StarFunc result for job id P52292

User Input

>input (529 residues)
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDA
TSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISE
QAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNK
NPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK
LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMS
NITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCG
IIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHE
NESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P52292	1.000	1.000	2.452E-65	529	1.000	1.000	P52292.pdb.gz	IMA1_HUMAN Importin subunit alpha-1 OS=Homo sapiens OX=9606 GN=KPNA2 PE=1 SV=1
2	PDB:3tpoA	0.819	0.988	1.531E-47	438	0.777	0.938	3tpoA.pdb.gz
3	AFDB:A0A060YJS5	0.874	0.891	4.657E-41	519	0.567	0.578	A0A060YJS5.pdb.gz	A0A060YJS5_ONCMY Importin subunit alpha OS=Oncorhynchus mykiss OX=8022 GN=KPNA7 PE=2 SV=1
4	AFDB:O00629	0.871	0.884	8.502E-40	521	0.499	0.507	O00629.pdb.gz	IMA3_HUMAN Importin subunit alpha-3 OS=Homo sapiens OX=9606 GN=KPNA4 PE=1 SV=1
5	AFDB:O00505	0.889	0.902	4.368E-38	521	0.495	0.503	O00505.pdb.gz	IMA4_HUMAN Importin subunit alpha-4 OS=Homo sapiens OX=9606 GN=KPNA3 PE=1 SV=2
6	AFDB:A9QM74	0.883	0.905	8.939E-38	516	0.527	0.541	A9QM74.pdb.gz	IMA8_HUMAN Importin subunit alpha-8 OS=Homo sapiens OX=9606 GN=KPNA7 PE=1 SV=1
7	AFDB:P52295	0.908	0.919	3.896E-37	522	0.499	0.506	P52295.pdb.gz	IMA_DROME Importin subunit alpha OS=Drosophila melanogaster OX=7227 GN=Pen PE=1 SV=2
8	AFDB:O76522	0.821	0.844	6.801E-37	514	0.486	0.500	O76522.pdb.gz	O76522_DROME Karyopherin alpha 3 (Fragment) OS=Drosophila melanogaster OX=7227 GN=Kap-alpha3 PE=2 SV=1
9	AFDB:O76521	0.894	0.872	8.635E-37	543	0.457	0.446	O76521.pdb.gz	O76521_DROME Importin subunit alpha OS=Drosophila melanogaster OX=7227 GN=Kap-alpha1 PE=2 SV=1
10	AFDB:C0LLJ0	0.831	0.879	1.141E-36	499	0.459	0.487	C0LLJ0.pdb.gz	IMA8_MOUSE Importin subunit alpha-8 OS=Mus musculus OX=10090 GN=Kpna7 PE=1 SV=1
11	AFDB:O04294	0.836	0.833	4.413E-36	531	0.454	0.452	O04294.pdb.gz	IMPA3_ARATH Importin subunit alpha-3 OS=Arabidopsis thaliana OX=3702 GN=IMPA3 PE=1 SV=2
12	PDB:5tbkA	0.757	0.953	3.817E-32	417	0.429	0.544	5tbkA.pdb.gz
13	PDB:1wa5B	0.769	0.868	7.812E-32	466	0.414	0.470	1wa5B.pdb.gz	Structural basis for the assembly of a nuclear export complex.
14	PDB:4tnmA	0.727	0.938	2.072E-27	407	0.372	0.484	4tnmA.pdb.gz
15	PDB:2z6gA	0.463	0.450	5.165E-12	550	0.170	0.164	2z6gA.pdb.gz
16	PDB:7rroH7	0.590	0.544	1.783E-10	580	0.147	0.134	7rroH7.pdb.gz	De novo identification of mammalian ciliary motility proteins using cryo-EM.
17	PDB:6kbnC	0.621	0.650	9.480E-10	504	0.159	0.167	6kbnC.pdb.gz	Quaternary structures of Vac8 differentially regulate the Cvt and PMN pathways.
18	PDB:4r0zA	0.490	0.469	2.101E-9	557	0.140	0.133	4r0zA.pdb.gz
19	PDB:7nscE	0.523	0.463	1.032E-8	615	0.123	0.106	7nscE.pdb.gz
20	PDB:1b3uA	0.359	0.331	6.468E-7	588	0.108	0.097	1b3uA.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A060YJS5	0.0	610	519	0.560	0.570	A0A060YJS5_ONCMY Importin subunit alpha OS=Oncorhynchus mykiss OX=8022 GN=KPNA7 PE=2 SV=1
