StarFunc result for job id P42356

User Input

>input (2102 residues)
MAAAPARGGGGGGGGGGGCSGSGSSASRGFYFNTVLSLARSLAVQRPASLEKVQKLLCMC
PVDFHGIFQLDERRRDAVIALGIFLIESDLQHKDCVVPYLLRLLKGLPKVYWVEESTARK
GRGALPVAESFSFCLVTLLSDVAYRDPSLRDEILEVLLQVLHVLLGMCQALEIQDKEYLC
KYAIPCLIGISRAFGRYSNMEESLLSKLFPKIPPHSLRVLEELEGVRRRSFNDFRSILPS
NLLTVCQEGTLKRKTSSVSSISQVSPERGMPPPSSPGGSAFHYFEASCLPDGTALEPEYY
FSTISSSFSVSPLFNGVTYKEFNIPLEMLRELLNLVKKIVEEAVLKSLDAIVASVMEANP
SADLYYTSFSDPLYLTMFKMLRDTLYYMKDLPTSFVKEIHDFVLEQFNTSQGELQKILHD
ADRIHNELSPLKLRCQANAACVDLMVWAVKDEQGAENLCIKLSEKLQSKTSSKVIIAHLP
LLICCLQGLGRLCERFPVVVHSVTPSLRDFLVIPSPVLVKLYKYHSQYHTVAGNDIKISV
TNEHSESTLNVMSGKKSQPSMYEQLRDIAIDNICRCLKAGLTVDPVIVEAFLASLSNRLY
ISQESDKDAHLIPDHTIRALGHIAVALRDTPKVMEPILQILQQKFCQPPSPLDVLIIDQL
GCLVITGNQYIYQEVWNLFQQISVKASSVVYSATKDYKDHGYRHCSLAVINALANIAANI
QDEHLVDELLMNLLELFVQLGLEGKRASERASEKGPALKASSSAGNLGVLIPVIAVLTRR
LPPIKEAKPRLQKLFRDFWLYSVLMGFAVEGSGLWPEEWYEGVCEIATKSPLLTFPSKEP
LRSVLQYNSAMKNDTVTPAELSELRSTIINLLDPPPEVSALINKLDFAMSTYLLSVYRLE
YMRVLRSTDPDRFQVMFCYFEDKAIQKDKSGMMQCVIAVADKVFDAFLNMMADKAKTKEN
EEELERHAQFLLVNFNHIHKRIRRVADKYLSGLVDKFPHLLWSGTVLKTMLDILQTLSLS
LSADIHKDQPYYDIPDAPYRITVPDTYEARESIVKDFAARCGMILQEAMKWAPTVTKSHL
QEYLNKHQNWVSGLSQHTGLAMATESILHFAGYNKQNTTLGATQLSERPACVKKDYSNFM
ASLNLRNRYAGEVYGMIRFSGTTGQMSDLNKMMVQDLHSALDRSHPQHYTQAMFKLTAML
ISSKDCDPQLLHHLCWGPLRMFNEHGMETALACWEWLLAGKDGVEVPFMREMAGAWHMTV
EQKFGLFSAEIKEADPLAASEASQPKPCPPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIF
SSLLQRSMSLNIGGAKGSMNRHVAAIGPRFKLLTLGLSLLHADVVPNATIRNVLREKIYS
TAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVPPDNQDTRSNLDI
TVGSRQQATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQLHKYYMKRRTLLLSLLATEI
ERLITWYNPLSAPELELDQAGENSVANWRSKYISLSEKQWKDNVNLAWSISPYLAVQLPA
RFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPTG
LSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGYVREYILWAASKS
QLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLDQLVEEITGSLSGPAKDFYQREFDFFNK
ITNVSAIIKPYPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAK
APYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKVGDDCRQDML
ALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDFGMYDYF
TRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMF
ESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTL
MLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKVIQSCFLSNRSRTYDMIQYYQNDI
PY

