StarFunc result for job id P61024

User Input

>input (79 residues)
MSHKQIYYSDKYDDEEFEYRHVMLPKDIAKLVPKTHLMSESEWRNLGVQQSQGWVHYMIH
EPEPHILLFRRPLPKKPKK

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P61024	1.000	1.000	1.650E-15	79	1.000	1.000	P61024.pdb.gz	CKS1_HUMAN Cyclin-dependent kinases regulatory subunit 1 OS=Homo sapiens OX=9606 GN=CKS1B PE=1 SV=1
2	AFDB:P33552	0.942	0.942	3.241E-13	79	0.810	0.810	P33552.pdb.gz	CKS2_HUMAN Cyclin-dependent kinases regulatory subunit 2 OS=Homo sapiens OX=9606 GN=CKS2 PE=1 SV=1
3	PDB:1dksA	0.898	0.931	7.894E-12	76	0.962	1.000	1dksA.pdb.gz	Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain.
4	AFDB:Q24152	0.885	0.945	1.361E-11	74	0.709	0.757	Q24152.pdb.gz	CKS1_DROME Cyclin-dependent kinases regulatory subunit OS=Drosophila melanogaster OX=7227 GN=Cks30A PE=3 SV=1
5	AFDB:Q17868	0.933	0.788	4.203E-11	94	0.620	0.521	Q17868.pdb.gz	CKS1_CAEEL Cyclin-dependent kinases regulatory subunit OS=Caenorhabditis elegans OX=6239 GN=cks-1 PE=1 SV=1
6	AFDB:O23249	0.871	0.792	7.168E-11	87	0.608	0.552	O23249.pdb.gz	CKS1_ARATH Cyclin-dependent kinases regulatory subunit 1 OS=Arabidopsis thaliana OX=3702 GN=CKS1 PE=1 SV=1
7	AFDB:Q9VHN1	0.899	0.742	7.168E-11	96	0.646	0.531	Q9VHN1.pdb.gz	Q9VHN1_DROME Cyclin-dependent kinases regulatory subunit OS=Drosophila melanogaster OX=7227 GN=Cks85A PE=1 SV=1
8	AFDB:Q381E7	0.855	0.693	3.557E-10	98	0.608	0.490	Q381E7.pdb.gz	Q381E7_TRYB2 Cyclin-dependent kinases regulatory subunit OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb11.01.8085 PE=3 SV=1
9	AFDB:P20486	0.787	0.425	2.548E-8	150	0.506	0.267	P20486.pdb.gz	CKS1_YEAST Cyclin-dependent kinases regulatory subunit OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=CKS1 PE=1 SV=1
10	AFDB:P08463	0.769	0.547	5.511E-8	113	0.481	0.336	P08463.pdb.gz	CKS1_SCHPO Cyclin-dependent kinases regulatory subunit OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=suc1 PE=1 SV=3
11	PDB:1cksB	0.757	0.767	1.683E-7	78	0.797	0.808	1cksB.pdb.gz
12	PDB:1sceC	0.610	0.444	2.079E-4	111	0.519	0.369	1sceC.pdb.gz
13	PDB:1qb3B	0.605	0.412	4.237E-4	119	0.506	0.336	1qb3B.pdb.gz
14	PDB:3w1zB	0.347	0.206	7.391E-2	143	0.203	0.112	3w1zB.pdb.gz
15	AFDB:O14368	0.416	0.252	2.174E-1	143	0.190	0.105	O14368.pdb.gz	HSP16_SCHPO Heat shock protein 16 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=hsp16 PE=1 SV=1
16	PDB:5g5lA	0.335	0.031	4.382E-1	1480	0.127	0.007	5g5lA.pdb.gz	RNA Polymerase I-Rrn3 Complex at 4.8 A Resolution
17	PDB:6a29E	0.187	0.075	4.382E-1	278	0.165	0.047	6a29E.pdb.gz
18	PDB:4zjaA	0.380	0.306	4.934E-1	106	0.190	0.142	4zjaA.pdb.gz
19	PDB:3jb9A	0.295	0.020	7.474E-1	1964	0.127	0.005	3jb9A.pdb.gz	Structure of a yeast spliceosome at 3.6-angstrom resolution
20	PDB:6a28A	0.129	0.068	1.132	238	0.089	0.029	6a28A.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P61024	3.77e-54	164	79	1.000	1.000	CKS1_HUMAN Cyclin-dependent kinases regulatory subunit 1 OS=Homo sapiens OX=9606 GN=CKS1B PE=1 SV=1
2	P61025	3.77e-54	164	79	1.000	1.000	CKS1_MOUSE Cyclin-dependent kinases regulatory subunit 1 OS=Mus musculus OX=10090 GN=Cks1b PE=3 SV=1
3	P56390	2.98e-43	136	79	0.810	0.810	CKS2_MOUSE Cyclin-dependent kinases regulatory subunit 2 OS=Mus musculus OX=10090 GN=Cks2 PE=1 SV=1
4	P33552	5.81e-43	135	79	0.810	0.810	CKS2_HUMAN Cyclin-dependent kinases regulatory subunit 2 OS=Homo sapiens OX=9606 GN=CKS2 PE=1 SV=1
5	Q24152	2.22e-38	124	74	0.684	0.730	CKS1_DROME Cyclin-dependent kinases regulatory subunit OS=Drosophila melanogaster OX=7227 GN=Cks30A PE=3 SV=1
6	Q17868	1.15e-34	115	94	0.620	0.521	CKS1_CAEEL Cyclin-dependent kinases regulatory subunit OS=Caenorhabditis elegans OX=6239 GN=cks-1 PE=1 SV=1
7	Q9VHN1	3.49e-34	114	96	0.646	0.531	Q9VHN1_DROME Cyclin-dependent kinases regulatory subunit OS=Drosophila melanogaster OX=7227 GN=Cks85A PE=1 SV=1
8	Q9SJJ5	6.73e-34	112	83	0.633	0.602	CKS2_ARATH Cyclin-dependent kinases regulatory subunit 2 OS=Arabidopsis thaliana OX=3702 GN=CKS2 PE=1 SV=1
9	O23249	1.11e-32	110	87	0.608	0.552	CKS1_ARATH Cyclin-dependent kinases regulatory subunit 1 OS=Arabidopsis thaliana OX=3702 GN=CKS1 PE=1 SV=1
10	Q381E7	2.63e-32	109	98	0.608	0.490	Q381E7_TRYB2 Cyclin-dependent kinases regulatory subunit OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb11.01.8085 PE=3 SV=1
11	Q8IEX0	2.63e-32	109	98	0.608	0.490	Q8IEX0_9TRYP Cyclin-dependent kinases regulatory subunit OS=Trypanosoma brucei OX=5691 GN=cks1 PE=3 SV=1
12	P20486	4.22e-23	87.8	150	0.506	0.267	CKS1_YEAST Cyclin-dependent kinases regulatory subunit OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=CKS1 PE=1 SV=1
13	P08463	1.93e-21	82.4	113	0.494	0.345	CKS1_SCHPO Cyclin-dependent kinases regulatory subunit OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=suc1 PE=1 SV=3
14	Q8MR31	1.2	29.3	767	0.266	0.027	SLIP1_DROME Slo-interacting protein 1 OS=Drosophila melanogaster OX=7227 GN=Slip1 PE=1 SV=2
15	O69681	6.9	26.9	296	0.152	0.041	O69681_MYCTU Cullin, a subunit of E3 ubiquitin ligase OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=Rv3714c PE=1 SV=3
16	P24192	7.4	26.9	373	0.215	0.046	HYPD_ECOLI Hydrogenase maturation factor HypD OS=Escherichia coli (strain K12) OX=83333 GN=hypD PE=1 SV=1
17	G3V5N8	9.7	26.6	789	0.190	0.019	G3V5N8_HUMAN Zinc finger FYVE-type containing 1 OS=Homo sapiens OX=9606 GN=ZFYVE1 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF01111 CKS	1.4e-34	129.5	Cyclin-dependent kinase regulatory subunit

