StarFunc result for job id P51787

User Input

>input (676 residues)
MAAASSPPRAERKRWGWGRLPGARRGSAGLAKKCPFSLELAEGGPAGGALYAPIAPGAPG
PAPPASPAAPAAPPVASDLGPRPPVSLDPRVSIYSTRRPVLARTHVQGRVYNFLERPTGW
KCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGC
RSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLH
VDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYA
DALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQR
QKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYIRKAPRSHTLLSPSPKPKKSVVVKK
KKFKLDKDNGVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFM
RTNSFAEDLDLEGETLLTPITHISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRD
VIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVT
QLDQRLALITDMLHQLLSLHGGSTPGSGGPPREGGAHITQPCGSGGSVDPELFLPSNTLP
TYEQLTVPRRGPDEGS

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P51787	1.000	1.000	4.446E-86	676	1.000	1.000	P51787.pdb.gz	KCNQ1_HUMAN Potassium voltage-gated channel subfamily KQT member 1 OS=Homo sapiens OX=9606 GN=KCNQ1 PE=1 SV=3
2	AFDB:P97414	0.798	0.807	2.518E-76	668	0.883	0.894	P97414.pdb.gz	KCNQ1_MOUSE Potassium voltage-gated channel subfamily KQT member 1 OS=Mus musculus OX=10090 GN=Kcnq1 PE=1 SV=3
3	AFDB:B0R0K2	0.645	0.665	7.077E-53	655	0.558	0.576	B0R0K2.pdb.gz	B0R0K2_DANRE Potassium voltage-gated channel subfamily KQT member 1 OS=Danio rerio OX=7955 GN=kcnq1 PE=4 SV=1
4	AFDB:Q9XWG9	0.601	0.651	1.975E-44	621	0.460	0.501	Q9XWG9.pdb.gz	Q9XWG9_CAEEL Potassium voltage-gated channel subfamily KQT member 1 OS=Caenorhabditis elegans OX=6239 GN=kqt-3 PE=1 SV=2
5	AFDB:A0A0B4KFJ4	0.622	0.542	6.120E-37	781	0.379	0.328	A0A0B4KFJ4.pdb.gz	A0A0B4KFJ4_DROME KCNQ potassium channel, isoform K OS=Drosophila melanogaster OX=7227 GN=KCNQ PE=4 SV=1
6	AFDB:A0A0B4KEH2	0.633	0.517	7.064E-37	839	0.379	0.305	A0A0B4KEH2.pdb.gz	A0A0B4KEH2_DROME KCNQ potassium channel, isoform I OS=Drosophila melanogaster OX=7227 GN=KCNQ PE=4 SV=1
7	AFDB:Q8MQC5	0.542	0.500	1.086E-36	740	0.382	0.349	Q8MQC5.pdb.gz	Q8MQC5_CAEEL Potassium voltage-gated channel subfamily KQT member 5 OS=Caenorhabditis elegans OX=6239 GN=kqt-1 PE=4 SV=1
8	AFDB:Q8IGU8	0.617	0.502	2.021E-36	840	0.376	0.302	Q8IGU8.pdb.gz	Q8IGU8_DROME RE26469p (Fragment) OS=Drosophila melanogaster OX=7227 GN=KCNQ PE=2 SV=1
9	AFDB:Q9JK45	0.571	0.423	4.512E-35	933	0.379	0.274	Q9JK45.pdb.gz	KCNQ5_MOUSE Potassium voltage-gated channel subfamily KQT member 5 OS=Mus musculus OX=10090 GN=Kcnq5 PE=1 SV=2
10	AFDB:Q9JK97	0.556	0.541	7.632E-35	696	0.391	0.379	Q9JK97.pdb.gz	KCNQ4_MOUSE Potassium voltage-gated channel subfamily KQT member 4 OS=Mus musculus OX=10090 GN=Kcnq4 PE=2 SV=2
11	PDB:7bylA	0.417	0.729	3.904E-25	354	0.300	0.573	7bylA.pdb.gz	Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs.
12	PDB:7vnrA	0.448	0.873	3.110E-21	333	0.290	0.589	7vnrA.pdb.gz	Structural insights into the lipid and ligand regulation of a human neuronal KCNQ channel.
13	PDB:7f3fA	0.319	0.452	8.858E-10	460	0.108	0.159	7f3fA.pdb.gz
14	PDB:7sizB	0.300	0.574	5.710E-9	334	0.101	0.204	7sizB.pdb.gz	Structural basis for C-type inactivation in a Shaker family voltage-gated K + channel.
15	PDB:7w6sB	0.309	0.449	5.990E-9	448	0.101	0.152	7w6sB.pdb.gz
16	PDB:7sszA	0.307	0.540	7.251E-9	362	0.096	0.180	7sszA.pdb.gz
17	PDB:7phhA	0.305	0.495	1.350E-8	396	0.095	0.162	7phhA.pdb.gz
18	PDB:3lutB	0.289	0.471	7.906E-8	390	0.104	0.179	3lutB.pdb.gz	Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement.
