StarFunc result for job id P36507

User Input

>input (400 residues)
MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQ
GTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRP
PGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADL
KMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q63932	0.979	0.977	1.456E-65	401	0.943	0.940	Q63932.pdb.gz	MP2K2_MOUSE Dual specificity mitogen-activated protein kinase kinase 2 OS=Mus musculus OX=10090 GN=Map2k2 PE=1 SV=2
2	AFDB:A4QPA9	0.881	0.896	5.950E-58	393	0.797	0.812	A4QPA9.pdb.gz	A4QPA9_HUMAN Mitogen-activated protein kinase kinase 1 OS=Homo sapiens OX=9606 GN=MAP2K1 PE=2 SV=1
3	AFDB:Q24324	0.850	0.858	2.282E-47	396	0.595	0.601	Q24324.pdb.gz	DSOR1_DROME Dual specificity mitogen-activated protein kinase kinase dSOR1 OS=Drosophila melanogaster OX=7227 GN=Dsor1 PE=1 SV=2
4	PDB:3eqdA	0.769	0.974	2.539E-47	315	0.703	0.892	3eqdA.pdb.gz	Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors.
5	AFDB:Q10664	0.788	0.814	3.556E-41	387	0.510	0.527	Q10664.pdb.gz	MEK2_CAEEL Dual specificity mitogen-activated protein kinase kinase mek-2 OS=Caenorhabditis elegans OX=6239 GN=mek-2 PE=1 SV=1
6	PDB:5eymA	0.721	0.985	4.667E-39	292	0.650	0.890	5eymA.pdb.gz	Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases.
7	AFDB:G4NEB8	0.697	0.672	1.901E-31	415	0.385	0.371	G4NEB8.pdb.gz	MST7_MAGO7 Mitogen-activated protein kinase kinae MST7 OS=Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) OX=242507 GN=MST7 PE=1 SV=1
8	AFDB:Q5B7Q8	0.688	0.513	1.593E-30	539	0.383	0.284	Q5B7Q8.pdb.gz	Q5B7Q8_EMENI MAP kinase kinase (Eurofung) OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=ANIA_03422 PE=4 SV=1
9	AFDB:A9JRD0	0.678	0.604	2.541E-30	450	0.345	0.307	A9JRD0.pdb.gz	A9JRD0_DANRE Dual specificity mitogen-activated protein kinase kinase 5 OS=Danio rerio OX=7955 GN=zgc:172137 PE=2 SV=1
10	AFDB:Q13163	0.686	0.615	3.293E-30	448	0.357	0.319	Q13163.pdb.gz	MP2K5_HUMAN Dual specificity mitogen-activated protein kinase kinase 5 OS=Homo sapiens OX=9606 GN=MAP2K5 PE=1 SV=2
11	AFDB:P10506	0.664	0.778	1.481E-29	340	0.378	0.444	P10506.pdb.gz	BYR1_SCHPO Protein kinase byr1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=byr1 PE=1 SV=1
12	AFDB:Q94A06	0.669	0.754	2.907E-29	354	0.292	0.331	Q94A06.pdb.gz	M2K1_ARATH Mitogen-activated protein kinase kinase 1 OS=Arabidopsis thaliana OX=3702 GN=MKK1 PE=1 SV=2
13	PDB:8a8mB	0.585	0.770	8.628E-19	298	0.282	0.379	8a8mB.pdb.gz	Architecture of the MKK6-p38 alpha complex defines the basis of MAPK specificity and activation.
14	PDB:1blxA	0.488	0.623	1.432E-15	305	0.205	0.269	1blxA.pdb.gz	Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d.
15	PDB:4eomC	0.505	0.712	3.459E-15	276	0.177	0.257	4eomC.pdb.gz	An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity.
16	PDB:6s73A	0.575	0.837	4.482E-15	269	0.195	0.290	6s73A.pdb.gz	Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine.
17	PDB:4ek6A	0.509	0.720	8.795E-15	279	0.193	0.276	4ek6A.pdb.gz	Crystal structure of the cdk2 in complex with aminopyrazole inhibitor
18	PDB:4krcA	0.508	0.675	1.403E-14	297	0.198	0.266	4krcA.pdb.gz	New Structural Insights into Phosphorylation-free Mechanism for Full Cyclin-dependent Kinase (CDK)-Cyclin Activity and Substrate Recognition.
