StarFunc result for job id P35711

User Input

>input (763 residues)
MLTDPDLPQEFERMSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHVSFPN
KPHSEEFQPVSLLTQETCGHRTPTSQHNTMEVDGNKVMSSFAPHNSSTSPQKAEEGGRQS
GESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAM
GSGNFGEIKGTPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMEL
AKQQQEQIARQQQQLLQQQHKINLLQQQIQVQGQLPPLMIPVFPPDQRTLAAAAQQGFLL
PPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGPLQLQQLYAAQLAAMQVSPGGKLPGI
PQGNLGAAVSPTSIHTDKSTNSPPPKSKDEVAQPLNLSAKPKTSDGKSPTSPTSPHMPAL
RINSGAGPLKASVPAALASPSARVSTIGYLNDHDAVTKAIQEARQMKEQLRREQQVLDGK
VAVVNSLGLNNCRTEKEKTTLESLTQQLAVKQNEEGKFSHAMMDFNLSGDSDGSAGVSES
RIYRESRGRGSNEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKAMTNL
EKQPYYEEQARLSKQHLEKYPDYKYKPRPKRTCLVDGKKLRIGEYKAIMRNRRQEMRQYF
NVGQQAQIPIATAGVVYPGAIAMAGMPSPHLPSEHSSVSSSPEPGMPVIQSTYGVKGEEP
HIKEEIQAEDINGEIYDEYDEEEDDPDVDYGSDSENHIAGQAN