2	A0A8I5Y0C8	0.0	989	506	0.905	0.947	A0A8I5Y0C8_RAT Importin subunit alpha OS=Rattus norvegicus OX=10116 GN=Kpna2 PE=1 SV=1
3	A9QM74	0.0	561	516	0.529	0.543	IMA8_HUMAN Importin subunit alpha-8 OS=Homo sapiens OX=9606 GN=KPNA7 PE=1 SV=1
4	O00629	0.0	526	521	0.503	0.511	IMA3_HUMAN Importin subunit alpha-3 OS=Homo sapiens OX=9606 GN=KPNA4 PE=1 SV=1
5	O35343	0.0	528	521	0.503	0.511	IMA3_MOUSE Importin subunit alpha-3 OS=Mus musculus OX=10090 GN=Kpna4 PE=1 SV=1
6	P52292	0.0	1089	529	1.000	1.000	IMA1_HUMAN Importin subunit alpha-1 OS=Homo sapiens OX=9606 GN=KPNA2 PE=1 SV=1
7	P52293	0.0	1038	529	0.945	0.945	IMA1_MOUSE Importin subunit alpha-1 OS=Mus musculus OX=10090 GN=Kpna2 PE=1 SV=2
8	Q6P6T9	0.0	1041	529	0.949	0.949	Q6P6T9_RAT Importin subunit alpha OS=Rattus norvegicus OX=10116 GN=Kpna2 PE=1 SV=1
9	Q7Z726	0.0	1088	529	0.998	0.998	Q7Z726_HUMAN Importin subunit alpha OS=Homo sapiens OX=9606 GN=KPNA2 PE=1 SV=1
10	Q9Z0N9	0.0	1038	529	0.947	0.947	Q9Z0N9_RAT Importin subunit alpha OS=Rattus norvegicus OX=10116 GN=importin alpha PE=2 SV=1
11	H7C4F6	2.47e-180	518	512	0.488	0.504	H7C4F6_HUMAN Importin subunit alpha OS=Homo sapiens OX=9606 GN=KPNA4 PE=1 SV=2
12	O00505	2.70e-177	511	521	0.490	0.497	IMA4_HUMAN Importin subunit alpha-4 OS=Homo sapiens OX=9606 GN=KPNA3 PE=1 SV=2
13	O76522	2.98e-173	500	514	0.488	0.502	O76522_DROME Karyopherin alpha 3 (Fragment) OS=Drosophila melanogaster OX=7227 GN=Kap-alpha3 PE=2 SV=1
14	Q9V455	3.96e-173	500	514	0.488	0.502	Q9V455_DROME Importin subunit alpha OS=Drosophila melanogaster OX=7227 GN=Kap-alpha3 PE=1 SV=1
15	Q9UB78	1.05e-172	499	514	0.488	0.502	Q9UB78_DROME Importin subunit alpha OS=Drosophila melanogaster OX=7227 GN=Kap-alpha3 PE=2 SV=1
16	P52295	1.03e-166	484	522	0.499	0.506	IMA_DROME Importin subunit alpha OS=Drosophila melanogaster OX=7227 GN=Pen PE=1 SV=2
17	C0LLJ0	1.81e-165	480	499	0.463	0.491	IMA8_MOUSE Importin subunit alpha-8 OS=Mus musculus OX=10090 GN=Kpna7 PE=1 SV=1
18	O94374	9.26e-163	474	539	0.471	0.462	IMA2_SCHPO Importin subunit alpha-2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=imp1 PE=1 SV=1
19	O76521	1.42e-161	472	543	0.471	0.459	O76521_DROME Importin subunit alpha OS=Drosophila melanogaster OX=7227 GN=Kap-alpha1 PE=2 SV=1
20	Q9U1H6	1.41e-158	464	542	0.469	0.458	Q9U1H6_DROME Importin subunit alpha OS=Drosophila melanogaster OX=7227 GN=Kap-alpha1 PE=3 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF01602 Adaptin_N	11	16.1	Adaptin N terminal region
2	PF00514 Arm	2.1e-84	286.5	Armadillo/beta-catenin-like repeat
3	PF04826 Arm_2	1.7	19.6	Armadillo-like
4	PF16186 Arm_3	1.5e-19	80.6	Atypical Arm repeat
5	PF12074 Gcn1_N	83	13.9	Generalcontrol nonderepressible 1 (Gcn1) N-terminal
6	PF02985 HEAT	1.2e-05	36.1	HEAT repeat
7	PF13646 HEAT_2	1.3e-08	46.5	HEAT repeats
8	PF13513 HEAT_EZ	1.7e-16	71.6	HEAT-like repeat
9	PF01749 IBB	1.3e-25	101.1	Importin beta binding domain
10	PF10274 ParcG	8.7e+02	11.4	Parkin co-regulated protein
11	PF12726 SEN1_N	3.5	17.4	SEN1 N terminal
12	PF11698 V-ATPase_H_C	0.23	23.0	V-ATPase subunit H

