StarFunc result for job id P62834

User Input

>input (184 residues)
MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAG
TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDL
EDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKS
CLLL

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:B5X2X6	0.988	0.983	2.083E-36	185	0.946	0.941	B5X2X6.pdb.gz	B5X2X6_SALSA small monomeric GTPase OS=Salmo salar OX=8030 GN=RAP1B PE=2 SV=1
2	AFDB:P08645	0.944	0.944	1.096E-34	184	0.870	0.870	P08645.pdb.gz	RAP1_DROME Ras-related protein Rap1 OS=Drosophila melanogaster OX=7227 GN=Rap1 PE=2 SV=2
3	AFDB:P18613	0.940	0.930	3.621E-34	186	0.772	0.763	P18613.pdb.gz	RAPA_DICDI Ras-related protein rapA OS=Dictyostelium discoideum OX=44689 GN=rapA PE=1 SV=1
4	AFDB:Q18246	0.925	0.906	6.379E-34	188	0.837	0.819	Q18246.pdb.gz	RAP1_CAEEL Ras-related protein Rap-1 OS=Caenorhabditis elegans OX=6239 GN=rap-1 PE=3 SV=1
5	PDB:6kykC	0.895	0.974	1.436E-32	169	0.891	0.970	6kykC.pdb.gz	Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms.
6	AFDB:P15064	0.894	0.871	2.387E-28	189	0.587	0.571	P15064.pdb.gz	RASG_DICDI Ras-like protein rasG OS=Dictyostelium discoideum OX=44689 GN=rasG PE=1 SV=1
7	AFDB:P32252	0.888	0.830	3.269E-28	197	0.543	0.508	P32252.pdb.gz	RASB_DICDI Ras-like protein rasB OS=Dictyostelium discoideum OX=44689 GN=rasB PE=1 SV=1
8	AFDB:A0A1D8PS50	0.900	0.670	3.948E-28	248	0.582	0.431	A0A1D8PS50.pdb.gz	A0A1D8PS50_CANAL Ras family GTPase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=RSR1 PE=4 SV=1
9	AFDB:A0A0G2JTW1	0.902	0.907	6.530E-28	183	0.614	0.617	A0A0G2JTW1.pdb.gz	A0A0G2JTW1_RAT Ras-related protein Rap-2 OS=Rattus norvegicus OX=10116 GN=Rap2a PE=3 SV=1
10	AFDB:P03967	0.891	0.876	8.398E-28	187	0.592	0.583	P03967.pdb.gz	RASD_DICDI Ras-like protein rasD OS=Dictyostelium discoideum OX=44689 GN=rasD PE=1 SV=2
11	AFDB:O17599	0.886	0.901	2.606E-27	181	0.587	0.597	O17599.pdb.gz	O17599_CAEEL small monomeric GTPase OS=Caenorhabditis elegans OX=6239 GN=rap-2 PE=1 SV=2
12	PDB:6zizA	0.888	0.960	3.087E-24	170	0.505	0.547	6zizA.pdb.gz	Drugging all RAS isoforms with one pocket.
13	PDB:7sd0B	0.869	0.918	8.993E-24	174	0.484	0.511	7sd0B.pdb.gz	Structural basis for SHOC2 modulation of RAS signalling.
14	PDB:1kaoA	0.863	0.948	1.584E-23	167	0.598	0.659	1kaoA.pdb.gz	Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS.
15	PDB:6zqtA	0.872	0.926	7.826E-22	173	0.435	0.462	6zqtA.pdb.gz	Affinity maturation of the RLIP76 Ral binding domain to inform the design of stapled peptides targeting the Ral GTPases.
16	PDB:2bovA	0.873	0.927	8.334E-22	173	0.467	0.497	2bovA.pdb.gz	Molecular Recognition of an Adp-Ribosylating Clostridium Botulinum C3 Exoenzyme by Rala Gtpase
17	PDB:7kyzA	0.802	0.786	5.858E-21	188	0.560	0.548	7kyzA.pdb.gz
18	PDB:2gf0B	0.822	0.867	1.449E-19	174	0.397	0.420	2gf0B.pdb.gz	The crystal structure of the human DiRas1 GTPase in the inactive GDP bound state
19	PDB:5szjA	0.871	0.915	8.980E-19	175	0.342	0.360	5szjA.pdb.gz	bMERB domains are bivalent Rab8 family effectors evolved by gene duplication.
