StarFunc result for job id P52815

User Input

>input (198 residues)
MLPAAARPLWGPCLGLRAAAFRLARRQVPCVCAVRHMRSSGHQRCEALAGAPLDNAPKEY
PPKIQQLVQDIASLTLLEISDLNELLKKTLKIQDVGLVPMGGVMSGAVPAAAAQEAVEED
IPIAKERTHFTVRLTEAKPVDKVKLIKEIKNYIQGINLVQAKKLVESLPQEIKANVAKAE
AEKIKAALEAVGGTVVLE

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q7YR75	0.396	0.396	7.661E-27	198	0.859	0.859	Q7YR75.pdb.gz	RM12_BOVIN Large ribosomal subunit protein bL12m OS=Bos taurus OX=9913 GN=MRPL12 PE=1 SV=1
2	AFDB:Q9DB15	0.440	0.433	2.841E-26	201	0.859	0.846	Q9DB15.pdb.gz	RM12_MOUSE Large ribosomal subunit protein bL12m OS=Mus musculus OX=10090 GN=Mrpl12 PE=1 SV=2
3	AFDB:B4DLN1	0.362	0.170	3.908E-25	442	0.970	0.434	B4DLN1.pdb.gz	B4DLN1_HUMAN cDNA FLJ60124, highly similar to Mitochondrial dicarboxylate carrier OS=Homo sapiens OX=9606 PE=2 SV=1
4	AFDB:Q9VSR5	0.393	0.426	6.517E-14	182	0.313	0.341	Q9VSR5.pdb.gz	Q9VSR5_DROME GM03767p OS=Drosophila melanogaster OX=7227 GN=mRpL12 PE=1 SV=1
5	AFDB:O18180	0.397	0.449	1.467E-13	173	0.343	0.393	O18180.pdb.gz	O18180_CAEEL Mitochondrial Ribosomal Protein, Large OS=Caenorhabditis elegans OX=6239 GN=mrpl-12 PE=1 SV=1
6	AFDB:G8BJN1	0.439	0.469	2.573E-13	182	0.343	0.374	G8BJN1.pdb.gz	G8BJN1_CANPC Ribosomal protein L7/L12 C-terminal domain-containing protein OS=Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) OX=578454 GN=MNP1 PE=3 SV=1
7	AFDB:P53163	0.373	0.381	5.792E-13	194	0.343	0.351	P53163.pdb.gz	MNP1_YEAST Large ribosomal subunit protein bL12m OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=MNP1 PE=1 SV=1
8	AFDB:Q9USJ9	0.430	0.486	5.831E-12	173	0.313	0.358	Q9USJ9.pdb.gz	MNP1_SCHPO Large ribosomal subunit protein bL12m OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=mrpl12 PE=3 SV=2
9	AFDB:P36211	0.397	0.406	2.302E-11	193	0.222	0.228	P36211.pdb.gz	RK122_ARATH Large ribosomal subunit protein bL12cy OS=Arabidopsis thaliana OX=3702 GN=RPL12B PE=3 SV=2
10	AFDB:O04527	0.378	0.360	3.145E-11	208	0.253	0.240	O04527.pdb.gz	O04527_ARATH F20P5.9 protein OS=Arabidopsis thaliana OX=3702 GN=At1g70190 PE=1 SV=1
11	PDB:6vlzTC	0.345	0.912	2.114E-9	71	0.359	1.000	6vlzTC.pdb.gz	Structures of the human mitochondrial ribosome bound to EF-G1 reveal distinct features of mitochondrial translation elongation.
12	PDB:1rquA	0.344	0.553	2.265E-8	120	0.192	0.317	1rquA.pdb.gz
13	PDB:4o2xA	0.294	0.135	1.727E-2	457	0.071	0.031	4o2xA.pdb.gz
14	PDB:3o2bC	0.314	0.548	3.887E-2	105	0.056	0.105	3o2bC.pdb.gz	The ClpS adaptor mediates staged delivery of N-end rule substrates to the AAA+ ClpAP protease.
15	PDB:5hvfA	0.228	0.135	3.677E-1	372	0.056	0.030	5hvfA.pdb.gz	Elucidation of the molecular mechanisms of two nanobodies that inhibit thrombin-activatable fibrinolysis inhibitor activation and activated thrombin-activatable fibrinolysis inhibitor activity.
16	PDB:4p10A	0.228	0.127	4.719E-1	402	0.066	0.032	4p10A.pdb.gz	Design and synthesis of conformationally restricted inhibitors of active thrombin activatable fibrinolysis inhibitor (TAFIa).
17	PDB:7mexA	0.273	0.037	4.719E-1	1737	0.020	0.002	7mexA.pdb.gz	Structural insights into Ubr1-mediated N-degron polyubiquitination.
18	PDB:6fonA	0.202	0.165	5.023E-1	252	0.045	0.036	6fonA.pdb.gz	Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS.
19	PDB:6ahrH	0.188	0.272	6.057E-1	121	0.096	0.157	6ahrH.pdb.gz	Cryo-EM Structure of the Human Ribonuclease P Holoenzyme.
