StarFunc result for job id P35225

User Input

>input (146 residues)
MHPLLNPLLLALGLMALLLTTVIALTCLGGFASPGPVPPSTALRELIEELVNITQNQKAP
LCNGSMVWSINLTAGMYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFSSLHVRD
TKIEVAQFVKDLLLHLKKLFREGRFN

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P35225	1.000	1.000	9.836E-26	146	1.000	1.000	P35225.pdb.gz	IL13_HUMAN Interleukin-13 OS=Homo sapiens OX=9606 GN=IL13 PE=1 SV=2
2	PDB:1ga3A	0.640	0.803	7.565E-16	113	0.767	0.991	1ga3A.pdb.gz
3	AFDB:Q95J68	0.682	0.756	1.841E-14	131	0.664	0.740	Q95J68.pdb.gz	IL13_PIG Interleukin-13 OS=Sus scrofa OX=9823 GN=IL13 PE=2 SV=1
4	PDB:5l6yC	0.619	0.950	2.642E-14	94	0.644	1.000	5l6yC.pdb.gz
5	AFDB:P20109	0.661	0.731	4.691E-12	131	0.507	0.565	P20109.pdb.gz	IL13_MOUSE Interleukin-13 OS=Mus musculus OX=10090 GN=Il13 PE=1 SV=1
6	AFDB:P42203	0.627	0.695	9.662E-12	131	0.534	0.595	P42203.pdb.gz	IL13_RAT Interleukin-13 OS=Rattus norvegicus OX=10116 GN=Il13 PE=2 SV=1
7	PDB:4ps4A	0.492	0.932	9.694E-8	76	0.500	0.961	4ps4A.pdb.gz
8	AFDB:F1CFE1	0.519	0.564	3.055E-3	133	0.178	0.195	F1CFE1.pdb.gz	F1CFE1_PIG Interleukin-4 OS=Sus scrofa OX=9823 GN=IL-4 PE=2 SV=1
9	AFDB:Q5W4U1	0.464	0.493	8.008E-3	136	0.171	0.184	Q5W4U1.pdb.gz	Q5W4U1_CHICK Interleukin-4 OS=Gallus gallus OX=9031 GN=IL-4 PE=2 SV=1
10	AFDB:P07750	0.496	0.515	1.221E-2	140	0.212	0.221	P07750.pdb.gz	IL4_MOUSE Interleukin-4 OS=Mus musculus OX=10090 GN=Il4 PE=1 SV=1
11	AFDB:B3IWZ9	0.436	0.409	1.649E-2	157	0.192	0.178	B3IWZ9.pdb.gz	B3IWZ9_DANRE Interleukin 13 OS=Danio rerio OX=7955 GN=IL4/13A PE=2 SV=1
12	PDB:1itlA	0.502	0.555	2.835E-2	130	0.123	0.138	1itlA.pdb.gz
13	AFDB:P15248	0.395	0.399	3.609E-2	144	0.205	0.208	P15248.pdb.gz	IL9_HUMAN Interleukin-9 OS=Homo sapiens OX=9606 GN=IL9 PE=1 SV=1
14	AFDB:P20096	0.531	0.527	4.071E-2	147	0.199	0.197	P20096.pdb.gz	IL4_RAT Interleukin-4 OS=Rattus norvegicus OX=10116 GN=Il4 PE=2 SV=2
15	PDB:5uwcI	0.287	0.351	1.948E-1	112	0.158	0.205	5uwcI.pdb.gz	A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.
16	PDB:4nemA	0.394	0.475	3.778E-1	114	0.110	0.140	4nemA.pdb.gz	Small molecular fragments bound to binding energy hot-spot in crystal contact interface of Interleukin-2
17	PDB:3qb1G	0.429	0.545	4.526E-1	111	0.075	0.099	3qb1G.pdb.gz
18	PDB:2gmfA	0.404	0.465	5.758E-1	121	0.144	0.174	2gmfA.pdb.gz
19	PDB:7ra9A	0.429	0.481	5.758E-1	126	0.089	0.103	7ra9A.pdb.gz
20	PDB:1irlA	0.398	0.426	7.327E-1	133	0.116	0.128	1irlA.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P35225	7.27e-105	297	146	1.000	1.000	IL13_HUMAN Interleukin-13 OS=Homo sapiens OX=9606 GN=IL13 PE=1 SV=2
2	Q4VB50	4.49e-94	270	145	0.897	0.903	Q4VB50_HUMAN Interleukin-13 OS=Homo sapiens OX=9606 GN=IL13 PE=1 SV=2
3	B3GDZ5	1.02e-68	205	130	0.685	0.769	B3GDZ5_PIG Interleukin-13 OS=Sus scrofa OX=9823 GN=IL13 PE=2 SV=1
4	Q95J68	7.35e-67	201	131	0.685	0.763	IL13_PIG Interleukin-13 OS=Sus scrofa OX=9823 GN=IL13 PE=2 SV=1
5	P42203	8.24e-49	155	131	0.562	0.626	IL13_RAT Interleukin-13 OS=Rattus norvegicus OX=10116 GN=Il13 PE=2 SV=1
6	P20109	2.50e-45	146	131	0.541	0.603	IL13_MOUSE Interleukin-13 OS=Mus musculus OX=10090 GN=Il13 PE=1 SV=1
7	B1AR51	0.21	33.5	4484	0.110	0.004	B1AR51_MOUSE Dynein, axonemal, heavy chain 9 OS=Mus musculus OX=10090 GN=Dnah9 PE=1 SV=1
8	Q6Z0E2	1.1	31.6	989	0.178	0.026	CCC1_ORYSJ Cation-chloride cotransporter 1 OS=Oryza sativa subsp. japonica OX=39947 GN=CCC1 PE=2 SV=1
9	A0A0F6B2Q8	1.6	30.4	192	0.096	0.073	A0A0F6B2Q8_SALT1 Flagellar transcriptional regulator FlhC OS=Salmonella typhimurium (strain 14028s / SGSC 2262) OX=588858 GN=flhC PE=3 SV=1
10	Q9NYC9	2.4	30.4	4486	0.089	0.003	DYH9_HUMAN Dynein axonemal heavy chain 9 OS=Homo sapiens OX=9606 GN=DNAH9 PE=1 SV=3
11	P0ABY7	5.7	28.9	192	0.089	0.068	FLHC_ECOLI Flagellar transcriptional regulator FlhC OS=Escherichia coli (strain K12) OX=83333 GN=flhC PE=1 SV=1
12	P0ABY9	5.7	28.9	192	0.089	0.068	FLHC_ECO57 Flagellar transcriptional regulator FlhC OS=Escherichia coli O157:H7 OX=83334 GN=flhC PE=3 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF03487 IL13	1.7e-67	236.6	Interleukin-13

