StarFunc result for job id P53582

User Input

>input (386 residues)
MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKA
KREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQ
ALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCY
PSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGE
VDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLF
HTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHT
LLVTDTGCEILTRRLDSARPHFMSQF

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P53582	1.000	1.000	1.142E-80	386	1.000	1.000	P53582.pdb.gz	MAP11_HUMAN Methionine aminopeptidase 1 OS=Homo sapiens OX=9606 GN=METAP1 PE=1 SV=2
2	AFDB:Q4QRK0	0.821	0.821	8.979E-72	386	0.868	0.868	Q4QRK0.pdb.gz	MAP11_DANRE Methionine aminopeptidase 1 OS=Danio rerio OX=7955 GN=metap1 PE=2 SV=2
3	PDB:4iu6A	0.784	0.996	7.117E-60	304	0.785	0.997	4iu6A.pdb.gz	Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.
4	AFDB:Q9SLN5	0.758	0.736	2.754E-52	398	0.562	0.545	Q9SLN5.pdb.gz	MAP1A_ARATH Methionine aminopeptidase 1A OS=Arabidopsis thaliana OX=3702 GN=MAP1A PE=1 SV=1
5	AFDB:Q01662	0.785	0.783	7.460E-50	387	0.487	0.486	Q01662.pdb.gz	MAP1_YEAST Methionine aminopeptidase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=MAP1 PE=1 SV=2
6	AFDB:O59730	0.781	0.795	2.313E-49	379	0.516	0.525	O59730.pdb.gz	MAP1_SCHPO Methionine aminopeptidase 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=fma1 PE=1 SV=1
7	AFDB:Q4FKC0	0.776	0.758	2.789E-48	395	0.516	0.504	Q4FKC0.pdb.gz	Q4FKC0_TRYB2 Methionine aminopeptidase OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb10.61.1210 PE=1 SV=1
8	AFDB:Q9FV52	0.678	0.708	2.690E-37	369	0.352	0.369	Q9FV52.pdb.gz	MAP1B_ARATH Methionine aminopeptidase 1B, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=MAP1B PE=2 SV=2
9	AFDB:Q9FV50	0.699	0.770	3.374E-37	350	0.368	0.406	Q9FV50.pdb.gz	MAP1D_ARATH Methionine aminopeptidase 1D, chloroplastic/mitochondrial OS=Arabidopsis thaliana OX=3702 GN=MAP1D PE=1 SV=1
10	AFDB:Q6UB28	0.721	0.829	1.046E-36	335	0.339	0.391	Q6UB28.pdb.gz	MAP12_HUMAN Methionine aminopeptidase 1D, mitochondrial OS=Homo sapiens OX=9606 GN=METAP1D PE=1 SV=1
11	AFDB:P9WK19	0.706	0.952	2.947E-35	285	0.358	0.484	P9WK19.pdb.gz	MAP12_MYCTU Methionine aminopeptidase 2 OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=map PE=1 SV=1
12	PDB:3iu7A	0.690	0.932	1.825E-34	284	0.352	0.479	3iu7A.pdb.gz	Catalysis and Inhibition of Mycobacterium tuberculosis Methionine Aminopeptidase
13	PDB:4matA	0.645	0.915	1.560E-30	271	0.311	0.443	4matA.pdb.gz
14	PDB:5cnxA	0.503	0.537	6.899E-16	360	0.142	0.153	5cnxA.pdb.gz	Structures and activities of widely conserved small prokaryotic aminopeptidases-P clarify classification of M24B peptidases
15	PDB:2bh3A	0.485	0.428	2.729E-14	440	0.137	0.120	2bh3A.pdb.gz	Structural and Functional Implications of Metal Ion Selection in Aminopeptidase P, a Metalloprotease with a Dinuclear Metal Center.
16	PDB:5x49A	0.482	0.424	1.408E-13	441	0.130	0.113	5x49A.pdb.gz	Structure of the human aminopeptidase XPNPEP3 and comparison of its in vitro activity with Icp55 orthologs: Insights into diverse cellular processes.
17	PDB:1b6aA	0.523	0.567	2.215E-13	355	0.171	0.186	1b6aA.pdb.gz	Structure of human methionine aminopeptidase-2 complexed with fumagillin.
18	PDB:6sxoA	0.543	0.558	1.020E-12	375	0.122	0.125	6sxoA.pdb.gz	MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments.