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:E9Q3L2	0.987	0.986	0.000	2105	0.974	0.973	E9Q3L2.pdb.gz	PI4KA_MOUSE Phosphatidylinositol 4-kinase alpha OS=Mus musculus OX=10090 GN=Pi4ka PE=1 SV=2
2	AFDB:F1RCP0	0.937	0.956	0.000	2059	0.809	0.826	F1RCP0.pdb.gz
3	AFDB:M9PDM4	0.860	0.841	0.000	2154	0.459	0.448	M9PDM4.pdb.gz	M9PDM4_DROME 1-phosphatidylinositol 4-kinase OS=Drosophila melanogaster OX=7227 GN=Pi4KIIIalpha PE=1 SV=1
4	AFDB:Q9SXA1	0.662	0.684	4.349E-70	2028	0.235	0.244	Q9SXA1.pdb.gz	P4KA1_ARATH Phosphatidylinositol 4-kinase alpha 1 OS=Arabidopsis thaliana OX=3702 GN=PI4KA1 PE=1 SV=2
5	AFDB:P37297	0.571	0.621	5.162E-64	1900	0.220	0.243	P37297.pdb.gz	STT4_YEAST Phosphatidylinositol 4-kinase STT4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=STT4 PE=1 SV=1
6	AFDB:A0A1D8PTE0	0.389	0.423	5.887E-63	1927	0.214	0.234	A0A1D8PTE0.pdb.gz	A0A1D8PTE0_CANAL 1-phosphatidylinositol 4-kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=STT4 PE=3 SV=1
7	AFDB:Q9USR3	0.384	0.428	9.140E-62	1877	0.226	0.254	Q9USR3.pdb.gz	STT4_SCHPO Phosphatidylinositol 4-kinase stt4 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=stt4 PE=3 SV=1
8	AFDB:Q57WD8	0.394	0.360	1.042E-48	2312	0.184	0.167	Q57WD8.pdb.gz	Q57WD8_TRYB2 1-phosphatidylinositol 4-kinase OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb03.28C22.100 PE=3 SV=1
9	AFDB:Q580E2	0.208	0.724	2.079E-19	581	0.067	0.241	Q580E2.pdb.gz	Q580E2_TRYB2 Phosphatidylinositol 4-kinase, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb04.5E12.290 PE=4 SV=1
10	AFDB:A0A0B4J1S8	0.213	0.524	3.723E-19	828	0.072	0.182	A0A0B4J1S8.pdb.gz	A0A0B4J1S8_HUMAN Phosphatidylinositol 4-kinase beta OS=Homo sapiens OX=9606 GN=PI4KB PE=1 SV=1
11	PDB:4yknA	0.208	0.352	1.218E-16	1205	0.062	0.108	4yknA.pdb.gz	Discovery of a Potent Class of PI3K alpha Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT).
12	PDB:5dxhD	0.199	0.411	2.108E-16	981	0.060	0.129	5dxhD.pdb.gz	The Rational Design of Selective Benzoxazepin Inhibitors of the alpha-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326).
13	PDB:5dxtA	0.206	0.468	6.535E-16	879	0.062	0.149	5dxtA.pdb.gz	The Rational Design of Selective Benzoxazepin Inhibitors of the alpha-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326).
14	PDB:5itdA	0.212	0.430	6.535E-16	995	0.062	0.131	5itdA.pdb.gz	Discovery and Pharmacological Characterization of Novel Quinazoline-Based PI3K Delta-Selective Inhibitors.
15	PDB:7sicA	0.193	0.152	1.253E-15	2773	0.137	0.104	7sicA.pdb.gz	Structure of the human ATM kinase and mechanism of Nbs1 binding.
16	PDB:8dcxA	0.200	0.431	1.649E-15	930	0.060	0.137	8dcxA.pdb.gz
17	PDB:5swpA	0.205	0.390	2.026E-15	1060	0.068	0.135	5swpA.pdb.gz	Identification of allosteric binding sites for PI3K alpha oncogenic mutant specific inhibitor design.
18	PDB:7ni5A	0.196	0.152	2.096E-15	2791	0.138	0.104	7ni5A.pdb.gz	Molecular basis of human ATM kinase inhibition.
19	PDB:7mezA	0.206	0.419	2.404E-15	989	0.060	0.128	7mezA.pdb.gz
20	PDB:6zwmB	0.162	0.157	2.953E-15	2185	0.139	0.134	6zwmB.pdb.gz	The 3.2- angstrom resolution structure of human mTORC2.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	E9Q3L2	0.0	4276	2105	0.975	0.974	PI4KA_MOUSE Phosphatidylinositol 4-kinase alpha OS=Mus musculus OX=10090 GN=Pi4ka PE=1 SV=2
