StarFunc result for job id P35557

User Input

>input (465 residues)
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P17712	0.998	0.998	3.249E-79	465	0.970	0.970	P17712.pdb.gz	HXK4_RAT Hexokinase-4 OS=Rattus norvegicus OX=10116 GN=Gck PE=1 SV=2
2	AFDB:A0A5F9ZHE0	0.991	0.948	2.155E-78	486	0.994	0.951	A0A5F9ZHE0.pdb.gz	A0A5F9ZHE0_HUMAN Phosphotransferase OS=Homo sapiens OX=9606 GN=GCK PE=1 SV=1
3	AFDB:O93314	0.982	0.969	4.869E-71	471	0.804	0.794	O93314.pdb.gz	O93314_ONCMY Phosphotransferase OS=Oncorhynchus mykiss OX=8022 GN=GK PE=2 SV=2
4	AFDB:F1RC38	0.981	0.958	1.638E-70	476	0.813	0.794	F1RC38.pdb.gz	F1RC38_DANRE Phosphotransferase OS=Danio rerio OX=7955 GN=fb57f10 PE=3 SV=2
5	AFDB:Q8JHA6	0.944	0.993	1.988E-70	442	0.841	0.885	Q8JHA6.pdb.gz	Q8JHA6_CHICK Phosphotransferase (Fragment) OS=Gallus gallus OX=9031 PE=2 SV=4
6	PDB:3idhA	0.948	0.972	6.900E-69	453	0.959	0.985	3idhA.pdb.gz	The active conformation of human glucokinase is not altered by allosteric activators
7	PDB:4dchA	0.762	0.812	7.529E-62	434	0.920	0.986	4dchA.pdb.gz	Insights into Mechanism of Glucokinase Activation: OBSERVATION OF MULTIPLE DISTINCT PROTEIN CONFORMATIONS.
8	AFDB:O08528	0.954	0.488	5.401E-56	917	0.529	0.268	O08528.pdb.gz	HXK2_MOUSE Hexokinase-2 OS=Mus musculus OX=10090 GN=Hk2 PE=1 SV=1
9	AFDB:Q8AYP7	0.958	0.490	6.247E-56	916	0.538	0.273	Q8AYP7.pdb.gz	Q8AYP7_CHICK hexokinase OS=Gallus gallus OX=9031 GN=HK2 PE=2 SV=1
10	PDB:5hfuB	0.884	0.472	2.065E-54	897	0.518	0.269	5hfuB.pdb.gz	Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors.
11	AFDB:Q8AYP8	0.968	0.494	3.180E-54	917	0.527	0.267	Q8AYP8.pdb.gz	Q8AYP8_CHICK hexokinase OS=Gallus gallus OX=9031 GN=HK1 PE=2 SV=1
12	AFDB:Q2TB90	0.964	0.492	4.255E-54	917	0.510	0.258	Q2TB90.pdb.gz	HKDC1_HUMAN Hexokinase HKDC1 OS=Homo sapiens OX=9606 GN=HKDC1 PE=1 SV=3
13	AFDB:P17710	0.959	0.461	9.708E-54	974	0.505	0.241	P17710.pdb.gz	HXK1_MOUSE Hexokinase-1 OS=Mus musculus OX=10090 GN=Hk1 PE=1 SV=3
14	PDB:1qhaA	0.948	0.493	1.483E-50	903	0.525	0.270	1qhaA.pdb.gz	Binding of non-catalytic ATP to human hexokinase I highlights the structural components for enzyme-membrane association control.
15	PDB:5hg1A	0.945	0.511	2.294E-50	867	0.540	0.290	5hg1A.pdb.gz	Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors.
16	PDB:2nztB	0.923	0.498	5.234E-50	867	0.520	0.279	2nztB.pdb.gz	The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation.
17	PDB:6jj7A	0.875	0.875	1.416E-37	465	0.361	0.361	6jj7A.pdb.gz	Crystal structure of OsHXK6-Glc complex
