StarFunc result for job id P78363

User Input

>input (2273 residues)
MGFVRQIQLLLWKNWTLRKRQKIRFVVELVWPLSLFLVLIWLRNANPLYSHHECHFPNKA
MPSAGMLPWLQGIFCNVNNPCFQSPTPGESPGIVSNYNNSILARVYRDFQELLMNAPESQ
HLGRIWTELHILSQFMDTLRTHPERIAGRGIRIRDILKDEETLTLFLIKNIGLSDSVVYL
LINSQVRPEQFAHGVPDLALKDIACSEALLERFIIFSQRRGAKTVRYALCSLSQGTLQWI
EDTLYANVDFFKLFRVLPTLLDSRSQGINLRSWGGILSDMSPRIQEFIHRPSMQDLLWVT
RPLMQNGGPETFTKLMGILSDLLCGYPEGGGSRVLSFNWYEDNNYKAFLGIDSTRKDPIY
SYDRRTTSFCNALIQSLESNPLTKIAWRAAKPLLMGKILYTPDSPAARRILKNANSTFEE
LEHVRKLVKAWEEVGPQIWYFFDNSTQMNMIRDTLGNPTVKDFLNRQLGEEGITAEAILN
FLYKGPRESQADDMANFDWRDIFNITDRTLRLVNQYLECLVLDKFESYNDETQLTQRALS
LLEENMFWAGVVFPDMYPWTSSLPPHVKYKIRMDIDVVEKTNKIKDRYWDSGPRADPVED
FRYIWGGFAYLQDMVEQGITRSQVQAEAPVGIYLQQMPYPCFVDDSFMIILNRCFPIFMV
LAWIYSVSMTVKSIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIM
HGRILHYSDPFILFLFLLAFSTATIMLCFLLSTFFSKASLAAACSGVIYFTLYLPHILCF
AWQDRMTAELKKAVSLLSPVAFGFGTEYLVRFEEQGLGLQWSNIGNSPTEGDEFSFLLSM
QMMLLDAAVYGLLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEPL
TEETEDPEHPEGIHDSFFEREHPGWVPGVCVKNLVKIFEPCGRPAVDRLNITFYENQITA
FLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIETSLDAVRQSLGMCPQHNILFHHLTV
AEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDA
KVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYC
SGTPLFLKNCFGTGLYLTLVRKMKNIQSQRKGSEGTCSCSSKGFSTTCPAHVDDLTPEQV
LDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEETLADLGLS
SFGISDTPLEEIFLKVTEDSDSGPLFAGGAQQKRENVNPRHPCLGPREKAGQTPQDSNVC
SPGAPAAHPEGQPPPEPECPGPQLNTGTQLVLQHVQALLVKRFQHTIRSHKDFLAQIVLP
ATFVFLALMLSIVIPPFGEYPALTLHPWIYGQQYTFFSMDEPGSEQFTVLADVLLNKPGF
GNRCLKEGWLPEYPCGNSTPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLP
ECPEGAGGLPPPQRTQRSTEILQDLTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGI
SIGGKLPVVPITGEALVGFLSDLGRIMNVSGGPITREASKEIPDFLKHLETEDNIKVWFN
NKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDA
VVAICVIFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAG
LVVGIFIGFQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPSTAYVALSCANL
FIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYAR
FGEEHSANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRHFFLSQWIAEPTKEPIVDEDDD
VAEERQRIITGGNKTDILRLHELTKIYPGTSSPAVDRLCVGVRPGECFGLLGVNGAGKTT
TFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLR
GVPAEEIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTG
MDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSK
FGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSLARIFQ
LLLSHKDSLLIEEYSVTQTTLDQVFVNFAKQQTESHDLPLHPRAAGASRQAQD

