StarFunc result for job id P60484

User Input

>input (403 residues)
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSK
HKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVA
AIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSY
LLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMY
FEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEI
DSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEAS
SSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:F1NT98	0.925	0.882	2.590E-76	423	0.933	0.889	F1NT98.pdb.gz
2	AFDB:A0A2R8RK27	0.918	0.929	3.141E-73	398	0.881	0.892	A0A2R8RK27.pdb.gz
3	AFDB:Q7ZZ56	0.881	0.889	1.283E-70	399	0.861	0.870	Q7ZZ56.pdb.gz	Q7ZZ56_DANRE Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Danio rerio OX=7955 GN=fa11a08 PE=2 SV=1
4	AFDB:A0A2R8Q8H3	0.878	0.842	1.524E-70	421	0.878	0.841	A0A2R8Q8H3.pdb.gz
5	AFDB:F1Q5Y5	0.869	0.791	1.810E-70	444	0.878	0.797	F1Q5Y5.pdb.gz
6	AFDB:E7FC59	0.901	0.781	1.916E-70	467	0.871	0.752	E7FC59.pdb.gz
7	AFDB:Q6TGR5	0.877	0.840	2.048E-66	422	0.859	0.820	Q6TGR5.pdb.gz
8	PDB:7jvxA	0.766	0.981	9.441E-58	314	0.777	0.997	7jvxA.pdb.gz
9	AFDB:A0A2R8PY11	0.599	0.670	9.580E-42	358	0.675	0.760	A0A2R8PY11.pdb.gz
10	AFDB:Q7KMQ6	0.738	0.583	4.496E-41	514	0.375	0.294	Q7KMQ6.pdb.gz	Q7KMQ6_DROME IP16020p OS=Drosophila melanogaster OX=7227 GN=Pten PE=2 SV=1
11	AFDB:Q8T9S7	0.743	0.564	1.245E-39	533	0.380	0.287	Q8T9S7.pdb.gz	PTEN_DICDI Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Dictyostelium discoideum OX=44689 GN=pteN PE=2 SV=1
12	PDB:4ercA	0.324	0.823	6.061E-7	150	0.067	0.180	4ercA.pdb.gz	New Aspects of the Phosphatase VHZ Revealed by a High-Resolution Structure with Vanadate and Substrate Screening.
13	PDB:1fq1A	0.330	0.674	3.788E-6	183	0.074	0.164	1fq1A.pdb.gz	Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2.
14	PDB:3s4oA	0.297	0.694	3.788E-6	163	0.069	0.172	3s4oA.pdb.gz
15	PDB:5bx1A	0.297	0.719	5.043E-6	153	0.082	0.216	5bx1A.pdb.gz	Crystal Structure of PRL-1 complex with compound analogy 3
16	PDB:5a50A	0.198	0.416	2.235E-5	165	0.055	0.133	5a50A.pdb.gz	Calcium-Dependent Oligomerization of Car Proteins at Cell Membrane Modulates Aba Signaling.
17	PDB:3f81A	0.292	0.606	4.444E-5	179	0.069	0.156	3f81A.pdb.gz	Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells.
18	PDB:2q05A	0.296	0.599	5.277E-5	181	0.092	0.204	2q05A.pdb.gz
19	PDB:5a52A	0.208	0.445	5.277E-5	154	0.057	0.149	5a52A.pdb.gz	Calcium-Dependent Oligomerization of Car Proteins at Cell Membrane Modulates Aba Signaling.
20	PDB:1r6hA	0.276	0.564	5.587E-5	172	0.084	0.198	1r6hA.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	B8XSI6	0.0	842	403	0.998	0.998	B8XSI6_PIG Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Sus scrofa OX=9823 GN=PTEN PE=2 SV=1
2	F6KD01	0.0	843	403	1.000	1.000	F6KD01_HUMAN Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Homo sapiens OX=9606 GN=PTEN PE=2 SV=1
