StarFunc result for job id P60321

User Input

>input (138 residues)
MQLPPFDMWKDYFNLSQVVWALIASRGQRLETQEIEEPSPGPPLGQDQGLGAPGANGGLG
TLCNFCKHNGESRHVYSSHQLKTPDGVVVCPILRHYVCPVCGATGDQAHTLKYCPLNGGQ
QSLYRRSGRNSAGRRVKR

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P60321	1.000	1.000	5.243E-27	138	1.000	1.000	P60321.pdb.gz	NANO2_HUMAN Nanos homolog 2 OS=Homo sapiens OX=9606 GN=NANOS2 PE=1 SV=1
2	AFDB:P60322	0.571	0.579	1.796E-18	136	0.761	0.772	P60322.pdb.gz	NANO2_MOUSE Nanos homolog 2 OS=Mus musculus OX=10090 GN=Nanos2 PE=1 SV=2
3	AFDB:P60324	0.578	0.466	1.455E-12	178	0.420	0.326	P60324.pdb.gz	NANO3_MOUSE Nanos homolog 3 OS=Mus musculus OX=10090 GN=Nanos3 PE=1 SV=1
4	AFDB:P60323	0.547	0.452	2.353E-12	173	0.471	0.376	P60323.pdb.gz	NANO3_HUMAN Nanos homolog 3 OS=Homo sapiens OX=9606 GN=NANOS3 PE=1 SV=1
5	AFDB:Q07937	0.414	0.447	8.671E-10	128	0.370	0.398	Q07937.pdb.gz	NANO1_XENLA Nanos homolog 1 OS=Xenopus laevis OX=8355 GN=nanos1 PE=1 SV=1
6	AFDB:E7FDB3	0.430	0.273	1.066E-9	228	0.362	0.219	E7FDB3.pdb.gz	NANO1_DANRE Nanos homolog 1 OS=Danio rerio OX=7955 GN=nanos1 PE=3 SV=1
7	AFDB:Q4QRE8	0.439	0.384	1.403E-9	159	0.362	0.314	Q4QRE8.pdb.gz
8	AFDB:A7XBY3	0.424	0.296	2.884E-8	201	0.399	0.274	A7XBY3.pdb.gz	A7XBY3_ORYLA NANOS3 OS=Oryzias latipes OX=8090 GN=nanos3 PE=2 SV=1
9	AFDB:Q80WY3	0.428	0.226	7.547E-8	267	0.355	0.184	Q80WY3.pdb.gz	NANO1_MOUSE Nanos homolog 1 OS=Mus musculus OX=10090 GN=Nanos1 PE=2 SV=2
10	AFDB:Q8WY41	0.427	0.208	2.427E-7	292	0.304	0.144	Q8WY41.pdb.gz	NANO1_HUMAN Nanos homolog 1 OS=Homo sapiens OX=9606 GN=NANOS1 PE=1 SV=2
11	PDB:2h3aA	0.087	0.144	9.530	72	0.051	0.097	2h3aA.pdb.gz	Structural Basis for Nucleic Acid and Toxin Recognition of the Bacterial Antitoxin CcdA

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P60321	1.43e-101	288	138	1.000	1.000	NANO2_HUMAN Nanos homolog 2 OS=Homo sapiens OX=9606 GN=NANOS2 PE=1 SV=1
2	P60322	3.89e-72	214	136	0.754	0.765	NANO2_MOUSE Nanos homolog 2 OS=Mus musculus OX=10090 GN=Nanos2 PE=1 SV=2
3	P60323	1.10e-35	122	173	0.471	0.376	NANO3_HUMAN Nanos homolog 3 OS=Homo sapiens OX=9606 GN=NANOS3 PE=1 SV=1
4	P60324	3.01e-32	114	178	0.428	0.331	NANO3_MOUSE Nanos homolog 3 OS=Mus musculus OX=10090 GN=Nanos3 PE=1 SV=1
5	Q90WW1	5.56e-25	95.1	159	0.362	0.314	NANO3_DANRE Nanos homolog 3 OS=Danio rerio OX=7955 GN=nanos3 PE=1 SV=1
6	Q07937	2.43e-24	92.4	128	0.326	0.352	NANO1_XENLA Nanos homolog 1 OS=Xenopus laevis OX=8355 GN=nanos1 PE=1 SV=1
7	E7FDB3	5.65e-24	94.4	228	0.348	0.211	NANO1_DANRE Nanos homolog 1 OS=Danio rerio OX=7955 GN=nanos1 PE=3 SV=1
8	Q80WY3	1.59e-20	86.3	267	0.312	0.161	NANO1_MOUSE Nanos homolog 1 OS=Mus musculus OX=10090 GN=Nanos1 PE=2 SV=2
9	A7XBY3	2.43e-20	84.3	201	0.348	0.239	A7XBY3_ORYLA NANOS3 OS=Oryzias latipes OX=8090 GN=nanos3 PE=2 SV=1
10	Q8WY41	4.78e-20	85.1	292	0.239	0.113	NANO1_HUMAN Nanos homolog 1 OS=Homo sapiens OX=9606 GN=NANOS1 PE=1 SV=2
11	A5Y5A4	4.58e-18	78.6	214	0.217	0.140	A5Y5A4_SCHMD Nanos-like protein OS=Schmidtea mediterranea OX=79327 PE=2 SV=1
12	P25724	5.69e-15	72.4	401	0.210	0.072	NANOS_DROME Protein nanos OS=Drosophila melanogaster OX=7227 GN=nanos PE=1 SV=1
13	Q09597	3.76e-05	43.9	311	0.138	0.061	Q09597_CAEEL Nanos-type domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=nos-1 PE=3 SV=1
14	Q23406	0.010	37.0	259	0.167	0.089	Q23406_CAEEL Nanos-type domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=nos-2 PE=3 SV=1
15	O62486	0.20	33.5	871	0.123	0.020	O62486_CAEEL Nanos-type domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=nos-3 PE=1 SV=1
16	O18218	0.21	33.5	867	0.123	0.020	O18218_CAEEL Nanos-type domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=nos-3 PE=1 SV=2
17	Q9P2Y4	2.0	30.4	722	0.152	0.029	ZN219_HUMAN Zinc finger protein 219 OS=Homo sapiens OX=9606 GN=ZNF219 PE=1 SV=2
18	F1NY98	2.7	30.0	2034	0.138	0.009	DSCAM_CHICK Cell adhesion molecule DSCAM OS=Gallus gallus OX=9031 GN=DSCAM PE=1 SV=3
19	Q925H1	3.6	29.6	1281	0.181	0.020	TRPS1_MOUSE Zinc finger transcription factor Trps1 OS=Mus musculus OX=10090 GN=Trps1 PE=1 SV=1
20	Q6PGZ3	5.5	29.3	629	0.145	0.032	MIPT3_DANRE TRAF3-interacting protein 1 OS=Danio rerio OX=7955 GN=traf3ip1 PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF14354 Lar_restr_allev	7.2e+02	11.9	Restriction alleviation protein Lar
2	PF01783 Ribosomal_L32p	8.1e+02	11.7	Ribosomal L32p protein family
3	PF05741 zf-nanos	2e-23	93.7	Nanos RNA binding domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000341021

