StarFunc result for job id P63135

User Input

>input (1459 residues)
NKSRKRRNRLSFLGAATVEPPKPIPLTWKTEKPVWVNQWPLPKQKLEALHLLANEQLEKG
HIEPSFSPWNSPVFVIQKKSGKWRMLTDLRAVNAVIQPMGPLQPGLPSPAMIPKDWPLII
IDLKDCFFTIPLAEQDCEKFAFTIPAINNKEPATRFQWKVLPQGMLNSPTICQTFVGRAL
QPVREKFSDCYIIHYIDDILCAAETRDKLIDCYTFLQAEVANAGLAIASDKIQTSTPFHY
LGMQIENRKIKQQKIEIRKDTLKTLNDFQKLLGDINWIRPTLGIPTYAMSNLFSILRGDS
DLNSKRILTPEATKEIKLVEEKIQSAQINRIDPLAPLQLLIFATAHSPTGIIIQNTDLVE
WSFLPHSTVKTFTLYLDQIATLIGQTRLRIIKLCGNDPDKIVVPLTKEQVRQAFINSGAW
QIGLANFVGIIDNHYPKTKIFQFLKLTTWILPKITRREPLENALTVFTDGSSNGKAAYTG
PKERVIKTPYQSAQRAELVAVITVLQDFDQPINIISDSAYVVQATRDVETALIKYSMDDQ
LNQLFNLLQQTVRKRNFPFYITHIRAHTNLPGPLTKANEQADLLVSSALIKAQELHALTH
VNAAGLKNKFDVTWKQAKDIVQHCTQCQILHLPTQEAGVNPRGLCPNALWQMDVTHVPSF
GRLSYVHVTVDTYSHFIWATCQTGESTSHVKKHLLSCFAVMGVPEKIKTDNGPGYCSKAF
QKFLSQWKISHTTGIPYNSQGQAIVERTNRTLKTQLVKQKEGGDSKECTTPQMQLNLALY
TLNFLNIYRNQTTTSAEQHLTGKKNSPHEGKLIWWKDNKNKTWEIGKVITWGRGFACVSP
GENQLPVWIPTRHLKFYNEPIGDAKKRASTEMVTPVTWMDNPIEIYVNDSVWVPGPIDDR
CPAKPEEEGMMINISIGYRYPPICLGRAPGCLMPAVQNWLVEVPTVSPISRFTYHMVSGM
SLRPRVNYLQDFSYQRSLKFRPKGKPCPKEIPKESKNTEVLVWEECVANSAVILQNNEFG
TIIDWAPRGQFYHNCSGQTQSCPSAQVSPAVDSDLTESLDKHKHKKLQSFYPWEWGEKGI
STPRPKIVSPVSGPEHPELWRLTVASHHIRIWSGNQTLETRDCKPFYTIDLNSSLTVPLQ
SCVKPPYMLVVGNIVIKPDSQTITCENCRLLTCIDSTFNWQHRILLVRAREGVWIPVSMD
RPWEASPSVHILTEVLKGVLNRSKRFIFTLIAVIMGLIAVTATAAVAGVALHSSVQSVNF
VNDWQKNSTRLWNSQSSIDQKLANQINDLRQTVIWMGDRLMSLEHRFQLQCDWNTSDFCI
TPQIYNESEHHWDMVRRHLQGREDNLTLDISKLKEQIFEASKAHLNLVPGTEAIAGVADG
LANLNPVTWVKTIGSTTIINLILILVCLFCLLLVCRCTQQLRRDSDHRERAMMTMAVLSK
RKGGNVGKSKRDQIVTVSV

