StarFunc result for job id P32249

User Input

>input (361 residues)
MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNR
KKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVN
FMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERIT
CMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNK
KALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFN
CCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNG
K

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P32249	1.000	1.000	2.342E-46	361	1.000	1.000	P32249.pdb.gz	GP183_HUMAN G-protein coupled receptor 183 OS=Homo sapiens OX=9606 GN=GPR183 PE=1 SV=3
2	AFDB:Q3U6B2	0.932	0.943	6.821E-41	357	0.870	0.880	Q3U6B2.pdb.gz	GP183_MOUSE G-protein coupled receptor 183 OS=Mus musculus OX=10090 GN=Gpr183 PE=1 SV=1
3	AFDB:A5PLE7	0.859	0.843	8.724E-28	368	0.524	0.514	A5PLE7.pdb.gz	GP83A_DANRE G-protein coupled receptor 183-A OS=Danio rerio OX=7955 GN=gpr183a PE=2 SV=1
4	PDB:7tuzR	0.742	0.933	5.425E-27	284	0.784	0.996	7tuzR.pdb.gz	Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response.
5	AFDB:Q8BLG2	0.742	0.725	5.983E-17	370	0.266	0.259	Q8BLG2.pdb.gz	LPAR4_MOUSE Lysophosphatidic acid receptor 4 OS=Mus musculus OX=10090 GN=Lpar4 PE=2 SV=2
6	AFDB:Q08BG4	0.747	0.755	1.461E-16	357	0.263	0.266	Q08BG4.pdb.gz	Q08BG4_DANRE Lysophosphatidic acid receptor 6 OS=Danio rerio OX=7955 GN=zgc:153784 PE=1 SV=1
7	AFDB:P43657	0.785	0.821	2.764E-16	344	0.274	0.288	P43657.pdb.gz	LPAR6_HUMAN Lysophosphatidic acid receptor 6 OS=Homo sapiens OX=9606 GN=LPAR6 PE=1 SV=3
8	AFDB:Q3U507	0.746	0.800	5.940E-16	335	0.252	0.272	Q3U507.pdb.gz	GP174_MOUSE Probable G-protein coupled receptor 174 OS=Mus musculus OX=10090 GN=Gpr174 PE=2 SV=1
9	AFDB:Q13304	0.738	0.726	1.077E-15	367	0.244	0.240	Q13304.pdb.gz	GPR17_HUMAN Uracil nucleotide/cysteinyl leukotriene receptor OS=Homo sapiens OX=9606 GN=GPR17 PE=1 SV=2
10	AFDB:E7FEL0	0.747	0.724	1.390E-15	373	0.235	0.228	E7FEL0.pdb.gz	E7FEL0_DANRE G-protein coupled receptor 4 OS=Danio rerio OX=7955 GN=gpr4 PE=3 SV=1
11	AFDB:B2R986	0.789	0.841	1.648E-15	337	0.230	0.246	B2R986.pdb.gz	B2R986_HUMAN HCG1774561 OS=Homo sapiens OX=9606 GN=hCG_1774561 PE=2 SV=1
12	PDB:7vl9R	0.713	0.841	5.569E-13	302	0.260	0.311	7vl9R.pdb.gz	Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1.
13	PDB:7f1qR	0.710	0.699	2.684E-12	367	0.227	0.223	7f1qR.pdb.gz
14	PDB:3vw7A	0.682	0.561	1.294E-11	442	0.255	0.208	3vw7A.pdb.gz	High-resolution crystal structure of human protease-activated receptor 1
15	PDB:7x9yR	0.671	0.812	1.600E-11	293	0.224	0.276	7x9yR.pdb.gz
16	PDB:5xszA	0.638	0.519	1.897E-11	448	0.249	0.201	5xszA.pdb.gz
17	PDB:7f1tA	0.698	0.602	2.346E-11	423	0.235	0.201	7f1tA.pdb.gz	Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5.
18	PDB:8ef5M	0.660	0.812	4.253E-11	288	0.224	0.281	8ef5M.pdb.gz	Molecular recognition of morphine and fentanyl by the human mu-opioid receptor.
19	PDB:6ibbA	0.700	0.831	6.235E-11	301	0.227	0.272	6ibbA.pdb.gz	Structural basis of species-selective antagonist binding to the succinate receptor.