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Length	ID1	ID2	Download	Description
1	PDB:5xjyA	0.662	0.783	1901	0.405	0.484	5xjyA.pdb.gz
2	PDB:7e7iA	0.826	0.929	2011	0.881	0.996	7e7iA.pdb.gz
3	PDB:7e7qA	0.642	0.728	1958	0.856	0.994	7e7qA.pdb.gz	Structural basis of substrate recognition and translocation by human ABCA4.
4	PDB:7lkzA	0.661	0.763	1920	0.842	0.997	7lkzA.pdb.gz	Molecular structures of the eukaryotic retinal importer ABCA4.
5	PDB:7m1pA	0.800	0.933	1938	0.831	0.974	7m1pA.pdb.gz
6	PDB:7m1qA	0.786	0.928	1911	0.832	0.989	7m1qA.pdb.gz	Cryo-EM structures of the ABCA4 importer reveal mechanisms underlying substrate binding and Stargardt disease.
7	PDB:7roqA	0.706	0.867	1831	0.418	0.518	7roqA.pdb.gz	Structure of the Human Lipid Exporter ABCA1.
8	PDB:7tbwA	0.645	0.744	1928	0.465	0.548	7tbwA.pdb.gz	Cholesterol efflux mechanism revealed by structural analysis of human ABCA1 conformational states.
9	PDB:7tbyA	0.729	0.919	1788	0.443	0.563	7tbyA.pdb.gz	Cholesterol efflux mechanism revealed by structural analysis of human ABCA1 conformational states.
10	PDB:7w01A	0.571	0.797	1598	0.249	0.355	7w01A.pdb.gz
11	AFDB:A0A0G2K1Q8	0.551	0.721	1704	0.250	0.334	A0A0G2K1Q8.pdb.gz	ABCA3_RAT Phospholipid-transporting ATPase ABCA3 OS=Rattus norvegicus OX=10116 GN=Abca3 PE=1 SV=1
12	AFDB:B8A446	0.878	0.880	2268	0.490	0.491	B8A446.pdb.gz	B8A446_DANRE ATP-binding cassette sub-family A member 1 OS=Danio rerio OX=7955 GN=abca1 PE=4 SV=1
13	AFDB:E9PWH4	0.554	0.740	1668	0.237	0.323	E9PWH4.pdb.gz	E9PWH4_MOUSE ATP-binding cassette, sub-family A (ABC1), member 15 OS=Mus musculus OX=10090 GN=Abca15 PE=1 SV=1
14	AFDB:E9PX95	0.557	0.715	1733	0.238	0.312	E9PX95.pdb.gz	ABCAH_MOUSE ATP-binding cassette sub-family A member 17 OS=Mus musculus OX=10090 GN=Abca17 PE=1 SV=1
15	AFDB:E9Q876	0.720	0.636	2595	0.327	0.287	E9Q876.pdb.gz	ABCAC_MOUSE Glucosylceramide transporter ABCA12 OS=Mus musculus OX=10090 GN=Abca12 PE=1 SV=1
16	AFDB:O35600	0.948	0.933	2310	0.883	0.869	O35600.pdb.gz	ABCA4_MOUSE Retinal-specific phospholipid-transporting ATPase ABCA4 OS=Mus musculus OX=10090 GN=Abca4 PE=1 SV=1
17	AFDB:O95477	0.755	0.759	2261	0.505	0.507	O95477.pdb.gz	ABCA1_HUMAN Phospholipid-transporting ATPase ABCA1 OS=Homo sapiens OX=9606 GN=ABCA1 PE=1 SV=3
18	AFDB:P78363	1.000	1.000	2273	1.000	1.000	P78363.pdb.gz	ABCA4_HUMAN Retinal-specific phospholipid-transporting ATPase ABCA4 OS=Homo sapiens OX=9606 GN=ABCA4 PE=1 SV=3
19	AFDB:Q385F7	0.545	0.699	1738	0.200	0.262	Q385F7.pdb.gz	Q385F7_TRYB2 ABC transporter, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb11.02.3950 PE=4 SV=1
20	AFDB:Q555Z5	0.580	0.798	1615	0.200	0.281	Q555Z5.pdb.gz	ABCA4_DICDI ABC transporter A family member 4 OS=Dictyostelium discoideum OX=44689 GN=abcA4 PE=3 SV=1

