StarFunc result for job id P61254

User Input

>input (145 residues)
MKFNPFVTSDRSKNRKRHFNAPSHIRRKIMSSPLSKELRQKYNVRSMPIRKDDEVQVVRG
HYKGQQIGKVVQVYRKKYVIYIERVQREKANGTTVHVGIHPSKVVITRLKLDKDRKKILE
RKAKSRQVGKEKGKYKEETIEKMQE

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P12749	0.961	0.961	2.800E-28	145	0.993	0.993	P12749.pdb.gz	RL26_RAT Large ribosomal subunit protein uL24 OS=Rattus norvegicus OX=10116 GN=Rpl26 PE=1 SV=1
2	PDB:7f5sLY	0.912	0.987	6.170E-25	134	0.924	1.000	7f5sLY.pdb.gz	METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance.
3	AFDB:Q9VVU2	0.902	0.878	5.575E-24	149	0.731	0.711	Q9VVU2.pdb.gz	Q9VVU2_DROME GEO07453p1 OS=Drosophila melanogaster OX=7227 GN=RpL26 PE=1 SV=1
4	AFDB:P51414	0.899	0.893	9.431E-23	146	0.703	0.699	P51414.pdb.gz	RL261_ARATH Large ribosomal subunit protein uL24z OS=Arabidopsis thaliana OX=3702 GN=RPL26A PE=2 SV=2
5	AFDB:Q9FJX2	0.899	0.893	4.411E-22	146	0.648	0.644	Q9FJX2.pdb.gz	RL262_ARATH Large ribosomal subunit protein uL24y OS=Arabidopsis thaliana OX=3702 GN=RPL26B PE=2 SV=1
6	PDB:4v6wCY	0.837	0.924	4.166E-20	131	0.662	0.733	4v6wCY.pdb.gz	Structures of the human and Drosophila 80S ribosome.
7	AFDB:Q38D25	0.828	0.839	3.311E-19	143	0.545	0.552	Q38D25.pdb.gz	Q38D25_TRYB2 60S ribosomal protein L26, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb09.211.4850 PE=1 SV=1
8	AFDB:P78946	0.827	0.950	1.651E-18	126	0.503	0.579	P78946.pdb.gz	RL26_SCHPO Large ribosomal subunit protein uL24 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=rpl26 PE=1 SV=1
9	AFDB:P05743	0.826	0.942	1.469E-17	127	0.448	0.512	P05743.pdb.gz	RL26A_YEAST Large ribosomal subunit protein uL24A OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=RPL26A PE=1 SV=3
10	AFDB:A0A1D8PCQ5	0.825	0.941	2.303E-17	127	0.483	0.551	A0A1D8PCQ5.pdb.gz	RL26B_CANAL Large ribosomal subunit protein uL24 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=RPL26B PE=1 SV=1
11	PDB:7pzy9	0.820	0.942	4.598E-17	126	0.483	0.556	7pzy9.pdb.gz	E-site drug specificity of the human pathogen Candida albicans ribosome.
12	PDB:4v8mBZ	0.763	0.884	4.704E-15	124	0.510	0.597	4v8mBZ.pdb.gz	High-Resolution Cryo-Electron Microscopy Structure of the Trypanosoma Brucei Ribosome.
13	PDB:2ww9L	0.707	0.796	5.074E-14	127	0.448	0.512	2ww9L.pdb.gz	Structure of Monomeric Yeast and Mammalian Sec61 Complexes Interacting with the Translating Ribosome.
14	AFDB:Q3SYS0	0.334	0.231	3.040E-4	216	0.166	0.111	Q3SYS0.pdb.gz	RM24_BOVIN Large ribosomal subunit protein uL24m OS=Bos taurus OX=9913 GN=MRPL24 PE=1 SV=1
15	AFDB:Q9CQ06	0.344	0.238	4.470E-4	216	0.172	0.116	Q9CQ06.pdb.gz	RM24_MOUSE Large ribosomal subunit protein uL24m OS=Mus musculus OX=10090 GN=Mrpl24 PE=1 SV=1
16	PDB:3p8bB	0.302	0.299	1.697E-3	147	0.097	0.095	3p8bB.pdb.gz	RNA polymerase and transcription elongation factor Spt4/5 complex structure.
17	PDB:7kgbU	0.357	0.554	2.838E-3	90	0.145	0.233	7kgbU.pdb.gz	Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents.
18	PDB:7zq6u	0.361	0.559	3.441E-3	91	0.138	0.220	7zq6u.pdb.gz	Modulating co-translational protein folding by rational design and ribosome engineering.