3	O08586	0.0	843	403	0.998	0.998	PTEN_MOUSE Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Mus musculus OX=10090 GN=Pten PE=1 SV=1
4	O54857	0.0	841	403	0.995	0.995	PTEN_RAT Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Rattus norvegicus OX=10116 GN=Pten PE=1 SV=1
5	P60484	0.0	843	403	1.000	1.000	PTEN_HUMAN Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Homo sapiens OX=9606 GN=PTEN PE=1 SV=1
6	Q6PC66	0.0	728	452	0.883	0.788	Q6PC66_DANRE Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Danio rerio OX=7955 GN=ptena PE=2 SV=1
7	Q6TGR7	0.0	743	431	0.883	0.826	Q6TGR7_DANRE Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Danio rerio OX=7955 GN=wu:fc52g04 PE=2 SV=1
8	Q7ZZ56	0.0	739	399	0.861	0.870	Q7ZZ56_DANRE Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Danio rerio OX=7955 GN=fa11a08 PE=2 SV=1
9	Q9Y0B6	2.50e-92	285	418	0.395	0.380	Q9Y0B6_DROME PTEN1 OS=Drosophila melanogaster OX=7227 GN=Pten PE=2 SV=1
10	Q9U470	2.69e-92	288	506	0.392	0.312	Q9U470_DROME Phosphatase and tensin homolog OS=Drosophila melanogaster OX=7227 GN=Pten PE=2 SV=1
11	Q9V3L4	2.98e-92	288	509	0.392	0.310	Q9V3L4_DROME PTEN3 OS=Drosophila melanogaster OX=7227 GN=Pten PE=2 SV=1
12	Q7KMQ6	3.69e-92	288	514	0.392	0.307	Q7KMQ6_DROME IP16020p OS=Drosophila melanogaster OX=7227 GN=Pten PE=2 SV=1
13	Q9Y0B5	4.12e-92	288	511	0.392	0.309	Q9Y0B5_DROME PTEN2 OS=Drosophila melanogaster OX=7227 GN=Pten PE=2 SV=1
14	Q8T9S7	1.27e-75	246	533	0.261	0.197	PTEN_DICDI Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Dictyostelium discoideum OX=44689 GN=pteN PE=2 SV=1
15	Q6XPS3	1.53e-65	219	522	0.330	0.255	TPTE2_HUMAN Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 OS=Homo sapiens OX=9606 GN=TPTE2 PE=1 SV=2
16	Q54MG8	3.15e-63	221	998	0.295	0.119	Q54MG8_DICDI LIM-domain containing phosphatase OS=Dictyostelium discoideum OX=44689 GN=DDB_G0285967 PE=2 SV=2
17	Q9LT75	3.84e-61	209	611	0.280	0.185	PTN2A_ARATH Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2A OS=Arabidopsis thaliana OX=3702 GN=PTEN2A PE=1 SV=1
18	Q8H106	6.35e-59	204	632	0.238	0.152	PTN2B_ARATH Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2B OS=Arabidopsis thaliana OX=3702 GN=PTEN2B PE=2 SV=1
19	P56180	7.70e-59	202	551	0.320	0.234	TPTE_HUMAN Putative tyrosine-protein phosphatase TPTE OS=Homo sapiens OX=9606 GN=TPTE PE=1 SV=3
20	Q9FLZ5	1.43e-55	190	412	0.216	0.211	PTEN1_ARATH Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN1 OS=Arabidopsis thaliana OX=3702 GN=PTEN1 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00782 DSPc	0.00012	33.4	Dual specificity phosphatase, catalytic domain
2	PF11644 DUF3256	32	15.5	Protein of unknown function (DUF3256)
3	PF10409 PTEN_C2	8.3e-44	160.0	C2 domain of PTEN tumour-suppressor protein
4	PF14566 PTPlike_phytase	8.6	17.9	Inositol hexakisphosphate
5	PF00102 Y_phosphatase	0.41	21.7	Protein-tyrosine phosphatase
6	PF13350 Y_phosphatase3	10	17.6	Tyrosine phosphatase family

