StarFunc result for job id P33897

User Input

>input (745 residues)
MPVLSRPRPWRGNTLKRTAVLLALAAYGAHKVYPLVRQCLAPARGLQAPAGEPTQEASGV
AAAKAGMNRVFLQRLLWLLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLAR
CIVRKDPRAFGWQLLQWLLIALPATFVNSAIRYLEGQLALSFRSRLVAHAYRLYFSQQTY
YRVSNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGT
AWPSAIAGLVVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHE
VELALLQRSYQDLASQINLILLERLWYVMLEQFLMKYVWSASGLLMVAVPIITATGYSES
DAEAVKKAALEKKEEELVSERTEAFTIARNLLTAAADAIERIMSSYKEVTELAGYTARVH
EMFQVFEDVQRCHFKRPRELEDAQAGSGTIGRSGVRVEGPLKIRGQVVDVEQGIICENIP
IVTPSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYGGVLYKPPPQRMF
YIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQREGGWEAMCD
WKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGIALLSITHR
PSLWKYHTHLLQFDGEGGWKFEKLDSAARLSLTEEKQRLEQQLAGIPKMQRRLQELCQIL
GEAVAPAHVPAPSPQGPGGLQGAST

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P33897	1.000	1.000	0.000	745	1.000	1.000	P33897.pdb.gz	ABCD1_HUMAN ATP-binding cassette sub-family D member 1 OS=Homo sapiens OX=9606 GN=ABCD1 PE=1 SV=2
2	AFDB:F1RBC8	0.897	0.873	4.333E-86	766	0.683	0.664	F1RBC8.pdb.gz	ABCD1_DANRE ATP-binding cassette sub-family D member 1 OS=Danio rerio OX=7955 GN=abcd1 PE=2 SV=1
3	AFDB:Q61285	0.846	0.851	4.163E-78	741	0.635	0.638	Q61285.pdb.gz	ABCD2_MOUSE ATP-binding cassette sub-family D member 2 OS=Mus musculus OX=10090 GN=Abcd2 PE=1 SV=2
4	PDB:7vwcA	0.668	0.798	2.506E-71	617	0.828	1.000	7vwcA.pdb.gz
5	PDB:7rraA	0.644	0.780	3.162E-71	602	0.808	1.000	7rraA.pdb.gz
6	PDB:7rr9A	0.689	0.904	8.060E-65	560	0.752	1.000	7rr9A.pdb.gz	Structures of the human peroxisomal fatty acid transporter ABCD1 in a lipid environment
7	AFDB:Q7JUN3	0.793	0.809	2.973E-63	730	0.456	0.466	Q7JUN3.pdb.gz	ABCD1_DROME ATP-binding cassette sub-family D member 1 OS=Drosophila melanogaster OX=7227 GN=Abcd1 PE=2 SV=1
8	AFDB:A0A3B3ITW3	0.752	0.847	1.932E-50	659	0.325	0.367	A0A3B3ITW3.pdb.gz	A0A3B3ITW3_HUMAN ATP binding cassette subfamily D member 3 OS=Homo sapiens OX=9606 GN=ABCD3 PE=1 SV=2
9	AFDB:P41909	0.760	0.654	1.688E-44	870	0.301	0.257	P41909.pdb.gz	PXA1_YEAST Peroxisomal long-chain fatty acid import protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=PXA1 PE=1 SV=2
10	AFDB:Q8T8P3	0.451	0.453	5.158E-44	741	0.299	0.301	Q8T8P3.pdb.gz	ABCD2_DICDI ABC transporter D family member 2 OS=Dictyostelium discoideum OX=44689 GN=abcD2 PE=3 SV=1
11	AFDB:Q386J8	0.728	0.843	5.799E-43	641	0.248	0.289	Q386J8.pdb.gz	Q386J8_TRYB2 ABC transporter, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb11.02.0630 PE=4 SV=1
12	AFDB:P34230	0.762	0.669	1.691E-42	853	0.302	0.264	P34230.pdb.gz	PXA2_YEAST Peroxisomal long-chain fatty acid import protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=PXA2 PE=1 SV=1
13	AFDB:Q57Y09	0.696	0.755	2.290E-41	683	0.250	0.272	Q57Y09.pdb.gz	Q57Y09_TRYB2 ABC transporter, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb04.1D20.510 PE=4 SV=1
14	PDB:6jbjA	0.644	0.830	2.106E-28	565	0.199	0.262	6jbjA.pdb.gz	Cryo-EM structure of human lysosomal cobalamin exporter ABCD4.