20	PDB:8a4cB	0.855	0.924	1.395E-18	170	0.337	0.365	8a4cB.pdb.gz	Rep15 interacts with several Rab GTPases and has a distinct fold for a Rab effector.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P62834	8.40e-136	378	184	1.000	1.000	RAP1A_HUMAN Ras-related protein Rap-1A OS=Homo sapiens OX=9606 GN=RAP1A PE=1 SV=1
2	P62835	8.40e-136	378	184	1.000	1.000	RAP1A_MOUSE Ras-related protein Rap-1A OS=Mus musculus OX=10090 GN=Rap1a PE=1 SV=1
3	P62836	8.40e-136	378	184	1.000	1.000	RAP1A_RAT Ras-related protein Rap-1A OS=Rattus norvegicus OX=10116 GN=Rap1a PE=1 SV=1
4	F1NSA8	4.26e-135	377	184	0.995	0.995	F1NSA8_CHICK small monomeric GTPase OS=Gallus gallus OX=9031 GN=RAP1A PE=1 SV=2
5	Q6IQP4	4.98e-129	361	185	0.967	0.962	Q6IQP4_DANRE small monomeric GTPase OS=Danio rerio OX=7955 GN=rap1a PE=1 SV=1
6	B5XFY1	5.38e-129	361	185	0.973	0.968	B5XFY1_SALSA small monomeric GTPase OS=Salmo salar OX=8030 GN=RAP1B PE=2 SV=1
7	B5XGC1	1.78e-128	360	184	0.951	0.951	B5XGC1_SALSA small monomeric GTPase OS=Salmo salar OX=8030 GN=RAP1B PE=2 SV=1
8	Q62636	2.07e-127	357	184	0.951	0.951	RAP1B_RAT Ras-related protein Rap-1b OS=Rattus norvegicus OX=10116 GN=Rap1b PE=1 SV=2
9	P61223	5.10e-127	356	184	0.951	0.951	RAP1B_BOVIN Ras-related protein Rap-1b OS=Bos taurus OX=9913 GN=RAP1B PE=2 SV=1
10	P61224	5.10e-127	356	184	0.951	0.951	RAP1B_HUMAN Ras-related protein Rap-1b OS=Homo sapiens OX=9606 GN=RAP1B PE=1 SV=1
11	Q99JI6	5.10e-127	356	184	0.951	0.951	RAP1B_MOUSE Ras-related protein Rap-1b OS=Mus musculus OX=10090 GN=Rap1b PE=1 SV=2
12	C0H8F9	1.88e-125	352	184	0.940	0.940	C0H8F9_SALSA small monomeric GTPase OS=Salmo salar OX=8030 GN=RAP1B PE=2 SV=1
13	Q6TEN1	2.74e-125	352	184	0.940	0.940	RAP1B_DANRE Ras-related protein Rap-1b OS=Danio rerio OX=7955 GN=rap1b PE=2 SV=1
14	B5X794	5.20e-122	343	185	0.962	0.957	B5X794_SALSA small monomeric GTPase OS=Salmo salar OX=8030 GN=RAP1B PE=2 SV=1
15	B9EMH1	1.05e-121	343	185	0.962	0.957	B9EMH1_SALSA small monomeric GTPase OS=Salmo salar OX=8030 GN=RAP1B PE=2 SV=1
16	B5X2X6	8.44e-121	340	185	0.957	0.951	B5X2X6_SALSA small monomeric GTPase OS=Salmo salar OX=8030 GN=RAP1B PE=2 SV=1
17	Q18246	3.26e-109	311	188	0.837	0.819	RAP1_CAEEL Ras-related protein Rap-1 OS=Caenorhabditis elegans OX=6239 GN=rap-1 PE=3 SV=1
18	P08645	8.31e-107	305	184	0.810	0.810	RAP1_DROME Ras-related protein Rap1 OS=Drosophila melanogaster OX=7227 GN=Rap1 PE=2 SV=2
19	P18613	2.79e-104	299	186	0.772	0.763	RAPA_DICDI Ras-related protein rapA OS=Dictyostelium discoideum OX=44689 GN=rapA PE=1 SV=1
20	P13856	8.28e-71	217	272	0.543	0.368	RSR1_YEAST Ras-related protein RSR1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=RSR1 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00025 Arf	2.4e-05	35.4	ADP-ribosylation factor family
2	PF00503 G-alpha	6.7	17.4	G-protein alpha subunit
3	PF00009 GTP_EFTU	0.12	23.5	Elongation factor Tu GTP binding domain
4	PF01926 MMR_HSR1	2.2	19.8	50S ribosome-binding GTPase
5	PF00071 Ras	7.6e-53	189.9	Ras family
6	PF08477 Roc	9.2e-17	72.8	Ras of Complex, Roc, domain of DAPkinase
7	PF03193 RsgA_GTPase	6.4	18.1	RsgA GTPase

