StarFunc result for job id P50591

User Input

>input (281 residues)
MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKE
DDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQ
RVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKG
FYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLY
SIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P50591	1.000	1.000	2.391E-49	281	1.000	1.000	P50591.pdb.gz	TNF10_HUMAN Tumor necrosis factor ligand superfamily member 10 OS=Homo sapiens OX=9606 GN=TNFSF10 PE=1 SV=1
2	AFDB:A0A0U5J7B5	0.799	0.772	5.319E-35	292	0.669	0.644	A0A0U5J7B5.pdb.gz	A0A0U5J7B5_RAT Tumor necrosis factor ligand superfamily member OS=Rattus norvegicus OX=10116 GN=Tnfsf10 PE=2 SV=1
3	AFDB:P50592	0.561	0.542	5.343E-33	291	0.630	0.608	P50592.pdb.gz	TNF10_MOUSE Tumor necrosis factor ligand superfamily member 10 OS=Mus musculus OX=10090 GN=Tnfsf10 PE=2 SV=1
4	AFDB:F1Q767	0.512	0.457	2.420E-19	317	0.302	0.268	F1Q767.pdb.gz
5	AFDB:O14788	0.471	0.429	5.848E-17	317	0.256	0.227	O14788.pdb.gz	TNF11_HUMAN Tumor necrosis factor ligand superfamily member 11 OS=Homo sapiens OX=9606 GN=TNFSF11 PE=1 SV=1
6	AFDB:Q9ESE2	0.479	0.427	5.561E-15	318	0.267	0.236	Q9ESE2.pdb.gz	TNF11_RAT Tumor necrosis factor ligand superfamily member 11 OS=Rattus norvegicus OX=10116 GN=Tnfsf11 PE=2 SV=1
7	AFDB:P29965	0.450	0.482	1.199E-14	261	0.203	0.218	P29965.pdb.gz	CD40L_HUMAN CD40 ligand OS=Homo sapiens OX=9606 GN=CD40LG PE=1 SV=1
8	AFDB:P48023	0.459	0.459	1.760E-14	281	0.203	0.203	P48023.pdb.gz	TNFL6_HUMAN Tumor necrosis factor ligand superfamily member 6 OS=Homo sapiens OX=9606 GN=FASLG PE=1 SV=1
9	AFDB:P41047	0.456	0.459	3.401E-14	279	0.189	0.190	P41047.pdb.gz	TNFL6_MOUSE Tumor necrosis factor ligand superfamily member 6 OS=Mus musculus OX=10090 GN=Faslg PE=1 SV=1
10	AFDB:P27548	0.426	0.459	5.275E-14	260	0.199	0.215	P27548.pdb.gz	CD40L_MOUSE CD40 ligand OS=Mus musculus OX=10090 GN=Cd40lg PE=1 SV=2
11	PDB:7e57B	0.282	0.599	3.429E-6	123	0.093	0.211	7e57B.pdb.gz	Atypical TNF-TNFR superfamily binding interface in the GITR-GITRL complex for T cell activation.
12	PDB:5h4bA	0.311	0.585	3.253E-5	136	0.085	0.176	5h4bA.pdb.gz
13	PDB:5kc6B	0.327	0.564	6.285E-5	144	0.075	0.146	5kc6B.pdb.gz
14	PDB:2cseA	0.183	0.097	2.230E-2	641	0.043	0.019	2cseA.pdb.gz
15	PDB:7drtB	0.175	0.114	2.630E-2	496	0.064	0.036	7drtB.pdb.gz	Cryo-EM structure of human Wntless in complex with Wnt3a.
16	PDB:1zvfA	0.108	0.148	3.275E-2	176	0.032	0.051	1zvfA.pdb.gz
17	PDB:4fixA	0.194	0.095	3.655E-2	629	0.036	0.016	4fixA.pdb.gz	Tetrameric Structure of the GlfT2 Galactofuranosyltransferase Reveals a Scaffold for the Assembly of Mycobacterial Arabinogalactan.
18	PDB:3fxiC	0.130	0.203	3.861E-2	140	0.053	0.107	3fxiC.pdb.gz
19	PDB:3b2dC	0.155	0.247	4.552E-2	139	0.050	0.101	3b2dC.pdb.gz	Crystal Structures of Mouse and Human RP105/MD-1 Complexes Reveal Unique Dimer Organization of the Toll-Like Receptor Family.
20	PDB:5vqfB	0.207	0.189	4.552E-2	320	0.089	0.078	5vqfB.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P50591	0.0	591	281	1.000	1.000	TNF10_HUMAN Tumor necrosis factor ligand superfamily member 10 OS=Homo sapiens OX=9606 GN=TNFSF10 PE=1 SV=1
