StarFunc result for job id P32320

User Input

>input (146 residues)
MAQKRPACTLKPECVQQLLVCSQEAKKSAYCPYSHFPVGAALLTQEGRIFKGCNIENACY
PLGICAERTAIQKAVSEGYKDFRAIAIASDMQDDFISPCGACRQVMREFGTNWPVYMTKP
DGTYIVMTVQELLPSSFGPEDLQKTQ

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P32320	1.000	1.000	1.483E-31	146	1.000	1.000	P32320.pdb.gz	CDD_HUMAN Cytidine deaminase OS=Homo sapiens OX=9606 GN=CDA PE=1 SV=2
2	AFDB:D4AC20	0.947	0.947	1.008E-27	146	0.808	0.808	D4AC20.pdb.gz	D4AC20_RAT Cytidine deaminase OS=Rattus norvegicus OX=10116 GN=Cda PE=3 SV=1
3	PDB:1mq0A	0.871	0.977	4.909E-25	130	0.870	0.977	1mq0A.pdb.gz	Structure of human cytidine deaminase bound to a potent inhibitor
4	PDB:2fr6A	0.902	0.961	1.029E-24	137	0.774	0.825	2fr6A.pdb.gz	The 1.48 A Resolution Crystal Structure of the Homotetrameric Cytidine Deaminase from Mouse
5	AFDB:Q20628	0.849	0.749	6.096E-18	166	0.438	0.386	Q20628.pdb.gz	Q20628_CAEEL Cytidine deaminase OS=Caenorhabditis elegans OX=6239 GN=cdd-2 PE=1 SV=1
6	AFDB:Q9VLR3	0.830	0.768	1.062E-17	158	0.432	0.399	Q9VLR3.pdb.gz	Q9VLR3_DROME Cytidine deaminase OS=Drosophila melanogaster OX=7227 GN=Dmel\CG8360 PE=1 SV=1
7	AFDB:Q09190	0.878	0.962	4.391E-17	133	0.418	0.459	Q09190.pdb.gz	CDD_SCHPO Putative cytidine deaminase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=pcd1 PE=3 SV=2
8	AFDB:Q22922	0.861	0.797	1.179E-16	158	0.390	0.361	Q22922.pdb.gz	Q22922_CAEEL Cytidine deaminase OS=Caenorhabditis elegans OX=6239 GN=cdd-1 PE=1 SV=1
9	AFDB:Q06549	0.912	0.937	4.873E-16	142	0.363	0.373	Q06549.pdb.gz	CDD_YEAST Cytidine deaminase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=CDD1 PE=1 SV=1
10	PDB:1r5tA	0.894	0.924	6.751E-16	141	0.363	0.376	1r5tA.pdb.gz	The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1.
11	AFDB:Q38FM3	0.850	0.690	2.638E-13	182	0.377	0.302	Q38FM3.pdb.gz	Q38FM3_TRYB2 Cytidine deaminase, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb09.160.1680 PE=4 SV=1
12	AFDB:P9WPH3	0.736	0.804	5.425E-12	133	0.322	0.353	P9WPH3.pdb.gz	CDD_MYCTU Cytidine deaminase OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=cdd PE=1 SV=1
13	PDB:4wigA	0.746	0.859	2.921E-11	126	0.301	0.349	4wigA.pdb.gz	Functional and structural evidence for the catalytic role played by glutamate-47 residue in the mode of action of Mycobacterium tuberculosis cytidine deaminase
14	PDB:1af2A	0.734	0.376	2.642E-9	294	0.267	0.133	1af2A.pdb.gz	The structure of the cytidine deaminase-product complex provides evidence for efficient proton transfer and ground-state destabilization.
15	PDB:6l08A	0.742	0.394	7.090E-9	285	0.281	0.144	6l08A.pdb.gz
16	AFDB:O65896	0.747	0.375	3.258E-8	301	0.267	0.130	O65896.pdb.gz	CDA1_ARATH Cytidine deaminase 1 OS=Arabidopsis thaliana OX=3702 GN=CDA1 PE=1 SV=1
17	PDB:2w4lC	0.474	0.486	1.376E-4	142	0.151	0.155	2w4lC.pdb.gz	The Crystal Structure of Human Dcmp Deaminase
