StarFunc result for job id P54709

User Input

>input (279 residues)
MTKNEKKSLNQSLAEWKLFIYNPTTGEFLGRTAKSWGLILLFYLVFYGFLAALFSFTMWV
MLQTLNDEVPKYRDQIPSPGLMVFPKPVTALEYTFSRSDPTSYAGYIEDLKKFLKPYTLE
EQKNLTVCPDGALFEQKGPVYVACQFPISLLQACSGMNDPDFGYSQGNPCILVKMNRIIG
LKPEGVPRIDCVSKNEDIPNVAVYPHNGMIDLKYFPYYGKKLHVGYLQPLVAVQVSFAPN
NTGKEVTVECKIDGSANLKSQDDRDKFLGRVMFKITARA

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P54709	1.000	1.000	6.611E-62	279	1.000	1.000	P54709.pdb.gz	AT1B3_HUMAN Sodium/potassium-transporting ATPase subunit beta-3 OS=Homo sapiens OX=9606 GN=ATP1B3 PE=1 SV=1
2	AFDB:Q63377	0.986	0.986	3.522E-51	279	0.749	0.749	Q63377.pdb.gz	AT1B3_RAT Sodium/potassium-transporting ATPase subunit beta-3 OS=Rattus norvegicus OX=10116 GN=Atp1b3 PE=1 SV=1
3	AFDB:P97370	0.988	0.991	1.006E-50	278	0.735	0.737	P97370.pdb.gz	AT1B3_MOUSE Sodium/potassium-transporting ATPase subunit beta-3 OS=Mus musculus OX=10090 GN=Atp1b3 PE=1 SV=1
4	AFDB:P13638	0.924	0.890	4.988E-36	290	0.473	0.455	P13638.pdb.gz	AT1B2_RAT Sodium/potassium-transporting ATPase subunit beta-2 OS=Rattus norvegicus OX=10116 GN=Atp1b2 PE=1 SV=1
5	AFDB:Q90Z34	0.892	0.854	2.595E-34	292	0.444	0.425	Q90Z34.pdb.gz	Q90Z34_DANRE Sodium/potassium-transporting ATPase subunit beta OS=Danio rerio OX=7955 GN=cb712 PE=1 SV=1
6	AFDB:P18434	0.919	0.885	5.118E-34	290	0.355	0.341	P18434.pdb.gz	ATP4B_PIG Potassium-transporting ATPase subunit beta OS=Sus scrofa OX=9823 GN=ATP4B PE=1 SV=1
7	AFDB:P18598	0.878	0.836	9.490E-34	294	0.373	0.354	P18598.pdb.gz	ATP4B_RAT Potassium-transporting ATPase subunit beta OS=Rattus norvegicus OX=10116 GN=Atp4b PE=2 SV=3
8	AFDB:P18597	0.870	0.837	1.142E-33	291	0.362	0.347	P18597.pdb.gz	ATP4B_RABIT Potassium-transporting ATPase subunit beta OS=Oryctolagus cuniculus OX=9986 GN=ATP4B PE=1 SV=1
9	AFDB:P51164	0.868	0.835	4.726E-33	291	0.355	0.340	P51164.pdb.gz	ATP4B_HUMAN Potassium-transporting ATPase subunit beta OS=Homo sapiens OX=9606 GN=ATP4B PE=1 SV=1
10	AFDB:Q9UN42	0.911	0.720	1.269E-32	357	0.358	0.280	Q9UN42.pdb.gz	AT1B4_HUMAN Protein ATP1B4 OS=Homo sapiens OX=9606 GN=ATP1B4 PE=1 SV=1
11	PDB:6jxkB	0.804	0.826	2.523E-28	271	0.333	0.343	6jxkB.pdb.gz	A single K + -binding site in the crystal structure of the gastric proton pump.
12	PDB:7x20B	0.755	0.733	1.289E-25	288	0.351	0.340	7x20B.pdb.gz	Structure and function of H + /K + pump mutants reveal Na + /K + pump mechanisms.
13	PDB:3wguB	0.789	0.730	1.917E-23	303	0.366	0.337	3wguB.pdb.gz	Crystal structure of a Na1-bound Na1,K1-ATPase preceding the E1P state
14	PDB:2xzbB	0.547	0.855	1.545E-11	175	0.204	0.326	2xzbB.pdb.gz
15	PDB:1rowA	0.214	0.452	1.045E-3	107	0.068	0.178	1rowA.pdb.gz
16	PDB:4b0mM	0.227	0.284	1.822E-3	212	0.061	0.080	4b0mM.pdb.gz
17	PDB:4aq1A	0.232	0.103	2.193E-3	721	0.039	0.015	4aq1A.pdb.gz	Sbsb Structure and Lattice Reconstruction Unveil Ca21 Triggered S-Layer Assembly
18	PDB:2mspA	0.213	0.397	2.333E-3	124	0.061	0.137	2mspA.pdb.gz
19	PDB:3dpaA	0.229	0.279	2.481E-3	218	0.039	0.050	3dpaA.pdb.gz