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000304915

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000360730	0.999	Interleukin-13 receptor subunit alpha-1
2	9606.ENSP00000361004	0.999	Interleukin-13 receptor subunit alpha-2
3	9606.ENSP00000379111	0.999	Interleukin-4 receptor subunit alpha
4	9606.ENSP00000398698	0.989	Tumor necrosis factor
5	9606.ENSP00000385675	0.987	Interleukin-6
6	9606.ENSP00000263341	0.986	Interleukin-1 beta
7	9606.ENSP00000306512	0.985	Interleukin-8
8	9606.ENSP00000225831	0.983	C-C motif chemokine 2
9	9606.ENSP00000368632	0.981	Trans-acting T-cell-specific transcription factor GATA-3
10	9606.ENSP00000263339	0.979	Interleukin-1 alpha
11	9606.ENSP00000280357	0.975	Interleukin-18
12	9606.ENSP00000441691	0.970	Integrin alpha-M
13	9606.ENSP00000219235	0.969	C-C motif chemokine 22
14	9606.ENSP00000454623	0.969	Integrin alpha-X
15	9606.ENSP00000294728	0.965	Vascular cell adhesion protein 1
16	9606.ENSP00000346839	0.953	Fibronectin type III domain containing
17	9606.ENSP00000327048	0.948	Transcription factor Maf
18	9606.ENSP00000264072	0.944	Low affinity immunoglobulin epsilon Fc receptor
19	9606.ENSP00000363512	0.944	Arachidonate 5-lipoxygenase
20	9606.ENSP00000458832	0.944	Arachidonate 15-lipoxygenase

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0005102	0.390	signaling receptor binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0050789	0.997	regulation of biological process
GO:0050794	0.994	regulation of cellular process
GO:0050896	0.980	response to stimulus
GO:0048519	0.977	negative regulation of biological process
GO:0048523	0.968	negative regulation of cellular process
GO:0051239	0.964	regulation of multicellular organismal process
GO:0010941	0.959	regulation of cell death
GO:0009987	0.955	cellular process
GO:0048518	0.947	positive regulation of biological process
GO:0060548	0.943	negative regulation of cell death
GO:0006950	0.938	response to stress
GO:0010468	0.932	regulation of gene expression
GO:0031341	0.917	regulation of cell killing
GO:0043066	0.916	negative regulation of apoptotic process
GO:0009893	0.885	positive regulation of metabolic process
GO:0006952	0.878	defense response
GO:0031342	0.860	negative regulation of cell killing
GO:0010604	0.852	positive regulation of macromolecule metabolic process
GO:2000351	0.838	regulation of endothelial cell apoptotic process
GO:0051240	0.823	positive regulation of multicellular organismal process
GO:1904036	0.804	negative regulation of epithelial cell apoptotic process
GO:0010628	0.783	positive regulation of gene expression
GO:0048583	0.775	regulation of response to stimulus
GO:0048522	0.738	positive regulation of cellular process
GO:0001817	0.724	regulation of cytokine production
GO:0002376	0.712	immune system process
GO:0032501	0.698	multicellular organismal process
GO:0051716	0.686	cellular response to stimulus
GO:0001819	0.550	positive regulation of cytokine production
GO:0032101	0.454	regulation of response to external stimulus
GO:0006954	0.452	inflammatory response
GO:0080134	0.447	regulation of response to stress
GO:0002682	0.411	regulation of immune system process
GO:0031347	0.393	regulation of defense response
GO:0042221	0.386	response to chemical
GO:0007165	0.312	signal transduction

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005576	0.999	extracellular region
GO:0005886	0.828	plasma membrane
GO:0005615	0.774	extracellular space
GO:0005622	0.632	intracellular anatomical structure
GO:0043231	0.481	intracellular membrane-bounded organelle

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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