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9668.ENSMPUP00000004802

Rank	PPI partner	STRING score	Description
1	9668.ENSMPUP00000008417	0.973	KRIT1, ankyrin repeat containing
2	9668.ENSMPUP00000017076	0.971	Raf-1 proto-oncogene, serine/threonine kinase
3	9668.ENSMPUP00000015950	0.960	RAP1 GTPase activating protein
4	9668.ENSMPUP00000011519	0.958	Uncharacterized protein
5	9668.ENSMPUP00000018000	0.958	Rap guanine nucleotide exchange factor (GEF) 2
6	9668.ENSMPUP00000000850	0.952	Rap guanine nucleotide exchange factor (GEF) 4
7	9668.ENSMPUP00000012657	0.952	RAS guanyl releasing protein 2 (calcium and DAG-regulated)
8	9668.ENSMPUP00000003381	0.948	B-Raf proto-oncogene, serine/threonine kinase
9	9668.ENSMPUP00000013247	0.946	Uncharacterized protein
10	9668.ENSMPUP00000006530	0.940	Afadin, adherens junction formation factor
11	9668.ENSMPUP00000012083	0.925	Amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
12	9668.ENSMPUP00000012335	0.907	Ral guanine nucleotide dissociation stimulator
13	9668.ENSMPUP00000012483	0.882	Rap guanine nucleotide exchange factor (GEF) 1
14	9668.ENSMPUP00000012734	0.881	RAP1 GTPase activating protein 2
15	9668.ENSMPUP00000011992	0.864	Uncharacterized protein
16	9668.ENSMPUP00000000404	0.859	Uncharacterized protein
17	9668.ENSMPUP00000005338	0.854	Talin 1
18	9668.ENSMPUP00000001054	0.826	T-cell lymphoma invasion and metastasis 1
19	9668.ENSMPUP00000007938	0.815	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
20	9668.ENSMPUP00000005859	0.811	Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0003924	0.999	GTPase activity
GO:0097367	0.998	carbohydrate derivative binding
GO:0019899	0.998	enzyme binding
GO:0017076	0.998	purine nucleotide binding
GO:0035639	0.996	purine ribonucleoside triphosphate binding
GO:0098772	0.993	molecular function regulator activity
GO:0019001	0.991	guanyl nucleotide binding
GO:0032555	0.978	purine ribonucleotide binding
GO:0032561	0.966	guanyl ribonucleotide binding
GO:0005525	0.964	GTP binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.984	cellular process
GO:0050794	0.984	regulation of cellular process
GO:0050896	0.982	response to stimulus
GO:0051716	0.974	cellular response to stimulus
GO:0032501	0.963	multicellular organismal process
GO:0048518	0.951	positive regulation of biological process
GO:0046683	0.944	response to organophosphorus
GO:0032502	0.942	developmental process
GO:0007264	0.941	small GTPase mediated signal transduction
GO:0048522	0.934	positive regulation of cellular process
GO:1901698	0.921	response to nitrogen compound
GO:0048856	0.914	anatomical structure development
GO:0010243	0.906	response to organonitrogen compound
GO:0014074	0.900	response to purine-containing compound
GO:0032879	0.887	regulation of localization
GO:0009719	0.878	response to endogenous stimulus
GO:0051128	0.862	regulation of cellular component organization
GO:0051591	0.851	response to cAMP