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	PDB:2jleA	0.324	0.812	1.195E-34	545	0.103	0.275	2jleA.pdb.gz	Novel Indazole Non-Nucleoside Reverse Transcriptase Inhibitors Using Molecular Hybridization Based on Crystallographic Overlays.
2	AFDB:P0CT40	0.267	0.290	1.547E-34	1333	0.108	0.118	P0CT40.pdb.gz	TF29_SCHPO Transposon Tf2-9 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=Tf2-9 PE=3 SV=1
3	AFDB:Q99315	0.157	0.149	1.772E-30	1547	0.105	0.099	Q99315.pdb.gz	YG31B_YEAST Transposon Ty3-G Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=TY3B-G PE=1 SV=3
4	AFDB:Q7LHG5	0.157	0.153	4.048E-30	1498	0.097	0.095	Q7LHG5.pdb.gz	YI31B_YEAST Transposon Ty3-I Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=TY3B-I PE=1 SV=2
5	AFDB:O13535	0.133	0.110	6.700E-11	1793	0.041	0.033	O13535.pdb.gz	YH11B_YEAST Transposon Ty1-H Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=TY1B-H PE=3 SV=1
6	AFDB:P47024	0.129	0.108	2.565E-10	1803	0.051	0.042	P47024.pdb.gz	YJ41B_YEAST Transposon Ty4-J Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=TY4B-J PE=3 SV=3
7	AFDB:Q12193	0.190	0.161	5.285E-10	1756	0.041	0.034	Q12193.pdb.gz	YB12B_YEAST Transposon Ty1-BR Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=TY1B-BR PE=3 SV=1
8	AFDB:P0C2J3	0.124	0.104	8.858E-10	1770	0.040	0.033	P0C2J3.pdb.gz	YL21B_YEAST Transposon Ty2-LR1 Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=TY2B-LR1 PE=3 SV=1
9	AFDB:P71639	0.132	0.362	4.868E-9	469	0.040	0.124	P71639.pdb.gz	P71639_MYCTU Probable transposase OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=Rv2812 PE=4 SV=2
10	AFDB:Q6ZNG9	0.126	0.343	3.124E-8	492	0.026	0.077	Q6ZNG9.pdb.gz	KRBA2_HUMAN KRAB-A domain-containing protein 2 OS=Homo sapiens OX=9606 GN=KRBA2 PE=1 SV=1
11	PDB:7q5bB	0.098	0.270	5.805E-8	482	0.042	0.127	7q5bB.pdb.gz	Structural basis of Ty3 retrotransposon integration at RNA Polymerase III-transcribed genes.
12	AFDB:P9WKH9	0.123	0.551	4.580E-7	278	0.032	0.165	P9WKH9.pdb.gz	TRA9_MYCTU Putative transposase for insertion sequence element IS986/IS6110 OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=Rv0796 PE=4 SV=1
13	PDB:6vrdA	0.069	0.573	1.829E-4	149	0.021	0.208	6vrdA.pdb.gz	Crystal structure of RNase H/RNA/PS-ASO complex at an atomic level
14	PDB:7lmaA	0.117	0.163	5.410E-4	1012	0.033	0.047	7lmaA.pdb.gz	Structures of telomerase at several steps of telomere repeat synthesis.
15	PDB:7qxaA	0.119	0.175	1.774E-3	954	0.028	0.043	7qxaA.pdb.gz	Structural basis of human telomerase recruitment by TPP1-POT1.
16	PDB:5eq6A	0.049	0.146	4.268E-3	357	0.027	0.109	5eq6A.pdb.gz	PilN Binding Modulates the Structure and Binding Partners of the Pseudomonas aeruginosa Type IVa Pilus Protein PilM.
17	PDB:6x5hA	0.054	0.110	7.152E-3	467	0.029	0.092	6x5hA.pdb.gz	Characterizing human alpha-1,6-fucosyltransferase (FUT8) substrate specificity and structural similarities with related fucosyltransferases.
18	PDB:4yduC	0.059	0.259	9.750E-3	230	0.022	0.139	4yduC.pdb.gz	The ATP-mediated formation of the YgjD-YeaZ-YjeE complex is required for the biosynthesis of tRNA t6A in Escherichia coli.
