StarFunc result for job id P43490

User Input

>input (491 residues)
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A0A024R718	0.994	0.994	4.500E-97	491	1.000	1.000	A0A024R718.pdb.gz
2	AFDB:E7F8T6	0.975	0.971	5.669E-86	493	0.862	0.858	E7F8T6.pdb.gz	E7F8T6_DANRE Nicotinamide phosphoribosyltransferase OS=Danio rerio OX=7955 GN=nampta PE=1 SV=1
3	PDB:4jnmB	0.947	0.982	2.400E-85	473	0.959	0.996	4jnmB.pdb.gz	Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties.
4	AFDB:P9WJI7	0.680	0.717	1.032E-18	463	0.163	0.173	P9WJI7.pdb.gz	PNCB2_MYCTU Nicotinate phosphoribosyltransferase pncB2 OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=pncB2 PE=1 SV=1
5	AFDB:P9WJI9	0.651	0.706	1.466E-17	448	0.151	0.165	P9WJI9.pdb.gz	PNCB1_MYCTU Nicotinate phosphoribosyltransferase pncB1 OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=pncB1 PE=1 SV=1
6	AFDB:C6KTC6	0.664	0.503	2.256E-15	665	0.181	0.134	C6KTC6.pdb.gz	C6KTC6_PLAF7 nicotinate phosphoribosyltransferase OS=Plasmodium falciparum (isolate 3D7) OX=36329 GN=PF3D7_0629100 PE=3 SV=1
7	AFDB:Q6XQN6	0.609	0.561	3.479E-15	538	0.175	0.160	Q6XQN6.pdb.gz	PNCB_HUMAN Nicotinate phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=NAPRT PE=1 SV=2
8	AFDB:Q6XQN1	0.579	0.534	1.028E-14	538	0.167	0.152	Q6XQN1.pdb.gz	PNCB_RAT Nicotinate phosphoribosyltransferase OS=Rattus norvegicus OX=10116 GN=Naprt PE=2 SV=1
9	PDB:4yubB	0.535	0.525	1.508E-11	501	0.169	0.166	4yubB.pdb.gz
10	PDB:1vlpB	0.324	0.373	5.994E-10	419	0.134	0.158	1vlpB.pdb.gz
11	AFDB:A0A1D8PRI0	0.346	0.398	2.365E-9	421	0.143	0.166	A0A1D8PRI0.pdb.gz	A0A1D8PRI0_CANAL Nicotinate phosphoribosyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=NPT1 PE=3 SV=1
12	AFDB:Q9UTK3	0.331	0.388	7.785E-9	410	0.132	0.159	Q9UTK3.pdb.gz	NPT1_SCHPO Probable nicotinate phosphoribosyltransferase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPAC1486.06 PE=3 SV=1
13	AFDB:P39683	0.308	0.347	1.574E-8	429	0.151	0.172	P39683.pdb.gz	NPT1_YEAST Nicotinate phosphoribosyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=NPT1 PE=1 SV=3
14	PDB:1qpnA	0.406	0.649	2.256E-8	284	0.092	0.158	1qpnA.pdb.gz	Crystal structure of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis: a potential TB drug target.
15	PDB:4kwvF	0.360	0.559	1.113E-6	291	0.086	0.144	4kwvF.pdb.gz
16	PDB:4i9aA	0.373	0.588	2.251E-6	288	0.092	0.156	4i9aA.pdb.gz	Crystal structure of Sus scrofa quinolinate phosphoribosyltransferase in complex with nicotinate mononucleotide
17	PDB:3c2vA	0.328	0.537	1.023E-3	270	0.067	0.122	3c2vA.pdb.gz	Comprehensive X-ray Structural Studies of the Quinolinate Phosphoribosyl Transferase (BNA6) from Saccharomyces cerevisiae.
18	PDB:4ff7A	0.258	0.438	2.783E-2	247	0.067	0.134	4ff7A.pdb.gz	Effects of a buried cysteine-to-serine mutation on yeast triosephosphate isomerase structure and stability.
19	PDB:7xc6A	0.127	0.130	4.530E-2	477	0.104	0.107	7xc6A.pdb.gz
20	PDB:2yvaA	0.126	0.206	5.329E-2	193	0.053	0.135	2yvaA.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	E7F8T6	0.0	892	493	0.855	0.852	E7F8T6_DANRE Nicotinamide phosphoribosyltransferase OS=Danio rerio OX=7955 GN=nampta PE=1 SV=1
2	P43490	0.0	1013	491	1.000	1.000	NAMPT_HUMAN Nicotinamide phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=NAMPT PE=1 SV=1
3	Q80Z29	0.0	950	491	0.951	0.951	NAMPT_RAT Nicotinamide phosphoribosyltransferase OS=Rattus norvegicus OX=10116 GN=Nampt PE=1 SV=1
4	Q99KQ4	0.0	954	491	0.957	0.957	NAMPT_MOUSE Nicotinamide phosphoribosyltransferase OS=Mus musculus OX=10090 GN=Nampt PE=1 SV=1
5	W5P316	0.0	982	491	0.961	0.961	W5P316_SHEEP Nicotinamide phosphoribosyltransferase OS=Ovis aries OX=9940 GN=NAMPT PE=3 SV=1
6	C9JG65	1.44e-54	179	88	0.179	1.000	C9JG65_HUMAN Nicotinamide phosphoribosyltransferase (Fragment) OS=Homo sapiens OX=9606 GN=NAMPT PE=1 SV=1
7	C8VPD7	0.55	35.4	647	0.051	0.039	C8VPD7_EMENI G1/S regulator OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=ANIA_01779 PE=4 SV=1
8	C8VRQ4	3.0	33.1	684	0.026	0.019	C8VRQ4_EMENI Transketolase OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=ANIA_00688 PE=3 SV=1
9	P29172	7.1	31.6	448	0.059	0.065	TAU_BOVIN Microtubule-associated protein tau OS=Bos taurus OX=9913 GN=MAPT PE=1 SV=3
10	Q8VYU4	8.1	31.6	754	0.055	0.036	CCR4F_ARATH Carbon catabolite repressor protein 4 homolog 6 OS=Arabidopsis thaliana OX=3702 GN=CCR4-6 PE=2 SV=2
11	Q9Z2I4	9.7	31.6	1366	0.061	0.022	ROBO3_MOUSE Roundabout homolog 3 OS=Mus musculus OX=10090 GN=Robo3 PE=1 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF18127 NAMPT_N	1.6e-41	151.9	Nicotinamide phosphoribosyltransferase, N-terminal domain
2	PF04095 NAPRTase	2.6e-87	304.0	Nicotinate phosphoribosyltransferase (NAPRTase) family
3	PF17956 NAPRTase_C	3.2e+02	13.1	Nicotinate phosphoribosyltransferase C-terminal domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000222553

