StarFunc result for job id P55316

User Input

>input (489 residues)
MLDMGDRKEVKMIPKSSFSINSLVPEAVQNDNHHASHGHHNSHHPQHHHHHHHHHHHPPP
PAPQPPPPPQQQQPPPPPPPAPQPPQTRGAPAADDDKGPQQLLLPPPPPPPPAAALDGAK
ADGLGGKGEPGGGPGELAPVGPDEKEKGAGAGGEEKKGAGEGGKDGEGGKEGEKKNGKYE
KPPFSYNALIMMAIRQSPEKRLTLNGIYEFIMKNFPYYRENKQGWQNSIRHNLSLNKCFV
KVPRHYDDPGKGNYWMLDPSSDDVFIGGTTGKLRRRSTTSRAKLAFKRGARLTSTGLTFM
DRAGSLYWPMSPFLSLHHPRASSTLSYNGTTSAYPSHPMPYSSVLTQNSLGNNHSFSTAN
GLSVDRLVNGEIPYATHHLTAAALAASVPCGLSVPCSGTYSLNPCSVNLLAGQTSYFFPH
VPHPSMTSQSSTSMSARAASSSTSPQAPSTLPCESLRPSLPSFTTGLSGGLSDYFTHQNQ
GSSSNPLIH

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P55316	0.999	0.999	7.809E-68	489	1.000	1.000	P55316.pdb.gz	FOXG1_HUMAN Forkhead box protein G1 OS=Homo sapiens OX=9606 GN=FOXG1 PE=1 SV=2
2	AFDB:Q12952	0.200	0.281	5.366E-15	345	0.237	0.336	Q12952.pdb.gz	FOXL1_HUMAN Forkhead box protein L1 OS=Homo sapiens OX=9606 GN=FOXL1 PE=2 SV=2
3	AFDB:B0R0B2	0.203	0.304	1.067E-14	321	0.178	0.271	B0R0B2.pdb.gz
4	AFDB:Q9QY14	0.191	0.318	1.210E-14	288	0.178	0.302	Q9QY14.pdb.gz	FOXE3_MOUSE Forkhead box protein E3 OS=Mus musculus OX=10090 GN=Foxe3 PE=1 SV=1
5	AFDB:Q7SY22	0.206	0.271	1.995E-14	363	0.194	0.262	Q7SY22.pdb.gz	Q7SY22_DANRE Forkhead box L1 OS=Danio rerio OX=7955 GN=zgc:63595 PE=2 SV=1
6	AFDB:A4L7N3	0.159	0.119	4.360E-11	662	0.229	0.169	A4L7N3.pdb.gz	FOXO1_PIG Forkhead box protein O1 OS=Sus scrofa OX=9823 GN=FOXO1 PE=2 SV=1
7	AFDB:A3RK75	0.153	0.120	1.836E-10	629	0.219	0.170	A3RK75.pdb.gz	FX1AB_DANRE Forkhead box protein O1-B OS=Danio rerio OX=7955 GN=foxo1b PE=2 SV=1
8	AFDB:O14270	0.192	0.129	2.672E-10	743	0.202	0.133	O14270.pdb.gz	FHL1_SCHPO Fork head transcription factor 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=fhl1 PE=3 SV=2
9	AFDB:Q5AS72	0.167	0.117	2.672E-10	717	0.215	0.146	Q5AS72.pdb.gz	Q5AS72_EMENI Forkhead transcription factor (Eurofung) OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=ANIA_08858 PE=4 SV=1
10	PDB:2hdcA	0.149	0.617	1.811E-8	97	0.121	0.608	2hdcA.pdb.gz	Dynamic DNA contacts observed in the NMR structure of winged helix protein-DNA complex.
11	AFDB:P11831	0.074	0.072	6.489E-3	508	0.178	0.171	P11831.pdb.gz	SRF_HUMAN Serum response factor OS=Homo sapiens OX=9606 GN=SRF PE=1 SV=1
12	PDB:6h1cB	0.119	0.376	3.607E-2	134	0.037	0.134	6h1cB.pdb.gz	Ferric uptake regulator with Mn and Zn form Pseudomonas aeruginosa
13	PDB:2fe3B	0.118	0.348	9.212E-2	143	0.033	0.112	2fe3B.pdb.gz	Crystal structure of the apo-PerR-Zn protein from Bacillus subtilis.
14	PDB:4a6dA	0.118	0.164	9.212E-2	345	0.022	0.032	4a6dA.pdb.gz	Crystal Structure and Functional Mapping of Human Asmt, the Last Enzyme of the Melatonin Synthesis Pathway.
15	PDB:4etsB	0.122	0.347	9.807E-2	149	0.039	0.128	4etsB.pdb.gz	Structure and regulon of Campylobacter jejuni ferric uptake regulator Fur define apo-Fur regulation.
16	PDB:6zmiCE	0.116	0.672	9.807E-2	72	0.025	0.167	6zmiCE.pdb.gz	Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
17	PDB:7k5yU	0.133	0.700	1.111E-1	75	0.029	0.187	7k5yU.pdb.gz	Distinct Structures and Dynamics of Chromatosomes with Different Human Linker Histone Isoforms.