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000320949	0.943	CCR4-NOT transcription complex subunit 1
2	9606.ENSP00000001146	0.909	Cytochrome P450 26B1
3	9606.ENSP00000338173	0.890	Pumilio homolog 2
4	9606.ENSP00000275764	0.833	Stimulated by retinoic acid gene 8 protein homolog
5	9606.ENSP00000391723	0.821	Pumilio homolog 1
6	9606.ENSP00000351159	0.818	CCR4-NOT transcription complex subunit 3
7	9606.ENSP00000250863	0.798	Deleted in azoospermia-like
8	9606.ENSP00000334952	0.785	Adhesion G protein-coupled receptor A3
9	9606.ENSP00000445366	0.761	Dead end protein homolog 1
10	9606.ENSP00000289382	0.756	CCR4-NOT transcription complex subunit 11
11	9606.ENSP00000245255	0.752	Piwi-like protein 1
12	9606.ENSP00000377024	0.746	CCR4-NOT transcription complex subunit 6
13	9606.ENSP00000355279	0.730	CCR4-NOT transcription complex subunit 7
14	9606.ENSP00000424838	0.722	Probable ATP-dependent RNA helicase DDX4
15	9606.ENSP00000347591	0.718	GDNF family receptor alpha-1
16	9606.ENSP00000430493	0.707	CCR4-NOT transcription complex subunit 8
17	9606.ENSP00000338157	0.705	Zinc finger and BTB domain-containing protein 16
18	9606.ENSP00000404438	0.697	Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1
19	9606.ENSP00000377478	0.688	Melanoma-associated antigen 12
20	9606.ENSP00000369210	0.686	Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:1901363	0.879	heterocyclic compound binding
GO:0097159	0.879	organic cyclic compound binding
GO:0003676	0.868	nucleic acid binding
GO:0003723	0.674	RNA binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0050789	0.995	regulation of biological process
GO:0060255	0.989	regulation of macromolecule metabolic process
GO:0048522	0.988	positive regulation of cellular process
GO:0048519	0.980	negative regulation of biological process
GO:0051254	0.976	positive regulation of RNA metabolic process
GO:0010605	0.968	negative regulation of macromolecule metabolic process
GO:0010468	0.949	regulation of gene expression
GO:1903313	0.948	positive regulation of mRNA metabolic process
GO:0009987	0.935	cellular process
GO:0048523	0.934	negative regulation of cellular process
GO:0010556	0.903	regulation of macromolecule biosynthetic process
GO:0051172	0.901	negative regulation of nitrogen compound metabolic process
GO:0031326	0.898	regulation of cellular biosynthetic process
GO:0031324	0.861	negative regulation of cellular metabolic process
GO:0043488	0.858	regulation of mRNA stability
GO:0010629	0.855	negative regulation of gene expression
GO:0031327	0.846	negative regulation of cellular biosynthetic process
GO:0051246	0.845	regulation of protein metabolic process
GO:0010558	0.839	negative regulation of macromolecule biosynthetic process
GO:0006417	0.820	regulation of translation
GO:0051248	0.797	negative regulation of protein metabolic process
GO:0061014	0.780	positive regulation of mRNA catabolic process
GO:0017148	0.766	negative regulation of translation
GO:0032501	0.626	multicellular organismal process
GO:0032502	0.574	developmental process
GO:0071704	0.432	organic substance metabolic process
GO:0044238	0.431	primary metabolic process
GO:0044237	0.401	cellular metabolic process
GO:0006807	0.395	nitrogen compound metabolic process
GO:0043170	0.355	macromolecule metabolic process
GO:0048856	0.353	anatomical structure development
GO:0000003	0.344	reproduction
GO:0022414	0.321	reproductive process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005634	0.999	nucleus
GO:0048471	0.995	perinuclear region of cytoplasm
GO:0043232	0.704	intracellular non-membrane-bounded organelle
GO:0099080	0.576	supramolecular complex
GO:0035770	0.571	ribonucleoprotein granule
GO:0036464	0.553	cytoplasmic ribonucleoprotein granule

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

[back to server]