StarFunc result for job id P68036

User Input

>input (154 residues)
MAASRRLMKELEEIRKCGMKNFRNIQVDEANLLTWQGLIVPDNPPYDKGAFRIEINFPAE
YPFKPPKITFKTKIYHPNIDEKGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHP
LRADLAEEYSKDRKKFCKNAEEFTKKYGEKRPVD

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	PDB:4q5eC	0.997	0.990	2.054E-30	155	0.987	0.981	4q5eC.pdb.gz
2	AFDB:Q7K738	0.982	0.982	3.872E-27	154	0.740	0.740	Q7K738.pdb.gz	UBC10_DROME Ubiquitin-conjugating enzyme E2-18 kDa OS=Drosophila melanogaster OX=7227 GN=Ubc10 PE=1 SV=1
3	AFDB:Q21633	0.962	0.968	4.026E-24	153	0.584	0.588	Q21633.pdb.gz	UBC18_CAEEL Ubiquitin-conjugating enzyme E2 ubc-18 OS=Caenorhabditis elegans OX=6239 GN=ubc-18 PE=1 SV=2
4	AFDB:O14933	0.977	0.984	1.858E-23	153	0.545	0.549	O14933.pdb.gz	UB2L6_HUMAN Ubiquitin/ISG15-conjugating enzyme E2 L6 OS=Homo sapiens OX=9606 GN=UBE2L6 PE=1 SV=4
5	PDB:1wzvA	0.951	0.976	5.725E-23	150	0.539	0.553	1wzvA.pdb.gz
6	AFDB:Q9QZU9	0.966	0.972	3.243E-21	153	0.500	0.503	Q9QZU9.pdb.gz	UB2L6_MOUSE Ubiquitin/ISG15-conjugating enzyme E2 L6 OS=Mus musculus OX=10090 GN=Ube2l6 PE=1 SV=3
7	AFDB:Q9UTN8	0.912	0.906	2.968E-18	155	0.338	0.335	Q9UTN8.pdb.gz	UBC14_SCHPO Ubiquitin-conjugating enzyme E2 14 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=ubc14 PE=3 SV=1
8	AFDB:Q9SLE4	0.898	0.933	3.344E-17	148	0.351	0.365	Q9SLE4.pdb.gz	UBC29_ARATH Ubiquitin-conjugating enzyme E2 29 OS=Arabidopsis thaliana OX=3702 GN=UBC29 PE=2 SV=1
9	AFDB:P70711	0.886	0.927	4.901E-17	147	0.364	0.381	P70711.pdb.gz	U2D2B_RAT Ubiquitin-conjugating enzyme E2 D2B OS=Rattus norvegicus OX=10116 GN=Ube2d2b PE=1 SV=1
10	AFDB:P15731	0.902	0.938	5.934E-17	148	0.377	0.392	P15731.pdb.gz	UBC4_YEAST Ubiquitin-conjugating enzyme E2 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=UBC4 PE=1 SV=1
11	AFDB:Q9FKT3	0.894	0.929	7.184E-17	148	0.351	0.365	Q9FKT3.pdb.gz	UBC30_ARATH Ubiquitin-conjugating enzyme E2 30 OS=Arabidopsis thaliana OX=3702 GN=UBC30 PE=1 SV=1
12	AFDB:F4JKF3	0.899	0.781	1.122E-16	178	0.351	0.303	F4JKF3.pdb.gz	F4JKF3_ARATH Ubiquitin conjugating enzyme 9 OS=Arabidopsis thaliana OX=3702 GN=UBC9 PE=3 SV=1
13	PDB:5aieB	0.892	0.915	1.170E-16	150	0.377	0.387	5aieB.pdb.gz	Architecture of the Ubiquitylation Module of the Yeast Ccr4-not Complex.
14	PDB:3ptfA	0.883	0.889	1.828E-16	153	0.364	0.366	3ptfA.pdb.gz
15	PDB:6zhtB	0.897	0.903	6.540E-16	153	0.364	0.366	6zhtB.pdb.gz
16	PDB:4x57C	0.893	0.921	1.089E-15	149	0.364	0.376	4x57C.pdb.gz
17	PDB:3bzhA	0.893	0.856	1.932E-15	161	0.338	0.323	3bzhA.pdb.gz
18	PDB:4ii2C	0.884	0.912	2.339E-15	149	0.357	0.369	4ii2C.pdb.gz	Structure of a ubiquitin E1-E2 complex: insights to E1-E2 thioester transfer.
19	PDB:7bbdC	0.841	0.846	5.026E-15	153	0.299	0.301	7bbdC.pdb.gz	RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination.
20	PDB:4ddgA	0.897	0.354	5.357E-15	399	0.351	0.135	4ddgA.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	D3Z8W5	2.28e-113	319	154	1.000	1.000	D3Z8W5_RAT Ube2l3 protein OS=Rattus norvegicus OX=10116 GN=Ube2l3 PE=1 SV=2