19	PDB:5guhA	0.053	0.091	1.552E-2	759	0.053	0.101	5guhA.pdb.gz	Crystal Structure of Silkworm PIWI-Clade Argonaute Siwi Bound to piRNA
20	PDB:6pbzA	0.044	0.101	1.812E-2	485	0.023	0.070	6pbzA.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P03354	1.84e-145	486	1603	0.217	0.198	POL_RSVP Gag-Pol polyprotein OS=Rous sarcoma virus subgroup C (strain Prague) OX=11888 GN=gag-pol PE=1 SV=2
2	O92956	8.69e-145	484	1603	0.214	0.195	POL_RSVSB Gag-Pol polyprotein OS=Rous sarcoma virus subgroup B (strain Schmidt-Ruppin) OX=269447 GN=gag-pol PE=1 SV=2
3	P03363	2.03e-93	334	1461	0.194	0.194	POL_HTLV2 Gag-Pro-Pol polyprotein OS=Human T-cell leukemia virus 2 OX=11909 GN=gag-pro-pol PE=1 SV=4
4	P03366	5.01e-65	246	1447	0.158	0.160	POL_HV1B1 Gag-Pol polyprotein OS=Human immunodeficiency virus type 1 group M subtype B (isolate BH10) OX=11678 GN=gag-pol PE=1 SV=3
5	P04585	1.06e-64	244	1435	0.157	0.160	POL_HV1H2 Gag-Pol polyprotein OS=Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) OX=11706 GN=gag-pol PE=1 SV=4
6	P35963	7.20e-64	242	1435	0.158	0.161	POL_HV1Y2 Gag-Pol polyprotein OS=Human immunodeficiency virus type 1 group M subtype B (isolate YU-2) OX=362651 GN=gag-pol PE=1 SV=3
7	P12497	9.55e-62	235	1435	0.155	0.157	POL_HV1N5 Gag-Pol polyprotein OS=Human immunodeficiency virus type 1 group M subtype B (isolate NY5) OX=11698 GN=gag-pol PE=1 SV=4
8	P11204	7.00e-57	218	1146	0.108	0.138	POL_EIAV9 Pol polyprotein OS=Equine infectious anemia virus (isolate 1369) OX=11670 GN=pol PE=1 SV=1
9	Q72547	6.95e-50	189	566	0.117	0.302	Q72547_9HIV1 Reverse transcriptase/RNaseH (Fragment) OS=Human immunodeficiency virus 1 OX=11676 GN=pol PE=1 SV=1
10	D9YZJ6	3.68e-29	127	617	0.061	0.144	D9YZJ6_9BETR Env polyprotein OS=Ovine enzootic nasal tumor virus OX=69576 GN=env PE=4 SV=1
11	P31621	1.13e-28	125	615	0.062	0.146	ENV_JSRV Envelope glycoprotein OS=Sheep pulmonary adenomatosis virus OX=11746 GN=env PE=1 SV=1
12	A1Z651	4.61e-19	96.7	1733	0.102	0.086	POL_XMRV6 Gag-Pol polyprotein OS=Xenotropic MuLV-related virus (isolate VP62) OX=373193 GN=gag-pol PE=1 SV=1
13	P03355	4.04e-18	93.6	1738	0.064	0.054	POL_MLVMS Gag-Pol polyprotein OS=Moloney murine leukemia virus (isolate Shinnick) OX=928306 GN=gag-pol PE=1 SV=5
14	Q8UN00	2.22e-17	91.3	1738	0.056	0.047	Q8UN00_MLVMO Gag-Pol polyprotein OS=Moloney murine leukemia virus OX=11801 GN=gag-pro-pol PE=1 SV=1
15	P0CT40	5.27e-13	76.6	1333	0.046	0.050	TF29_SCHPO Transposon Tf2-9 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=Tf2-9 PE=3 SV=1
16	Q99315	2.45e-12	74.7	1547	0.043	0.041	YG31B_YEAST Transposon Ty3-G Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=TY3B-G PE=1 SV=3
17	Q7LHG5	2.67e-12	74.3	1498	0.043	0.042	YI31B_YEAST Transposon Ty3-I Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=TY3B-I PE=1 SV=2
18	Q76353	1.48e-10	66.2	288	0.034	0.174	Q76353_9HIV1 Integrase (Fragment) OS=Human immunodeficiency virus 1 OX=11676 PE=1 SV=1
19	P14350	1.12e-09	65.9	1143	0.056	0.071	POL_FOAMV Pro-Pol polyprotein OS=Human spumaretrovirus OX=11963 GN=pol PE=1 SV=2
20	P37007	1.82e-07	57.4	384	0.032	0.120	YAGA_ECOLI Uncharacterized protein YagA OS=Escherichia coli (strain K12) OX=83333 GN=yagA PE=2 SV=3

