StarFunc result for job id P57073

User Input

>input (446 residues)
MLDMSEARSQPPCSPSGTASSMSHVEDSDSDAPPSPAGSEGLGRAGVAVGGARGDPAEAA
DERFPACIRDAVSQVLKGYDWSLVPMPVRGGGGGALKAKPHVKRPMNAFMVWAQAARRKL
ADQYPHLHNAELSKTLGKLWRLLSESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRKSAK
AGHSDSDSGAELGPHPGGGAVYKAEAGLGDGHHHGDHTGQTHGPPTPPTTPKTELQQAGA
KPELKLEGRRPVDSGRQNIDFSNVDISELSSEVMGTMDAFDVHEFDQYLPLGGPAPPEPG
QAYGGAYFHAGASPVWAHKSAPSASASPTETGPPRPHIKTEQPSPGHYGDQPRGSPDYGS
CSGQSSATPAAPAGPFAGSQGDYGDLQASSYYGAYPGYAPGLYQYPCFHSPRRPYASPLL
NGLALPPAHSPTSHWDQPVYTTLTRP

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P57073	0.999	0.999	6.128E-60	446	1.000	1.000	P57073.pdb.gz	SOX8_HUMAN Transcription factor SOX-8 OS=Homo sapiens OX=9606 GN=SOX8 PE=2 SV=1
2	AFDB:Q04886	0.484	0.468	6.867E-46	464	0.845	0.812	Q04886.pdb.gz	SOX8_MOUSE Transcription factor SOX-8 OS=Mus musculus OX=10090 GN=Sox8 PE=2 SV=2
3	AFDB:P57074	0.417	0.399	9.533E-42	470	0.751	0.713	P57074.pdb.gz	SOX8_CHICK Transcription factor SOX-8 OS=Gallus gallus OX=9031 GN=SOX8 PE=2 SV=1
4	AFDB:Q6VVD7	0.450	0.440	7.956E-40	459	0.715	0.695	Q6VVD7.pdb.gz	SOX8_XENLA Transcription factor Sox-8 OS=Xenopus laevis OX=8355 GN=sox8 PE=2 SV=1
5	AFDB:P48434	0.383	0.350	3.813E-29	494	0.540	0.488	P48434.pdb.gz	SOX9_CHICK Transcription factor SOX-9 OS=Gallus gallus OX=9031 GN=SOX9 PE=1 SV=3
6	AFDB:Q9DFH2	0.366	0.355	7.598E-29	462	0.491	0.474	Q9DFH2.pdb.gz	Q9DFH2_DANRE HMG box transcription factor Sox9a OS=Danio rerio OX=7955 GN=jef PE=2 SV=1
7	AFDB:O18896	0.315	0.284	9.562E-29	509	0.522	0.458	O18896.pdb.gz	SOX9_PIG Transcription factor SOX-9 OS=Sus scrofa OX=9823 GN=SOX9 PE=2 SV=1
8	AFDB:Q6F2E7	0.213	0.198	2.690E-28	482	0.536	0.496	Q6F2E7.pdb.gz	SOX9_XENTR Transcription factor Sox-9 OS=Xenopus tropicalis OX=8364 GN=sox9 PE=1 SV=1
9	AFDB:Q9DFH1	0.348	0.375	1.198E-27	407	0.498	0.545	Q9DFH1.pdb.gz	Q9DFH1_DANRE HMG box transcription factor Sox9b OS=Danio rerio OX=7955 GN=fb18d01 PE=2 SV=1
10	AFDB:Q9W757	0.265	0.257	1.784E-26	461	0.507	0.490	Q9W757.pdb.gz	SOX10_CHICK Transcription factor SOX-10 OS=Gallus gallus OX=9031 GN=SOX10 PE=2 SV=2
11	PDB:1j5nA	0.143	0.600	1.308E-1	93	0.040	0.194	1j5nA.pdb.gz	The S. cerevisiae architectural HMGB protein NHP6A complexed with DNA: DNA and protein conformational changes upon binding
12	PDB:7zs9M	0.099	0.135	1.639	310	0.020	0.029	7zs9M.pdb.gz	Structures of transcription preinitiation complex engaged with the +1 nucleosome.
13	PDB:3dv0E	0.069	0.082	2.749	344	0.025	0.032	3dv0E.pdb.gz	Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multienzyme complex
14	PDB:7ploI	0.102	0.101	3.084	451	0.022	0.022	7ploI.pdb.gz	A conserved mechanism for regulating replisome disassembly in eukaryotes.
15	PDB:5w3fB	0.056	0.058	3.459	427	0.009	0.009	5w3fB.pdb.gz	Structural differences between yeast and mammalian microtubules revealed by cryo-EM.
16	PDB:3dufA	0.065	0.077	3.881	365	0.029	0.036	3dufA.pdb.gz	Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multienzyme complex