20	PDB:2gqqC	0.188	0.218	7.305E-1	157	0.096	0.121	2gqqC.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P52815	3.72e-142	395	198	1.000	1.000	RM12_HUMAN Large ribosomal subunit protein bL12m OS=Homo sapiens OX=9606 GN=MRPL12 PE=1 SV=2
2	B4DLN1	8.57e-134	384	442	0.960	0.430	B4DLN1_HUMAN cDNA FLJ60124, highly similar to Mitochondrial dicarboxylate carrier OS=Homo sapiens OX=9606 PE=2 SV=1
3	Q7YR75	1.05e-110	316	198	0.859	0.859	RM12_BOVIN Large ribosomal subunit protein bL12m OS=Bos taurus OX=9913 GN=MRPL12 PE=1 SV=1
4	Q9DB15	3.78e-110	315	201	0.854	0.841	RM12_MOUSE Large ribosomal subunit protein bL12m OS=Mus musculus OX=10090 GN=Mrpl12 PE=1 SV=2
5	O18180	2.51e-24	95.9	173	0.318	0.364	O18180_CAEEL Mitochondrial Ribosomal Protein, Large OS=Caenorhabditis elegans OX=6239 GN=mrpl-12 PE=1 SV=1
6	G8BJN1	2.51e-21	88.6	182	0.359	0.390	G8BJN1_CANPC Ribosomal protein L7/L12 C-terminal domain-containing protein OS=Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) OX=578454 GN=MNP1 PE=3 SV=1
7	Q9VSR5	1.07e-20	86.7	182	0.323	0.352	Q9VSR5_DROME GM03767p OS=Drosophila melanogaster OX=7227 GN=mRpL12 PE=1 SV=1
8	P53163	2.50e-19	83.6	194	0.328	0.335	MNP1_YEAST Large ribosomal subunit protein bL12m OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=MNP1 PE=1 SV=1
9	Q2XYH0	5.39e-19	82.0	169	0.263	0.308	Q2XYH0_DROME CG5012 (Fragment) OS=Drosophila melanogaster OX=7227 GN=mRpL12 PE=3 SV=1
10	O04527	3.17e-13	67.4	208	0.273	0.260	O04527_ARATH F20P5.9 protein OS=Arabidopsis thaliana OX=3702 GN=At1g70190 PE=1 SV=1
11	Q9USJ9	5.81e-12	63.5	173	0.298	0.341	MNP1_SCHPO Large ribosomal subunit protein bL12m OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=mrpl12 PE=3 SV=2
12	Q57X71	1.08e-06	49.3	183	0.263	0.284	Q57X71_TRYB2 60S ribosomal protein-like OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb07.26A24.780 PE=4 SV=1
13	P0A471	1.79e-06	47.4	122	0.162	0.262	RL7_STRPN Large ribosomal subunit protein bL12 OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) OX=170187 GN=rplL PE=1 SV=2
14	O51351	3.48e-06	46.6	124	0.152	0.242	RL7_BORBU Large ribosomal subunit protein bL12 OS=Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) OX=224326 GN=rplL PE=3 SV=1
15	P36210	9.06e-06	46.6	191	0.222	0.230	RK121_ARATH Large ribosomal subunit protein bL12cz OS=Arabidopsis thaliana OX=3702 GN=RPL12A PE=2 SV=1
16	P55834	9.10e-06	45.4	125	0.212	0.336	RL7_HELPY Large ribosomal subunit protein bL12 OS=Helicobacter pylori (strain ATCC 700392 / 26695) OX=85962 GN=rplL PE=1 SV=1
17	P36212	9.51e-06	46.6	187	0.222	0.235	RK123_ARATH Large ribosomal subunit protein bL12cx OS=Arabidopsis thaliana OX=3702 GN=RPL12C PE=2 SV=2
18	P02394	2.00e-05	44.7	123	0.146	0.236	RL7_BACSU Large ribosomal subunit protein bL12 OS=Bacillus subtilis (strain 168) OX=224308 GN=rplL PE=1 SV=4
19	P0A7K2	5.73e-05	43.1	121	0.152	0.248	RL7_ECOLI Large ribosomal subunit protein bL12 OS=Escherichia coli (strain K12) OX=83333 GN=rplL PE=1 SV=2
20	P36211	0.002	39.7	193	0.177	0.181	RK122_ARATH Large ribosomal subunit protein bL12cy OS=Arabidopsis thaliana OX=3702 GN=RPL12B PE=3 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF14933 CEP19	3.7e+02	12.8	CEP19-like protein
2	PF00542 Ribosomal_L12	1e-14	66.0	Ribosomal protein L7/L12 C-terminal domain
3	PF16320 Ribosomal_L12_N	6.2e-09	46.7	Ribosomal protein L7/L12 dimerisation domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000333837