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000212015	0.984	NAD-dependent protein deacetylase sirtuin-1
2	9606.ENSP00000337332	0.981	NAD-dependent protein deacetylase sirtuin-6
3	9606.ENSP00000366410	0.981	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
4	9606.ENSP00000202967	0.979	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial
5	9606.ENSP00000249396	0.979	NAD-dependent protein deacetylase sirtuin-2
6	9606.ENSP00000372191	0.979	NAD-dependent protein deacetylase sirtuin-3, mitochondrial
7	9606.ENSP00000476228	0.977	NAD-dependent protein deacylase sirtuin-5, mitochondrial
8	9606.ENSP00000329466	0.975	NAD-dependent protein deacetylase sirtuin-7
9	9606.ENSP00000340523	0.975	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3
10	9606.ENSP00000354387	0.971	Nicotinamide riboside kinase 1
11	9606.ENSP00000287713	0.970	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
12	9606.ENSP00000308741	0.970	Circadian locomoter output cycles protein kaput
13	9606.ENSP00000384517	0.970	Aryl hydrocarbon receptor nuclear translocator-like protein 1
14	9606.ENSP00000265016	0.956	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
15	9606.ENSP00000480091	0.952	Nicotinamide riboside kinase 2
16	9606.ENSP00000226279	0.950	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
17	9606.ENSP00000338283	0.950	Neuronal PAS domain-containing protein 2
18	9606.ENSP00000441434	0.950	Nicotinamide N-methyltransferase
19	9606.ENSP00000230792	0.946	Peroxisomal NADH pyrophosphatase NUDT12
20	9606.ENSP00000354532	0.942	Purine nucleoside phosphorylase