2	M9PDM4	0.0	1732	2154	0.467	0.456	M9PDM4_DROME 1-phosphatidylinositol 4-kinase OS=Drosophila melanogaster OX=7227 GN=Pi4KIIIalpha PE=1 SV=1
3	O08662	0.0	4254	2096	0.970	0.973	PI4KA_RAT Phosphatidylinositol 4-kinase alpha OS=Rattus norvegicus OX=10116 GN=Pi4ka PE=1 SV=2
4	P42356	0.0	4377	2102	1.000	1.000	PI4KA_HUMAN Phosphatidylinositol 4-kinase alpha OS=Homo sapiens OX=9606 GN=PI4KA PE=1 SV=4
5	Q49GP4	0.0	3456	2059	0.810	0.827	Q49GP4_DANRE 1-phosphatidylinositol 4-kinase OS=Danio rerio OX=7955 GN=pi4kIII alpha PE=1 SV=1
6	Q8MYR7	0.0	1284	1308	0.321	0.515	Q8MYR7_DROME 1-phosphatidylinositol 4-kinase OS=Drosophila melanogaster OX=7227 GN=Pi4KIIIalpha PE=2 SV=1
7	Q9U1K8	0.0	1623	2160	0.421	0.410	Q9U1K8_DROME 1-phosphatidylinositol 4-kinase OS=Drosophila melanogaster OX=7227 GN=Pi4KIIIalpha PE=3 SV=1
8	Q9W4X4	0.0	1743	2134	0.467	0.460	Q9W4X4_DROME 1-phosphatidylinositol 4-kinase OS=Drosophila melanogaster OX=7227 GN=Pi4KIIIalpha PE=1 SV=3
9	Q9SXA1	1.25e-172	583	2028	0.213	0.221	P4KA1_ARATH Phosphatidylinositol 4-kinase alpha 1 OS=Arabidopsis thaliana OX=3702 GN=PI4KA1 PE=1 SV=2
10	Q9USR3	2.55e-152	521	1877	0.118	0.132	STT4_SCHPO Phosphatidylinositol 4-kinase stt4 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=stt4 PE=3 SV=1
11	A0A1D8PTE0	2.70e-143	496	1927	0.119	0.130	A0A1D8PTE0_CANAL 1-phosphatidylinositol 4-kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=STT4 PE=3 SV=1
12	P37297	2.57e-137	477	1900	0.122	0.135	STT4_YEAST Phosphatidylinositol 4-kinase STT4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=STT4 PE=1 SV=1
13	Q57WD8	1.54e-89	328	2312	0.126	0.115	Q57WD8_TRYB2 1-phosphatidylinositol 4-kinase OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb03.28C22.100 PE=3 SV=1
14	P54677	2.19e-55	215	1180	0.053	0.095	PI4K_DICDI Phosphatidylinositol 4-kinase OS=Dictyostelium discoideum OX=44689 GN=pikD PE=3 SV=3
15	Q9UBF8	2.87e-52	202	816	0.050	0.129	PI4KB_HUMAN Phosphatidylinositol 4-kinase beta OS=Homo sapiens OX=9606 GN=PI4KB PE=1 SV=1
16	A0A0B4J1S8	3.12e-52	202	828	0.050	0.127	A0A0B4J1S8_HUMAN Phosphatidylinositol 4-kinase beta OS=Homo sapiens OX=9606 GN=PI4KB PE=1 SV=1
17	O08561	4.59e-52	201	816	0.050	0.129	PI4KB_RAT Phosphatidylinositol 4-kinase beta OS=Rattus norvegicus OX=10116 GN=Pi4kb PE=1 SV=1
18	O02810	1.07e-51	200	816	0.050	0.129	PI4KB_BOVIN Phosphatidylinositol 4-kinase beta OS=Bos taurus OX=9913 GN=PI4KB PE=1 SV=2
19	Q9FMJ0	6.78e-51	200	1121	0.052	0.098	P4KB1_ARATH Phosphatidylinositol 4-kinase beta 1 OS=Arabidopsis thaliana OX=3702 GN=PI4KB1 PE=1 SV=1
20	Q9BKJ2	9.19e-51	201	1338	0.050	0.078	Q9BKJ2_DROME Four wheel drive, isoform C OS=Drosophila melanogaster OX=7227 GN=fwd PE=2 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF03109 ABC1	86	13.7	ABC1 atypical kinase-like domain
2	PF12333 Ipi1_N	6.4e+02	12.4	Rix1 complex component involved in 60S ribosome maturation
3	PF00613 PI3Ka	1.8e-31	120.5	Phosphoinositide 3-kinase family, accessory domain (PIK domain)
4	PF00454 PI3_PI4_kinase	1.7e-37	141.1	Phosphatidylinositol 3- and 4-kinase
5	PF19274 PI4K_N	0	1147.2	PI4-kinase N-terminal region