20	PDB:7sk8A	0.658	0.764	7.083E-11	306	0.230	0.271	7sk8A.pdb.gz	Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P32249	0.0	749	361	1.000	1.000	GP183_HUMAN G-protein coupled receptor 183 OS=Homo sapiens OX=9606 GN=GPR183 PE=1 SV=3
2	Q3U6B2	0.0	645	357	0.870	0.880	GP183_MOUSE G-protein coupled receptor 183 OS=Mus musculus OX=10090 GN=Gpr183 PE=1 SV=1
3	A5PLE7	9.70e-133	385	368	0.521	0.511	GP83A_DANRE G-protein coupled receptor 183-A OS=Danio rerio OX=7955 GN=gpr183a PE=2 SV=1
4	Q09QM4	2.52e-48	168	339	0.249	0.265	GPR17_RAT Uracil nucleotide/cysteinyl leukotriene receptor OS=Rattus norvegicus OX=10116 GN=Gpr17 PE=2 SV=1
5	Q08BG4	3.91e-48	168	357	0.271	0.275	Q08BG4_DANRE Lysophosphatidic acid receptor 6 OS=Danio rerio OX=7955 GN=zgc:153784 PE=1 SV=1
6	Q6NS65	6.40e-48	167	339	0.247	0.263	GPR17_MOUSE Uracil nucleotide/cysteinyl leukotriene receptor OS=Mus musculus OX=10090 GN=Gpr17 PE=1 SV=1
7	Q13304	1.53e-46	164	367	0.247	0.243	GPR17_HUMAN Uracil nucleotide/cysteinyl leukotriene receptor OS=Homo sapiens OX=9606 GN=GPR17 PE=1 SV=2
8	Q8BMC0	2.57e-46	163	344	0.271	0.285	LPAR6_MOUSE Lysophosphatidic acid receptor 6 OS=Mus musculus OX=10090 GN=Lpar6 PE=1 SV=1
9	Q924T8	8.26e-46	161	339	0.255	0.271	CLTR1_RAT Cysteinyl leukotriene receptor 1 OS=Rattus norvegicus OX=10116 GN=Cysltr1 PE=2 SV=1
10	P32246	1.78e-45	161	355	0.285	0.290	CCR1_HUMAN C-C chemokine receptor type 1 OS=Homo sapiens OX=9606 GN=CCR1 PE=1 SV=1
11	Q99JA4	4.11e-45	160	352	0.258	0.264	CLTR1_MOUSE Cysteinyl leukotriene receptor 1 OS=Mus musculus OX=10090 GN=Cysltr1 PE=1 SV=1
12	P43657	1.74e-44	158	344	0.244	0.256	LPAR6_HUMAN Lysophosphatidic acid receptor 6 OS=Homo sapiens OX=9606 GN=LPAR6 PE=1 SV=3
13	Q920A1	2.48e-43	154	309	0.247	0.288	CLTR2_MOUSE Cysteinyl leukotriene receptor 2 OS=Mus musculus OX=10090 GN=Cysltr2 PE=2 SV=2
14	Q924T9	5.95e-43	153	309	0.252	0.294	CLTR2_RAT Cysteinyl leukotriene receptor 2 OS=Rattus norvegicus OX=10116 GN=Cysltr2 PE=2 SV=1
15	Q99677	7.03e-43	154	370	0.277	0.270	LPAR4_HUMAN Lysophosphatidic acid receptor 4 OS=Homo sapiens OX=9606 GN=LPAR4 PE=1 SV=1
16	A0A2R8PYR8	2.37e-42	153	360	0.238	0.239	A0A2R8PYR8_DANRE Atypical chemokine receptor 3a OS=Danio rerio OX=7955 GN=cxcr7a PE=3 SV=1
17	Q8BLG2	3.83e-42	152	370	0.277	0.270	LPAR4_MOUSE Lysophosphatidic acid receptor 4 OS=Mus musculus OX=10090 GN=Lpar4 PE=2 SV=2
18	A0A0N4STT7	1.90e-41	150	351	0.249	0.256	A0A0N4STT7_DANRE Lysophosphatidic acid receptor 4 OS=Danio rerio OX=7955 GN=lpar4 PE=3 SV=1
19	O35811	4.25e-41	149	361	0.255	0.255	P2RY4_RAT P2Y purinoceptor 4 OS=Rattus norvegicus OX=10116 GN=P2ry4 PE=2 SV=1
20	Q9JJS7	6.26e-41	149	361	0.258	0.258	P2RY4_MOUSE P2Y purinoceptor 4 OS=Mus musculus OX=10090 GN=P2ry4 PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00001 7tm_1	3.5e-48	175.8	7 transmembrane receptor (rhodopsin family)
2	PF13853 7tm_4	0.093	24.1	Olfactory receptor
3	PF10328 7TM_GPCR_Srx	7.8e-06	37.2	Serpentine type 7TM GPCR chemoreceptor Srx