18	PDB:3b8aX	0.877	0.869	4.117E-37	470	0.331	0.328	3b8aX.pdb.gz	Crystal structure of yeast hexokinase PI in complex with glucose: A classical "induced fit" example revised.
19	PDB:4qs7A	0.865	0.883	1.257E-36	455	0.320	0.327	4qs7A.pdb.gz	Biochemical and structural study of Arabidopsis hexokinase 1
20	PDB:1ig8A	0.823	0.817	9.901E-35	469	0.305	0.303	1ig8A.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A5F9ZGW4	0.0	941	456	0.981	1.000	A0A5F9ZGW4_HUMAN Phosphotransferase OS=Homo sapiens OX=9606 GN=GCK PE=1 SV=1
2	A0A5F9ZHE0	0.0	941	486	0.994	0.951	A0A5F9ZHE0_HUMAN Phosphotransferase OS=Homo sapiens OX=9606 GN=GCK PE=1 SV=1
3	C9JQD1	0.0	912	448	0.963	1.000	C9JQD1_HUMAN Phosphotransferase OS=Homo sapiens OX=9606 GN=GCK PE=1 SV=1
4	F1RC38	0.0	739	476	0.806	0.788	F1RC38_DANRE Phosphotransferase OS=Danio rerio OX=7955 GN=fb57f10 PE=3 SV=2
5	O08528	0.0	532	917	0.529	0.268	HXK2_MOUSE Hexokinase-2 OS=Mus musculus OX=10090 GN=Hk2 PE=1 SV=1
6	O93314	0.0	762	471	0.804	0.794	O93314_ONCMY Phosphotransferase OS=Oncorhynchus mykiss OX=8022 GN=GK PE=2 SV=2
7	P17712	0.0	939	465	0.970	0.970	HXK4_RAT Hexokinase-4 OS=Rattus norvegicus OX=10116 GN=Gck PE=1 SV=2
8	P27881	0.0	532	917	0.529	0.268	HXK2_RAT Hexokinase-2 OS=Rattus norvegicus OX=10116 GN=Hk2 PE=1 SV=1
9	P35557	0.0	961	465	1.000	1.000	HXK4_HUMAN Hexokinase-4 OS=Homo sapiens OX=9606 GN=GCK PE=1 SV=1
10	P52792	0.0	910	465	0.959	0.959	HXK4_MOUSE Hexokinase-4 OS=Mus musculus OX=10090 GN=Gck PE=1 SV=1
11	Q53Y25	0.0	961	465	1.000	1.000	Q53Y25_HUMAN Phosphotransferase OS=Homo sapiens OX=9606 GN=GCK PE=2 SV=1
12	Q8AYP7	0.0	536	916	0.555	0.282	Q8AYP7_CHICK hexokinase OS=Gallus gallus OX=9031 GN=HK2 PE=2 SV=1
13	Q8JHA6	0.0	820	442	0.841	0.885	Q8JHA6_CHICK Phosphotransferase (Fragment) OS=Gallus gallus OX=9031 PE=2 SV=4
14	E9PB90	7.84e-180	528	889	0.538	0.281	E9PB90_HUMAN hexokinase OS=Homo sapiens OX=9606 GN=HK2 PE=1 SV=1
15	P52789	1.23e-179	528	917	0.538	0.273	HXK2_HUMAN Hexokinase-2 OS=Homo sapiens OX=9606 GN=HK2 PE=1 SV=2
16	Q8AYP8	3.07e-177	522	917	0.525	0.266	Q8AYP8_CHICK hexokinase OS=Gallus gallus OX=9031 GN=HK1 PE=2 SV=1
17	P19367	1.44e-176	520	917	0.525	0.266	HXK1_HUMAN Hexokinase-1 OS=Homo sapiens OX=9606 GN=HK1 PE=1 SV=3
18	P05708	1.73e-173	512	918	0.508	0.257	HXK1_RAT Hexokinase-1 OS=Rattus norvegicus OX=10116 GN=Hk1 PE=1 SV=4
19	Q91W97	2.18e-171	507	915	0.512	0.260	HKDC1_MOUSE Hexokinase HKDC1 OS=Mus musculus OX=10090 GN=Hkdc1 PE=2 SV=1
20	Q2TB90	4.31e-171	506	917	0.508	0.257	HKDC1_HUMAN Hexokinase HKDC1 OS=Homo sapiens OX=9606 GN=HKDC1 PE=1 SV=3