19	PDB:5mc1B	0.488	0.394	1.080E-12	485	0.122	0.097	5mc1B.pdb.gz	Structural basis for prolidase deficiency disease mechanisms.
20	PDB:6yo9A	0.472	0.458	3.968E-12	398	0.109	0.106	6yo9A.pdb.gz	Degradation of the microbial stress protectants and chemical chaperones ectoine and hydroxyectoine by a bacterial hydrolase-deacetylase complex.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P53582	0.0	813	386	1.000	1.000	MAP11_HUMAN Methionine aminopeptidase 1 OS=Homo sapiens OX=9606 GN=METAP1 PE=1 SV=2
2	Q4QRK0	0.0	714	386	0.868	0.868	MAP11_DANRE Methionine aminopeptidase 1 OS=Danio rerio OX=7955 GN=metap1 PE=2 SV=2
3	Q8BP48	0.0	803	386	0.982	0.982	MAP11_MOUSE Methionine aminopeptidase 1 OS=Mus musculus OX=10090 GN=Metap1 PE=1 SV=1
4	Q9SLN5	9.78e-150	431	398	0.560	0.543	MAP1A_ARATH Methionine aminopeptidase 1A OS=Arabidopsis thaliana OX=3702 GN=MAP1A PE=1 SV=1
5	O59730	4.57e-140	405	379	0.521	0.530	MAP1_SCHPO Methionine aminopeptidase 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=fma1 PE=1 SV=1
6	Q4FKC0	5.02e-134	390	395	0.505	0.494	Q4FKC0_TRYB2 Methionine aminopeptidase OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb10.61.1210 PE=1 SV=1
7	Q01662	4.06e-131	383	387	0.492	0.491	MAP1_YEAST Methionine aminopeptidase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=MAP1 PE=1 SV=2
8	Q9FV50	1.84e-89	275	350	0.368	0.406	MAP1D_ARATH Methionine aminopeptidase 1D, chloroplastic/mitochondrial OS=Arabidopsis thaliana OX=3702 GN=MAP1D PE=1 SV=1
9	Q9FV52	3.28e-88	273	369	0.394	0.412	MAP1B_ARATH Methionine aminopeptidase 1B, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=MAP1B PE=2 SV=2
10	P9WK19	3.33e-86	265	285	0.355	0.481	MAP12_MYCTU Methionine aminopeptidase 2 OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=map PE=1 SV=1
11	Q9CPW9	6.30e-82	255	335	0.334	0.385	MAP12_MOUSE Methionine aminopeptidase 1D, mitochondrial OS=Mus musculus OX=10090 GN=Metap1d PE=2 SV=1
12	Q6UB28	3.05e-81	254	335	0.329	0.379	MAP12_HUMAN Methionine aminopeptidase 1D, mitochondrial OS=Homo sapiens OX=9606 GN=METAP1D PE=1 SV=1
13	Q9FV51	9.52e-78	245	344	0.319	0.358	MAP1C_ARATH Methionine aminopeptidase 1C, chloroplastic/mitochondrial OS=Arabidopsis thaliana OX=3702 GN=MAP1C PE=2 SV=2
14	P0AE18	8.54e-77	240	264	0.313	0.458	MAP1_ECOLI Methionine aminopeptidase OS=Escherichia coli (strain K12) OX=83333 GN=map PE=1 SV=1
15	P9WK21	4.11e-36	134	266	0.194	0.282	MAP11_MYCTU Methionine aminopeptidase 1 OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=map-1 PE=1 SV=1
16	P76524	1.23e-06	52.4	361	0.148	0.158	YPDF_ECOLI Aminopeptidase YpdF OS=Escherichia coli (strain K12) OX=83333 GN=ypdF PE=1 SV=1
17	Q9HVS3	1.55e-06	52.0	405	0.117	0.111	Q9HVS3_PSEAE Probable metallopeptidase OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964 GN=PA4498 PE=3 SV=1
18	Q387N9	7.21e-06	50.1	382	0.083	0.084	Q387N9_TRYB2 Aminopeptidase, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb10.61.1870 PE=3 SV=1
19	M1CZC0	1.39e-04	45.8	387	0.083	0.083	EBP1_SOLTU ERBB-3 BINDING PROTEIN 1 OS=Solanum tuberosum OX=4113 GN=EBP1 PE=2 SV=1
20	F4HZG9	0.002	42.7	493	0.168	0.132	ICP55_ARATH Intermediate cleaving peptidase 55, mitochondrial OS=Arabidopsis thaliana OX=3702 GN=ICP55 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00557 Peptidase_M24	6.8e-48	174.7	Metallopeptidase family M24
2	PF15801 zf-C6H2	7.1e-17	72.6	zf-MYND-like zinc finger, mRNA-binding
3	PF04438 zf-HIT	7.5e+02	11.4	HIT zinc finger
4	PF01753 zf-MYND	1.2	20.6	MYND finger

