StarFunc result for job id P33176

User Input

>input (963 residues)
MADLAECNIKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVIASKPYAFDRVFQSSTSQEQ
VYNDCAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIY
SMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVM
DTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSK
TGAEGAVLDEAKNINKSLSALGNVISALAEGSTYVPYRDSKMTRILQDSLGGNCRTTIVI
CCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQW
LENELNRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRK
CEEEIAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAE
NDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKL
KEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSE
VKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQHEAKIKSLTEYLQNVEQKKRQL
EESVDALSEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLR
DEVEAKAKLITDLQDQNQKMMLEQERLRVEHEKLKATDQEKSRKLHELTVMQDRREQARQ
DLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEIDSDDTGGSAAQKQKISFLENNLE
QLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENASRDRKRYQQEVD
RIKEAVRSKNMARRGHSAQIAKPIRPGQHPAASPTHPSAIRGGGAFVQNSQPVAVRGGGG
KQV

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A0A286YA13	0.370	0.385	0.000	924	0.827	0.861	A0A286YA13.pdb.gz
2	AFDB:F1R5M2	0.522	0.520	0.000	968	0.862	0.857	F1R5M2.pdb.gz	F1R5M2_DANRE Kinesin-like protein OS=Danio rerio OX=7955 GN=kif5ba PE=1 SV=1
3	AFDB:O60282	0.720	0.724	0.000	957	0.751	0.755	O60282.pdb.gz	KIF5C_HUMAN Kinesin heavy chain isoform 5C OS=Homo sapiens OX=9606 GN=KIF5C PE=1 SV=1
4	AFDB:P33176	1.000	1.000	0.000	963	1.000	1.000	P33176.pdb.gz	KINH_HUMAN Kinesin-1 heavy chain OS=Homo sapiens OX=9606 GN=KIF5B PE=1 SV=1
5	AFDB:Q12840	0.402	0.376	0.000	1032	0.706	0.659	Q12840.pdb.gz	KIF5A_HUMAN Kinesin heavy chain isoform 5A OS=Homo sapiens OX=9606 GN=KIF5A PE=1 SV=2
6	AFDB:A0A0R4IWI7	0.390	0.365	5.980E-98	1033	0.661	0.617	A0A0R4IWI7.pdb.gz	A0A0R4IWI7_DANRE Kinesin family member 5A OS=Danio rerio OX=7955 GN=kif5a PE=3 SV=1
7	AFDB:P17210	0.383	0.378	4.265E-93	975	0.605	0.598	P17210.pdb.gz	KINH_DROME Kinesin heavy chain OS=Drosophila melanogaster OX=7227 GN=Khc PE=1 SV=2
8	AFDB:P34540	0.391	0.461	6.626E-74	815	0.441	0.521	P34540.pdb.gz	KINH_CAEEL Kinesin heavy chain OS=Caenorhabditis elegans OX=6239 GN=unc-116 PE=2 SV=2
9	AFDB:P48467	0.410	0.424	2.248E-57	928	0.344	0.357	P48467.pdb.gz	KINH_NEUCR Kinesin heavy chain OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) OX=367110 GN=kin PE=1 SV=2
10	AFDB:Q54TL0	0.354	0.274	1.388E-46	1255	0.185	0.142	Q54TL0.pdb.gz	KIF7_DICDI Kinesin-related protein 7 OS=Dictyostelium discoideum OX=44689 GN=kif7 PE=2 SV=1
11	PDB:7wrgB	0.316	0.386	5.409E-32	783	0.133	0.163	7wrgB.pdb.gz	The architecture of kinesin-3 KLP-6 reveals a multilevel-lockdown mechanism for autoinhibition.
12	PDB:7wrgA	0.317	0.374	1.009E-31	812	0.132	0.156	7wrgA.pdb.gz	The architecture of kinesin-3 KLP-6 reveals a multilevel-lockdown mechanism for autoinhibition.
13	PDB:4h1gA	0.276	0.393	2.973E-26	670	0.110	0.158	4h1gA.pdb.gz	Crystal structure of the Candida albicans Kar3 kinesin motor domain fused to maltose-binding protein.
14	PDB:6e1iA	0.062	0.122	8.165E-2	389	0.019	0.046	6e1iA.pdb.gz