2	P50592	1.70e-129	371	291	0.630	0.608	TNF10_MOUSE Tumor necrosis factor ligand superfamily member 10 OS=Mus musculus OX=10090 GN=Tnfsf10 PE=2 SV=1
3	A0A0U5J7B5	2.78e-126	363	292	0.673	0.647	A0A0U5J7B5_RAT Tumor necrosis factor ligand superfamily member OS=Rattus norvegicus OX=10116 GN=Tnfsf10 PE=2 SV=1
4	A0A8I5ZY27	1.41e-121	350	289	0.651	0.633	A0A8I5ZY27_RAT Tumor necrosis factor ligand superfamily member OS=Rattus norvegicus OX=10116 GN=Tnfsf10 PE=3 SV=1
5	Q7ZYX9	3.47e-31	120	317	0.221	0.196	Q7ZYX9_DANRE TNF superfamily member 10, like OS=Danio rerio OX=7955 GN=wu:fc12f06 PE=2 SV=1
6	Q9ESE2	2.20e-22	96.3	318	0.267	0.236	TNF11_RAT Tumor necrosis factor ligand superfamily member 11 OS=Rattus norvegicus OX=10116 GN=Tnfsf11 PE=2 SV=1
7	O35235	6.12e-21	92.4	316	0.260	0.231	TNF11_MOUSE Tumor necrosis factor ligand superfamily member 11 OS=Mus musculus OX=10090 GN=Tnfsf11 PE=1 SV=2
8	O14788	1.84e-20	91.3	317	0.253	0.224	TNF11_HUMAN Tumor necrosis factor ligand superfamily member 11 OS=Homo sapiens OX=9606 GN=TNFSF11 PE=1 SV=1
9	Q8K3Y7	1.09e-12	68.6	252	0.196	0.218	TNF15_RAT Tumor necrosis factor ligand superfamily member 15 OS=Rattus norvegicus OX=10116 GN=Tnfsf15 PE=2 SV=1
10	P41047	1.53e-12	68.6	279	0.174	0.176	TNFL6_MOUSE Tumor necrosis factor ligand superfamily member 6 OS=Mus musculus OX=10090 GN=Faslg PE=1 SV=1
11	E7F3U1	6.64e-12	66.2	251	0.139	0.155	E7F3U1_DANRE TNF superfamily member 11 OS=Danio rerio OX=7955 GN=tnfsf11 PE=3 SV=1
12	P36940	1.79e-11	65.5	278	0.178	0.180	TNFL6_RAT Tumor necrosis factor ligand superfamily member 6 OS=Rattus norvegicus OX=10116 GN=Faslg PE=2 SV=1
13	P48023	2.15e-11	65.1	281	0.181	0.181	TNFL6_HUMAN Tumor necrosis factor ligand superfamily member 6 OS=Homo sapiens OX=9606 GN=FASLG PE=1 SV=1
14	Q53ZZ1	2.15e-11	65.1	281	0.181	0.181	Q53ZZ1_HUMAN Tumor necrosis factor ligand superfamily member 6 OS=Homo sapiens OX=9606 GN=TNFSF6 PE=2 SV=1
15	O95150	5.06e-11	63.5	251	0.174	0.195	TNF15_HUMAN Tumor necrosis factor ligand superfamily member 15 OS=Homo sapiens OX=9606 GN=TNFSF15 PE=1 SV=2
16	Q0VHD7	5.57e-11	63.9	281	0.181	0.181	Q0VHD7_HUMAN Tumor necrosis factor ligand superfamily member 6 OS=Homo sapiens OX=9606 GN=FASLG PE=2 SV=1
17	O43557	1.68e-10	62.0	240	0.189	0.221	TNF14_HUMAN Tumor necrosis factor ligand superfamily member 14 OS=Homo sapiens OX=9606 GN=TNFSF14 PE=1 SV=2
18	Q9QYH9	1.92e-10	62.0	239	0.167	0.197	TNF14_MOUSE Tumor necrosis factor ligand superfamily member 14 OS=Mus musculus OX=10090 GN=Tnfsf14 PE=2 SV=1
19	Q4W898	1.26e-08	56.6	242	0.125	0.145	Q4W898_DANRE Lymphotoxin-alpha OS=Danio rerio OX=7955 GN=tnf PE=2 SV=1
20	B3GDZ6	6.90e-07	51.2	232	0.149	0.181	B3GDZ6_PIG Tumor necrosis factor OS=Sus scrofa OX=9823 GN=TNFa PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00386 C1q	67	15.1	C1q domain
2	PF08378 NERD	1.3e+02	14.5	Nuclease-related domain
3	PF00229 TNF	1.6e-40	149.4	TNF(Tumour Necrosis Factor) family