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000296411

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000325312	0.990	Methionine aminopeptidase 2
2	9606.ENSP00000232461	0.900	Guanine nucleotide-binding protein G(t) subunit alpha-1
3	9606.ENSP00000259199	0.851	COBW domain containing 2
4	9606.ENSP00000288022	0.828	Peptide deformylase, mitochondrial
5	9606.ENSP00000295268	0.768	Sperm-tail PG-rich repeat-containing protein 2
6	9606.ENSP00000366617	0.763	COBW domain containing 1
7	9606.ENSP00000340454	0.730	Rap1 GTPase-GDP dissociation stimulator 1
8	9606.ENSP00000259469	0.718	60S ribosomal protein L35
9	9606.ENSP00000256383	0.691	Eukaryotic translation initiation factor 2 subunit 1
10	9606.ENSP00000308057	0.677	Beta-synuclein
11	9606.ENSP00000404381	0.676	DnaJ homolog subfamily B member 14
12	9606.ENSP00000348673	0.662	Zinc finger protein 770
13	9606.ENSP00000307701	0.659	Tetraspanin-5
14	9606.ENSP00000367024	0.647	N-alpha-acetyltransferase 40
15	9606.ENSP00000363478	0.631	Belongs to the UPF0220 family
16	9606.ENSP00000349456	0.621	Chloride channel CLIC-like protein 1
17	9606.ENSP00000316891	0.618	LIM and calponin homology domains 1
18	9606.ENSP00000315295	0.605	UPF0606 protein KIAA1549L
19	9606.ENSP00000332737	0.603	Netrin receptor UNC5A
20	9606.ENSP00000270357	0.597	Aminopeptidase RNPEPL1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005488	0.999	binding
GO:0070006	0.995	metalloaminopeptidase activity
GO:0005515	0.979	protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071704	0.995	organic substance metabolic process
GO:0044238	0.993	primary metabolic process
GO:0006807	0.989	nitrogen compound metabolic process
GO:0043170	0.976	macromolecule metabolic process
GO:1901564	0.942	organonitrogen compound metabolic process
GO:0019538	0.910	protein metabolic process
GO:0043412	0.894	macromolecule modification
GO:0036211	0.849	protein modification process
GO:0010467	0.651	gene expression
GO:0009987	0.623	cellular process
GO:0065007	0.340	biological regulation
GO:0050789	0.310	regulation of biological process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005829	0.996	cytosol
GO:0043226	0.849	organelle
GO:0043227	0.819	membrane-bounded organelle
GO:0043231	0.721	intracellular membrane-bounded organelle
GO:0070013	0.661	intracellular organelle lumen
GO:0005634	0.566	nucleus

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:3.4.11.-	1.000	Aminopeptidases.

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