StarFunc result for job id P35713

User Input

>input (384 residues)
MQRSPPGYGAQDDPPARRDCAWAPGHGAAADTRGLAAGPAALAAPAAPASPPSPQRSPPR
SPEPGRYGLSPAGRGERQAADESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLG
KAWKELNAAEKRPFVEEAERLRVQHLRDHPNYKYRPRRKKQARKARRLEPGLLLPGLAPP
QPPPEPFPAASGSARAFRELPPLGAEFDGLGLPTPERSPLDGLEPGEAAFFPPPAAPEDC
ALRPFRAPYAPTELSRDPGGCYGAPLAEALRTAPPAAPLAGLYYGTLGTPGPYPGPLSPP
PEAPPLESAEPLGPAADLWADVDLTEFDQYLNCSRTRPDAPGLPYHVALAKLGPRAMSCP
EESSLISALSDASSAVYYSACISG

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P35713	0.999	0.999	6.367E-58	384	1.000	1.000	P35713.pdb.gz	SOX18_HUMAN Transcription factor SOX-18 OS=Homo sapiens OX=9606 GN=SOX18 PE=1 SV=2
2	AFDB:P43680	0.344	0.350	1.076E-47	377	0.865	0.881	P43680.pdb.gz	SOX18_MOUSE Transcription factor SOX-18 OS=Mus musculus OX=10090 GN=Sox18 PE=1 SV=3
3	AFDB:Q90ZH8	0.336	0.354	2.573E-24	363	0.482	0.510	Q90ZH8.pdb.gz	SX18A_XENLA Transcription factor Sox-18A OS=Xenopus laevis OX=8355 GN=sox18-a PE=1 SV=1
4	AFDB:E7F9I2	0.258	0.234	5.350E-23	431	0.497	0.443	E7F9I2.pdb.gz	E7F9I2_DANRE SRY-box transcription factor 18 OS=Danio rerio OX=7955 GN=sox18 PE=4 SV=1
5	AFDB:Q3KQ35	0.280	0.283	1.294E-18	380	0.365	0.368	Q3KQ35.pdb.gz	S17AA_XENLA Transcription factor Sox-17-alpha-A OS=Xenopus laevis OX=8355 GN=sox17a-a PE=1 SV=1
6	AFDB:Q9BT81	0.275	0.273	3.971E-18	388	0.388	0.384	Q9BT81.pdb.gz	SOX7_HUMAN Transcription factor SOX-7 OS=Homo sapiens OX=9606 GN=SOX7 PE=1 SV=1
7	AFDB:P40646	0.261	0.263	4.531E-18	380	0.398	0.403	P40646.pdb.gz	SOX7_MOUSE Transcription factor SOX-7 OS=Mus musculus OX=10090 GN=Sox7 PE=1 SV=2
8	AFDB:Q61473	0.298	0.276	4.268E-17	419	0.414	0.379	Q61473.pdb.gz	SOX17_MOUSE Transcription factor SOX-17 OS=Mus musculus OX=10090 GN=Sox17 PE=1 SV=1
9	AFDB:O42601	0.270	0.277	1.013E-15	373	0.305	0.314	O42601.pdb.gz	S17B1_XENLA Transcription factor Sox-17-beta.1 OS=Xenopus laevis OX=8355 GN=sox17b.1 PE=1 SV=1
10	AFDB:Q5PQZ5	0.242	0.225	3.788E-15	413	0.297	0.276	Q5PQZ5.pdb.gz	Q5PQZ5_DANRE SRY-box 17 OS=Danio rerio OX=7955 GN=sox17 PE=2 SV=1
11	PDB:1j5nA	0.161	0.607	7.928E-3	93	0.060	0.247	1j5nA.pdb.gz	The S. cerevisiae architectural HMGB protein NHP6A complexed with DNA: DNA and protein conformational changes upon binding
12	PDB:7ploI	0.119	0.102	2.985E-1	451	0.031	0.027	7ploI.pdb.gz	A conserved mechanism for regulating replisome disassembly in eukaryotes.
13	PDB:5n9jV	0.075	0.196	1.659	99	0.036	0.141	5n9jV.pdb.gz
14	PDB:1lotA	0.076	0.067	2.022	436	0.034	0.030	1lotA.pdb.gz	Crystal structure of the complex between actin and human vitamin D-binding protein at 2.5 A resolution.
15	PDB:6zm7CE	0.100	0.294	2.307	124	0.036	0.113	6zm7CE.pdb.gz	Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
16	PDB:4bwrA	0.083	0.071	3.427	467	0.031	0.026	4bwrA.pdb.gz	Crystal Structure of C5321: A Protective Antigen Present in Uropathogenic Escherichia Coli Strains Displaying an Slr Fold.
17	PDB:4wa6B	0.091	0.304	3.661	96	0.021	0.083	4wa6B.pdb.gz	Structure of yeast SAGA DUBm with Sgf73 N59D mutant at 2.36 angstroms resolution