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 10029.XP_007612621.1

Rank	PPI partner	STRING score	Description
1	10029.XP_007624225.1	0.997	S-phase kinase-associated protein 2
2	10029.XP_007613157.1	0.995	Cell division control protein 2-like
3	10029.NP_001230956.1	0.994	Cyclin-dependent kinase 2
4	10029.XP_007611217.1	0.990	Belongs to the SKP1 family.
5	10029.XP_007634889.1	0.981	Cyclin A2
6	10029.XP_007615887.1	0.970	Belongs to the protein kinase superfamily.
7	10029.XP_007632562.1	0.968	Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
8	10029.XP_007608076.1	0.962	Belongs to the cyclin family.
9	10029.XP_007623068.1	0.951	Essential for the control of the cell cycle at the G2/M (mitosis) transition
10	10029.NP_001233754.1	0.935	Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
11	10029.XP_007617364.1	0.920	Cell division cycle protein 20-like
12	10029.XP_007634028.1	0.910	Belongs to the cullin family. ProRule:PRU00330, ECO:0000256\|RuleBase:RU003829,
13	10029.XP_007619879.1	0.881	40S ribosomal protein S2
14	10029.XP_007617743.1	0.875	cyclin-A1 isoform X2
15	10029.XP_007617941.1	0.856	G2/mitotic-specific cyclin-B3
16	10029.XP_007620164.1	0.856	Dual specificity protein kinase TTK
17	10029.XP_007607462.1	0.853	Mitotic spindle assembly checkpoint protein MAD2A
18	10029.XP_007632770.1	0.832	Belongs to the protein kinase superfamily.
19	10029.XP_007634205.1	0.829	Condensin complex subunit 3
20	10029.XP_007608551.1	0.826	Belongs to the ubiquitin-conjugating enzyme family.

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0009987	0.997	cellular process
GO:0007049	0.950	cell cycle
GO:0065007	0.941	biological regulation
GO:0000278	0.940	mitotic cell cycle
GO:0050794	0.932	regulation of cellular process
GO:0022402	0.840	cell cycle process
GO:0048144	0.788	fibroblast proliferation
GO:0019222	0.748	regulation of metabolic process
GO:0051171	0.743	regulation of nitrogen compound metabolic process
GO:0080090	0.742	regulation of primary metabolic process
GO:0031323	0.742	regulation of cellular metabolic process
GO:0060255	0.689	regulation of macromolecule metabolic process
GO:0009889	0.651	regulation of biosynthetic process
GO:0019219	0.606	regulation of nucleobase-containing compound metabolic process
GO:0010556	0.585	regulation of macromolecule biosynthetic process
GO:0031326	0.585	regulation of cellular biosynthetic process
GO:2001141	0.573	regulation of RNA biosynthetic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005634	0.999	nucleus
GO:0031981	0.989	nuclear lumen
GO:0005654	0.976	nucleoplasm
GO:0005737	0.555	cytoplasm

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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