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0042802	1.000	identical protein binding
GO:0047280	1.000	nicotinamide phosphoribosyltransferase activity
GO:0005125	1.000	cytokine activity
GO:0097159	0.579	organic cyclic compound binding
GO:1901363	0.576	heterocyclic compound binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0071704	0.993	organic substance metabolic process
GO:0044238	0.993	primary metabolic process
GO:0044237	0.992	cellular metabolic process
GO:0006807	0.989	nitrogen compound metabolic process
GO:0050789	0.986	regulation of biological process
GO:1901564	0.979	organonitrogen compound metabolic process
GO:0006725	0.978	cellular aromatic compound metabolic process
GO:0010468	0.975	regulation of gene expression
GO:0009058	0.964	biosynthetic process
GO:0009117	0.956	nucleotide metabolic process
GO:0072524	0.947	pyridine-containing compound metabolic process
GO:0050794	0.945	regulation of cellular process
GO:1901576	0.926	organic substance biosynthetic process
GO:0072521	0.911	purine-containing compound metabolic process
GO:0034654	0.905	nucleobase-containing compound biosynthetic process
GO:0019362	0.890	pyridine nucleotide metabolic process
GO:0009165	0.890	nucleotide biosynthetic process
GO:0050896	0.870	response to stimulus
GO:0048518	0.833	positive regulation of biological process
GO:0072525	0.828	pyridine-containing compound biosynthetic process
GO:0006163	0.807	purine nucleotide metabolic process
GO:0046496	0.776	nicotinamide nucleotide metabolic process
GO:0019363	0.774	pyridine nucleotide biosynthetic process
GO:0031323	0.675	regulation of cellular metabolic process
GO:0048522	0.666	positive regulation of cellular process
GO:0019674	0.637	NAD metabolic process
GO:0051716	0.611	cellular response to stimulus
GO:0072522	0.607	purine-containing compound biosynthetic process
GO:0019359	0.535	nicotinamide nucleotide biosynthetic process
GO:0080090	0.470	regulation of primary metabolic process
GO:0051171	0.454	regulation of nitrogen compound metabolic process
GO:0009893	0.435	positive regulation of metabolic process
GO:0042127	0.432	regulation of cell population proliferation
GO:0009889	0.428	regulation of biosynthetic process
GO:0007154	0.413	cell communication
GO:0031326	0.406	regulation of cellular biosynthetic process
GO:0010604	0.388	positive regulation of macromolecule metabolic process
GO:0009435	0.358	NAD biosynthetic process
GO:0019219	0.355	regulation of nucleobase-containing compound metabolic process
GO:0031325	0.335	positive regulation of cellular metabolic process
GO:0010556	0.329	regulation of macromolecule biosynthetic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005737	0.999	cytoplasm
GO:0005654	0.996	nucleoplasm
GO:0005829	0.983	cytosol
GO:0016020	0.944	membrane
GO:0071944	0.839	cell periphery
GO:0005886	0.771	plasma membrane
GO:0016604	0.682	nuclear body
GO:0030054	0.587	cell junction
GO:0005576	0.513	extracellular region
GO:0012505	0.468	endomembrane system
GO:0016607	0.429	nuclear speck
GO:0070062	0.398	extracellular exosome

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:16149	1.000	beta-nicotinamide D-ribonucleotide + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide
EC:2.4.2.12	1.000	nicotinamide phosphoribosyltransferase.

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