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 482537.XP_008574034.1

Rank	PPI partner	STRING score	Description
1	482537.XP_008572060.1	0.995	Cellular tumor antigen p53
2	482537.XP_008584201.1	0.994	Disks large homolog 1-like
3	482537.XP_008582398.1	0.991	E3 ubiquitin-protein ligase NEDD4 isoform X1
4	482537.XP_008564655.1	0.987	Microtubule-associated serine/threonine-protein kinase 2 isoform X1
5	482537.XP_008566335.1	0.987	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
6	482537.XP_008566632.1	0.986	Focal adhesion kinase 1 isoform X1
7	482537.XP_008566370.1	0.984	Disks large homolog 1
8	482537.XP_008566114.1	0.981	Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 12 mRNAs, 61 Proteins, and 100% coverage of the annotated genomic feature by RNAseq alignments, including 1 sample with support for all annotated introns
9	482537.XP_008570017.1	0.981	Speckle-type POZ protein
10	482537.XP_008567674.1	0.979	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
11	482537.XP_008586483.1	0.978	Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform X1
12	482537.XP_008566090.1	0.971	Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 1 mRNA, 9 Proteins, and 62% coverage of the annotated genomic feature by RNAseq alignments
13	482537.XP_008581473.1	0.969	Type II inositol 3,4-bisphosphate 4-phosphatase
14	482537.XP_008574932.1	0.968	Phosphatidylinositol 3-kinase regulatory subunit beta
15	482537.XP_008563304.1	0.967	Ubiquitin carboxyl-terminal hydrolase 7
16	482537.XP_008565184.1	0.963	The sequence of the model RefSeq protein was modified relative to its source genomic sequence to represent the inferred CDS: inserted 2 bases in 2 codons
17	482537.XP_008580186.1	0.958	Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 12 Proteins, and 82% coverage of the annotated genomic feature by RNAseq alignments
18	482537.XP_008561248.1	0.953	Type I inositol 3,4-bisphosphate 4-phosphatase-like
19	482537.XP_008577428.1	0.953	Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 8 mRNAs, 14 Proteins, and 99% coverage of the annotated genomic feature by RNAseq alignments, including 2 samples with support for all annotated introns
20	482537.XP_008564658.1	0.951	The sequence of the model RefSeq protein was modified relative to its source genomic sequence to represent the inferred CDS: substituted 1 base at 1 genomic stop codon

