StarFunc result for job id P48551

User Input

>input (515 residues)
MLLSQNAFIFRSLNLVLMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHS
IVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLF
SCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKK
HKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAE
SAKIGGIITVFLIALVLTSTIVTLKWIGYICLRNSLPKVLNFHNFLAWPFPNLPPLEAMD
MVEVIYINRKKKVWDYNYDDESDSDTEAAPRTSGGGYTMHGLTVRPLGQASATSTESQLI
DPESEEEPDLPEVDVELPTMPKDSPQQLELLSGPCERRKSPLQDPFPEEDYSSTEGSGGR
ITFNVDLNSVFLRVLDDEDSDDLEAPLMLSSHLEEMVDPEDPDNVQSNHLLASGEGTQPT
FPSPSSEGLWSEDAPSDQSDTSESDVDLGDGYIMR

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P48551	1.000	1.000	2.970E-80	515	1.000	1.000	P48551.pdb.gz	INAR2_HUMAN Interferon alpha/beta receptor 2 OS=Homo sapiens OX=9606 GN=IFNAR2 PE=1 SV=1
2	AFDB:Q8N6P7	0.326	0.298	7.471E-18	574	0.186	0.167	Q8N6P7.pdb.gz	I22R1_HUMAN Interleukin-22 receptor subunit alpha-1 OS=Homo sapiens OX=9606 GN=IL22RA1 PE=1 SV=1
3	AFDB:Q80XZ4	0.319	0.288	3.555E-17	581	0.186	0.165	Q80XZ4.pdb.gz	I22R1_MOUSE Interleukin-22 receptor subunit alpha-1 OS=Mus musculus OX=10090 GN=Il22ra1 PE=1 SV=1
4	AFDB:D9IL84	0.283	0.259	6.425E-17	573	0.159	0.143	D9IL84.pdb.gz	D9IL84_DANRE Cytokine receptor family member b14 OS=Danio rerio OX=7955 GN=crfb14 PE=2 SV=1
5	AFDB:K9JA28	0.343	0.316	3.090E-15	567	0.163	0.148	K9JA28.pdb.gz	INLR1_CHICK Interferon lambda receptor 1 OS=Gallus gallus OX=9031 GN=IFNLR1 PE=2 SV=1
6	AFDB:Q13651	0.293	0.266	1.393E-14	578	0.179	0.159	Q13651.pdb.gz	I10R1_HUMAN Interleukin-10 receptor subunit alpha OS=Homo sapiens OX=9606 GN=IL10RA PE=1 SV=2
7	AFDB:Q00560	0.176	0.112	4.853E-13	917	0.128	0.072	Q00560.pdb.gz	IL6RB_MOUSE Interleukin-6 receptor subunit beta OS=Mus musculus OX=10090 GN=Il6st PE=1 SV=2
8	AFDB:P40190	0.174	0.112	2.188E-12	918	0.132	0.074	P40190.pdb.gz	IL6RB_RAT Interleukin-6 receptor subunit beta OS=Rattus norvegicus OX=10116 GN=Il6st PE=1 SV=1
9	AFDB:P40189	0.181	0.112	2.437E-12	918	0.118	0.066	P40189.pdb.gz	IL6RB_HUMAN Interleukin-6 receptor subunit beta OS=Homo sapiens OX=9606 GN=IL6ST PE=1 SV=2
10	AFDB:G5EBF1	0.172	0.080	3.022E-12	1273	0.126	0.051	G5EBF1.pdb.gz	SAX3_CAEEL Protein sax-3 OS=Caenorhabditis elegans OX=6239 GN=sax-3 PE=2 SV=1
11	PDB:7u7nC	0.287	0.641	1.614E-8	200	0.066	0.170	7u7nC.pdb.gz
12	PDB:3besR	0.263	0.472	5.563E-8	250	0.049	0.100	3besR.pdb.gz
13	PDB:7z0lB	0.239	0.313	3.144E-6	370	0.072	0.100	7z0lB.pdb.gz
14	PDB:6pxvA	0.185	0.125	7.046E-6	823	0.060	0.038	6pxvA.pdb.gz
15	PDB:7bwaA	0.173	0.140	2.704E-5	674	0.058	0.045	7bwaA.pdb.gz