19	PDB:4zn3A	0.315	0.311	8.464E-3	147	0.103	0.102	4zn3A.pdb.gz	Structural and biochemical insights into the DNA-binding mode of MjSpt4p:Spt5 complex at the exit tunnel of RNAPII
20	PDB:4v6iBU	0.280	0.257	1.095E-2	160	0.172	0.156	4v6iBU.pdb.gz	Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P61254	3.97e-102	290	145	1.000	1.000	RL26_HUMAN Large ribosomal subunit protein uL24 OS=Homo sapiens OX=9606 GN=RPL26 PE=1 SV=1
2	P61255	3.97e-102	290	145	1.000	1.000	RL26_MOUSE Large ribosomal subunit protein uL24 OS=Mus musculus OX=10090 GN=Rpl26 PE=1 SV=1
3	P12749	6.96e-101	287	145	0.993	0.993	RL26_RAT Large ribosomal subunit protein uL24 OS=Rattus norvegicus OX=10116 GN=Rpl26 PE=1 SV=1
4	Q9UNX3	7.43e-101	287	145	0.986	0.986	RL26L_HUMAN Ribosomal protein uL24-like OS=Homo sapiens OX=9606 GN=RPL26L1 PE=1 SV=1
5	Q7SXA1	1.42e-95	273	145	0.959	0.959	Q7SXA1_DANRE 60S ribosomal protein L26 OS=Danio rerio OX=7955 GN=atp6v0e1 PE=1 SV=1
6	Q9VVU2	1.58e-76	226	149	0.738	0.718	Q9VVU2_DROME GEO07453p1 OS=Drosophila melanogaster OX=7227 GN=RpL26 PE=1 SV=1
7	P51414	1.84e-64	195	146	0.703	0.699	RL261_ARATH Large ribosomal subunit protein uL24z OS=Arabidopsis thaliana OX=3702 GN=RPL26A PE=2 SV=2
8	Q9FJX2	1.45e-61	187	146	0.648	0.644	RL262_ARATH Large ribosomal subunit protein uL24y OS=Arabidopsis thaliana OX=3702 GN=RPL26B PE=2 SV=1
9	Q57YL9	9.06e-49	155	143	0.552	0.559	Q57YL9_TRYB2 60S ribosomal protein L26, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb08.11J15.540 PE=3 SV=1
10	Q38D25	1.00e-48	155	143	0.552	0.559	Q38D25_TRYB2 60S ribosomal protein L26, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb09.211.4850 PE=1 SV=1
11	P78946	1.73e-47	151	126	0.503	0.579	RL26_SCHPO Large ribosomal subunit protein uL24 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=rpl26 PE=1 SV=1
12	A0A1D8PCQ5	8.22e-43	139	127	0.483	0.551	RL26B_CANAL Large ribosomal subunit protein uL24 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=RPL26B PE=1 SV=1
13	P05743	5.10e-42	137	127	0.441	0.504	RL26A_YEAST Large ribosomal subunit protein uL24A OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=RPL26A PE=1 SV=3
14	P53221	5.16e-42	137	127	0.441	0.504	RL26B_YEAST Large ribosomal subunit protein uL24B OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=RPL26B PE=1 SV=2
15	P16627	5.9	29.3	641	0.221	0.050	HS71L_MOUSE Heat shock 70 kDa protein 1-like OS=Mus musculus OX=10090 GN=Hspa1l PE=1 SV=4
16	A0A140VJI9	6.3	28.9	333	0.179	0.078	A0A140VJI9_HUMAN Non-structural maintenance of chromosomes element 4 OS=Homo sapiens OX=9606 PE=2 SV=1
17	Q8N140	6.3	28.9	333	0.179	0.078	EID3_HUMAN EP300-interacting inhibitor of differentiation 3 OS=Homo sapiens OX=9606 GN=EID3 PE=1 SV=1
18	P55063	6.5	29.3	641	0.221	0.050	HS71L_RAT Heat shock 70 kDa protein 1-like OS=Rattus norvegicus OX=10116 GN=Hspa1l PE=2 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF05289 BLYB	1.1e+02	14.4	Borrelia hemolysin accessory protein
2	PF00467 KOW	0.0001	33.3	KOW motif
3	PF16906 Ribosomal_L26	2.8e-39	144.8	Ribosomal proteins L26 eukaryotic, L24P archaeal