19	PDB:4c0tA	0.535	0.716	1.477E-14	291	0.160	0.220	4c0tA.pdb.gz
20	PDB:4gcjA	0.525	0.682	2.899E-14	304	0.195	0.257	4gcjA.pdb.gz	Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A4QPA9	0.0	631	393	0.797	0.812	A4QPA9_HUMAN Mitogen-activated protein kinase kinase 1 OS=Homo sapiens OX=9606 GN=MAP2K1 PE=2 SV=1
2	I3L5D4	0.0	606	302	0.723	0.957	I3L5D4_PIG Mitogen-activated protein kinase kinase 2 OS=Sus scrofa OX=9823 GN=MAP2K2 PE=1 SV=3
3	P29678	0.0	629	393	0.795	0.809	MP2K1_RABIT Dual specificity mitogen-activated protein kinase kinase 1 OS=Oryctolagus cuniculus OX=9986 GN=MAP2K1 PE=1 SV=2
4	P31938	0.0	631	393	0.797	0.812	MP2K1_MOUSE Dual specificity mitogen-activated protein kinase kinase 1 OS=Mus musculus OX=10090 GN=Map2k1 PE=1 SV=2
5	P36506	0.0	759	400	0.940	0.940	MP2K2_RAT Dual specificity mitogen-activated protein kinase kinase 2 OS=Rattus norvegicus OX=10116 GN=Map2k2 PE=1 SV=1
6	P36507	0.0	821	400	1.000	1.000	MP2K2_HUMAN Dual specificity mitogen-activated protein kinase kinase 2 OS=Homo sapiens OX=9606 GN=MAP2K2 PE=1 SV=1
7	Q01986	0.0	632	393	0.797	0.812	MP2K1_RAT Dual specificity mitogen-activated protein kinase kinase 1 OS=Rattus norvegicus OX=10116 GN=Map2k1 PE=1 SV=2
8	Q02750	0.0	631	393	0.797	0.812	MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 OS=Homo sapiens OX=9606 GN=MAP2K1 PE=1 SV=2
9	Q63932	0.0	757	401	0.943	0.940	MP2K2_MOUSE Dual specificity mitogen-activated protein kinase kinase 2 OS=Mus musculus OX=10090 GN=Map2k2 PE=1 SV=2
10	Q24324	4.82e-172	488	396	0.588	0.593	DSOR1_DROME Dual specificity mitogen-activated protein kinase kinase dSOR1 OS=Drosophila melanogaster OX=7227 GN=Dsor1 PE=1 SV=2
11	Q10664	9.01e-137	398	387	0.522	0.540	MEK2_CAEEL Dual specificity mitogen-activated protein kinase kinase mek-2 OS=Caenorhabditis elegans OX=6239 GN=mek-2 PE=1 SV=1
12	Q5B7Q8	3.32e-91	286	539	0.365	0.271	Q5B7Q8_EMENI MAP kinase kinase (Eurofung) OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=ANIA_03422 PE=4 SV=1
13	G4NEB8	4.78e-90	280	415	0.365	0.352	MST7_MAGO7 Mitogen-activated protein kinase kinae MST7 OS=Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) OX=242507 GN=MST7 PE=1 SV=1
14	P10506	1.98e-86	268	340	0.385	0.453	BYR1_SCHPO Protein kinase byr1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=byr1 PE=1 SV=1
15	Q13163	1.06e-82	261	448	0.352	0.315	MP2K5_HUMAN Dual specificity mitogen-activated protein kinase kinase 5 OS=Homo sapiens OX=9606 GN=MAP2K5 PE=1 SV=2
16	Q62862	3.31e-82	260	448	0.352	0.315	MP2K5_RAT Dual specificity mitogen-activated protein kinase kinase 5 OS=Rattus norvegicus OX=10116 GN=Map2k5 PE=1 SV=1
17	Q9WVS7	3.39e-82	260	448	0.352	0.315	MP2K5_MOUSE Dual specificity mitogen-activated protein kinase kinase 5 OS=Mus musculus OX=10090 GN=Map2k5 PE=1 SV=1
18	B1NA67	4.09e-80	255	449	0.343	0.305	B1NA67_DANRE Dual specificity mitogen-activated protein kinase kinase 5 isoform X1 OS=Danio rerio OX=7955 GN=wu:fb73f02 PE=2 SV=1
19	A9JRD0	1.35e-79	254	450	0.335	0.298	A9JRD0_DANRE Dual specificity mitogen-activated protein kinase kinase 5 OS=Danio rerio OX=7955 GN=zgc:172137 PE=2 SV=1
20	P08018	9.56e-79	257	668	0.340	0.204	PBS2_YEAST MAP kinase kinase PBS2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=PBS2 PE=1 SV=4