GO:0043410	0.850	positive regulation of MAPK cascade
GO:1901699	0.849	cellular response to nitrogen compound
GO:0007275	0.839	multicellular organism development
GO:0065008	0.809	regulation of biological quality
GO:0044087	0.803	regulation of cellular component biogenesis
GO:0071495	0.800	cellular response to endogenous stimulus
GO:0071417	0.793	cellular response to organonitrogen compound
GO:1901701	0.771	cellular response to oxygen-containing compound
GO:0070374	0.768	positive regulation of ERK1 and ERK2 cascade
GO:0048731	0.750	system development
GO:0048519	0.748	negative regulation of biological process
GO:0048869	0.745	cellular developmental process
GO:0048523	0.731	negative regulation of cellular process
GO:0051130	0.722	positive regulation of cellular component organization
GO:0030154	0.716	cell differentiation
GO:0071320	0.716	cellular response to cAMP
GO:0051179	0.709	localization
GO:1901888	0.707	regulation of cell junction assembly
GO:0006810	0.695	transport
GO:0051049	0.695	regulation of transport
GO:0009888	0.668	tissue development
GO:0007265	0.668	Ras protein signal transduction
GO:0003158	0.660	endothelium development
GO:0048513	0.648	animal organ development
GO:0045446	0.641	endothelial cell differentiation
GO:0009653	0.629	anatomical structure morphogenesis
GO:0048468	0.625	cell development
GO:0001885	0.610	endothelial cell development
GO:0002009	0.592	morphogenesis of an epithelium
GO:0051046	0.573	regulation of secretion
GO:0051641	0.570	cellular localization
GO:0009887	0.523	animal organ morphogenesis
GO:0060627	0.497	regulation of vesicle-mediated transport
GO:0071840	0.488	cellular component organization or biogenesis
GO:0019222	0.478	regulation of metabolic process
GO:0060255	0.445	regulation of macromolecule metabolic process
GO:0016043	0.431	cellular component organization
GO:1903530	0.421	regulation of secretion by cell
GO:0031323	0.366	regulation of cellular metabolic process
GO:0080090	0.337	regulation of primary metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0043227	1.000	membrane-bounded organelle
GO:0005622	0.995	intracellular anatomical structure
GO:0005737	0.969	cytoplasm
GO:0016020	0.959	membrane
GO:0031982	0.958	vesicle
GO:0043229	0.879	intracellular organelle
GO:0005576	0.871	extracellular region
GO:0071944	0.861	cell periphery
GO:0030054	0.834	cell junction
GO:0005886	0.829	plasma membrane
GO:0005615	0.805	extracellular space
GO:0043231	0.796	intracellular membrane-bounded organelle
GO:0005829	0.784	cytosol
GO:0043230	0.738	extracellular organelle
GO:0065010	0.729	extracellular membrane-bounded organelle
GO:0012505	0.725	endomembrane system
GO:1903561	0.723	extracellular vesicle
GO:0070062	0.713	extracellular exosome
GO:0045202	0.477	synapse

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:19669	0.999	GTP + H2O = GDP + H(+) + phosphate

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