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:F1M8W4	0.278	0.278	1.587E-99	763	0.965	0.965	F1M8W4.pdb.gz	SOX5_RAT Transcription factor SOX-5 OS=Rattus norvegicus OX=10116 GN=Sox5 PE=1 SV=2
2	AFDB:P40647	0.210	0.211	1.605E-81	757	0.834	0.840	P40647.pdb.gz	SOX5_XENLA Transcription factor Sox-5 OS=Xenopus laevis OX=8355 GN=sox5 PE=2 SV=2
3	AFDB:B3DJE0	0.369	0.370	1.084E-75	759	0.751	0.755	B3DJE0.pdb.gz
4	AFDB:P35712	0.170	0.159	3.603E-57	828	0.620	0.571	P35712.pdb.gz	SOX6_HUMAN Transcription factor SOX-6 OS=Homo sapiens OX=9606 GN=SOX6 PE=1 SV=3
5	AFDB:G5EHY9	0.118	0.192	2.917E-7	442	0.083	0.143	G5EHY9.pdb.gz	G5EHY9_MAGO7 Mating-type protein mat a-1 OS=Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) OX=242507 GN=MGCH7_ch7g756 PE=4 SV=1
6	AFDB:P41225	0.105	0.177	9.083E-6	446	0.107	0.184	P41225.pdb.gz	SOX3_HUMAN Transcription factor SOX-3 OS=Homo sapiens OX=9606 GN=SOX3 PE=1 SV=2
7	AFDB:O57399	0.097	0.201	1.542E-5	367	0.098	0.204	O57399.pdb.gz	O57399_ONCMY Transcription factor SOX OS=Oncorhynchus mykiss OX=8022 GN=GSONMT00079394001 PE=2 SV=1
8	AFDB:P0C1G9	0.104	0.197	2.478E-4	395	0.085	0.165	P0C1G9.pdb.gz	SOX11_RAT Transcription factor SOX-11 OS=Rattus norvegicus OX=10116 GN=Sox11 PE=2 SV=1
9	AFDB:Q9YHE8	0.102	0.137	3.448E-4	560	0.100	0.136	Q9YHE8.pdb.gz	T7L1A_DANRE Transcription factor 7-like 1-A OS=Danio rerio OX=7955 GN=tcf7l1a PE=1 SV=1
10	AFDB:Q9VLH8	0.114	0.144	5.127E-4	572	0.110	0.147	Q9VLH8.pdb.gz	Q9VLH8_DROME LD44245p OS=Drosophila melanogaster OX=7227 GN=SoxN PE=1 SV=1
11	PDB:1j5nA	0.087	0.611	5.502E-4	93	0.033	0.269	1j5nA.pdb.gz	The S. cerevisiae architectural HMGB protein NHP6A complexed with DNA: DNA and protein conformational changes upon binding
12	PDB:7n9qA	0.042	0.016	5.765	2315	0.013	0.004	7n9qA.pdb.gz
13	PDB:6qw65B	0.042	0.022	6.159	2001	0.039	0.015	6qw65B.pdb.gz	Mechanism of 5' splice site transfer for human spliceosome activation.
14	PDB:7ajtCJ	0.048	0.108	6.159	282	0.012	0.032	7ajtCJ.pdb.gz	Structure of the Maturing 90S Pre-ribosome in Association with the RNA Exosome.
15	PDB:3mxzA	0.046	0.219	6.580	107	0.012	0.084	3mxzA.pdb.gz
16	PDB:6qnxA	0.049	0.041	6.580	928	0.010	0.009	6qnxA.pdb.gz	The structural basis for cohesin-CTCF-anchored loops.
17	PDB:4l80C	0.026	0.048	7.510	347	0.014	0.032	4l80C.pdb.gz	The crystal structures of the tri-functional Chloroflexus aurantiacus and bi-functional Rhodobacter sphaeroides malyl-CoA lyases and comparison with CitE-like superfamily enzymes and malate synthases.
18	PDB:7o3hG	0.052	0.285	7.510	80	0.014	0.138	7o3hG.pdb.gz	Structure and assembly of the mammalian mitochondrial supercomplex CIII 2 CIV.
19	PDB:6ww7E	0.045	0.219	8.023	101	0.005	0.040	6ww7E.pdb.gz	Structural basis for membrane insertion by the human ER membrane protein complex.
20	PDB:6jcxF	0.046	0.142	9.783	186	0.012	0.048	6jcxF.pdb.gz	Structures and mechanism of transcription initiation by bacterial ECF factors.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A0G2JTZ2	0.0	785	827	0.624	0.576	SOX6_RAT Transcription factor SOX-6 OS=Rattus norvegicus OX=10116 GN=Sox6 PE=1 SV=2
2	F1M8W4	0.0	1523	763	0.966	0.966	SOX5_RAT Transcription factor SOX-5 OS=Rattus norvegicus OX=10116 GN=Sox5 PE=1 SV=2
3	F8W2H3	0.0	809	768	0.608	0.604	F8W2H3_DANRE SRY-box containing protein 6 OS=Danio rerio OX=7955 GN=fc35a10 PE=1 SV=2
4	P35710	0.0	1526	763	0.969	0.969	SOX5_MOUSE Transcription factor SOX-5 OS=Mus musculus OX=10090 GN=Sox5 PE=1 SV=2
5	P35711	0.0	1572	763	1.000	1.000	SOX5_HUMAN Transcription factor SOX-5 OS=Homo sapiens OX=9606 GN=SOX5 PE=1 SV=3
6	P35712	0.0	787	828	0.630	0.581	SOX6_HUMAN Transcription factor SOX-6 OS=Homo sapiens OX=9606 GN=SOX6 PE=1 SV=3
7	P40645	0.0	786	827	0.625	0.577	SOX6_MOUSE Transcription factor SOX-6 OS=Mus musculus OX=10090 GN=Sox6 PE=1 SV=2
8	P40647	0.0	1114	757	0.834	0.840	SOX5_XENLA Transcription factor Sox-5 OS=Xenopus laevis OX=8355 GN=sox5 PE=2 SV=2
9	Q3ZM07	0.0	982	759	0.723	0.727	Q3ZM07_DANRE SRY-box-containing protein 5 OS=Danio rerio OX=7955 GN=id:ibd5067 PE=1 SV=1
10	Q04891	5.71e-118	370	613	0.364	0.454	SOX13_MOUSE Transcription factor SOX-13 OS=Mus musculus OX=10090 GN=Sox13 PE=1 SV=4
11	Q9UN79	4.41e-117	368	622	0.372	0.457	SOX13_HUMAN Transcription factor SOX-13 OS=Homo sapiens OX=9606 GN=SOX13 PE=1 SV=3
12	O57396	1.10e-97	316	585	0.298	0.388	O57396_ONCMY RtSox23 OS=Oncorhynchus mykiss OX=8022 PE=2 SV=1
13	Q9V480	2.27e-56	205	580	0.113	0.148	Q9V480_DROME Sox102F, isoform A OS=Drosophila melanogaster OX=7227 GN=Sox102F PE=4 SV=1
14	Q59DN5	4.80e-56	204	618	0.113	0.139	Q59DN5_DROME FI18025p1 OS=Drosophila melanogaster OX=7227 GN=Sox102F PE=2 SV=1
15	Q23045	1.51e-51	189	470	0.101	0.164	EGL13_CAEEL Transcription factor egl-13 OS=Caenorhabditis elegans OX=6239 GN=egl-13 PE=1 SV=2
16	Q5PQZ5	3.20e-26	114	413	0.059	0.109	Q5PQZ5_DANRE SRY-box 17 OS=Danio rerio OX=7955 GN=sox17 PE=2 SV=1
17	Q6TEN5	1.06e-25	112	390	0.066	0.128	Q6TEN5_DANRE SRY-box 7 OS=Danio rerio OX=7955 GN=SOX7 PE=2 SV=1
18	Q90ZH8	1.12e-25	111	363	0.076	0.160	SX18A_XENLA Transcription factor Sox-18A OS=Xenopus laevis OX=8355 GN=sox18-a PE=1 SV=1
19	O42342	1.52e-25	111	362	0.073	0.155	SOX7_XENLA Transcription factor Sox-7 OS=Xenopus laevis OX=8355 GN=sox7 PE=2 SV=1
20	Q28GD5	1.79e-25	110	362	0.073	0.155	SOX7_XENTR Transcription factor Sox-7 OS=Xenopus tropicalis OX=8364 GN=sox7 PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00505 HMG_box	8.8e-19	79.0	HMG (high mobility group) box
2	PF09011 HMG_box_2	1.9e-05	36.5	HMG-box domain
3	PF17060 MPS2	8.1e+02	10.8	Monopolar spindle protein 2

