StarFunc result for job id P54886

User Input

>input (795 residues)
MLSQVYRCGFQPFNQHLLPWVKCTTVFRSHCIQPSVIRHVRSWSNIPFITVPLSRTHGKS
FAHRSELKHAKRIVVKLGSAVVTRGDECGLALGRLASIVEQVSVLQNQGREMMLVTSGAV
AFGKQRLRHEILLSQSVRQALHSGQNQLKEMAIPVLEARACAAAGQSGLMALYEAMFTQY
SICAAQILVTNLDFHDEQKRRNLNGTLHELLRMNIVPIVNTNDAVVPPAEPNSDLQGVNV
ISVKDNDSLAARLAVEMKTDLLIVLSDVEGLFDSPPGSDDAKLIDIFYPGDQQSVTFGTK
SRVGMGGMEAKVKAALWALQGGTSVVIANGTHPKVSGHVITDIVEGKKVGTFFSEVKPAG
PTVEQQGEMARSGGRMLATLEPEQRAEIIHHLADLLTDQRDEILLANKKDLEEAEGRLAA
PLLKRLSLSTSKLNSLAIGLRQIAASSQDSVGRVLRRTRIAKNLELEQVTVPIGVLLVIF
ESRPDCLPQVAALAIASGNGLLLKGGKEAAHSNRILHLLTQEALSIHGVKEAVQLVNTRE
EVEDLCRLDKMIDLIIPRGSSQLVRDIQKAAKGIPVMGHSEGICHMYVDSEASVDKVTRL
VRDSKCEYPAACNALETLLIHRDLLRTPLFDQIIDMLRVEQVKIHAGPKFASYLTFSPSE
VKSLRTEYGDLELCIEVVDNVQDAIDHIHKYGSSHTDVIVTEDENTAEFFLQHVDSACVF
WNASTRFSDGYRFGLGAEVGISTSRIHARGPVGLEGLLTTKWLLRGKDHVVSDFSEHGSL
KYLHENLPIPQRNTN