18	PDB:2w4lE	0.488	0.444	4.443E-4	162	0.164	0.148	2w4lE.pdb.gz	The Crystal Structure of Human Dcmp Deaminase
19	PDB:1ox7B	0.440	0.405	1.497E-2	161	0.116	0.106	1ox7B.pdb.gz	The 1.14 a crystal structure of yeast Cytosine deaminase. Evolution of nucleotide salvage enzymes and implications for genetic chemotherapy.
20	PDB:1z3aA	0.357	0.340	3.777E-2	156	0.116	0.109	1z3aA.pdb.gz	Structural and kinetic characterization of Escherichia coli TadA, the wobble-specific tRNA deaminase.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P32320	2.49e-108	306	146	1.000	1.000	CDD_HUMAN Cytidine deaminase OS=Homo sapiens OX=9606 GN=CDA PE=1 SV=2
2	D4AC20	7.89e-91	261	146	0.815	0.815	D4AC20_RAT Cytidine deaminase OS=Rattus norvegicus OX=10116 GN=Cda PE=3 SV=1
3	P56389	1.84e-90	261	146	0.815	0.815	CDD_MOUSE Cytidine deaminase OS=Mus musculus OX=10090 GN=Cda PE=1 SV=2
4	Q20628	1.96e-37	127	166	0.425	0.373	Q20628_CAEEL Cytidine deaminase OS=Caenorhabditis elegans OX=6239 GN=cdd-2 PE=1 SV=1
5	Q9VLR3	2.15e-37	127	158	0.432	0.399	Q9VLR3_DROME Cytidine deaminase OS=Drosophila melanogaster OX=7227 GN=Dmel\CG8360 PE=1 SV=1
6	Q09190	3.34e-36	123	133	0.452	0.496	CDD_SCHPO Putative cytidine deaminase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=pcd1 PE=3 SV=2
7	Q22922	2.69e-28	103	158	0.377	0.348	Q22922_CAEEL Cytidine deaminase OS=Caenorhabditis elegans OX=6239 GN=cdd-1 PE=1 SV=1
8	Q06549	1.61e-27	101	142	0.349	0.359	CDD_YEAST Cytidine deaminase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=CDD1 PE=1 SV=1
9	Q38FM3	1.06e-19	82.4	182	0.370	0.297	Q38FM3_TRYB2 Cytidine deaminase, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb09.160.1680 PE=4 SV=1
10	P9WPH3	2.30e-19	80.1	133	0.315	0.346	CDD_MYCTU Cytidine deaminase OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=cdd PE=1 SV=1
11	P0ABF6	2.10e-08	53.5	294	0.247	0.122	CDD_ECOLI Cytidine deaminase OS=Escherichia coli (strain K12) OX=83333 GN=cdd PE=1 SV=1
12	O65896	2.25e-08	53.5	301	0.281	0.136	CDA1_ARATH Cytidine deaminase 1 OS=Arabidopsis thaliana OX=3702 GN=CDA1 PE=1 SV=1
13	P39524	0.63	32.3	1355	0.151	0.016	ATC3_YEAST Phospholipid-transporting ATPase DRS2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=DRS2 PE=1 SV=2
14	Q8I7H2	4.0	29.3	183	0.103	0.082	Q8I7H2_CAEEL Crossover junction endonuclease MUS81 OS=Caenorhabditis elegans OX=6239 GN=mus-81 PE=3 SV=1
15	P27800	5.8	29.3	323	0.158	0.071	ALDX_SPOSA Aldehyde reductase 1 OS=Sporidiobolus salmonicolor OX=5005 GN=ARI PE=1 SV=3
16	P91153	8.6	28.9	445	0.103	0.034	P91153_CAEEL Crossover junction endonuclease MUS81 OS=Caenorhabditis elegans OX=6239 GN=mus-81 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00383 dCMP_cyt_deam_1	7.2e-14	62.8	Cytidine and deoxycytidylate deaminase zinc-binding region
2	PF08211 dCMP_cyt_deam_2	3.6e-10	51.6	Cytidine and deoxycytidylate deaminase zinc-binding region
3	PF14421 LmjF365940-deam	2e+02	12.9	A distinct subfamily of CDD/CDA-like deaminases