2	P68036	2.28e-113	319	154	1.000	1.000	UB2L3_HUMAN Ubiquitin-conjugating enzyme E2 L3 OS=Homo sapiens OX=9606 GN=UBE2L3 PE=1 SV=1
3	P68037	2.28e-113	319	154	1.000	1.000	UB2L3_MOUSE Ubiquitin-conjugating enzyme E2 L3 OS=Mus musculus OX=10090 GN=Ube2l3 PE=1 SV=1
4	Q7K738	2.48e-86	251	154	0.740	0.740	UBC10_DROME Ubiquitin-conjugating enzyme E2-18 kDa OS=Drosophila melanogaster OX=7227 GN=Ubc10 PE=1 SV=1
5	Q21633	8.51e-73	217	153	0.584	0.588	UBC18_CAEEL Ubiquitin-conjugating enzyme E2 ubc-18 OS=Caenorhabditis elegans OX=6239 GN=ubc-18 PE=1 SV=2
6	O14933	2.84e-58	180	153	0.545	0.549	UB2L6_HUMAN Ubiquitin/ISG15-conjugating enzyme E2 L6 OS=Homo sapiens OX=9606 GN=UBE2L6 PE=1 SV=4
7	Q9QZU9	8.51e-50	158	153	0.500	0.503	UB2L6_MOUSE Ubiquitin/ISG15-conjugating enzyme E2 L6 OS=Mus musculus OX=10090 GN=Ube2l6 PE=1 SV=3
8	P35134	2.55e-37	127	148	0.396	0.412	UBC11_ARATH Ubiquitin-conjugating enzyme E2 11 OS=Arabidopsis thaliana OX=3702 GN=UBC11 PE=1 SV=2
9	Q84K93	1.03e-35	122	148	0.377	0.392	Q84K93_GOSHI Ubiquitin-conjugating enzyme E2 OS=Gossypium hirsutum OX=3635 GN=UBC2 PE=2 SV=1
10	P35131	2.52e-35	121	148	0.377	0.392	UBC8_ARATH Ubiquitin-conjugating enzyme E2 8 OS=Arabidopsis thaliana OX=3702 GN=UBC8 PE=1 SV=1
11	Q8S919	2.75e-35	121	148	0.377	0.392	UBC5B_ORYSJ Ubiquitin-conjugating enzyme E2 5B OS=Oryza sativa subsp. japonica OX=39947 GN=UBC5B PE=2 SV=1
12	Q84K64	4.34e-35	121	148	0.377	0.392	Q84K64_GOSHI Ubiquitin-conjugating enzyme E2 OS=Gossypium hirsutum OX=3635 GN=UBC1 PE=2 SV=1
13	P35133	5.64e-35	120	148	0.370	0.385	UBC10_ARATH Ubiquitin-conjugating enzyme E2 10 OS=Arabidopsis thaliana OX=3702 GN=UBC10 PE=1 SV=1
14	F4JKF3	1.10e-34	121	178	0.370	0.320	F4JKF3_ARATH Ubiquitin conjugating enzyme 9 OS=Arabidopsis thaliana OX=3702 GN=UBC9 PE=3 SV=1
15	P15731	1.35e-34	120	148	0.390	0.405	UBC4_YEAST Ubiquitin-conjugating enzyme E2 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=UBC4 PE=1 SV=1
16	Q9Y2X8	1.40e-34	119	147	0.377	0.395	UB2D4_HUMAN Ubiquitin-conjugating enzyme E2 D4 OS=Homo sapiens OX=9606 GN=UBE2D4 PE=1 SV=1
17	P70711	1.64e-34	119	147	0.377	0.395	U2D2B_RAT Ubiquitin-conjugating enzyme E2 D2B OS=Rattus norvegicus OX=10116 GN=Ube2d2b PE=1 SV=1
18	Q8S920	1.98e-34	119	147	0.364	0.381	UBC5A_ORYSJ Ubiquitin-conjugating enzyme E2 5A OS=Oryza sativa subsp. japonica OX=39947 GN=UBC5A PE=2 SV=1
19	P15732	2.32e-34	119	148	0.377	0.392	UBC5_YEAST Ubiquitin-conjugating enzyme E2-16 kDa OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=UBC5 PE=1 SV=1
20	A5PKP9	2.46e-34	119	147	0.377	0.395	UB2D4_XENLA Ubiquitin-conjugating enzyme E2 D4 OS=Xenopus laevis OX=8355 GN=ube2d4 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF14461 Prok-E2_B	1.4e+02	13.9	Prokaryotic E2 family B
2	PF05773 RWD	0.14	23.9	RWD domain
3	PF05743 UEV	0.12	23.6	UEV domain
4	PF00179 UQ_con	4.5e-42	154.5	Ubiquitin-conjugating enzyme