16	PDB:4pygA	0.198	0.162	6.748E-5	685	0.052	0.039	4pygA.pdb.gz	Crystal structure of transglutaminase 2 with GTP complex and amino acid sequence evidence of evolution of GTP binding site.
17	PDB:8dtlA	0.165	0.124	1.596E-4	741	0.050	0.035	8dtlA.pdb.gz
18	PDB:5mj3A	0.229	0.353	2.325E-4	302	0.039	0.066	5mj3A.pdb.gz
19	PDB:6kzbC	0.188	0.158	2.733E-4	649	0.058	0.046	6kzbC.pdb.gz	Competitive Binding of Magnesium to Calcium Binding Sites Reciprocally Regulates Transamidase and GTP Hydrolysis Activity of Transglutaminase 2.
20	PDB:5f0jB	0.115	0.178	4.202E-4	306	0.050	0.085	5f0jB.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P48551	0.0	1056	515	1.000	1.000	INAR2_HUMAN Interferon alpha/beta receptor 2 OS=Homo sapiens OX=9606 GN=IFNAR2 PE=1 SV=1
2	O35664	4.18e-145	428	513	0.478	0.480	INAR2_MOUSE Interferon alpha/beta receptor 2 OS=Mus musculus OX=10090 GN=Ifnar2 PE=1 SV=2
3	B0UXH1	9.85e-07	53.5	469	0.124	0.136	B0UXH1_DANRE Cytokine receptor family member b2 OS=Danio rerio OX=7955 GN=crfb2 PE=4 SV=1
4	Q6PHB0	0.001	44.3	546	0.109	0.103	I20RA_MOUSE Interleukin-20 receptor subunit alpha OS=Mus musculus OX=10090 GN=Il20ra PE=2 SV=2
5	Q9UHF4	0.004	42.4	553	0.076	0.071	I20RA_HUMAN Interleukin-20 receptor subunit alpha OS=Homo sapiens OX=9606 GN=IL20RA PE=1 SV=2
6	Q80XF5	0.005	41.2	230	0.099	0.222	I22R2_MOUSE Interleukin-22 receptor subunit alpha-2 OS=Mus musculus OX=10090 GN=Il22ra2 PE=1 SV=2
7	A1IMH9	0.092	37.7	391	0.047	0.061	A1IMH9_ONCMY Interferon-gamma receptor alpha chain OS=Oncorhynchus mykiss OX=8022 GN=ifngr1 PE=2 SV=1
8	Q8N6P7	0.11	37.7	574	0.052	0.047	I22R1_HUMAN Interleukin-22 receptor subunit alpha-1 OS=Homo sapiens OX=9606 GN=IL22RA1 PE=1 SV=1
9	Q80XZ4	0.19	37.0	581	0.054	0.048	I22R1_MOUSE Interleukin-22 receptor subunit alpha-1 OS=Mus musculus OX=10090 GN=Il22ra1 PE=1 SV=1
10	B6RLL0	0.61	35.0	389	0.045	0.059	B6RLL0_ONCMY Interferon-gamma receptor 1 (Fragment) OS=Oncorhynchus mykiss OX=8022 GN=IFNGR1 PE=2 SV=1
11	P42533	0.72	34.7	295	0.039	0.068	TF_RAT Tissue factor OS=Rattus norvegicus OX=10116 GN=F3 PE=2 SV=1
12	P20352	0.79	34.7	294	0.039	0.068	TF_MOUSE Tissue factor OS=Mus musculus OX=10090 GN=F3 PE=1 SV=2
13	A0A060YX94	1.1	33.5	182	0.045	0.126	A0A060YX94_ONCMY Fibronectin type-III domain-containing protein OS=Oncorhynchus mykiss OX=8022 GN=GSONMT00042872001 PE=4 SV=1
14	P13726	2.6	32.7	295	0.047	0.081	TF_HUMAN Tissue factor OS=Homo sapiens OX=9606 GN=F3 PE=1 SV=1
15	O95486	9.9	31.6	1093	0.031	0.015	SC24A_HUMAN Protein transport protein Sec24A OS=Homo sapiens OX=9606 GN=SEC24A PE=1 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF09294 Interfer-bind	2.5e-14	64.8	Interferon-alpha/beta receptor, fibronectin type III
2	PF01108 Tissue_fac	5e-22	89.1	Tissue factor