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000364212

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000379038	0.996	Thymidine phosphorylase
2	9606.ENSP00000286648	0.985	Deoxycytidine kinase
3	9606.ENSP00000330032	0.973	Uridine phosphorylase 1
4	9606.ENSP00000346155	0.970	Uridine-cytidine kinase-like 1
5	9606.ENSP00000301634	0.963	Thymidine kinase, cytosolic
6	9606.ENSP00000354532	0.962	Purine nucleoside phosphorylase
7	9606.ENSP00000356853	0.952	Uridine-cytidine kinase 2
8	9606.ENSP00000361285	0.949	Uridine-cytidine kinase 1
9	9606.ENSP00000474090	0.949	Uridine phosphorylase 2
10	9606.ENSP00000299697	0.942	Thymidine kinase 2, mitochondrial
11	9606.ENSP00000339479	0.941	Cytosolic purine 5'-nucleotidase
12	9606.ENSP00000257770	0.937	5'-nucleotidase
13	9606.ENSP00000245552	0.930	5'(3')-deoxyribonucleotidase, cytosolic type
14	9606.ENSP00000317842	0.924	Cocaine esterase
15	9606.ENSP00000484415	0.923	Cytosolic 5'-nucleotidase 3A
16	9606.ENSP00000353720	0.922	Liver carboxylesterase 1
17	9606.ENSP00000235628	0.921	Cytosolic 5'-nucleotidase 1A
18	9606.ENSP00000349576	0.914	Deoxycytidylate deaminase
19	9606.ENSP00000373674	0.913	5'(3')-deoxyribonucleotidase, mitochondrial
20	9606.ENSP00000352904	0.908	Cytosolic 5'-nucleotidase 1B

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0042802	1.000	identical protein binding
GO:0004126	1.000	cytidine deaminase activity
GO:0043167	0.991	ion binding
GO:1901363	0.970	heterocyclic compound binding
GO:0097159	0.970	organic cyclic compound binding
GO:0046914	0.969	transition metal ion binding
GO:0008270	0.957	zinc ion binding
GO:0046983	0.894	protein dimerization activity
GO:0036094	0.866	small molecule binding
GO:0042803	0.866	protein homodimerization activity
GO:0097367	0.551	carbohydrate derivative binding
GO:0003676	0.543	nucleic acid binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0006139	0.985	nucleobase-containing compound metabolic process
GO:0034655	0.976	nucleobase-containing compound catabolic process
GO:0009116	0.969	nucleoside metabolic process
GO:0009164	0.962	nucleoside catabolic process
GO:0072529	0.917	pyrimidine-containing compound catabolic process
GO:0009119	0.905	ribonucleoside metabolic process
GO:0042454	0.888	ribonucleoside catabolic process
GO:0065007	0.575	biological regulation
GO:0050789	0.567	regulation of biological process
GO:0050794	0.535	regulation of cellular process
GO:0006213	0.379	pyrimidine nucleoside metabolic process
GO:0009972	0.355	cytidine deamination
GO:0009117	0.354	nucleotide metabolic process
GO:0034654	0.349	nucleobase-containing compound biosynthetic process
GO:0019222	0.345	regulation of metabolic process
GO:0050896	0.324	response to stimulus

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005829	0.999	cytosol
GO:0070013	0.991	intracellular organelle lumen
GO:0043231	0.978	intracellular membrane-bounded organelle
GO:0005634	0.839	nucleus
GO:0031982	0.765	vesicle
GO:0012505	0.757	endomembrane system
GO:0031981	0.518	nuclear lumen
GO:0005654	0.488	nucleoplasm
GO:0005576	0.438	extracellular region
GO:0005615	0.424	extracellular space
GO:0031410	0.396	cytoplasmic vesicle
GO:0099503	0.327	secretory vesicle
GO:0030141	0.321	secretory granule
GO:0043230	0.305	extracellular organelle
GO:1903561	0.301	extracellular vesicle

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:16069	1.000	cytidine + H(+) + H2O = NH4(+) + uridine
EC:3.5.4.5	1.000	cytidine deaminase.

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