18	PDB:1fp1D	0.124	0.168	1.951E-1	340	0.029	0.041	1fp1D.pdb.gz	Structures of two natural product methyltransferases reveal the basis for substrate specificity in plant O-methyltransferases.
19	PDB:2qbyB	0.119	0.152	2.505E-1	368	0.018	0.024	2qbyB.pdb.gz	Replication origin recognition and deformation by a heterodimeric archaeal Orc1 complex.
20	PDB:1k96A	0.087	0.351	3.022E-1	89	0.018	0.101	1k96A.pdb.gz	Crystal structures of S100A6 in the Ca(2+)-free and Ca(2+)-bound states: the calcium sensor mechanism of S100 proteins revealed at atomic resolution.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	O73862	0.0	544	420	0.634	0.738	O73862_DANRE Forkhead box protein G1 OS=Danio rerio OX=7955 GN=BF-1 PE=2 SV=1
2	P55316	0.0	994	489	1.000	1.000	FOXG1_HUMAN Forkhead box protein G1 OS=Homo sapiens OX=9606 GN=FOXG1 PE=1 SV=2
3	Q00939	0.0	941	480	0.959	0.977	FOXG1_RAT Forkhead box protein G1 OS=Rattus norvegicus OX=10116 GN=Foxg1 PE=2 SV=1
4	Q568V0	0.0	563	420	0.699	0.814	Q568V0_DANRE Forkhead box protein G1 OS=Danio rerio OX=7955 GN=foxg1 PE=2 SV=1
5	Q60987	0.0	939	481	0.957	0.973	FOXG1_MOUSE Forkhead box protein G1 OS=Mus musculus OX=10090 GN=Foxg1 PE=1 SV=1
6	Q9YHC5	0.0	580	436	0.626	0.702	FOXG1_XENLA Forkhead box protein G1 OS=Xenopus laevis OX=8355 GN=foxg1 PE=2 SV=1
7	Q22510	1.12e-55	189	270	0.176	0.319	FKH02_CAEEL Forkhead box protein fkh-2 OS=Caenorhabditis elegans OX=6239 GN=fkh-2 PE=2 SV=1
8	P32030	4.92e-53	183	322	0.172	0.261	SLP1_DROME Fork head domain transcription factor slp1 OS=Drosophila melanogaster OX=7227 GN=slp1 PE=2 SV=1
9	Q9DEN4	2.84e-38	145	371	0.145	0.191	FXD3A_XENLA Forkhead box protein D3-A OS=Xenopus laevis OX=8355 GN=foxd3-a PE=1 SV=1
10	Q61850	4.05e-38	147	494	0.129	0.128	FOXC2_MOUSE Forkhead box protein C2 OS=Mus musculus OX=10090 GN=Foxc2 PE=1 SV=2
11	Q64731	4.20e-38	144	336	0.125	0.182	FOXL1_MOUSE Forkhead box protein L1 OS=Mus musculus OX=10090 GN=Foxl1 PE=2 SV=2
12	Q63246	4.61e-38	147	494	0.129	0.128	FOXC2_RAT Forkhead box protein C2 OS=Rattus norvegicus OX=10116 GN=Foxc2 PE=1 SV=2
13	B0UXI3	5.36e-38	145	422	0.160	0.185	B0UXI3_DANRE Forkhead box E3 OS=Danio rerio OX=7955 GN=foxe3 PE=2 SV=1
14	Q99958	5.85e-38	147	501	0.129	0.126	FOXC2_HUMAN Forkhead box protein C2 OS=Homo sapiens OX=9606 GN=FOXC2 PE=1 SV=1
15	Q7SY22	1.16e-37	143	363	0.139	0.187	Q7SY22_DANRE Forkhead box L1 OS=Danio rerio OX=7955 GN=zgc:63595 PE=2 SV=1
16	Q9DE25	1.47e-37	145	476	0.127	0.130	FXC1A_DANRE Forkhead box C1-A OS=Danio rerio OX=7955 GN=foxc1a PE=2 SV=1
17	Q9PVY9	1.81e-37	145	465	0.127	0.133	FXC2A_XENLA Forkhead box protein C2-A OS=Xenopus laevis OX=8355 GN=foxc2-a PE=2 SV=1
18	Q12952	3.75e-37	141	345	0.125	0.177	FOXL1_HUMAN Forkhead box protein L1 OS=Homo sapiens OX=9606 GN=FOXL1 PE=2 SV=2
19	Q9DEN3	4.12e-37	142	371	0.153	0.202	FXD3B_XENLA Forkhead box protein D3-B OS=Xenopus laevis OX=8355 GN=foxd3-b PE=2 SV=1
20	Q9PVZ3	4.39e-37	144	492	0.125	0.124	FXC1A_XENLA Forkhead box protein C1-A OS=Xenopus laevis OX=8355 GN=foxc1-a PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00250 Forkhead	6.6e-36	133.6	Forkhead domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000339004