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 1026970.XP_008840452.1

Rank	PPI partner	STRING score	Description
1	1026970.XP_008825428.1	0.987	E3 ubiquitin-protein ligase parkin-like
2	1026970.XP_008834960.1	0.987	E3 ubiquitin-protein ligase parkin
3	1026970.XP_008834664.1	0.984	E3 ubiquitin-protein ligase ARIH1
4	1026970.XP_008822760.1	0.975	ubiquitin-60S ribosomal protein L40
5	1026970.XP_008821230.1	0.971	Ribosomal protein S27a
6	1026970.XP_008822307.1	0.953	Ubiquitin like modifier activating enzyme 1
7	1026970.XP_008831848.1	0.942	Ubiquitin-protein ligase E3A isoform X1
8	1026970.XP_008834371.1	0.915	Ubiquitin conjugating enzyme E2 L6
9	1026970.XP_008824205.1	0.914	Cbl proto-oncogene
10	1026970.XP_008843039.1	0.912	Ring-box 1
11	1026970.XP_008828711.1	0.895	Uncharacterized protein LOC103731980
12	1026970.XP_008832106.1	0.895	The sequence of the model RefSeq protein was modified relative to its source genomic sequence to represent the inferred CDS: inserted 1 base in 1 codon
13	1026970.XP_008839809.1	0.895	Ubiquitin-conjugating enzyme E2 variant 2-like
14	1026970.XP_008839828.1	0.887	SMAD specific E3 ubiquitin protein ligase 2
15	1026970.XP_008852047.1	0.876	Ubiquitin like modifier activating enzyme 6
16	1026970.XP_008833385.1	0.873	Ubiquitin-conjugating enzyme E2 variant 1 isoform X1
17	1026970.XP_008851444.1	0.867	E3 ubiquitin-protein ligase ARIH2 isoform X1
18	1026970.XP_008827684.1	0.850	WW domain containing E3 ubiquitin protein ligase 1
19	1026970.XP_008831924.1	0.847	NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1
20	1026970.XP_008827981.1	0.844	Ubiquitin-conjugating enzyme E2 variant 2-like

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.999	protein binding
GO:0061631	0.996	ubiquitin conjugating enzyme activity
GO:0031625	0.696	ubiquitin protein ligase binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.989	cellular process
GO:0043170	0.988	macromolecule metabolic process
GO:0044238	0.981	primary metabolic process
GO:0006807	0.974	nitrogen compound metabolic process
GO:0043632	0.966	modification-dependent macromolecule catabolic process
GO:0019941	0.959	modification-dependent protein catabolic process
GO:0006511	0.915	ubiquitin-dependent protein catabolic process
GO:0065007	0.825	biological regulation
GO:0050789	0.824	regulation of biological process
GO:0032446	0.737	protein modification by small protein conjugation
GO:0050794	0.678	regulation of cellular process
GO:0050896	0.541	response to stimulus
GO:0032501	0.476	multicellular organismal process
GO:0032502	0.429	developmental process
GO:0048518	0.425	positive regulation of biological process
GO:0019222	0.422	regulation of metabolic process
GO:0060255	0.396	regulation of macromolecule metabolic process
GO:0080090	0.387	regulation of primary metabolic process
GO:0048856	0.361	anatomical structure development
GO:0051171	0.338	regulation of nitrogen compound metabolic process
GO:0016567	0.335	protein ubiquitination
GO:0051716	0.311	cellular response to stimulus
GO:0007275	0.306	multicellular organism development

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0043229	0.995	intracellular organelle
GO:0005829	0.995	cytosol
GO:0043231	0.989	intracellular membrane-bounded organelle
GO:0005634	0.975	nucleus
GO:0032991	0.953	protein-containing complex
GO:0070013	0.950	intracellular organelle lumen
GO:0031981	0.811	nuclear lumen
GO:0005654	0.758	nucleoplasm
GO:1902494	0.374	catalytic complex
GO:1990234	0.364	transferase complex
GO:0140535	0.343	intracellular protein-containing complex

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:2.3.2.23	0.996	E2 ubiquitin-conjugating enzyme.

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