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000343957

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000215794	0.999	Ubl carboxyl-terminal hydrolase 18
2	9606.ENSP00000270139	0.999	Interferon alpha/beta receptor 1
3	9606.ENSP00000315768	0.999	Signal transducer and activator of transcription 2
4	9606.ENSP00000343204	0.999	Tyrosine-protein kinase JAK1
5	9606.ENSP00000369554	0.999	Interferon alpha-2
6	9606.ENSP00000431885	0.999	Non-receptor tyrosine-protein kinase TYK2
7	9606.ENSP00000369581	0.998	Interferon beta
8	9606.ENSP00000276927	0.996	Interferon alpha-1/13
9	9606.ENSP00000354394	0.995	Signal transducer and activator of transcription 1-alpha/beta
10	9606.ENSP00000369578	0.992	Interferon omega 1
11	9606.ENSP00000380073	0.990	Interferon regulatory factor 9
12	9606.ENSP00000426909	0.979	Receptor of activated protein C kinase 1
13	9606.ENSP00000369553	0.958	Interferon alpha-8
14	9606.ENSP00000356713	0.953	Interferon gamma receptor 1
15	9606.ENSP00000290219	0.950	Interferon gamma receptor 2
16	9606.ENSP00000369574	0.945	Interferon alpha-21
17	9606.ENSP00000411940	0.945	Interferon alpha-17
18	9606.ENSP00000369558	0.943	Interferon alpha-6
19	9606.ENSP00000340944	0.936	Tyrosine-protein phosphatase non-receptor type 11
20	9606.ENSP00000412897	0.931	Interferon alpha-4

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0019955	1.000	cytokine binding
GO:0019901	1.000	protein kinase binding
GO:0004905	1.000	type I interferon receptor activity
GO:0019961	0.990	interferon binding
GO:0019962	0.981	type I interferon binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0009987	0.996	cellular process
GO:0019221	0.990	cytokine-mediated signaling pathway
GO:0051607	0.986	defense response to virus
GO:0045087	0.986	innate immune response
GO:0140888	0.981	interferon-mediated signaling pathway
GO:0071357	0.975	cellular response to type I interferon
GO:0035456	0.925	response to interferon-beta
GO:0019222	0.783	regulation of metabolic process
GO:0060255	0.758	regulation of macromolecule metabolic process
GO:0097696	0.741	receptor signaling pathway via STAT
GO:0031323	0.650	regulation of cellular metabolic process
GO:0007259	0.641	receptor signaling pathway via JAK-STAT
GO:0010468	0.538	regulation of gene expression
GO:0080090	0.514	regulation of primary metabolic process
GO:0051171	0.513	regulation of nitrogen compound metabolic process
GO:0048518	0.367	positive regulation of biological process
GO:0032501	0.363	multicellular organismal process
GO:0048522	0.337	positive regulation of cellular process
GO:0009893	0.334	positive regulation of metabolic process
GO:0048583	0.332	regulation of response to stimulus
GO:0019219	0.329	regulation of nucleobase-containing compound metabolic process
GO:0009889	0.325	regulation of biosynthetic process
GO:0051252	0.321	regulation of RNA metabolic process
GO:0010604	0.320	positive regulation of macromolecule metabolic process
GO:0031326	0.310	regulation of cellular biosynthetic process
GO:2001141	0.301	regulation of RNA biosynthetic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005615	0.999	extracellular space
GO:0005886	0.997	plasma membrane
GO:0043227	0.565	membrane-bounded organelle
GO:0043231	0.519	intracellular membrane-bounded organelle
GO:0005737	0.432	cytoplasm

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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