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000365596

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000356429	0.810	Regulator of G-protein signaling 1
2	9606.ENSP00000310721	0.764	25-hydroxycholesterol 7-alpha-hydroxylase
3	9606.ENSP00000360918	0.738	Cholesterol 25-hydroxylase
4	9606.ENSP00000343428	0.724	N-arachidonyl glycine receptor
5	9606.ENSP00000356033	0.685	T-cell activation Rho GTPase-activating protein
6	9606.ENSP00000363596	0.667	Cannabinoid receptor 2
7	9606.ENSP00000411355	0.663	Receptor-type tyrosine-protein phosphatase C
8	9606.ENSP00000355156	0.659	Succinate receptor 1
9	9606.ENSP00000375894	0.656	G-protein coupled receptor 55
10	9606.ENSP00000264192	0.655	Cytohesin-interacting protein
11	9606.ENSP00000234313	0.635	Pleckstrin
12	9606.ENSP00000375066	0.630	Hydroxycarboxylic acid receptor 2
13	9606.ENSP00000298440	0.617	2-oxoglutarate receptor 1
14	9606.ENSP00000358513	0.614	Cannabinoid receptor 1
15	9606.ENSP00000268638	0.612	Interferon regulatory factor 8
16	9606.ENSP00000302811	0.604	Melatonin receptor type 1A
17	9606.ENSP00000257068	0.600	Melatonin receptor type 1B
18	9606.ENSP00000267549	0.599	Psychosine receptor
19	9606.ENSP00000271324	0.589	Leukocyte surface antigen CD53
20	9606.ENSP00000262629	0.586	TYRO protein tyrosine kinase-binding protein

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0008289	1.000	lipid binding
GO:0004930	1.000	G protein-coupled receptor activity
GO:0097159	0.996	organic cyclic compound binding
GO:0005515	0.996	protein binding
GO:0032934	0.993	sterol binding
GO:0008528	0.408	G protein-coupled peptide receptor activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0050794	0.996	regulation of cellular process
GO:0050896	0.990	response to stimulus
GO:0007154	0.985	cell communication
GO:0023052	0.974	signaling
GO:0051716	0.938	cellular response to stimulus
GO:0050865	0.923	regulation of cell activation
GO:0048522	0.922	positive regulation of cellular process
GO:0002682	0.904	regulation of immune system process
GO:0002376	0.898	immune system process
GO:0007165	0.875	signal transduction
GO:0002684	0.798	positive regulation of immune system process
GO:0040011	0.787	locomotion
GO:0002694	0.760	regulation of leukocyte activation
GO:0048583	0.733	regulation of response to stimulus
GO:0010646	0.729	regulation of cell communication
GO:0042221	0.716	response to chemical
GO:0070663	0.716	regulation of leukocyte proliferation
GO:0032944	0.702	regulation of mononuclear cell proliferation
GO:0009605	0.606	response to external stimulus
GO:0048584	0.475	positive regulation of response to stimulus
GO:0051240	0.463	positive regulation of multicellular organismal process
GO:0032501	0.459	multicellular organismal process
GO:0048519	0.434	negative regulation of biological process
GO:0009966	0.418	regulation of signal transduction
GO:0007186	0.410	G protein-coupled receptor signaling pathway
GO:0019222	0.395	regulation of metabolic process
GO:0006935	0.385	chemotaxis
GO:0060255	0.357	regulation of macromolecule metabolic process
GO:0006955	0.356	immune response
GO:0051249	0.354	regulation of lymphocyte activation
GO:0002696	0.331	positive regulation of leukocyte activation
GO:0048523	0.319	negative regulation of cellular process
GO:0050670	0.316	regulation of lymphocyte proliferation
GO:0009893	0.302	positive regulation of metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005886	1.000	plasma membrane
GO:0005622	0.758	intracellular anatomical structure
GO:0043226	0.538	organelle
GO:0005737	0.512	cytoplasm
GO:0043227	0.510	membrane-bounded organelle
GO:0043229	0.471	intracellular organelle

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

[back to server]