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0016791	1.000	phosphatase activity
GO:0005515	0.985	protein binding
GO:0034594	0.980	phosphatidylinositol trisphosphate phosphatase activity
GO:0140096	0.893	catalytic activity, acting on a protein
GO:0019899	0.825	enzyme binding
GO:0042577	0.757	lipid phosphatase activity
GO:0004721	0.442	phosphoprotein phosphatase activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0071704	0.994	organic substance metabolic process
GO:0044238	0.994	primary metabolic process
GO:0048522	0.991	positive regulation of cellular process
GO:0065009	0.987	regulation of molecular function
GO:0023051	0.987	regulation of signaling
GO:0010646	0.987	regulation of cell communication
GO:0048523	0.987	negative regulation of cellular process
GO:0016311	0.987	dephosphorylation
GO:0051246	0.987	regulation of protein metabolic process
GO:0050896	0.986	response to stimulus
GO:0048583	0.986	regulation of response to stimulus
GO:0051241	0.986	negative regulation of multicellular organismal process
GO:0051093	0.986	negative regulation of developmental process
GO:0051716	0.982	cellular response to stimulus
GO:0080134	0.981	regulation of response to stress
GO:0016043	0.979	cellular component organization
GO:0048638	0.978	regulation of developmental growth
GO:0042981	0.978	regulation of apoptotic process
GO:0010975	0.978	regulation of neuron projection development
GO:0009968	0.977	negative regulation of signal transduction
GO:0009893	0.976	positive regulation of metabolic process
GO:0051174	0.976	regulation of phosphorus metabolic process
GO:0043065	0.973	positive regulation of apoptotic process
GO:0051898	0.971	negative regulation of protein kinase B signaling
GO:0051129	0.967	negative regulation of cellular component organization
GO:0019220	0.965	regulation of phosphate metabolic process
GO:0010604	0.965	positive regulation of macromolecule metabolic process
GO:0007162	0.963	negative regulation of cell adhesion
GO:0010563	0.963	negative regulation of phosphorus metabolic process
GO:0010977	0.962	negative regulation of neuron projection development
GO:0046488	0.962	phosphatidylinositol metabolic process
GO:0046620	0.961	regulation of organ growth
GO:0043170	0.960	macromolecule metabolic process
GO:0048640	0.957	negative regulation of developmental growth
GO:0030258	0.955	lipid modification
GO:0042127	0.954	regulation of cell population proliferation
GO:0046856	0.953	phosphatidylinositol dephosphorylation
GO:0050790	0.952	regulation of catalytic activity
GO:0051173	0.951	positive regulation of nitrogen compound metabolic process
GO:0045936	0.948	negative regulation of phosphate metabolic process
GO:0031399	0.945	regulation of protein modification process
GO:0042325	0.943	regulation of phosphorylation
GO:0032501	0.939	multicellular organismal process
GO:0048856	0.939	anatomical structure development
GO:0044092	0.938	negative regulation of molecular function
GO:0080135	0.930	regulation of cellular response to stress
GO:0023056	0.927	positive regulation of signaling
GO:0010647	0.927	positive regulation of cell communication
GO:0007165	0.926	signal transduction
GO:0046621	0.923	negative regulation of organ growth
GO:0051247	0.915	positive regulation of protein metabolic process
GO:0007166	0.914	cell surface receptor signaling pathway
GO:0007275	0.911	multicellular organism development
GO:1901343	0.905	negative regulation of vasculature development
GO:0006066	0.902	alcohol metabolic process
GO:2000181	0.899	negative regulation of blood vessel morphogenesis
GO:0002376	0.898	immune system process
GO:0042221	0.889	response to chemical
GO:0006807	0.881	nitrogen compound metabolic process
GO:0016525	0.877	negative regulation of angiogenesis
GO:0048869	0.868	cellular developmental process
GO:0048584	0.862	positive regulation of response to stimulus
GO:0048731	0.861	system development
GO:0030154	0.859	cell differentiation
GO:0006950	0.848	response to stress
GO:0010605	0.845	negative regulation of macromolecule metabolic process
GO:0006955	0.839	immune response
GO:0065008	0.836	regulation of biological quality
GO:0043085	0.814	positive regulation of catalytic activity
GO:1901564	0.808	organonitrogen compound metabolic process
GO:0032879	0.803	regulation of localization
GO:0019538	0.800	protein metabolic process
GO:0009056	0.784	catabolic process
GO:0048468	0.775	cell development
GO:0043412	0.769	macromolecule modification
GO:0022008	0.767	neurogenesis
GO:0030097	0.764	hemopoiesis
GO:0006470	0.756	protein dephosphorylation
GO:0048513	0.738	animal organ development
GO:0010468	0.731	regulation of gene expression
GO:0033554	0.726	cellular response to stress
GO:0031175	0.726	neuron projection development
GO:0001775	0.721	cell activation
GO:0035556	0.699	intracellular signal transduction
GO:0070887	0.698	cellular response to chemical stimulus
GO:0045321	0.695	leukocyte activation
GO:0002252	0.694	immune effector process
GO:0010033	0.678	response to organic substance
GO:0032101	0.677	regulation of response to external stimulus
GO:0009605	0.671	response to external stimulus
GO:0001568	0.668	blood vessel development
GO:0031325	0.662	positive regulation of cellular metabolic process
GO:1901700	0.620	response to oxygen-containing compound
GO:0031102	0.611	neuron projection regeneration
GO:0009888	0.596	tissue development
GO:0048678	0.592	response to axon injury
GO:0019219	0.584	regulation of nucleobase-containing compound metabolic process
GO:0009628	0.577	response to abiotic stimulus
GO:0061564	0.521	axon development
GO:0022607	0.517	cellular component assembly
GO:0030162	0.503	regulation of proteolysis
GO:0051345	0.501	positive regulation of hydrolase activity
GO:0051252	0.488	regulation of RNA metabolic process
GO:0010556	0.393	regulation of macromolecule biosynthetic process
GO:0031326	0.393	regulation of cellular biosynthetic process
GO:0002263	0.387	cell activation involved in immune response
GO:0002274	0.371	myeloid leukocyte activation
GO:0045862	0.360	positive regulation of proteolysis
GO:0051179	0.325	localization

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005634	0.999	nucleus
GO:0005737	0.981	cytoplasm
GO:0005829	0.875	cytosol
GO:0031974	0.625	membrane-enclosed lumen
GO:0042995	0.607	cell projection
GO:0070013	0.604	intracellular organelle lumen
GO:0031981	0.567	nuclear lumen
GO:0032991	0.515	protein-containing complex
GO:0016020	0.509	membrane
GO:0005654	0.457	nucleoplasm
GO:0071944	0.372	cell periphery
GO:0005886	0.361	plasma membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:3.1.3.-	1.000	Phosphoric monoester hydrolases.

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