19	PDB:2a79B	0.175	0.423	1.194E-5	259	0.071	0.185	2a79B.pdb.gz	Crystal structure of a mammalian voltage-dependent Shaker family K+ channel.
20	PDB:7pquA	0.253	0.488	3.415E-5	328	0.081	0.168	7pquA.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A286YA22	0.0	758	643	0.559	0.588	A0A286YA22_DANRE Potassium voltage-gated channel subfamily KQT member 1 OS=Danio rerio OX=7955 GN=kcnq1 PE=3 SV=1
2	A0A2R8YEQ9	0.0	523	310	0.386	0.842	A0A2R8YEQ9_HUMAN IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1 (Fragment) OS=Homo sapiens OX=9606 GN=KCNQ1 PE=1 SV=1
3	B0R0K2	0.0	756	655	0.562	0.580	B0R0K2_DANRE Potassium voltage-gated channel subfamily KQT member 1 OS=Danio rerio OX=7955 GN=kcnq1 PE=4 SV=1
4	B7FAS2	0.0	600	617	0.464	0.509	B7FAS2_CAEEL Potassium voltage-gated channel subfamily KQT member 1 OS=Caenorhabditis elegans OX=6239 GN=kqt-3 PE=1 SV=1
5	G5EE44	0.0	600	580	0.464	0.541	G5EE44_CAEEL KQT-3 potassium channel OS=Caenorhabditis elegans OX=6239 GN=kqt-3 PE=1 SV=1
6	P51787	0.0	1384	676	1.000	1.000	KCNQ1_HUMAN Potassium voltage-gated channel subfamily KQT member 1 OS=Homo sapiens OX=9606 GN=KCNQ1 PE=1 SV=3
7	P97414	0.0	1170	668	0.885	0.895	KCNQ1_MOUSE Potassium voltage-gated channel subfamily KQT member 1 OS=Mus musculus OX=10090 GN=Kcnq1 PE=1 SV=3
8	Q9XWG9	0.0	601	621	0.464	0.506	Q9XWG9_CAEEL Potassium voltage-gated channel subfamily KQT member 1 OS=Caenorhabditis elegans OX=6239 GN=kqt-3 PE=1 SV=2
9	Q9Z0N7	0.0	1172	669	0.892	0.901	KCNQ1_RAT Potassium voltage-gated channel subfamily KQT member 1 OS=Rattus norvegicus OX=10116 GN=Kcnq1 PE=1 SV=1
10	B7YZR4	5.78e-149	450	683	0.376	0.372	B7YZR4_DROME KCNQ potassium channel, isoform C OS=Drosophila melanogaster OX=7227 GN=KCNQ PE=4 SV=1
11	Q8IT87	1.63e-148	447	649	0.367	0.382	Q8IT87_DROME Potassium channel OS=Drosophila melanogaster OX=7227 GN=KCNQ PE=2 SV=1
12	A0A0B4KFJ4	7.39e-148	450	781	0.376	0.325	A0A0B4KFJ4_DROME KCNQ potassium channel, isoform K OS=Drosophila melanogaster OX=7227 GN=KCNQ PE=4 SV=1
13	A0A0B4KF62	7.84e-148	451	805	0.376	0.316	A0A0B4KF62_DROME KCNQ potassium channel, isoform G OS=Drosophila melanogaster OX=7227 GN=KCNQ PE=4 SV=1
14	Q5PXF9	9.38e-148	451	808	0.376	0.314	Q5PXF9_DROME KCNQ potassium channel, isoform E OS=Drosophila melanogaster OX=7227 GN=KCNQ PE=2 SV=1
15	B7YZR3	1.26e-147	449	774	0.367	0.320	B7YZR3_DROME KCNQ potassium channel, isoform D OS=Drosophila melanogaster OX=7227 GN=KCNQ PE=4 SV=1
16	A0A0B4KEI9	2.20e-147	450	823	0.377	0.310	A0A0B4KEI9_DROME KCNQ potassium channel, isoform H OS=Drosophila melanogaster OX=7227 GN=KCNQ PE=4 SV=1
17	Q8IGU8	5.66e-147	450	840	0.376	0.302	Q8IGU8_DROME RE26469p (Fragment) OS=Drosophila melanogaster OX=7227 GN=KCNQ PE=2 SV=1
18	A0A0B4KEH2	1.00e-145	446	839	0.380	0.306	A0A0B4KEH2_DROME KCNQ potassium channel, isoform I OS=Drosophila melanogaster OX=7227 GN=KCNQ PE=4 SV=1
19	A0A0B4KEP9	6.84e-145	444	827	0.374	0.306	A0A0B4KEP9_DROME KCNQ potassium channel, isoform J OS=Drosophila melanogaster OX=7227 GN=KCNQ PE=4 SV=1
20	G5EDN5	1.61e-143	436	692	0.371	0.363	G5EDN5_CAEEL KQT-1 potassium channel OS=Caenorhabditis elegans OX=6239 GN=kqt-1 PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF20563 DUF6773	6.8e+02	11.5	Family of unknown function (DUF6773)
2	PF00520 Ion_trans	3.4e-22	90.4	Ion transport protein
3	PF07885 Ion_trans_2	4.3e-08	44.3	Ion channel
4	PF03520 KCNQ_channel	2.6e-21	87.7	KCNQ voltage-gated potassium channel
5	PF15390 WDCP	47	13.8	WD repeat and coiled-coil-containing protein family