20	PDB:5dfkA	0.205	0.282	9.074E-3	185	0.036	0.054	5dfkA.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P54709	0.0	578	279	1.000	1.000	AT1B3_HUMAN Sodium/potassium-transporting ATPase subunit beta-3 OS=Homo sapiens OX=9606 GN=ATP1B3 PE=1 SV=1
2	Q63377	3.65e-161	450	279	0.749	0.749	AT1B3_RAT Sodium/potassium-transporting ATPase subunit beta-3 OS=Rattus norvegicus OX=10116 GN=Atp1b3 PE=1 SV=1
3	P97370	4.62e-153	430	278	0.735	0.737	AT1B3_MOUSE Sodium/potassium-transporting ATPase subunit beta-3 OS=Mus musculus OX=10090 GN=Atp1b3 PE=1 SV=1
4	C9JA36	1.48e-95	279	133	0.477	1.000	C9JA36_HUMAN ATPase Na+/K+ transporting subunit beta 3 (Fragment) OS=Homo sapiens OX=9606 GN=ATP1B3 PE=1 SV=1
5	P14231	3.84e-85	258	290	0.502	0.483	AT1B2_MOUSE Sodium/potassium-transporting ATPase subunit beta-2 OS=Mus musculus OX=10090 GN=Atp1b2 PE=1 SV=2
6	P13638	1.28e-83	254	290	0.495	0.476	AT1B2_RAT Sodium/potassium-transporting ATPase subunit beta-2 OS=Rattus norvegicus OX=10116 GN=Atp1b2 PE=1 SV=1
7	P14415	1.49e-83	254	290	0.487	0.469	AT1B2_HUMAN Sodium/potassium-transporting ATPase subunit beta-2 OS=Homo sapiens OX=9606 GN=ATP1B2 PE=1 SV=3
8	Q90Z34	3.85e-71	223	292	0.452	0.432	Q90Z34_DANRE Sodium/potassium-transporting ATPase subunit beta OS=Danio rerio OX=7955 GN=cb712 PE=1 SV=1
9	P18598	6.12e-58	189	294	0.384	0.364	ATP4B_RAT Potassium-transporting ATPase subunit beta OS=Rattus norvegicus OX=10116 GN=Atp4b PE=2 SV=3
10	Q9UN42	2.16e-57	189	357	0.376	0.294	AT1B4_HUMAN Protein ATP1B4 OS=Homo sapiens OX=9606 GN=ATP1B4 PE=1 SV=1
11	P08251	2.35e-56	185	305	0.434	0.397	AT1B1_CHICK Sodium/potassium-transporting ATPase subunit beta-1 OS=Gallus gallus OX=9031 GN=ATP1B1 PE=1 SV=1
12	P18434	1.22e-55	182	290	0.362	0.348	ATP4B_PIG Potassium-transporting ATPase subunit beta OS=Sus scrofa OX=9823 GN=ATP4B PE=1 SV=1
13	P18597	3.32e-55	181	291	0.373	0.357	ATP4B_RABIT Potassium-transporting ATPase subunit beta OS=Oryctolagus cuniculus OX=9986 GN=ATP4B PE=1 SV=1
14	P51164	8.94e-55	181	291	0.358	0.344	ATP4B_HUMAN Potassium-transporting ATPase subunit beta OS=Homo sapiens OX=9606 GN=ATP4B PE=1 SV=1
15	Q9BDK6	1.62e-53	179	355	0.366	0.287	AT1B4_PIG Protein ATP1B4 OS=Sus scrofa OX=9823 GN=ATP1B4 PE=1 SV=1
16	Q9TT37	3.24e-53	177	303	0.401	0.370	AT1B1_RABIT Sodium/potassium-transporting ATPase subunit beta-1 OS=Oryctolagus cuniculus OX=9986 GN=ATP1B1 PE=1 SV=1
17	P07340	6.22e-53	176	304	0.394	0.362	AT1B1_RAT Sodium/potassium-transporting ATPase subunit beta-1 OS=Rattus norvegicus OX=10116 GN=Atp1b1 PE=1 SV=1
18	P14094	6.42e-53	176	304	0.398	0.365	AT1B1_MOUSE Sodium/potassium-transporting ATPase subunit beta-1 OS=Mus musculus OX=10090 GN=Atp1b1 PE=1 SV=1
19	Q91580	6.42e-53	176	304	0.412	0.378	Q91580_XENLA Sodium/potassium-transporting ATPase subunit beta OS=Xenopus laevis OX=8355 GN=atp1b1.S PE=2 SV=1
20	Q9R193	8.33e-53	177	356	0.362	0.284	AT1B4_RAT Protein ATP1B4 OS=Rattus norvegicus OX=10116 GN=Atp1b4 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00287 Na_K-ATPase	7.8e-92	319.1	Sodium / potassium ATPase beta chain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000286371