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 61622.XP_010373756.1

Rank	PPI partner	STRING score	Description
1	61622.XP_010369065.1	0.765	Thyroid hormone receptor interactor 12
2	61622.XP_010387751.1	0.727	Transcription factor SOX-9-like
3	61622.XP_010372596.1	0.715	Catenin beta-1
4	61622.XP_010354758.1	0.713	Brain-specific homeobox protein homolog
5	61622.XP_010374555.1	0.707	Ethanolamine kinase 1
6	61622.XP_010371637.1	0.646	NK2 homeobox 5
7	61622.XP_010356209.1	0.644	Forkhead box protein I2
8	61622.XP_010353974.1	0.635	Centrosomal protein of 85 kDa isoform X1
9	61622.XP_010373949.1	0.628	Quiescin sulfhydryl oxidase 1
10	61622.XP_010352456.1	0.627	Collagen type II alpha 1 chain
11	61622.XP_010366627.1	0.620	Muskelin
12	61622.XP_010370838.1	0.617	Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX
13	61622.XP_010385597.1	0.614	Forkhead box protein R2
14	61622.XP_010356134.1	0.606	FEZ family zinc finger 2
15	61622.XP_010358215.1	0.589	Neurogenin-1
16	61622.XP_010357573.1	0.583	Transcription factor Maf
17	61622.XP_010379547.1	0.583	Transcription factor Maf
18	61622.XP_010385204.1	0.572	Zinc finger and BTB domain-containing protein 20 isoform X1
19	61622.XP_010360606.1	0.569	Aggrecan
20	61622.XP_010385266.1	0.565	Zinc finger protein 274

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0003700	1.000	DNA-binding transcription factor activity
GO:0000976	1.000	transcription cis-regulatory region binding
GO:0000987	0.930	cis-regulatory region sequence-specific DNA binding
GO:0000981	0.540	DNA-binding transcription factor activity, RNA polymerase II-specific

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0050789	0.990	regulation of biological process
GO:0032502	0.987	developmental process
GO:0009987	0.987	cellular process
GO:0050794	0.982	regulation of cellular process
GO:0048518	0.917	positive regulation of biological process
GO:0048856	0.868	anatomical structure development
GO:0032501	0.842	multicellular organismal process
GO:0019222	0.838	regulation of metabolic process
GO:0048522	0.829	positive regulation of cellular process
GO:0060255	0.815	regulation of macromolecule metabolic process
GO:0031323	0.809	regulation of cellular metabolic process
GO:0010468	0.784	regulation of gene expression
GO:0051252	0.778	regulation of RNA metabolic process
GO:0006355	0.770	regulation of DNA-templated transcription
GO:0007275	0.654	multicellular organism development
GO:0048869	0.630	cellular developmental process
GO:0030154	0.622	cell differentiation
GO:0048519	0.564	negative regulation of biological process
GO:0048523	0.553	negative regulation of cellular process
GO:0048731	0.540	system development
GO:0048513	0.504	animal organ development
GO:0050793	0.432	regulation of developmental process
GO:0051239	0.429	regulation of multicellular organismal process
GO:0050896	0.414	response to stimulus
GO:0006357	0.375	regulation of transcription by RNA polymerase II
GO:0051172	0.355	negative regulation of nitrogen compound metabolic process
GO:0010605	0.354	negative regulation of macromolecule metabolic process
GO:0031324	0.353	negative regulation of cellular metabolic process
GO:0061035	0.346	regulation of cartilage development
GO:0045934	0.323	negative regulation of nucleobase-containing compound metabolic process
GO:0045595	0.306	regulation of cell differentiation

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005654	0.995	nucleoplasm
GO:0032991	0.991	protein-containing complex
GO:0005667	0.849	transcription regulator complex
GO:0005737	0.724	cytoplasm
GO:0005829	0.410	cytosol

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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