cell communication
GO:0042221	0.476	response to chemical
GO:0019222	0.458	regulation of metabolic process
GO:0006807	0.446	nitrogen compound metabolic process
GO:0070887	0.445	cellular response to chemical stimulus
GO:0006950	0.440	response to stress
GO:0048856	0.435	anatomical structure development
GO:0048519	0.429	negative regulation of biological process
GO:0060255	0.422	regulation of macromolecule metabolic process
GO:0065009	0.403	regulation of molecular function
GO:0080090	0.402	regulation of primary metabolic process
GO:0051171	0.398	regulation of nitrogen compound metabolic process
GO:0031323	0.396	regulation of cellular metabolic process
GO:0009893	0.395	positive regulation of metabolic process
GO:0048523	0.394	negative regulation of cellular process
GO:0007275	0.364	multicellular organism development
GO:0031325	0.353	positive regulation of cellular metabolic process
GO:0010604	0.343	positive regulation of macromolecule metabolic process
GO:0051179	0.335	localization
GO:0032879	0.325	regulation of localization
GO:0010033	0.324	response to organic substance
GO:0009966	0.319	regulation of signal transduction
GO:0048584	0.312	positive regulation of response to stimulus
GO:0051246	0.307	regulation of protein metabolic process
GO:0051049	0.305	regulation of transport

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005886	1.000	plasma membrane
GO:0005622	0.968	intracellular anatomical structure
GO:0043227	0.833	membrane-bounded organelle
GO:0005737	0.832	cytoplasm
GO:0043231	0.744	intracellular membrane-bounded organelle
GO:0031982	0.507	vesicle
GO:0012505	0.466	endomembrane system

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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