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000155840

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000337255	0.999	Potassium voltage-gated channel subfamily E member 1
2	9606.ENSP00000348573	0.999	A-kinase anchor protein 9
3	9606.ENSP00000290310	0.998	Potassium voltage-gated channel subfamily E member 2
4	9606.ENSP00000310557	0.998	Potassium voltage-gated channel subfamily E member 3
5	9606.ENSP00000291295	0.992	Calmodulin 3 (phosphorylase kinase, delta)
6	9606.ENSP00000262186	0.987	Potassium voltage-gated channel subfamily H member 2
7	9606.ENSP00000243457	0.980	Inward rectifier potassium channel 2
8	9606.ENSP00000272298	0.967	Calmodulin 2 (phosphorylase kinase, delta)
9	9606.ENSP00000281830	0.945	Potassium voltage-gated channel subfamily E member 4
10	9606.ENSP00000294016	0.943	Adenylate cyclase type 9
11	9606.ENSP00000349467	0.938	Calmodulin-1
12	9606.ENSP00000485125	0.925	annotation not available
13	9606.ENSP00000262461	0.912	Solute carrier family 12 member 2
14	9606.ENSP00000383199	0.907	E3 ubiquitin-protein ligase NEDD4-like
15	9606.ENSP00000463778	0.905	ATP-sensitive inward rectifier potassium channel 12
16	9606.ENSP00000410257	0.893	Sodium channel protein type 5 subunit alpha
17	9606.ENSP00000306497	0.892	Inward rectifier potassium channel 4
18	9606.ENSP00000352527	0.892	Potassium channel subfamily K member 5
19	9606.ENSP00000361173	0.891	Potassium voltage-gated channel subfamily E regulatory beta subunit 5
20	9606.ENSP00000352035	0.866	Potassium voltage-gated channel subfamily KQT member 2

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.998	protein binding
GO:0005249	0.998	voltage-gated potassium channel activity
GO:0015271	0.901	outward rectifier potassium channel activity
GO:0005251	0.886	delayed rectifier potassium channel activity
GO:0005543	0.693	phospholipid binding
GO:0019899	0.306	enzyme binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0006813	0.990	potassium ion transport
GO:0065007	0.987	biological regulation
GO:0050789	0.983	regulation of biological process
GO:0003008	0.981	system process
GO:0009987	0.968	cellular process
GO:0042391	0.895	regulation of membrane potential
GO:0050794	0.734	regulation of cellular process
GO:0050896	0.661	response to stimulus
GO:0051239	0.560	regulation of multicellular organismal process
GO:0034220	0.529	monoatomic ion transmembrane transport
GO:0044057	0.456	regulation of system process
GO:0007600	0.417	sensory perception
GO:0048518	0.413	positive regulation of biological process
GO:0098662	0.406	inorganic cation transmembrane transport
GO:0098655	0.389	monoatomic cation transmembrane transport
GO:0051049	0.374	regulation of transport
GO:1903522	0.365	regulation of blood circulation
GO:0008016	0.358	regulation of heart contraction
GO:0007154	0.357	cell communication
GO:0032502	0.350	developmental process
GO:0048856	0.322	anatomical structure development
GO:0034762	0.311	regulation of transmembrane transport
GO:0043269	0.309	regulation of monoatomic ion transport
GO:0042221	0.304	response to chemical
GO:0002027	0.304	regulation of heart rate
GO:0071805	0.302	potassium ion transmembrane transport
GO:0006936	0.301	muscle contraction

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0098797	0.998	plasma membrane protein complex
GO:0034703	0.998	cation channel complex
GO:0008076	0.990	voltage-gated potassium channel complex
GO:0012505	0.975	endomembrane system
GO:0005622	0.972	intracellular anatomical structure
GO:0043226	0.969	organelle
GO:0005737	0.964	cytoplasm
GO:0043231	0.962	intracellular membrane-bounded organelle
GO:0031982	0.846	vesicle
GO:0098590	0.729	plasma membrane region
GO:0031410	0.611	cytoplasmic vesicle
GO:0045178	0.520	basal part of cell

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:29463	0.998	K(+)(in) = K(+)(out)

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