17	PDB:6ylgt	0.078	0.079	4.110	431	0.031	0.032	6ylgt.pdb.gz	Construction of the Central Protuberance and L1 Stalk during 60S Subunit Biogenesis.
18	PDB:6f1eA	0.097	0.216	4.353	143	0.040	0.126	6f1eA.pdb.gz
19	PDB:1cqxA	0.083	0.090	5.478	403	0.013	0.015	1cqxA.pdb.gz	Crystal structure of the flavohemoglobin from Alcaligenes eutrophus at 1.75 A resolution.
20	PDB:7kpvB	0.074	0.107	5.802	290	0.013	0.021	7kpvB.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P57073	0.0	898	446	1.000	1.000	SOX8_HUMAN Transcription factor SOX-8 OS=Homo sapiens OX=9606 GN=SOX8 PE=2 SV=1
2	P57074	0.0	564	470	0.742	0.704	SOX8_CHICK Transcription factor SOX-8 OS=Gallus gallus OX=9031 GN=SOX8 PE=2 SV=1
3	Q04886	0.0	626	464	0.834	0.802	SOX8_MOUSE Transcription factor SOX-8 OS=Mus musculus OX=10090 GN=Sox8 PE=2 SV=2
4	Q6VVD7	0.0	538	459	0.717	0.697	SOX8_XENLA Transcription factor Sox-8 OS=Xenopus laevis OX=8355 GN=sox8 PE=2 SV=1
5	Q6F2E7	1.98e-122	366	482	0.552	0.510	SOX9_XENTR Transcription factor Sox-9 OS=Xenopus tropicalis OX=8364 GN=sox9 PE=1 SV=1
6	B7ZR65	3.03e-121	363	477	0.543	0.507	SOX9A_XENLA Transcription factor Sox-9-A OS=Xenopus laevis OX=8355 GN=sox9-a PE=1 SV=1
7	Q04887	4.76e-116	351	507	0.525	0.462	SOX9_MOUSE Transcription factor SOX-9 OS=Mus musculus OX=10090 GN=Sox9 PE=1 SV=2
8	P48434	2.18e-115	349	494	0.554	0.500	SOX9_CHICK Transcription factor SOX-9 OS=Gallus gallus OX=9031 GN=SOX9 PE=1 SV=3
9	F1LYL9	4.72e-115	348	507	0.522	0.460	SOX9_RAT Transcription factor SOX-9 OS=Rattus norvegicus OX=10116 GN=Sox9 PE=1 SV=2
10	P48436	6.56e-114	345	509	0.525	0.460	SOX9_HUMAN Transcription factor SOX-9 OS=Homo sapiens OX=9606 GN=SOX9 PE=1 SV=1
11	Q9DFH2	1.38e-111	338	462	0.504	0.487	Q9DFH2_DANRE HMG box transcription factor Sox9a OS=Danio rerio OX=7955 GN=jef PE=2 SV=1
12	O18896	3.48e-110	336	509	0.527	0.462	SOX9_PIG Transcription factor SOX-9 OS=Sus scrofa OX=9823 GN=SOX9 PE=2 SV=1
13	Q8AXX8	2.61e-107	327	446	0.473	0.473	SOX10_XENLA Transcription factor Sox-10 OS=Xenopus laevis OX=8355 GN=sox10 PE=1 SV=1
14	Q9DFH1	7.67e-107	324	407	0.502	0.550	Q9DFH1_DANRE HMG box transcription factor Sox9b OS=Danio rerio OX=7955 GN=fb18d01 PE=2 SV=1
15	Q9W757	7.79e-105	321	461	0.487	0.471	SOX10_CHICK Transcription factor SOX-10 OS=Gallus gallus OX=9031 GN=SOX10 PE=2 SV=2
16	O55170	3.69e-104	319	466	0.484	0.464	SOX10_RAT Transcription factor SOX-10 OS=Rattus norvegicus OX=10116 GN=Sox10 PE=1 SV=1
17	P56693	3.73e-104	319	466	0.496	0.474	SOX10_HUMAN Transcription factor SOX-10 OS=Homo sapiens OX=9606 GN=SOX10 PE=1 SV=1
18	Q04888	4.83e-104	319	466	0.484	0.464	SOX10_MOUSE Transcription factor SOX-10 OS=Mus musculus OX=10090 GN=Sox10 PE=1 SV=2
19	Q90XD1	4.00e-98	304	485	0.507	0.466	Q90XD1_DANRE HMG-box transcription factor Sox10 OS=Danio rerio OX=7955 GN=cls/sox10 PE=2 SV=1
20	Q9VA16	3.58e-41	155	529	0.161	0.136	Q9VA16_DROME Sox100B protein OS=Drosophila melanogaster OX=7227 GN=Sox100B PE=2 SV=3