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000444688	0.980	Sodium/potassium-transporting ATPase subunit alpha-3
2	9606.ENSP00000445306	0.963	Sodium/potassium-transporting ATPase subunit alpha-1
3	9606.ENSP00000357060	0.948	Sodium/potassium-transporting ATPase subunit alpha-4
4	9606.ENSP00000354490	0.933	Sodium/potassium-transporting ATPase subunit alpha-2
5	9606.ENSP00000292079	0.925	Sodium/potassium-transporting ATPase subunit gamma
6	9606.ENSP00000218548	0.859	Potassium-transporting ATPase alpha chain 2
7	9606.ENSP00000440045	0.830	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
8	9606.ENSP00000481244	0.829	Phospholemman
9	9606.ENSP00000356790	0.825	Sodium/potassium-transporting ATPase subunit beta-1
10	9606.ENSP00000218008	0.819	Protein ATP1B4
11	9606.ENSP00000250111	0.812	Sodium/potassium-transporting ATPase subunit beta-2
12	9606.ENSP00000244221	0.769	Polyadenylate-binding protein-interacting protein 2B
13	9606.ENSP00000311405	0.764	Adenylate cyclase type 6
14	9606.ENSP00000262352	0.744	Excitatory amino acid transporter 3
15	9606.ENSP00000260645	0.728	ATP-binding cassette sub-family G member 5
16	9606.ENSP00000272286	0.728	ATP-binding cassette sub-family G member 8
17	9606.ENSP00000297504	0.726	ATP-binding cassette sub-family B member 8, mitochondrial
18	9606.ENSP00000344155	0.726	ATP-binding cassette sub-family A member 2
19	9606.ENSP00000349396	0.726	ATP-binding cassette sub-family D member 4
20	9606.ENSP00000263980	0.720	Sodium/hydrogen exchanger 1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0098772	0.996	molecular function regulator activity
GO:0060590	0.991	ATPase regulator activity
GO:0001671	0.979	ATPase activator activity
GO:0005215	0.950	transporter activity
GO:0022857	0.930	transmembrane transporter activity
GO:0015318	0.823	inorganic molecular entity transmembrane transporter activity
GO:0060090	0.803	molecular adaptor activity
GO:0022890	0.729	inorganic cation transmembrane transporter activity
GO:0140657	0.648	ATP-dependent activity
GO:0015075	0.645	monoatomic ion transmembrane transporter activity
GO:0019899	0.644	enzyme binding
GO:0022804	0.643	active transmembrane transporter activity
GO:0042626	0.558	ATPase-coupled transmembrane transporter activity
GO:1901702	0.538	salt transmembrane transporter activity
GO:0008324	0.532	monoatomic cation transmembrane transporter activity
GO:0022853	0.526	active monoatomic ion transmembrane transporter activity
GO:0046873	0.523	metal ion transmembrane transporter activity
GO:0140358	0.453	P-type transmembrane transporter activity
GO:0019829	0.440	ATPase-coupled monoatomic cation transmembrane transporter activity
GO:0015662	0.435	P-type ion transporter activity
GO:0015079	0.426	potassium ion transmembrane transporter activity
GO:0008556	0.404	P-type potassium transmembrane transporter activity
GO:0030674	0.333	protein-macromolecule adaptor activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0006811	0.990	monoatomic ion transport
GO:0050789	0.985	regulation of biological process
GO:0009987	0.982	cellular process
GO:0065008	0.976	regulation of biological quality
GO:0030001	0.976	metal ion transport
GO:0050794	0.968	regulation of cellular process
GO:0006814	0.966	sodium ion transport
GO:0006813	0.965	potassium ion transport