15	PDB:7w85A	0.076	0.140	1.807E-1	435	0.036	0.080	7w85A.pdb.gz
16	PDB:3sqbE	0.046	0.151	2.024E-1	176	0.020	0.108	3sqbE.pdb.gz
17	PDB:1m2vA	0.058	0.074	2.142E-1	705	0.030	0.041	1m2vA.pdb.gz	Structure of the Sec23/24-Sar1 pre-budding complex of the COPII vesicle coat
18	PDB:6d7gA	0.049	0.101	3.777E-1	386	0.007	0.018	6d7gA.pdb.gz
19	PDB:5ghuA	0.047	0.154	4.477E-1	201	0.012	0.060	5ghuA.pdb.gz
20	PDB:4y5xB	0.043	0.221	5.946E-1	111	0.010	0.090	4y5xB.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A0R4IRM1	0.0	1674	959	0.864	0.868	A0A0R4IRM1_DANRE Kinesin-like protein OS=Danio rerio OX=7955 GN=kif5bb PE=1 SV=1
2	A0A0R4IWI7	0.0	1250	1033	0.670	0.624	A0A0R4IWI7_DANRE Kinesin family member 5A OS=Danio rerio OX=7955 GN=kif5a PE=3 SV=1
3	F1R5M2	0.0	1714	968	0.866	0.862	F1R5M2_DANRE Kinesin-like protein OS=Danio rerio OX=7955 GN=kif5ba PE=1 SV=1
4	O60282	0.0	1403	957	0.750	0.754	KIF5C_HUMAN Kinesin heavy chain isoform 5C OS=Homo sapiens OX=9606 GN=KIF5C PE=1 SV=1
5	P17210	0.0	1151	975	0.617	0.609	KINH_DROME Kinesin heavy chain OS=Drosophila melanogaster OX=7227 GN=Khc PE=1 SV=2
6	P28738	0.0	1400	956	0.755	0.760	KIF5C_MOUSE Kinesin heavy chain isoform 5C OS=Mus musculus OX=10090 GN=Kif5c PE=1 SV=3
7	P33175	0.0	1345	1027	0.697	0.653	KIF5A_MOUSE Kinesin heavy chain isoform 5A OS=Mus musculus OX=10090 GN=Kif5a PE=1 SV=3
8	P33176	0.0	1984	963	1.000	1.000	KINH_HUMAN Kinesin-1 heavy chain OS=Homo sapiens OX=9606 GN=KIF5B PE=1 SV=1
9	P34540	0.0	615	815	0.332	0.393	KINH_CAEEL Kinesin heavy chain OS=Caenorhabditis elegans OX=6239 GN=unc-116 PE=2 SV=2
10	P56536	0.0	1413	955	0.756	0.762	KIF5C_RAT Kinesin heavy chain isoform 5C OS=Rattus norvegicus OX=10116 GN=Kif5c PE=1 SV=3
11	Q12840	0.0	1355	1032	0.703	0.656	KIF5A_HUMAN Kinesin heavy chain isoform 5A OS=Homo sapiens OX=9606 GN=KIF5A PE=1 SV=2
12	Q2PQA9	0.0	1942	963	0.973	0.973	KINH_RAT Kinesin-1 heavy chain OS=Rattus norvegicus OX=10116 GN=Kif5b PE=1 SV=1
13	Q504B9	0.0	623	349	0.295	0.814	Q504B9_DANRE Kinesin-like protein (Fragment) OS=Danio rerio OX=7955 GN=LOC553428 PE=2 SV=1
14	Q61768	0.0	1941	963	0.971	0.971	KINH_MOUSE Kinesin-1 heavy chain OS=Mus musculus OX=10090 GN=Kif5b PE=1 SV=3
15	Q6QLM7	0.0	1340	1027	0.695	0.651	KIF5A_RAT Kinesin heavy chain isoform 5A OS=Rattus norvegicus OX=10116 GN=Kif5a PE=1 SV=1
16	V9HW29	0.0	1984	963	1.000	1.000	V9HW29_HUMAN Kinesin-like protein OS=Homo sapiens OX=9606 GN=HEL-S-61 PE=1 SV=1
17	P48467	1.57e-130	418	928	0.213	0.221	KINH_NEUCR Kinesin heavy chain OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) OX=367110 GN=kin PE=1 SV=2
18	Q54UC9	6.74e-115	383	1193	0.194	0.157	KIF3_DICDI Kinesin-related protein 3 OS=Dictyostelium discoideum OX=44689 GN=kif3 PE=1 SV=1
19	Q5A3K5	1.92e-104	348	904	0.190	0.202	Q5A3K5_CANAL Kip4p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=KIP4 PE=3 SV=1
20	Q9US60	6.76e-98	320	554	0.197	0.343	KLP3_SCHPO Kinesin-like protein 3 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=klp3 PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00225 Kinesin	2.6e-109	376.8	Kinesin motor domain
2	PF16796 Microtub_bd	3.4e-24	97.0	Microtubule binding