15	PDB:6tqeA	0.633	0.733	1.329E-22	634	0.180	0.211	6tqeA.pdb.gz	A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds.
16	PDB:5mkkB	0.556	0.694	2.680E-18	577	0.150	0.194	5mkkB.pdb.gz
17	PDB:4q4aA	0.574	0.725	3.081E-18	572	0.134	0.175	4q4aA.pdb.gz	Structural basis for allosteric cross-talk between the asymmetric nucleotide binding sites of a heterodimeric ABC exporter.
18	PDB:5u1dA	0.502	0.648	3.543E-18	561	0.144	0.191	5u1dA.pdb.gz
19	PDB:5u1dB	0.538	0.706	6.193E-18	552	0.140	0.188	5u1dB.pdb.gz
20	PDB:3qf4B	0.540	0.663	8.577E-18	588	0.148	0.187	3qf4B.pdb.gz	Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	D3ZHR2	0.0	1332	737	0.899	0.909	ABCD1_RAT ATP-binding cassette sub-family D member 1 OS=Rattus norvegicus OX=10116 GN=Abcd1 PE=1 SV=1
2	F1RBC8	0.0	1063	766	0.689	0.670	ABCD1_DANRE ATP-binding cassette sub-family D member 1 OS=Danio rerio OX=7955 GN=abcd1 PE=2 SV=1
3	P33897	0.0	1523	745	1.000	1.000	ABCD1_HUMAN ATP-binding cassette sub-family D member 1 OS=Homo sapiens OX=9606 GN=ABCD1 PE=1 SV=2
4	P48410	0.0	1350	736	0.905	0.916	ABCD1_MOUSE ATP-binding cassette sub-family D member 1 OS=Mus musculus OX=10090 GN=Abcd1 PE=1 SV=1
5	Q61285	0.0	965	741	0.613	0.617	ABCD2_MOUSE ATP-binding cassette sub-family D member 2 OS=Mus musculus OX=10090 GN=Abcd2 PE=1 SV=2
6	Q7JUN3	0.0	696	730	0.450	0.459	ABCD1_DROME ATP-binding cassette sub-family D member 1 OS=Drosophila melanogaster OX=7227 GN=Abcd1 PE=2 SV=1
7	Q9QY44	0.0	964	741	0.613	0.617	ABCD2_RAT ATP-binding cassette sub-family D member 2 OS=Rattus norvegicus OX=10116 GN=Abcd2 PE=1 SV=2
8	Q9UBJ2	0.0	979	740	0.619	0.623	ABCD2_HUMAN ATP-binding cassette sub-family D member 2 OS=Homo sapiens OX=9606 GN=ABCD2 PE=1 SV=1
9	P28288	1.28e-157	474	659	0.346	0.392	ABCD3_HUMAN ATP-binding cassette sub-family D member 3 OS=Homo sapiens OX=9606 GN=ABCD3 PE=1 SV=1
10	A0A3B3ITW3	2.36e-157	473	659	0.344	0.388	A0A3B3ITW3_HUMAN ATP binding cassette subfamily D member 3 OS=Homo sapiens OX=9606 GN=ABCD3 PE=1 SV=2
11	P55096	8.91e-155	466	659	0.337	0.381	ABCD3_MOUSE ATP-binding cassette sub-family D member 3 OS=Mus musculus OX=10090 GN=Abcd3 PE=1 SV=2
12	P16970	1.04e-154	466	659	0.336	0.379	ABCD3_RAT ATP-binding cassette sub-family D member 3 OS=Rattus norvegicus OX=10116 GN=Abcd3 PE=1 SV=3
13	Q8T8P3	2.79e-122	385	741	0.295	0.297	ABCD2_DICDI ABC transporter D family member 2 OS=Dictyostelium discoideum OX=44689 GN=abcD2 PE=3 SV=1
14	P41909	3.42e-115	370	870	0.311	0.267	PXA1_YEAST Peroxisomal long-chain fatty acid import protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=PXA1 PE=1 SV=2
15	Q94FB9	1.36e-97	331	1337	0.278	0.155	AB1D_ARATH ABC transporter D family member 1 OS=Arabidopsis thaliana OX=3702 GN=ABCD1 PE=1 SV=1
16	F4JJ27	1.67e-97	331	1352	0.278	0.153	F4JJ27_ARATH Peroxisomal ABC transporter 1 OS=Arabidopsis thaliana OX=3702 GN=ABCD1 PE=1 SV=1