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00505 HMG_box	1.2e-22	91.4	HMG (high mobility group) box
2	PF09011 HMG_box_2	1e-07	43.7	HMG-box domain
3	PF12444 Sox_N	6.4e-22	89.7	Sox developmental protein N terminal

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000293894

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000333188	0.744	Forkhead box protein L2
2	9606.ENSP00000331040	0.724	Oligodendrocyte transcription factor 2
3	9606.ENSP00000360157	0.683	Forkhead box protein D3
4	9606.ENSP00000375921	0.669	Paired box protein Pax-3
5	9606.ENSP00000344456	0.653	Catenin beta-1
6	9606.ENSP00000356331	0.653	Nuclear receptor subfamily 5 group A member 2
7	9606.ENSP00000354826	0.635	Caldesmon
8	9606.ENSP00000371785	0.630	Oligodendrocyte transcription factor 1
9	9606.ENSP00000221496	0.626	Muellerian-inhibiting factor
10	9606.ENSP00000362690	0.615	Steroidogenic factor 1
11	9606.ENSP00000380034	0.613	Zinc finger protein SNAI2
12	9606.ENSP00000282928	0.607	Zinc finger protein ZIC 1
13	9606.ENSP00000371711	0.599	Doublesex- and mab-3-related transcription factor 1
14	9606.ENSP00000293549	0.592	Proto-oncogene Wnt-1
15	9606.ENSP00000290167	0.581	Protein Wnt-4
16	9606.ENSP00000355001	0.575	POU domain, class 3, transcription factor 3
17	9606.ENSP00000256689	0.558	Sodium-coupled neutral amino acid transporter 2
18	9606.ENSP00000259915	0.554	POU domain, class 5, transcription factor 1
19	9606.ENSP00000348944	0.550	R-spondin-1
20	9606.ENSP00000372035	0.548	Serine/threonine-protein kinase LATS2

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:1990837	1.000	sequence-specific double-stranded DNA binding
GO:0005515	0.998	protein binding
GO:0003700	0.978	DNA-binding transcription factor activity
GO:0000976	0.968	transcription cis-regulatory region binding
GO:0000981	0.936	DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987	0.862	cis-regulatory region sequence-specific DNA binding
GO:0001216	0.647	DNA-binding transcription activator activity
GO:0000977	0.612	RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978	0.604	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001228	0.440	DNA-binding transcription activator activity, RNA polymerase II-specific

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0050794	0.993	regulation of cellular process
GO:0019222	0.986	regulation of metabolic process
GO:0009889	0.982	regulation of biosynthetic process
GO:0048518	0.981	positive regulation of biological process
GO:0060255	0.977	regulation of macromolecule metabolic process
GO:0019219	0.976	regulation of nucleobase-containing compound metabolic process
GO:2001141	0.960	regulation of RNA biosynthetic process
GO:0048856	0.959	anatomical structure development
GO:0009987	0.931	cellular process
GO:0010468	0.927	regulation of gene expression
GO:1903506	0.911	regulation of nucleic acid-templated transcription
GO:0006355	0.903	regulation of DNA-templated transcription
GO:0009893	0.897	positive regulation of metabolic process
GO:0048522	0.889	positive regulation of cellular process
GO:0032501	0.874	multicellular organismal process
GO:0010604	0.867	positive regulation of macromolecule metabolic process
GO:0009891	0.863	positive regulation of biosynthetic process
GO:0006357	0.861	regulation of transcription by RNA polymerase II
GO:0007275	0.842	multicellular organism development
GO:0045893	0.729	positive regulation of DNA-templated transcription
GO:0048513	0.714	animal organ development
GO:0045944	0.710	positive regulation of transcription by RNA polymerase II
GO:0048731	0.704	system development
GO:0030154	0.548	cell differentiation
GO:0009653	0.532	anatomical structure morphogenesis
GO:0009888	0.524	tissue development
GO:0048519	0.466	negative regulation of biological process
GO:0048523	0.389	negative regulation of cellular process
GO:0050896	0.341	response to stimulus

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005634	1.000	nucleus
GO:0005654	0.960	nucleoplasm
GO:0005737	0.533	cytoplasm

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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