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000255882

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000373713	0.980	Phosphatidylinositide phosphatase SAC1
2	9606.ENSP00000264380	0.979	1-phosphatidylinositol 3-phosphate 5-kinase
3	9606.ENSP00000357869	0.970	Phosphatidylinositol 4-kinase beta
4	9606.ENSP00000466363	0.970	Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
5	9606.ENSP00000265382	0.963	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta
6	9606.ENSP00000264864	0.962	Phosphatidylinositol 4-kinase type 2-beta
7	9606.ENSP00000357883	0.960	Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
8	9606.ENSP00000219789	0.959	CDP-diacylglycerol--inositol 3-phosphatidyltransferase
9	9606.ENSP00000482548	0.959	Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
10	9606.ENSP00000359665	0.957	Phosphatidylinositol 4-kinase type 2-alpha
11	9606.ENSP00000378320	0.942	Tetratricopeptide repeat protein 7A
12	9606.ENSP00000373399	0.937	Phosphatidylinositol 4-phosphate 5-kinase-like protein 1
13	9606.ENSP00000262039	0.936	Phosphatidylinositol 3-kinase catalytic subunit type 3
14	9606.ENSP00000361021	0.928	Phosphatase and tensin homolog
15	9606.ENSP00000384081	0.926	Protein EFR3 homolog B
16	9606.ENSP00000265970	0.923	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
17	9606.ENSP00000356155	0.922	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
18	9606.ENSP00000445381	0.917	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
19	9606.ENSP00000378699	0.916	Cyclin-dependent kinase 1
20	9606.ENSP00000256442	0.914	G2/mitotic-specific cyclin-B1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0004430	1.000	1-phosphatidylinositol 4-kinase activity
GO:0005488	0.957	binding
GO:0005515	0.951	protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071704	0.998	organic substance metabolic process
GO:0044238	0.998	primary metabolic process
GO:0044237	0.998	cellular metabolic process
GO:0019637	0.993	organophosphate metabolic process
GO:0044255	0.993	cellular lipid metabolic process
GO:0006796	0.989	phosphate-containing compound metabolic process
GO:0046474	0.982	glycerophospholipid biosynthetic process
GO:0046488	0.975	phosphatidylinositol metabolic process
GO:0006661	0.974	phosphatidylinositol biosynthetic process
GO:0065007	0.628	biological regulation
GO:0050789	0.536	regulation of biological process
GO:0050794	0.425	regulation of cellular process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0016020	1.000	membrane
GO:0005737	1.000	cytoplasm
GO:0031982	1.000	vesicle
GO:0043229	0.993	intracellular organelle
GO:0005829	0.992	cytosol
GO:0031090	0.978	organelle membrane
GO:0043231	0.976	intracellular membrane-bounded organelle
GO:0005576	0.950	extracellular region
GO:0005886	0.945	plasma membrane
GO:0098588	0.904	bounding membrane of organelle
GO:0070062	0.894	extracellular exosome
GO:0031410	0.891	cytoplasmic vesicle
GO:0030054	0.578	cell junction
GO:0070161	0.572	anchoring junction
GO:0012505	0.535	endomembrane system
GO:0030659	0.526	cytoplasmic vesicle membrane
GO:0030055	0.475	cell-substrate junction
GO:0005925	0.447	focal adhesion
GO:0070013	0.381	intracellular organelle lumen
GO:0005634	0.376	nucleus
GO:0031981	0.371	nuclear lumen
GO:0005654	0.323	nucleoplasm

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:19877	1.000	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)
EC:2.7.1.67	1.000	1-phosphatidylinositol 4-kinase.

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