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P54886	1.000	1.000	0.000	795	1.000	1.000	P54886.pdb.gz	P5CS_HUMAN Delta-1-pyrroline-5-carboxylate synthase OS=Homo sapiens OX=9606 GN=ALDH18A1 PE=1 SV=2
2	AFDB:Q9VNW6	0.850	0.870	5.044E-99	776	0.546	0.559	Q9VNW6.pdb.gz	Q9VNW6_DROME Delta-1-pyrroline-5-carboxylate synthase OS=Drosophila melanogaster OX=7227 GN=P5CS PE=1 SV=1
3	AFDB:P54889	0.803	0.796	7.269E-94	802	0.513	0.509	P54889.pdb.gz	ALH13_CAEEL Probable delta-1-pyrroline-5-carboxylate synthase OS=Caenorhabditis elegans OX=6239 GN=alh-13 PE=3 SV=2
4	AFDB:P54888	0.695	0.752	2.849E-81	726	0.434	0.475	P54888.pdb.gz	P5CS2_ARATH Delta-1-pyrroline-5-carboxylate synthase B OS=Arabidopsis thaliana OX=3702 GN=P5CSB PE=2 SV=1
5	AFDB:O04226	0.620	0.675	1.479E-80	716	0.428	0.475	O04226.pdb.gz	P5CS1_ORYSJ Delta-1-pyrroline-5-carboxylate synthase 1 OS=Oryza sativa subsp. japonica OX=39947 GN=P5CS1 PE=2 SV=2
6	AFDB:Q941T1	0.824	0.888	2.544E-79	735	0.419	0.453	Q941T1.pdb.gz	P5CS2_ORYSJ Delta-1-pyrroline-5-carboxylate synthase 2 OS=Oryza sativa subsp. japonica OX=39947 GN=P5CS2 PE=2 SV=1
7	AFDB:P54887	0.801	0.882	1.695E-78	717	0.423	0.469	P54887.pdb.gz	P5CS1_ARATH Delta-1-pyrroline-5-carboxylate synthase A OS=Arabidopsis thaliana OX=3702 GN=P5CSA PE=1 SV=1
8	PDB:7f5vA	0.795	0.909	2.592E-78	690	0.527	0.607	7f5vA.pdb.gz
9	AFDB:Q6FUU0	0.519	0.893	5.179E-44	455	0.233	0.407	Q6FUU0.pdb.gz	Q6FUU0_CANGA glutamate-5-semialdehyde dehydrogenase OS=Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) OX=284593 GN=PRO2 PE=3 SV=1
10	AFDB:Q9UT44	0.518	0.902	8.968E-44	451	0.221	0.390	Q9UT44.pdb.gz	PROA_SCHPO Probable gamma-glutamyl phosphate reductase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=pro1 PE=3 SV=1
11	AFDB:P54885	0.514	0.883	1.143E-42	456	0.230	0.401	P54885.pdb.gz	PROA_YEAST Gamma-glutamyl phosphate reductase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=PRO2 PE=1 SV=1
12	PDB:1vluB	0.290	0.566	7.471E-28	397	0.192	0.385	1vluB.pdb.gz
13	PDB:2j5tD	0.290	0.611	2.215E-18	365	0.121	0.263	2j5tD.pdb.gz	A Novel Two-Domain Architecture within the Amino Acid Kinase Enzyme Family Revealed by the Crystal Structure of Escherichia Coli Glutamate 5-Kinase.
14	PDB:5x5tA	0.390	0.619	2.573E-18	476	0.092	0.153	5x5tA.pdb.gz	Structural insights into the production of 3-hydroxypropionic acid by aldehyde dehydrogenase from Azospirillum brasilense.
15	PDB:6o4dB	0.378	0.565	4.923E-18	510	0.079	0.124	6o4dB.pdb.gz	Structural and biochemical consequences of pyridoxine-dependent epilepsy mutations that target the aldehyde binding site of aldehyde dehydrogenase ALDH7A1.
16	PDB:3hazA	0.367	0.304	6.011E-18	983	0.152	0.123	3hazA.pdb.gz	Crystal structure of the bifunctional proline utilization A flavoenzyme from Bradyrhizobium japonicum
17	PDB:5izdA	0.391	0.602	6.011E-18	494	0.094	0.152	5izdA.pdb.gz	Structure of wild-type glyceraldehyde dehydrogenase from Thermoplasma acidophilum in complex with NADP
18	PDB:3pqaB	0.394	0.647	6.982E-18	458	0.092	0.159	3pqaB.pdb.gz
19	PDB:2esdA	0.388	0.619	7.339E-18	474	0.101	0.169	2esdA.pdb.gz	The first crystal structure of a thioacylenzyme intermediate in the ALDH family: new coenzyme conformation and relevance to catalysis
20	PDB:7bvpA	0.392	0.361	2.313E-17	869	0.086	0.078	7bvpA.pdb.gz	Aldehyde-alcohol dehydrogenase undergoes structural transition to form extended spirosomes for substrate channeling.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A8I6AAN3	0.0	1541	791	0.947	0.952	A0A8I6AAN3_RAT Delta-1-pyrroline-5-carboxylate synthase OS=Rattus norvegicus OX=10116 GN=Aldh18a1 PE=3 SV=1
2	O04226	0.0	627	716	0.433	0.480	P5CS1_ORYSJ Delta-1-pyrroline-5-carboxylate synthase 1 OS=Oryza sativa subsp. japonica OX=39947 GN=P5CS1 PE=2 SV=2
3	P54886	0.0	1636	795	1.000	1.000	P5CS_HUMAN Delta-1-pyrroline-5-carboxylate synthase OS=Homo sapiens OX=9606 GN=ALDH18A1 PE=1 SV=2
4	P54887	0.0	578	717	0.430	0.477	P5CS1_ARATH Delta-1-pyrroline-5-carboxylate synthase A OS=Arabidopsis thaliana OX=3702 GN=P5CSA PE=1 SV=1
5	P54888	0.0	605	726	0.440	0.482	P5CS2_ARATH Delta-1-pyrroline-5-carboxylate synthase B OS=Arabidopsis thaliana OX=3702 GN=P5CSB PE=2 SV=1
6	P54889	0.0	810	802	0.506	0.501	ALH13_CAEEL Probable delta-1-pyrroline-5-carboxylate synthase OS=Caenorhabditis elegans OX=6239 GN=alh-13 PE=3 SV=2
7	Q941T1	0.0	590	735	0.426	0.461	P5CS2_ORYSJ Delta-1-pyrroline-5-carboxylate synthase 2 OS=Oryza sativa subsp. japonica OX=39947 GN=P5CS2 PE=2 SV=1
8	Q9VNW6	0.0	850	776	0.547	0.561	Q9VNW6_DROME Delta-1-pyrroline-5-carboxylate synthase OS=Drosophila melanogaster OX=7227 GN=P5CS PE=1 SV=1
9	Q9Z110	0.0	1559	795	0.955	0.955	P5CS_MOUSE Delta-1-pyrroline-5-carboxylate synthase OS=Mus musculus OX=10090 GN=Aldh18a1 PE=1 SV=2
10	Q6FUU0	1.16e-104	331	455	0.236	0.413	Q6FUU0_CANGA glutamate-5-semialdehyde dehydrogenase OS=Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) OX=284593 GN=PRO2 PE=3 SV=1
11	Q9UT44	1.13e-100	320	451	0.224	0.395	PROA_SCHPO Probable gamma-glutamyl phosphate reductase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=pro1 PE=3 SV=1
12	P54885	2.85e-99	317	456	0.238	0.414	PROA_YEAST Gamma-glutamyl phosphate reductase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=PRO2 PE=1 SV=1
13	P07004	3.24e-77	257	417	0.185	0.353	PROA_ECOLI Gamma-glutamyl phosphate reductase OS=Escherichia coli (strain K12) OX=83333 GN=proA PE=1 SV=2
14	P9WHV1	1.04e-76	256	415	0.194	0.371	PROA_MYCTU Gamma-glutamyl phosphate reductase OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=proA PE=1 SV=1
15	P0A7B5	2.16e-33	134	367	0.123	0.267	PROB_ECOLI Glutamate 5-kinase OS=Escherichia coli (strain K12) OX=83333 GN=proB PE=1 SV=1
16	O13810	2.66e-24	108	402	0.104	0.206	PROB_SCHPO Probable glutamate 5-kinase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPAC17H9.13c PE=3 SV=1
17	P38690	9.98e-24	107	423	0.108	0.203	YHJ3_YEAST Uncharacterized protein YHR033W OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=YHR033W PE=3 SV=1
18	P32264	1.00e-23	107	428	0.107	0.199	PROB_YEAST Glutamate 5-kinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=PRO1 PE=1 SV=2
19	A0A0R6Y3I5	5.58e-22	98.6	263	0.093	0.281	G5K_LEIDO Glutamate 5-kinase OS=Leishmania donovani OX=5661 GN=G5K PE=1 SV=1
20	P19037	0.16	36.2	161	0.023	0.112	HS181_ARATH 18.1 kDa class I heat shock protein OS=Arabidopsis thaliana OX=3702 GN=HSP18.1 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00696 AA_kinase	2.8e-37	140.2	Amino acid kinase family
2	PF00171 Aldedh	1.9e-08	45.0	Aldehyde dehydrogenase family