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000307078

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000414982	0.998	Kinesin light chain 1
2	9606.ENSP00000399403	0.996	Kinesin light chain 2
3	9606.ENSP00000283195	0.993	E3 SUMO-protein ligase RanBP2
4	9606.ENSP00000259708	0.989	Kinesin light chain 4
5	9606.ENSP00000375810	0.980	Kinesin light chain 3
6	9606.ENSP00000407118	0.976	Syntabulin
7	9606.ENSP00000328875	0.946	Trafficking kinesin-binding protein 2
8	9606.ENSP00000382004	0.942	Catenin delta-1
9	9606.ENSP00000439065	0.937	Uncharacterized protein
10	9606.ENSP00000408979	0.930	Kinesin heavy chain isoform 5A
11	9606.ENSP00000393379	0.928	Kinesin heavy chain isoform 5C
12	9606.ENSP00000344456	0.927	Catenin beta-1
13	9606.ENSP00000354791	0.925	Dynactin subunit 1
14	9606.ENSP00000301071	0.921	Tubulin alpha-1A chain
15	9606.ENSP00000380432	0.917	Insulin
16	9606.ENSP00000269141	0.916	Cadherin-2
17	9606.ENSP00000377508	0.908	Junction plakoglobin
18	9606.ENSP00000304669	0.904	Catenin alpha-1
19	9606.ENSP00000328998	0.897	Trafficking kinesin-binding protein 1
20	9606.ENSP00000353401	0.890	Homeobox protein cut-like 1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.999	protein binding
GO:0003777	0.995	microtubule motor activity
GO:0008092	0.876	cytoskeletal protein binding
GO:0015631	0.788	tubulin binding
GO:0008017	0.761	microtubule binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0009987	0.999	cellular process
GO:0032502	0.922	developmental process
GO:0032501	0.901	multicellular organismal process
GO:0048856	0.843	anatomical structure development
GO:0050789	0.815	regulation of biological process
GO:0050794	0.812	regulation of cellular process
GO:0051179	0.781	localization
GO:0007017	0.762	microtubule-based process
GO:0071840	0.680	cellular component organization or biogenesis
GO:0051234	0.660	establishment of localization
GO:0006810	0.631	transport
GO:0051641	0.630	cellular localization
GO:0016043	0.630	cellular component organization
GO:0051649	0.569	establishment of localization in cell
GO:0046907	0.535	intracellular transport
GO:0050896	0.466	response to stimulus
GO:0007275	0.464	multicellular organism development
GO:0006996	0.436	organelle organization
GO:0007018	0.435	microtubule-based movement
GO:0048518	0.407	positive regulation of biological process
GO:0048513	0.392	animal organ development
GO:0048522	0.381	positive regulation of cellular process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005737	0.999	cytoplasm
GO:0015630	0.998	microtubule cytoskeleton
GO:0032991	0.993	protein-containing complex
GO:0005829	0.988	cytosol
GO:0043227	0.975	membrane-bounded organelle
GO:0043231	0.963	intracellular membrane-bounded organelle
GO:0016020	0.950	membrane
GO:0005875	0.929	microtubule associated complex
GO:0031982	0.902	vesicle
GO:0005871	0.902	kinesin complex
GO:0120025	0.768	plasma membrane bounded cell projection
GO:0043005	0.619	neuron projection
GO:0005929	0.446	cilium
GO:0099512	0.418	supramolecular fiber
GO:0005874	0.409	microtubule
GO:0071944	0.384	cell periphery
GO:0005815	0.365	microtubule organizing center
GO:0097708	0.329	intracellular vesicle
GO:0031410	0.324	cytoplasmic vesicle
GO:0005813	0.324	centrosome
GO:0005634	0.317	nucleus

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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