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000438483

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000290158	0.999	Importin subunit beta-1
2	9606.ENSP00000444029	0.997	Nuclear pore complex protein Nup153
3	9606.ENSP00000300403	0.994	Targeting protein for Xklp2
4	9606.ENSP00000364289	0.993	Nuclear cap-binding protein subunit 1
5	9606.ENSP00000362937	0.990	Regulator of chromosome condensation
6	9606.ENSP00000446215	0.989	GTP-binding nuclear protein Ran
7	9606.ENSP00000326806	0.987	Nuclear cap-binding protein subunit 2
8	9606.ENSP00000262982	0.985	Exportin-2
9	9606.ENSP00000401564	0.978	Ran-specific GTPase-activating protein
10	9606.ENSP00000259915	0.977	POU domain, class 5, transcription factor 1
11	9606.ENSP00000401470	0.976	Ran GTPase-activating protein 1
12	9606.ENSP00000378699	0.974	Cyclin-dependent kinase 1
13	9606.ENSP00000219169	0.968	Nuclear transport factor 2
14	9606.ENSP00000471191	0.966	Nuclear pore glycoprotein p62
15	9606.ENSP00000283195	0.962	E3 SUMO-protein ligase RanBP2
16	9606.ENSP00000256442	0.961	G2/mitotic-specific cyclin-B1
17	9606.ENSP00000299440	0.959	V(D)J recombination-activating protein 1
18	9606.ENSP00000352400	0.945	Nuclear pore complex protein Nup214
19	9606.ENSP00000288207	0.942	G2/mitotic-specific cyclin-B2
20	9606.ENSP00000345895	0.935	Nuclear pore complex protein Nup50

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.999	protein binding
GO:0033218	0.698	amide binding
GO:0008139	0.693	nuclear localization sequence binding
GO:0061608	0.307	nuclear import signal receptor activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0009987	0.996	cellular process
GO:0050789	0.986	regulation of biological process
GO:0050794	0.980	regulation of cellular process
GO:0006606	0.956	protein import into nucleus
GO:0009889	0.834	regulation of biosynthetic process
GO:0060255	0.791	regulation of macromolecule metabolic process
GO:0051171	0.787	regulation of nitrogen compound metabolic process
GO:0080090	0.779	regulation of primary metabolic process
GO:0031323	0.775	regulation of cellular metabolic process
GO:0019219	0.715	regulation of nucleobase-containing compound metabolic process
GO:0010556	0.656	regulation of macromolecule biosynthetic process
GO:0031326	0.647	regulation of cellular biosynthetic process
GO:0048518	0.628	positive regulation of biological process
GO:0008152	0.582	metabolic process
GO:0071704	0.551	organic substance metabolic process
GO:0050896	0.535	response to stimulus
GO:0010468	0.533	regulation of gene expression
GO:0044238	0.513	primary metabolic process
GO:0006807	0.484	nitrogen compound metabolic process
GO:0044237	0.440	cellular metabolic process
GO:0051716	0.429	cellular response to stimulus
GO:0043170	0.425	macromolecule metabolic process
GO:0051252	0.343	regulation of RNA metabolic process
GO:0048522	0.315	positive regulation of cellular process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005654	1.000	nucleoplasm
GO:0005829	0.999	cytosol
GO:0032991	0.976	protein-containing complex
GO:0016020	0.945	membrane
GO:0043228	0.697	non-membrane-bounded organelle
GO:0043232	0.658	intracellular non-membrane-bounded organelle
GO:0031074	0.528	nucleocytoplasmic transport complex
GO:0012505	0.407	endomembrane system

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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