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000360268

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000357838	0.998	Ornithine aminotransferase, mitochondrial
2	9606.ENSP00000364490	0.992	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
3	9606.ENSP00000384949	0.987	Pyrroline-5-carboxylate reductase 1, mitochondrial
4	9606.ENSP00000342502	0.974	Pyrroline-5-carboxylate reductase 2
5	9606.ENSP00000220966	0.969	Pyrroline-5-carboxylate reductase 3
6	9606.ENSP00000277865	0.966	Glutamate dehydrogenase 1, mitochondrial
7	9606.ENSP00000327589	0.965	Glutamate dehydrogenase 2, mitochondrial
8	9606.ENSP00000307900	0.960	Glutamine synthetase
9	9606.ENSP00000481127	0.948	Proline dehydrogenase 1, mitochondrial
10	9606.ENSP00000349577	0.947	Proline dehydrogenase
11	9606.ENSP00000361471	0.907	Argininosuccinate synthase
12	9606.ENSP00000377282	0.901	Protrudin
13	9606.ENSP00000414068	0.896	Uncharacterized protein
14	9606.ENSP00000350928	0.894	Glutamate decarboxylase 1
15	9606.ENSP00000365437	0.892	Glutamate decarboxylase 2
16	9606.ENSP00000293404	0.883	N-acetylglutamate synthase, mitochondrial
17	9606.ENSP00000307188	0.874	Argininosuccinate lyase
18	9606.ENSP00000370215	0.872	NADP-dependent oxidoreductase domain-containing protein 1
19	9606.ENSP00000365773	0.861	Phosphoserine aminotransferase
20	9606.ENSP00000293350	0.852	Aldehyde dehydrogenase 16 family member A1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0016620	1.000	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0004349	1.000	glutamate 5-kinase activity
GO:0005488	0.997	binding
GO:0005515	0.993	protein binding
GO:0004350	0.968	glutamate-5-semialdehyde dehydrogenase activity
GO:0097159	0.926	organic cyclic compound binding
GO:1901363	0.919	heterocyclic compound binding
GO:0042802	0.912	identical protein binding
GO:0003676	0.657	nucleic acid binding
GO:0003723	0.597	RNA binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071704	0.998	organic substance metabolic process
GO:0044238	0.998	primary metabolic process
GO:0044237	0.998	cellular metabolic process
GO:0006807	0.997	nitrogen compound metabolic process
GO:1901564	0.993	organonitrogen compound metabolic process
GO:0019752	0.988	carboxylic acid metabolic process
GO:0008652	0.980	amino acid biosynthetic process
GO:0009064	0.926	glutamine family amino acid metabolic process
GO:0043603	0.785	amide metabolic process
GO:1901607	0.760	alpha-amino acid biosynthetic process
GO:0009084	0.706	glutamine family amino acid biosynthetic process
GO:0006560	0.702	proline metabolic process
GO:0043648	0.658	dicarboxylic acid metabolic process
GO:0006536	0.353	glutamate metabolic process
GO:0050896	0.333	response to stimulus

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005739	0.999	mitochondrion
GO:0016020	0.979	membrane
GO:0031090	0.836	organelle membrane
GO:0070013	0.822	intracellular organelle lumen
GO:0031975	0.779	envelope
GO:0031967	0.752	organelle envelope
GO:0005740	0.579	mitochondrial envelope
GO:0031966	0.488	mitochondrial membrane
GO:0005743	0.349	mitochondrial inner membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:1.2.1.-	1.000	With NAD(+) or NADP(+) as acceptor.
RHEA:14877	1.000	ATP + L-glutamate = ADP + L-glutamyl 5-phosphate
EC:2.7.2.11	1.000	glutamate 5-kinase.
RHEA:19541	0.968	L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH
EC:1.2.1.41	0.968	glutamate-5-semialdehyde dehydrogenase.

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