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000365682	0.996	Transducin-like enhancer protein 1
2	9606.ENSP00000265354	0.993	Serum response factor
3	9606.ENSP00000332973	0.957	Mothers against decapentaplegic homolog 3
4	9606.ENSP00000368880	0.947	Forkhead box protein O1
5	9606.ENSP00000262160	0.941	Mothers against decapentaplegic homolog 2
6	9606.ENSP00000385824	0.941	Forkhead box protein O3
7	9606.ENSP00000363377	0.940	Forkhead box protein O4
8	9606.ENSP00000341551	0.938	Mothers against decapentaplegic homolog 4
9	9606.ENSP00000356234	0.904	Lysine-specific demethylase 5B
10	9606.ENSP00000395535	0.894	Methyl-CpG-binding protein 2
11	9606.ENSP00000404100	0.845	Paired box protein Pax-6
12	9606.ENSP00000450962	0.798	Homeobox protein EMX2
13	9606.ENSP00000374205	0.781	T-box brain protein 1
14	9606.ENSP00000212015	0.779	NAD-dependent protein deacetylase sirtuin-1
15	9606.ENSP00000369325	0.775	Cyclin-dependent kinase-like 5
16	9606.ENSP00000258106	0.767	Homeobox protein EMX1
17	9606.ENSP00000451828	0.751	RAC-alpha serine/threonine-protein kinase
18	9606.ENSP00000343819	0.745	Homeobox protein OTX2
19	9606.ENSP00000362717	0.741	LIM/homeobox protein Lhx2
20	9606.ENSP00000319118	0.739	GS homeobox 2

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:1990837	1.000	sequence-specific double-stranded DNA binding
GO:0003700	0.969	DNA-binding transcription factor activity
GO:0000976	0.895	transcription cis-regulatory region binding
GO:0000981	0.727	DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000977	0.331	RNA polymerase II transcription regulatory region sequence-specific DNA binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0032501	0.988	multicellular organismal process
GO:0048856	0.987	anatomical structure development
GO:0050794	0.986	regulation of cellular process
GO:0060255	0.965	regulation of macromolecule metabolic process
GO:0080090	0.964	regulation of primary metabolic process
GO:0051171	0.964	regulation of nitrogen compound metabolic process
GO:0031323	0.964	regulation of cellular metabolic process
GO:0010468	0.935	regulation of gene expression
GO:0006355	0.928	regulation of DNA-templated transcription
GO:0007275	0.911	multicellular organism development
GO:0048519	0.906	negative regulation of biological process
GO:0048731	0.902	system development
GO:0048513	0.897	animal organ development
GO:0048523	0.866	negative regulation of cellular process
GO:0007399	0.861	nervous system development
GO:0009987	0.823	cellular process
GO:0007417	0.796	central nervous system development
GO:0060322	0.766	head development
GO:0009892	0.736	negative regulation of metabolic process
GO:0010605	0.695	negative regulation of macromolecule metabolic process
GO:0031324	0.650	negative regulation of cellular metabolic process
GO:0048518	0.581	positive regulation of biological process
GO:0048522	0.564	positive regulation of cellular process
GO:0031327	0.563	negative regulation of cellular biosynthetic process
GO:0010558	0.561	negative regulation of macromolecule biosynthetic process
GO:0051172	0.558	negative regulation of nitrogen compound metabolic process
GO:0045934	0.545	negative regulation of nucleobase-containing compound metabolic process
GO:0051253	0.541	negative regulation of RNA metabolic process
GO:0007420	0.534	brain development
GO:0050896	0.491	response to stimulus
GO:0045892	0.464	negative regulation of DNA-templated transcription
GO:0009893	0.450	positive regulation of metabolic process
GO:0010604	0.443	positive regulation of macromolecule metabolic process
GO:0051173	0.407	positive regulation of nitrogen compound metabolic process
GO:0031325	0.403	positive regulation of cellular metabolic process
GO:0006357	0.369	regulation of transcription by RNA polymerase II
GO:0010557	0.336	positive regulation of macromolecule biosynthetic process
GO:0045935	0.332	positive regulation of nucleobase-containing compound metabolic process
GO:0031328	0.330	positive regulation of cellular biosynthetic process
GO:0045893	0.320	positive regulation of DNA-templated transcription

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005654	1.000	nucleoplasm
GO:0005737	0.601	cytoplasm

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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