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000301585	0.999	Peptidyl-tRNA hydrolase ICT1, mitochondrial
2	9606.ENSP00000288937	0.998	Mitochondrial ribosomal protein L17
3	9606.ENSP00000306548	0.998	Mitochondrial ribosomal protein L13
4	9606.ENSP00000308897	0.998	Mitochondrial ribosomal protein L11
5	9606.ENSP00000253099	0.997	Mitochondrial ribosomal protein L4
6	9606.ENSP00000264995	0.997	Mitochondrial ribosomal protein L3
7	9606.ENSP00000290208	0.997	Mitochondrial ribosomal protein L10
8	9606.ENSP00000377486	0.997	Mitochondrial ribosomal protein L19
9	9606.ENSP00000417602	0.997	Belongs to the universal ribosomal protein uL29 family.
10	9606.ENSP00000223324	0.996	Mitochondrial ribosomal protein L32
11	9606.ENSP00000225969	0.996	Mitochondrial ribosomal protein L27
12	9606.ENSP00000260102	0.996	Mitochondrial ribosomal protein L15
13	9606.ENSP00000296102	0.996	Mitochondrial ribosomal protein L33
14	9606.ENSP00000341082	0.996	Mitochondrial ribosomal protein L20
15	9606.ENSP00000354580	0.996	Mitochondrial ribosomal protein L21
16	9606.ENSP00000357823	0.996	Mitochondrial ribosomal protein L9
17	9606.ENSP00000360498	0.996	39S ribosomal protein L41, mitochondrial
18	9606.ENSP00000423399	0.995	Mitochondrial ribosomal protein L36
19	9606.ENSP00000431040	0.994	Mitochondrial ribosomal protein L22
20	9606.ENSP00000258383	0.993	39S ribosomal protein L44, mitochondrial

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0003735	1.000	structural constituent of ribosome
GO:0003723	0.999	RNA binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071704	0.995	organic substance metabolic process
GO:0044238	0.995	primary metabolic process
GO:0044237	0.995	cellular metabolic process
GO:0140053	0.992	mitochondrial gene expression
GO:0016070	0.985	RNA metabolic process
GO:0051171	0.981	regulation of nitrogen compound metabolic process
GO:0080090	0.980	regulation of primary metabolic process
GO:0060255	0.979	regulation of macromolecule metabolic process
GO:0048518	0.978	positive regulation of biological process
GO:0031323	0.977	regulation of cellular metabolic process
GO:0009059	0.971	macromolecule biosynthetic process
GO:0044271	0.970	cellular nitrogen compound biosynthetic process
GO:0048522	0.968	positive regulation of cellular process
GO:0000959	0.917	mitochondrial RNA metabolic process
GO:0019219	0.909	regulation of nucleobase-containing compound metabolic process
GO:0051252	0.896	regulation of RNA metabolic process
GO:0010468	0.890	regulation of gene expression
GO:0034654	0.882	nucleobase-containing compound biosynthetic process
GO:0006351	0.861	DNA-templated transcription
GO:0031326	0.857	regulation of cellular biosynthetic process
GO:0010556	0.838	regulation of macromolecule biosynthetic process
GO:0009893	0.796	positive regulation of metabolic process
GO:0010604	0.770	positive regulation of macromolecule metabolic process
GO:0051173	0.758	positive regulation of nitrogen compound metabolic process
GO:2001141	0.617	regulation of RNA biosynthetic process
GO:0031325	0.590	positive regulation of cellular metabolic process
GO:0051254	0.567	positive regulation of RNA metabolic process
GO:0006412	0.533	translation
GO:0031328	0.490	positive regulation of cellular biosynthetic process
GO:0010557	0.480	positive regulation of macromolecule biosynthetic process
GO:0006355	0.479	regulation of DNA-templated transcription
GO:0045893	0.454	positive regulation of DNA-templated transcription

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005739	0.999	mitochondrion
GO:0070013	0.995	intracellular organelle lumen
GO:0016020	0.990	membrane
GO:0032991	0.987	protein-containing complex
GO:0043232	0.983	intracellular non-membrane-bounded organelle
GO:0031966	0.959	mitochondrial membrane
GO:0005743	0.951	mitochondrial inner membrane
GO:0005840	0.943	ribosome
GO:1990904	0.941	ribonucleoprotein complex
GO:0044391	0.934	ribosomal subunit
GO:0005759	0.922	mitochondrial matrix
GO:0098798	0.910	mitochondrial protein-containing complex
GO:0015934	0.901	large ribosomal subunit
GO:0005761	0.877	mitochondrial ribosome
GO:0005762	0.612	mitochondrial large ribosomal subunit

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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