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF13610 DDE_Tnp_IS240	29	16.3	DDE domain
2	PF00517 GP41	1.8e-17	75.5	Retroviral envelope protein
3	PF13804 HERV-K_env_2	1.2e-117	401.0	Retro-transcribing viruses envelope glycoprotein
4	PF02022 Integrase_Zn	8.9e-14	62.5	Integrase Zinc binding domain
5	PF00552 IN_DBD_C	0.00052	30.6	Integrase DNA binding domain
6	PF00075 RNase_H	9.5e-19	79.5	RNase H
7	PF00665 rve	2.8e-19	80.6	Integrase core domain
8	PF00078 RVT_1	1.2e-34	131.4	Reverse transcriptase (RNA-dependent DNA polymerase)
9	PF06817 RVT_thumb	7.9e-28	107.4	Reverse transcriptase thumb domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9978.XP_004580917.1

Rank	PPI partner	STRING score	Description
1	9978.XP_004584002.1	0.946	Corticosteroid 11-beta-dehydrogenase isozyme 2
2	9978.XP_004591918.1	0.945	Testosterone 17-beta-dehydrogenase 3
3	9978.XP_004580289.1	0.939	Steroid 17-alpha-hydroxylase/17,20 lyase-like
4	9978.XP_004598819.1	0.937	Steroid 21-hydroxylase-like
5	9978.XP_004578739.1	0.936	Corticosteroid 11-beta-dehydrogenase isozyme 1
6	9978.XP_004578134.1	0.934	Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 9 mRNAs, 4 Proteins
7	9978.XP_004597951.1	0.930	3-oxo-5-alpha-steroid 4-dehydrogenase 1
8	9978.XP_004582772.1	0.924	3-oxo-5-alpha-steroid 4-dehydrogenase 2
9	9978.XP_004590927.1	0.914	Polyprenol reductase isoform X1
10	9978.XP_004590320.1	0.910	Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 4 mRNAs, 9 Proteins
11	9978.XP_004588603.1	0.900	Aldo-keto reductase family 1 member C1 homolog
12	9978.XP_004585270.1	0.887	Adrenodoxin-like
13	9978.XP_004581915.1	0.850	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase-like isoform X1
14	9978.XP_004581917.1	0.850	Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 26 Proteins
15	9978.XP_004598566.1	0.785	Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 7 mRNAs, 10 Proteins
16	9978.XP_004584270.1	0.766	Estradiol 17-beta-dehydrogenase 2
17	9978.XP_004599780.1	0.766	Estradiol 17-beta-dehydrogenase 2-like
18	9978.XP_004588156.1	0.743	25-hydroxycholesterol 7-alpha-hydroxylase-like
19	9978.XP_004594430.1	0.731	3-oxo-5-beta-steroid 4-dehydrogenase-like isoform X1
20	9978.XP_004594433.1	0.731	Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 3 mRNAs, 22 Proteins

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0042802	0.952	identical protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0006807	0.989	nitrogen compound metabolic process
GO:0046483	0.989	heterocycle metabolic process
GO:1901360	0.987	organic cyclic compound metabolic process
GO:0006725	0.979	cellular aromatic compound metabolic process
GO:0006139	0.965	nucleobase-containing compound metabolic process
GO:1901576	0.466	organic substance biosynthetic process
GO:1901362	0.457	organic cyclic compound biosynthetic process
GO:0019438	0.448	aromatic compound biosynthetic process
GO:0044271	0.448	cellular nitrogen compound biosynthetic process
GO:0018130	0.447	heterocycle biosynthetic process
GO:0006259	0.416	DNA metabolic process
GO:0034654	0.416	nucleobase-containing compound biosynthetic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0110165	0.998	cellular anatomical entity
GO:0005622	0.978	intracellular anatomical structure
GO:0043229	0.899	intracellular organelle
GO:0043231	0.874	intracellular membrane-bounded organelle
GO:0005634	0.812	nucleus
GO:0005737	0.447	cytoplasm

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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