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 1026970.XP_008853968.1

Rank	PPI partner	STRING score	Description
1	1026970.XP_008844101.1	0.984	Ribosomal protein L31
2	1026970.XP_008831459.1	0.983	60S ribosomal protein L9
3	1026970.XP_008834569.1	0.983	60S ribosomal protein L4
4	1026970.XP_008832600.1	0.981	Ribosomal protein L8
5	1026970.XP_008833573.1	0.980	60S ribosomal protein L27
6	1026970.XP_008823295.1	0.979	60S ribosomal protein L21
7	1026970.XP_008841813.1	0.979	Ribosomal protein L34
8	1026970.XP_008836782.1	0.978	60S ribosomal protein L35a
9	1026970.XP_008847109.1	0.978	Ribosomal protein L7
10	1026970.XP_008838322.1	0.977	60S ribosomal protein L10a
11	1026970.XP_008826905.1	0.976	60S ribosomal protein L23a
12	1026970.XP_008831372.1	0.976	Ribosomal protein L15
13	1026970.XP_008845728.1	0.976	Ribosomal protein L6
14	1026970.XP_008848054.1	0.976	40S ribosomal protein S24 isoform X1
15	1026970.XP_008825153.1	0.975	40S ribosomal protein S15a
16	1026970.XP_008842124.1	0.975	60S ribosomal protein L7a
17	1026970.XP_008852472.1	0.975	40S ribosomal protein S3a
18	1026970.XP_008826880.1	0.974	60S ribosomal protein L17
19	1026970.XP_008843214.1	0.972	Ribosomal protein L18
20	1026970.XP_008843288.1	0.972	Ribosomal protein L13a

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0003735	1.000	structural constituent of ribosome
GO:0005515	0.999	protein binding
GO:0003676	0.986	nucleic acid binding
GO:0003723	0.978	RNA binding
GO:0003729	0.354	mRNA binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.974	cellular process
GO:0009314	0.972	response to radiation
GO:0051716	0.951	cellular response to stimulus
GO:0006950	0.923	response to stress
GO:0065007	0.919	biological regulation
GO:0008152	0.913	metabolic process
GO:0071704	0.896	organic substance metabolic process
GO:0050789	0.888	regulation of biological process
GO:0050794	0.881	regulation of cellular process
GO:0044237	0.874	cellular metabolic process
GO:0033554	0.842	cellular response to stress
GO:0007154	0.823	cell communication
GO:0006807	0.803	nitrogen compound metabolic process
GO:0044238	0.801	primary metabolic process
GO:0043170	0.753	macromolecule metabolic process
GO:0104004	0.748	cellular response to environmental stimulus
GO:0034641	0.746	cellular nitrogen compound metabolic process
GO:0044260	0.744	cellular macromolecule metabolic process
GO:0048518	0.707	positive regulation of biological process
GO:1901564	0.695	organonitrogen compound metabolic process
GO:0048522	0.660	positive regulation of cellular process
GO:2001233	0.646	regulation of apoptotic signaling pathway
GO:0048519	0.588	negative regulation of biological process
GO:0048523	0.579	negative regulation of cellular process
GO:0072331	0.574	signal transduction by p53 class mediator
GO:0019538	0.572	protein metabolic process
GO:0006412	0.544	translation
GO:2001242	0.517	regulation of intrinsic apoptotic signaling pathway
GO:1901796	0.481	regulation of signal transduction by p53 class mediator
GO:1901990	0.464	regulation of mitotic cell cycle phase transition
GO:0010212	0.462	response to ionizing radiation
GO:1902807	0.442	negative regulation of cell cycle G1/S phase transition
GO:1901991	0.428	negative regulation of mitotic cell cycle phase transition
GO:2000134	0.422	negative regulation of G1/S transition of mitotic cell cycle
GO:0044774	0.421	mitotic DNA integrity checkpoint signaling
GO:0044819	0.412	mitotic G1/S transition checkpoint signaling
GO:0071479	0.392	cellular response to ionizing radiation
GO:0000077	0.388	DNA damage checkpoint signaling
GO:0009605	0.382	response to external stimulus
GO:0048584	0.382	positive regulation of response to stimulus
GO:0032501	0.380	multicellular organismal process
GO:2001020	0.371	regulation of response to DNA damage stimulus
GO:1990928	0.334	response to amino acid starvation
GO:0044773	0.322	mitotic DNA damage checkpoint signaling
GO:0019222	0.311	regulation of metabolic process
GO:0009416	0.311	response to light stimulus

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0022626	0.998	cytosolic ribosome
GO:0015934	0.998	large ribosomal subunit
GO:0043227	0.994	membrane-bounded organelle
GO:0022625	0.991	cytosolic large ribosomal subunit
GO:0043231	0.945	intracellular membrane-bounded organelle
GO:0016020	0.862	membrane
GO:0043233	0.822	organelle lumen
GO:0070013	0.803	intracellular organelle lumen
GO:0005634	0.793	nucleus
GO:0030054	0.765	cell junction
GO:0031981	0.671	nuclear lumen
GO:0005576	0.548	extracellular region
GO:0005654	0.457	nucleoplasm
GO:1903561	0.435	extracellular vesicle
GO:0070062	0.434	extracellular exosome
GO:0045202	0.367	synapse

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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