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00349 Hexokinase_1	1e-65	232.9	Hexokinase
2	PF03727 Hexokinase_2	6.1e-73	256.7	Hexokinase
3	PF01988 VIT1	5.5e+02	11.8	VIT family

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9555.ENSPANP00000006278

Rank	PPI partner	STRING score	Description
1	9555.ENSPANP00000009029	0.996	Glucokinase (hexokinase 4) regulator
2	9555.ENSPANP00000001712	0.978	Glucose-6-phosphate isomerase
3	9555.ENSPANP00000005221	0.976	Trehalase (brush-border membrane glycoprotein)
4	9555.ENSPANP00000014240	0.961	ADP-dependent glucokinase
5	9555.ENSPANP00000018550	0.959	Phosphoglucomutase 2
6	9555.ENSPANP00000020770	0.959	Glucose-6-phosphatase
7	9555.ENSPANP00000005092	0.953	Converts alpha-aldose to the beta-anomer.
8	9555.ENSPANP00000006937	0.953	Lactase
9	9555.ENSPANP00000020738	0.949	Glucose-6-phosphatase, catalytic subunit
10	9555.ENSPANP00000018179	0.946	Hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
11	9555.ENSPANP00000008292	0.937	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
12	9555.ENSPANP00000019027	0.929	Belongs to the class I fructose-bisphosphate aldolase family
13	9555.ENSPANP00000019823	0.929	Belongs to the class I fructose-bisphosphate aldolase family
14	9555.ENSPANP00000001054	0.924	Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis
15	9555.ENSPANP00000009531	0.919	Uncharacterized protein
16	9555.ENSPANP00000002624	0.916	Hexokinase 2
17	9555.ENSPANP00000004628	0.915	Transketolase
18	9555.ENSPANP00000010735	0.903	Phosphotransferase
19	9555.ENSPANP00000019269	0.896	Phosphoglucomutase 5
20	9555.ENSPANP00000020420	0.894	Hexokinase domain containing 1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0004340	0.997	glucokinase activity
GO:0005515	0.992	protein binding
GO:0097159	0.406	organic cyclic compound binding
GO:1901363	0.382	heterocyclic compound binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0033500	0.989	carbohydrate homeostasis
GO:0009987	0.988	cellular process
GO:0071704	0.988	organic substance metabolic process
GO:0065007	0.987	biological regulation
GO:0042593	0.984	glucose homeostasis
GO:0044238	0.979	primary metabolic process
GO:0032879	0.976	regulation of localization
GO:0044237	0.972	cellular metabolic process
GO:0050794	0.944	regulation of cellular process
GO:0051049	0.938	regulation of transport
GO:0005975	0.929	carbohydrate metabolic process
GO:0044281	0.918	small molecule metabolic process
GO:0048518	0.905	positive regulation of biological process
GO:0051046	0.902	regulation of secretion
GO:0032880	0.892	regulation of protein localization
GO:0005996	0.881	monosaccharide metabolic process
GO:0048522	0.870	positive regulation of cellular process
GO:0051050	0.867	positive regulation of transport
GO:0006753	0.861	nucleoside phosphate metabolic process
GO:0050708	0.858	regulation of protein secretion
GO:0019318	0.852	hexose metabolic process
GO:1903532	0.852	positive regulation of secretion by cell
GO:0072521	0.826	purine-containing compound metabolic process
GO:0051222	0.813	positive regulation of protein transport
GO:0001678	0.801	intracellular glucose homeostasis
GO:0050714	0.800	positive regulation of protein secretion
GO:0006006	0.785	glucose metabolic process
GO:0050896	0.676	response to stimulus
GO:0002791	0.621	regulation of peptide secretion
GO:0019222	0.620	regulation of metabolic process
GO:0090276	0.613	regulation of peptide hormone secretion
GO:0050796	0.568	regulation of insulin secretion
GO:0090277	0.501	positive regulation of peptide hormone secretion
GO:0016310	0.496	phosphorylation
GO:0042221	0.482	response to chemical
GO:0032024	0.458	positive regulation of insulin secretion
GO:0080090	0.453	regulation of primary metabolic process
GO:0006163	0.407	purine nucleotide metabolic process
GO:0051716	0.363	cellular response to stimulus
GO:1901135	0.335	carbohydrate derivative metabolic process
GO:0010033	0.329	response to organic substance
GO:0031323	0.313	regulation of cellular metabolic process
GO:0060255	0.304	regulation of macromolecule metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005829	0.999	cytosol
GO:0043231	0.937	intracellular membrane-bounded organelle
GO:0070013	0.548	intracellular organelle lumen
GO:0005634	0.450	nucleus
GO:0031981	0.311	nuclear lumen

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:17825	0.997	ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+)
EC:2.7.1.2	0.997	glucokinase.

[back to server]