17	P34230	3.68e-95	316	853	0.298	0.260	PXA2_YEAST Peroxisomal long-chain fatty acid import protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=PXA2 PE=1 SV=1
18	Q57Y09	5.02e-87	290	683	0.271	0.296	Q57Y09_TRYB2 ABC transporter, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb04.1D20.510 PE=4 SV=1
19	Q386J8	1.90e-77	263	641	0.266	0.309	Q386J8_TRYB2 ABC transporter, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb11.02.0630 PE=4 SV=1
20	O14678	1.51e-65	230	606	0.239	0.294	ABCD4_HUMAN Lysosomal cobalamin transporter ABCD4 OS=Homo sapiens OX=9606 GN=ABCD4 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF13191 AAA_16	2.3e+02	13.5	AAA ATPase domain
2	PF13304 AAA_21	1.8	19.9	AAA domain, putative AbiEii toxin, Type IV TA system
3	PF13476 AAA_23	53	15.8	AAA domain
4	PF13555 AAA_29	42	15.3	P-loop containing region of AAA domain
5	PF06472 ABC_membrane_2	6.7e-95	329.1	ABC transporter transmembrane region 2
6	PF00005 ABC_tran	3.3e-13	61.8	ABC transporter
7	PF02456 Adeno_IVa2	3.3e+02	11.5	Adenovirus IVa2 protein
8	PF01265 Cyto_heme_lyase	10	17.2	Cytochrome c/c1 heme lyase
9	PF03215 Rad17	1e+02	14.2	Rad17 P-loop domain
10	PF02463 SMC_N	1.7e+02	13.0	RecF/RecN/SMC N terminal domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000218104

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000357051	0.993	Peroxisomal biogenesis factor 19
2	9606.ENSP00000390722	0.993	Peroxisomal membrane protein PMP34
3	9606.ENSP00000295030	0.979	Peroxisomal membrane protein PEX13
4	9606.ENSP00000358312	0.974	Peroxisomal membrane protein 11B
5	9606.ENSP00000482609	0.969	Peroxisome assembly protein 12
6	9606.ENSP00000241041	0.965	Peroxisomal membrane protein PEX16
7	9606.ENSP00000349016	0.960	Peroxisomal membrane protein PEX14
8	9606.ENSP00000359233	0.959	ATP-binding cassette sub-family D member 3
9	9606.ENSP00000356563	0.953	Peroxisomal biogenesis factor 3
10	9606.ENSP00000386385	0.951	Peroxisomal membrane protein 4
11	9606.ENSP00000379568	0.947	Acyl-CoA-binding domain-containing protein 5
12	9606.ENSP00000331106	0.945	Peroxisome assembly protein 26
13	9606.ENSP00000349543	0.936	Peroxisome biogenesis factor 2
14	9606.ENSP00000339017	0.935	ATPase family AAA domain-containing protein 1
15	9606.ENSP00000321271	0.924	Peroxisomal membrane protein 2
16	9606.ENSP00000345774	0.924	Fatty aldehyde dehydrogenase
17	9606.ENSP00000223136	0.918	Mitochondrial fission 1 protein
18	9606.ENSP00000220822	0.915	Ganglioside-induced differentiation-associated protein 1
19	9606.ENSP00000310688	0.902	ATP-binding cassette sub-family D member 2
20	9606.ENSP00000258873	0.886	Long-chain-fatty-acid--CoA ligase ACSBG1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0042803	0.998	protein homodimerization activity
GO:0005524	0.998	ATP binding
GO:0042626	0.996	ATPase-coupled transmembrane transporter activity
GO:0003824	0.984	catalytic activity
GO:0005324	0.975	long-chain fatty acid transporter activity
GO:0047617	0.947	acyl-CoA hydrolase activity