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000241261

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000221132	0.999	Tumor necrosis factor receptor superfamily member 10A
2	9606.ENSP00000276431	0.999	Tumor necrosis factor receptor superfamily member 10B
3	9606.ENSP00000301838	0.998	FAS-associated death domain protein
4	9606.ENSP00000351273	0.998	Caspase-8
5	9606.ENSP00000310263	0.996	Tumor necrosis factor receptor superfamily member 10D
6	9606.ENSP00000349324	0.996	Tumor necrosis factor receptor superfamily member 10C
7	9606.ENSP00000312455	0.989	CASP8 and FADD-like apoptosis regulator
8	9606.ENSP00000286186	0.982	Caspase-10
9	9606.ENSP00000259808	0.975	Receptor-interacting serine/threonine-protein kinase 1
10	9606.ENSP00000311032	0.974	Caspase-3
11	9606.ENSP00000341268	0.960	Tumor necrosis factor receptor type 1-associated DEATH domain protein
12	9606.ENSP00000247668	0.951	TNF receptor-associated factor 2
13	9606.ENSP00000216274	0.950	Receptor-interacting serine/threonine-protein kinase 3
14	9606.ENSP00000318822	0.948	BH3-interacting domain death agonist
15	9606.ENSP00000357320	0.943	28S ribosomal protein S29, mitochondrial
16	9606.ENSP00000359424	0.931	Inhibitor of nuclear factor kappa-B kinase subunit alpha
17	9606.ENSP00000263025	0.929	Mitogen-activated protein kinase 3
18	9606.ENSP00000430684	0.929	Inhibitor of nuclear factor kappa-B kinase subunit beta
19	9606.ENSP00000483825	0.929	NF-kappa-B essential modulator
20	9606.ENSP00000215832	0.920	Mitogen-activated protein kinase 1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0042802	1.000	identical protein binding
GO:0005102	1.000	signaling receptor binding
GO:0008270	1.000	zinc ion binding
GO:0005126	0.819	cytokine receptor binding
GO:0098772	0.704	molecular function regulator activity
GO:0032813	0.696	tumor necrosis factor receptor superfamily binding
GO:0140677	0.317	molecular function activator activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0048522	0.997	positive regulation of cellular process
GO:0048583	0.996	regulation of response to stimulus
GO:0050896	0.992	response to stimulus
GO:0009987	0.980	cellular process
GO:0048584	0.972	positive regulation of response to stimulus
GO:0043068	0.966	positive regulation of programmed cell death
GO:0023051	0.965	regulation of signaling
GO:0010646	0.965	regulation of cell communication
GO:0043065	0.963	positive regulation of apoptotic process
GO:2001233	0.955	regulation of apoptotic signaling pathway
GO:2001235	0.953	positive regulation of apoptotic signaling pathway
GO:0019222	0.948	regulation of metabolic process
GO:0060255	0.929	regulation of macromolecule metabolic process
GO:0080090	0.909	regulation of primary metabolic process
GO:0051171	0.909	regulation of nitrogen compound metabolic process
GO:0010604	0.889	positive regulation of macromolecule metabolic process
GO:0051716	0.880	cellular response to stimulus
GO:0007165	0.864	signal transduction
GO:2001236	0.857	regulation of extrinsic apoptotic signaling pathway
GO:0051345	0.852	positive regulation of hydrolase activity
GO:0030162	0.845	regulation of proteolysis
GO:0051247	0.830	positive regulation of protein metabolic process
GO:0052547	0.827	regulation of peptidase activity
GO:0052548	0.804	regulation of endopeptidase activity
GO:2000116	0.760	regulation of cysteine-type endopeptidase activity
GO:2001238	0.748	positive regulation of extrinsic apoptotic signaling pathway
GO:0010952	0.747	positive regulation of peptidase activity
GO:0010950	0.717	positive regulation of endopeptidase activity
GO:1902531	0.713	regulation of intracellular signal transduction
GO:2001056	0.691	positive regulation of cysteine-type endopeptidase activity
GO:0008219	0.650	cell death
GO:0051128	0.637	regulation of cellular component organization
GO:1902533	0.619	positive regulation of intracellular signal transduction
GO:0012501	0.587	programmed cell death
GO:0006915	0.574	apoptotic process
GO:0042221	0.573	response to chemical
GO:0048519	0.497	negative regulation of biological process
GO:0010821	0.471	regulation of mitochondrion organization
GO:0043122	0.437	regulation of I-kappaB kinase/NF-kappaB signaling
GO:0010033	0.428	response to organic substance
GO:0031323	0.390	regulation of cellular metabolic process
GO:0048523	0.379	negative regulation of cellular process
GO:0032501	0.377	multicellular organismal process
GO:0043123	0.364	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032502	0.329	developmental process
GO:0043281	0.325	regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0048856	0.321	anatomical structure development
GO:0051130	0.315	positive regulation of cellular component organization

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005576	0.999	extracellular region
GO:0005886	0.999	plasma membrane
GO:0043227	0.998	membrane-bounded organelle
GO:0005615	0.994	extracellular space
GO:0031982	0.975	vesicle
GO:0065010	0.879	extracellular membrane-bounded organelle
GO:1903561	0.870	extracellular vesicle
GO:0070062	0.850	extracellular exosome
GO:0005622	0.801	intracellular anatomical structure
GO:0043231	0.749	intracellular membrane-bounded organelle
GO:0005737	0.594	cytoplasm
GO:0005829	0.495	cytosol

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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