18	PDB:3j79T	0.086	0.144	3.911	181	0.034	0.072	3j79T.pdb.gz	Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine.
19	PDB:7edxk	0.059	0.180	3.911	98	0.029	0.112	7edxk.pdb.gz	Structural insights into preinitiation complex assembly on core promoters.
20	PDB:6kkmE	0.075	0.083	4.177	334	0.047	0.054	6kkmE.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P35713	0.0	742	384	1.000	1.000	SOX18_HUMAN Transcription factor SOX-18 OS=Homo sapiens OX=9606 GN=SOX18 PE=1 SV=2
2	P43680	0.0	561	377	0.865	0.881	SOX18_MOUSE Transcription factor SOX-18 OS=Mus musculus OX=10090 GN=Sox18 PE=1 SV=3
3	Q90ZH8	2.65e-93	285	363	0.458	0.485	SX18A_XENLA Transcription factor Sox-18A OS=Xenopus laevis OX=8355 GN=sox18-a PE=1 SV=1
4	Q90ZH7	3.86e-92	282	361	0.456	0.485	SX18B_XENLA Transcription factor Sox-18B OS=Xenopus laevis OX=8355 GN=sox18-b PE=1 SV=1
5	E7F9I2	4.71e-89	277	431	0.469	0.418	E7F9I2_DANRE SRY-box transcription factor 18 OS=Danio rerio OX=7955 GN=sox18 PE=4 SV=1
6	O42342	1.45e-72	232	362	0.393	0.417	SOX7_XENLA Transcription factor Sox-7 OS=Xenopus laevis OX=8355 GN=sox7 PE=2 SV=1
7	Q28GD5	6.00e-72	231	362	0.391	0.414	SOX7_XENTR Transcription factor Sox-7 OS=Xenopus tropicalis OX=8364 GN=sox7 PE=2 SV=1
8	Q3KQ35	1.52e-69	225	380	0.383	0.387	S17AA_XENLA Transcription factor Sox-17-alpha-A OS=Xenopus laevis OX=8355 GN=sox17a-a PE=1 SV=1
9	Q90ZH9	7.85e-68	220	377	0.380	0.387	S17AB_XENLA Transcription factor Sox-17-alpha-B OS=Xenopus laevis OX=8355 GN=sox17a-b PE=1 SV=1
10	P40646	3.42e-61	203	380	0.385	0.389	SOX7_MOUSE Transcription factor SOX-7 OS=Mus musculus OX=10090 GN=Sox7 PE=1 SV=2
11	Q9BT81	1.11e-60	202	388	0.406	0.402	SOX7_HUMAN Transcription factor SOX-7 OS=Homo sapiens OX=9606 GN=SOX7 PE=1 SV=1
12	Q61473	1.82e-57	195	419	0.391	0.358	SOX17_MOUSE Transcription factor SOX-17 OS=Mus musculus OX=10090 GN=Sox17 PE=1 SV=1
13	Q6TEN5	2.10e-57	194	390	0.378	0.372	Q6TEN5_DANRE SRY-box 7 OS=Danio rerio OX=7955 GN=SOX7 PE=2 SV=1
14	Q9H6I2	9.26e-54	185	414	0.281	0.261	SOX17_HUMAN Transcription factor SOX-17 OS=Homo sapiens OX=9606 GN=SOX17 PE=1 SV=1
15	Q5PQZ5	2.51e-50	176	413	0.242	0.225	Q5PQZ5_DANRE SRY-box 17 OS=Danio rerio OX=7955 GN=sox17 PE=2 SV=1
16	O42601	8.71e-50	173	373	0.326	0.335	S17B1_XENLA Transcription factor Sox-17-beta.1 OS=Xenopus laevis OX=8355 GN=sox17b.1 PE=1 SV=1
17	P40657	1.65e-38	149	784	0.203	0.099	SOX15_DROME Putative transcription factor SOX-15 OS=Drosophila melanogaster OX=7227 GN=Sox15 PE=2 SV=2
18	Q90Z46	7.67e-33	127	307	0.135	0.169	Q90Z46_DANRE Casanova OS=Danio rerio OX=7955 GN=cas PE=2 SV=1
19	P55863	1.41e-31	123	309	0.141	0.175	SOX3A_XENLA Transcription factor Sox-3-A OS=Xenopus laevis OX=8355 GN=sox3-a PE=1 SV=1
20	Q6EJB7	1.79e-31	123	300	0.154	0.197	SOX3_DANRE Transcription factor Sox-3 OS=Danio rerio OX=7955 GN=sox3 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00505 HMG_box	8.7e-21	85.4	HMG (high mobility group) box
2	PF09011 HMG_box_2	3.4e-06	38.9	HMG-box domain
3	PF12067 Sox17_18_mid	3.1e-12	57.6	Sox 17/18 central domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000341815