GO:0042887	0.896	amide transmembrane transporter activity
GO:0140359	0.834	ABC-type transporter activity
GO:0015216	0.810	purine nucleotide transmembrane transporter activity
GO:1901505	0.808	carbohydrate derivative transmembrane transporter activity
GO:0043531	0.803	ADP binding
GO:0016462	0.779	pyrophosphatase activity
GO:0005346	0.774	purine ribonucleotide transmembrane transporter activity
GO:0017111	0.765	ribonucleoside triphosphate phosphatase activity
GO:0000295	0.736	adenine nucleotide transmembrane transporter activity
GO:1901682	0.720	sulfur compound transmembrane transporter activity
GO:0016887	0.712	ATP hydrolysis activity
GO:0019899	0.603	enzyme binding
GO:0008514	0.557	organic anion transmembrane transporter activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:1901575	0.991	organic substance catabolic process
GO:0044248	0.990	cellular catabolic process
GO:0044282	0.988	small molecule catabolic process
GO:0044255	0.985	cellular lipid metabolic process
GO:0032787	0.985	monocarboxylic acid metabolic process
GO:0046395	0.973	carboxylic acid catabolic process
GO:0044242	0.969	cellular lipid catabolic process
GO:0000038	0.962	very long-chain fatty acid metabolic process
GO:0072329	0.959	monocarboxylic acid catabolic process
GO:0009062	0.937	fatty acid catabolic process
GO:0006869	0.792	lipid transport
GO:0034440	0.787	lipid oxidation
GO:0019395	0.784	fatty acid oxidation
GO:0015718	0.726	monocarboxylic acid transport
GO:0006635	0.708	fatty acid beta-oxidation
GO:0015908	0.673	fatty acid transport
GO:0065007	0.671	biological regulation
GO:0050789	0.652	regulation of biological process
GO:0050794	0.585	regulation of cellular process
GO:0006807	0.548	nitrogen compound metabolic process
GO:0051641	0.544	cellular localization
GO:0046907	0.519	intracellular transport
GO:0043574	0.514	peroxisomal transport
GO:0015919	0.492	peroxisomal membrane transport
GO:0007031	0.476	peroxisome organization
GO:1901564	0.414	organonitrogen compound metabolic process
GO:0055085	0.320	transmembrane transport
GO:0048518	0.305	positive regulation of biological process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005778	0.999	peroxisomal membrane
GO:0012505	0.985	endomembrane system
GO:0005739	0.948	mitochondrion
GO:0005829	0.913	cytosol
GO:0005783	0.704	endoplasmic reticulum
GO:0005789	0.311	endoplasmic reticulum membrane
GO:0031975	0.306	envelope

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:7.-.-.-	0.996	Translocases.
RHEA:16781	0.947	a fatty acyl-CoA + H2O = a fatty acid + CoA + H(+)
EC:3.1.2.20	0.947	acyl-CoA hydrolase.
EC:3.6.1.-	0.779	In phosphorus-containing anhydrides.
RHEA:23680	0.765	a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H(+) + phosphate
EC:3.6.1.15	0.765	nucleoside-triphosphate phosphatase.
RHEA:13065	0.712	ATP + H2O = ADP + H(+) + phosphate

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