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF03109 ABC1	0.00038	31.2	ABC1 atypical kinase-like domain
2	PF01636 APH	58	15.0	Phosphotransferase enzyme family
3	PF17095 CAMSAP_CC1	3.2e+02	12.6	Spectrin-binding region of Ca2+-Calmodulin
4	PF12330 Haspin_kinase	58	14.1	Haspin like kinase domain
5	PF06293 Kdo	1.5e+02	13.1	Lipopolysaccharide kinase (Kdo/WaaP) family
6	PF14531 Kinase-like	10	16.9	Kinase-like
7	PF00069 Pkinase	9.8e-58	207.2	Protein kinase domain
8	PF17667 Pkinase_fungal	0.028	24.8	Fungal protein kinase
9	PF07714 PK_Tyr_Ser-Thr	4.5e-31	119.7	Protein tyrosine and serine/threonine kinase
10	PF07387 Seadorna_VP7	1.1e+02	13.3	Seadornavirus VP7

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000262948

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000215832	0.999	Mitogen-activated protein kinase 1
2	9606.ENSP00000251849	0.997	RAF proto-oncogene serine/threonine-protein kinase
3	9606.ENSP00000288602	0.996	Serine/threonine-protein kinase B-raf
4	9606.ENSP00000263025	0.995	Mitogen-activated protein kinase 3
5	9606.ENSP00000290277	0.995	Serine/threonine-protein kinase A-Raf
6	9606.ENSP00000381958	0.993	Kinase suppressor of Ras 1
7	9606.ENSP00000407586	0.978	GTPase HRas
8	9606.ENSP00000387784	0.976	Son of sevenless homolog 1
9	9606.ENSP00000340944	0.971	Tyrosine-protein phosphatase non-receptor type 11
10	9606.ENSP00000302486	0.970	Dual specificity mitogen-activated protein kinase kinase 1
11	9606.ENSP00000376345	0.965	Growth factor receptor-bound protein 2
12	9606.ENSP00000256078	0.964	GTPase KRas
13	9606.ENSP00000358548	0.964	GTPase NRas
14	9606.ENSP00000361930	0.957	14-3-3 protein beta/alpha
15	9606.ENSP00000263967	0.947	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
16	9606.ENSP00000382423	0.945	Mitogen-activated protein kinase kinase kinase 1
17	9606.ENSP00000264335	0.943	14-3-3 protein epsilon
18	9606.ENSP00000348461	0.943	Ras-related C3 botulinum toxin substrate 1
19	9606.ENSP00000389140	0.942	Netrin receptor DCC
20	9606.ENSP00000173229	0.937	Netrin-1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.999	protein binding
GO:0004712	0.999	protein serine/threonine/tyrosine kinase activity
GO:0004708	0.986	MAP kinase kinase activity
GO:0004674	0.962	protein serine/threonine kinase activity
GO:0008047	0.764	enzyme activator activity
GO:0019207	0.750	kinase regulator activity
GO:0019887	0.737	protein kinase regulator activity
GO:0019209	0.684	kinase activator activity
GO:0043539	0.573	protein serine/threonine kinase activator activity
GO:0019899	0.334	enzyme binding
GO:0060090	0.312	molecular adaptor activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0009987	0.998	cellular process
GO:0050794	0.998	regulation of cellular process
GO:0050896	0.990	response to stimulus
GO:0043170	0.990	macromolecule metabolic process
GO:0060341	0.990	regulation of cellular localization
GO:0048583	0.989	regulation of response to stimulus
GO:0023051	0.989	regulation of signaling
GO:0010646	0.989	regulation of cell communication
GO:0051049	0.987	regulation of transport
GO:0044237	0.986	cellular metabolic process
GO:0044238	0.985	primary metabolic process
GO:1903649	0.983	regulation of cytoplasmic transport
GO:0070302	0.983	regulation of stress-activated protein kinase signaling cascade
GO:0019538	0.981	protein metabolic process
GO:0048522	0.976	positive regulation of cellular process
GO:0007154	0.974	cell communication
GO:0006468	0.966	protein phosphorylation
GO:0035556	0.929	intracellular signal transduction
GO:0043408	0.916	regulation of MAPK cascade
GO:0032872	0.851	regulation of stress-activated MAPK cascade
GO:0019222	0.729	regulation of metabolic process
GO:0060255	0.618	regulation of macromolecule metabolic process
GO:0031323	0.547	regulation of cellular metabolic process
GO:0048519	0.456	negative regulation of biological process
GO:0080090	0.446	regulation of primary metabolic process
GO:0051171	0.436	regulation of nitrogen compound metabolic process
GO:0009893	0.425	positive regulation of metabolic process
GO:0010468	0.420	regulation of gene expression
GO:0032501	0.401	multicellular organismal process
GO:0010604	0.395	positive regulation of macromolecule metabolic process
GO:0065009	0.393	regulation of molecular function
GO:0048584	0.390	positive regulation of response to stimulus
GO:0051246	0.390	regulation of protein metabolic process
GO:0032502	0.376	developmental process
GO:0048523	0.353	negative regulation of cellular process
GO:0048856	0.341	anatomical structure development
GO:0051128	0.322	regulation of cellular component organization

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0012505	1.000	endomembrane system
GO:0005829	1.000	cytosol
GO:0071944	0.997	cell periphery
GO:0005634	0.996	nucleus
GO:0030054	0.994	cell junction
GO:0016020	0.993	membrane
GO:0031410	0.986	cytoplasmic vesicle
GO:0005886	0.969	plasma membrane
GO:0070161	0.933	anchoring junction
GO:0030055	0.923	cell-substrate junction
GO:0005925	0.876	focal adhesion
GO:0005768	0.875	endosome
GO:0005770	0.841	late endosome
GO:0005769	0.837	early endosome
GO:0005794	0.816	Golgi apparatus
GO:0005739	0.763	mitochondrion
GO:0043232	0.327	intracellular non-membrane-bounded organelle
GO:0070013	0.306	intracellular organelle lumen
GO:0031981	0.301	nuclear lumen

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:2.7.12.1	0.999	dual-specificity kinase.
EC:2.7.12.2	0.986	mitogen-activated protein kinase kinase.

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