GO:0042592	0.951	homeostatic process
GO:0048518	0.951	positive regulation of biological process
GO:0034220	0.919	monoatomic ion transmembrane transport
GO:1904062	0.917	regulation of monoatomic cation transmembrane transport
GO:0055080	0.906	monoatomic cation homeostasis
GO:0098655	0.886	monoatomic cation transmembrane transport
GO:0098771	0.879	inorganic ion homeostasis
GO:0098660	0.875	inorganic ion transmembrane transport
GO:0010959	0.870	regulation of metal ion transport
GO:0098662	0.869	inorganic cation transmembrane transport
GO:0043266	0.827	regulation of potassium ion transport
GO:0065009	0.814	regulation of molecular function
GO:0043270	0.812	positive regulation of monoatomic ion transport
GO:0048522	0.810	positive regulation of cellular process
GO:0140115	0.762	export across plasma membrane
GO:0032412	0.750	regulation of monoatomic ion transmembrane transporter activity
GO:0035725	0.729	sodium ion transmembrane transport
GO:0010765	0.725	positive regulation of sodium ion transport
GO:1901379	0.725	regulation of potassium ion transmembrane transport
GO:1904064	0.725	positive regulation of cation transmembrane transport
GO:1902305	0.723	regulation of sodium ion transmembrane transport
GO:0032414	0.723	positive regulation of ion transmembrane transporter activity
GO:0043462	0.722	regulation of ATP-dependent activity
GO:0055075	0.712	potassium ion homeostasis
GO:1901381	0.709	positive regulation of potassium ion transmembrane transport
GO:1901016	0.708	regulation of potassium ion transmembrane transporter activity
GO:0019725	0.686	cellular homeostasis
GO:1901018	0.684	positive regulation of potassium ion transmembrane transporter activity
GO:1902307	0.656	positive regulation of sodium ion transmembrane transport
GO:0055078	0.637	sodium ion homeostasis
GO:0071805	0.592	potassium ion transmembrane transport
GO:0098657	0.581	import into cell
GO:0032781	0.562	positive regulation of ATP-dependent activity
GO:1990778	0.512	protein localization to cell periphery
GO:0098739	0.487	import across plasma membrane
GO:0030003	0.460	intracellular monoatomic cation homeostasis
GO:0099587	0.442	inorganic ion import across plasma membrane
GO:0098659	0.384	inorganic cation import across plasma membrane
GO:0072657	0.383	protein localization to membrane
GO:0042391	0.370	regulation of membrane potential
GO:0050896	0.317	response to stimulus

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005886	0.999	plasma membrane
GO:1902495	0.997	transmembrane transporter complex
GO:0005890	0.986	sodium:potassium-exchanging ATPase complex
GO:0043226	0.976	organelle
GO:0043227	0.973	membrane-bounded organelle
GO:0005622	0.965	intracellular anatomical structure
GO:0005737	0.951	cytoplasm
GO:0043231	0.780	intracellular membrane-bounded organelle
GO:0043230	0.423	extracellular organelle
GO:0031982	0.370	vesicle
GO:0065010	0.370	extracellular membrane-bounded organelle
GO:1903561	0.355	extracellular vesicle
GO:0070062	0.336	extracellular exosome

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:7.-.-.-	0.560	Translocases.
RHEA:29463	0.426	K(+)(in) = K(+)(out)
RHEA:16777	0.404	ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate
EC:7.2.2.6	0.404	P-type K(+) transporter.

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