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000340874	0.933	Myocyte-specific enhancer factor 2C
2	9606.ENSP00000377721	0.868	COUP transcription factor 2
3	9606.ENSP00000261937	0.845	Vascular endothelial growth factor receptor 3
4	9606.ENSP00000480043	0.845	Vascular endothelial growth factor C
5	9606.ENSP00000345206	0.840	Recombining binding protein suppressor of hairless
6	9606.ENSP00000256178	0.810	Lymphatic vessel endothelial hyaluronic acid receptor 1
7	9606.ENSP00000404464	0.803	Collagen and calcium-binding EGF domain-containing protein 1
8	9606.ENSP00000326371	0.704	Forkhead box protein C2
9	9606.ENSP00000355925	0.676	Prospero homeobox protein 1
10	9606.ENSP00000216366	0.668	AP-4 complex subunit sigma-1
11	9606.ENSP00000480476	0.661	5-oxoprolinase
12	9606.ENSP00000260227	0.631	Matrilysin
13	9606.ENSP00000245323	0.612	Ephrin-B2
14	9606.ENSP00000366902	0.600	Telomere zinc finger-associated protein
15	9606.ENSP00000379619	0.600	WD repeat-containing protein 72
16	9606.ENSP00000344115	0.566	Cadherin-5
17	9606.ENSP00000344456	0.565	Catenin beta-1
18	9606.ENSP00000304945	0.556	Roundabout homolog 4
19	9606.ENSP00000249749	0.554	Delta-like protein 4
20	9606.ENSP00000263923	0.551	Vascular endothelial growth factor receptor 2

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0001228	1.000	DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0000987	1.000	cis-regulatory region sequence-specific DNA binding
GO:0000977	1.000	RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978	0.993	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0005515	0.983	protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0050794	0.995	regulation of cellular process
GO:0009987	0.989	cellular process
GO:0007275	0.981	multicellular organism development
GO:0048522	0.980	positive regulation of cellular process
GO:0060255	0.977	regulation of macromolecule metabolic process
GO:0080090	0.953	regulation of primary metabolic process
GO:0031323	0.953	regulation of cellular metabolic process
GO:0010604	0.952	positive regulation of macromolecule metabolic process
GO:0051173	0.950	positive regulation of nitrogen compound metabolic process
GO:0031325	0.940	positive regulation of cellular metabolic process
GO:0010557	0.925	positive regulation of macromolecule biosynthetic process
GO:0051254	0.923	positive regulation of RNA metabolic process
GO:0072359	0.921	circulatory system development
GO:0030154	0.920	cell differentiation
GO:0048519	0.909	negative regulation of biological process
GO:0031328	0.906	positive regulation of cellular biosynthetic process
GO:0045893	0.903	positive regulation of DNA-templated transcription
GO:0048523	0.897	negative regulation of cellular process
GO:0009653	0.893	anatomical structure morphogenesis
GO:0006357	0.721	regulation of transcription by RNA polymerase II
GO:0048646	0.638	anatomical structure formation involved in morphogenesis
GO:0009892	0.629	negative regulation of metabolic process
GO:0010605	0.609	negative regulation of macromolecule metabolic process
GO:0045944	0.607	positive regulation of transcription by RNA polymerase II
GO:0001944	0.571	vasculature development
GO:0009888	0.567	tissue development
GO:0048513	0.555	animal organ development
GO:0031324	0.488	negative regulation of cellular metabolic process
GO:0051172	0.439	negative regulation of nitrogen compound metabolic process
GO:0045892	0.406	negative regulation of DNA-templated transcription
GO:0035239	0.342	tube morphogenesis
GO:0050896	0.332	response to stimulus
GO:0042127	0.315	regulation of cell population proliferation

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005634	1.000	nucleus
GO:0043232	0.957	intracellular non-membrane-bounded organelle
GO:0070013	0.930	intracellular organelle lumen
GO:0032991	0.872	protein-containing complex
GO:0005694	0.782	chromosome
GO:0005737	0.682	cytoplasm
GO:0000785	0.537	chromatin

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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