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	Bit-score	Length	ID1	ID2	Description
1	A0A087WXK5	704	2466	0.182	0.167	A0A087WXK5_HUMAN ATP-binding cassette sub-family A member 2 OS=Homo sapiens OX=9606 GN=ABCA2 PE=1 SV=1
2	A0A8I5ZLK5	2251	2263	0.513	0.515	A0A8I5ZLK5_RAT ATP binding cassette subfamily A member 1 OS=Rattus norvegicus OX=10116 GN=Abca1 PE=1 SV=1
3	A0A8I6ATT1	2160	2190	0.495	0.513	A0A8I6ATT1_RAT ATP binding cassette subfamily A member 1 OS=Rattus norvegicus OX=10116 GN=Abca1 PE=1 SV=1
4	B2RY11	1148	2595	0.302	0.265	B2RY11_MOUSE Abca12 protein OS=Mus musculus OX=10090 GN=Abca12 PE=2 SV=1
5	B2RY21	1150	2595	0.303	0.265	B2RY21_MOUSE Abca12 protein OS=Mus musculus OX=10090 GN=Abca12 PE=2 SV=1
6	B8A446	2202	2268	0.495	0.496	B8A446_DANRE ATP-binding cassette sub-family A member 1 OS=Danio rerio OX=7955 GN=abca1 PE=4 SV=1
7	E9Q876	1150	2595	0.303	0.265	ABCAC_MOUSE Glucosylceramide transporter ABCA12 OS=Mus musculus OX=10090 GN=Abca12 PE=1 SV=1
8	F1LNL3	2184	2201	0.498	0.514	F1LNL3_RAT ATP binding cassette subfamily A member 1 OS=Rattus norvegicus OX=10116 GN=Abca1 PE=1 SV=4
9	F1MWM0	4234	2281	0.894	0.891	ABCA4_BOVIN Retinal-specific phospholipid-transporting ATPase ABCA4 OS=Bos taurus OX=9913 GN=ABCA4 PE=1 SV=2
10	K9J4V5	2279	2262	0.509	0.511	K9J4V5_PIG ATP-binding cassette sub-family A member 1 OS=Sus scrofa OX=9823 GN=ABCA1 PE=2 SV=1
11	O35600	4202	2310	0.884	0.870	ABCA4_MOUSE Retinal-specific phospholipid-transporting ATPase ABCA4 OS=Mus musculus OX=10090 GN=Abca4 PE=1 SV=1
12	O95477	2246	2261	0.506	0.509	ABCA1_HUMAN Phospholipid-transporting ATPase ABCA1 OS=Homo sapiens OX=9606 GN=ABCA1 PE=1 SV=3
13	P41233	2251	2261	0.509	0.512	ABCA1_MOUSE Phospholipid-transporting ATPase ABCA1 OS=Mus musculus OX=10090 GN=Abca1 PE=1 SV=4
14	P41234	623	2434	0.158	0.147	ABCA2_MOUSE ATP-binding cassette sub-family A member 2 OS=Mus musculus OX=10090 GN=Abca2 PE=1 SV=4
15	P78363	4711	2273	1.000	1.000	ABCA4_HUMAN Retinal-specific phospholipid-transporting ATPase ABCA4 OS=Homo sapiens OX=9606 GN=ABCA4 PE=1 SV=3
16	Q5SSE9	1024	5034	0.313	0.141	ABCAD_MOUSE ATP-binding cassette sub-family A member 13 OS=Mus musculus OX=10090 GN=Abca13 PE=1 SV=1
17	Q7TNJ2	1720	2170	0.407	0.427	ABCA7_RAT ATP-binding cassette sub-family A member 7 OS=Rattus norvegicus OX=10116 GN=Abca7 PE=1 SV=1
18	Q80ZB2	2159	2201	0.495	0.511	Q80ZB2_RAT ATP-binding cassette 1 OS=Rattus norvegicus OX=10116 GN=Abca1 PE=2 SV=1
19	Q86UK0	1127	2595	0.301	0.264	ABCAC_HUMAN Glucosylceramide transporter ABCA12 OS=Homo sapiens OX=9606 GN=ABCA12 PE=1 SV=3
20	Q86UQ4	1020	5058	0.316	0.142	ABCAD_HUMAN ATP-binding cassette sub-family A member 13 OS=Homo sapiens OX=9606 GN=ABCA13 PE=2 SV=3

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF13175 AAA_15	1.8	19.6	AAA ATPase domain
2	PF13304 AAA_21	3.6e-17	74.7	AAA domain, putative AbiEii toxin, Type IV TA system
3	PF13476 AAA_23	5.4	19.0	AAA domain
4	PF13555 AAA_29	64	14.7	P-loop containing region of AAA domain
5	PF13604 AAA_30	2.1e+02	13.0	AAA domain
6	PF12698 ABC2_membrane_3	6.8e-53	191.6	ABC-2 family transporter protein
7	PF00005 ABC_tran	1.7e-50	182.5	ABC transporter
8	PF13732 DUF4162	1.1e+02	15.0	Domain of unknown function (DUF4162)
9	PF13558 SbcC_Walker_B	3.5e+02	12.9	SbcC/RAD50-like, Walker B motif
10	PF02463 SMC_N	4.3e+02	11.7	RecF/RecN/SMC N terminal domain
11	PF00448 SRP54	29	15.7	SRP54-type protein, GTPase domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000359245

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000262340	0.809	Retinoid isomerohydrolase
2	9606.ENSP00000466058	0.790	Retinol dehydrogenase 8
3	9606.ENSP00000358831	0.769	Elongation of very long chain fatty acids protein 4
4	9606.ENSP00000305941	0.766	Usherin
5	9606.ENSP00000367766	0.758	X-linked retinitis pigmentosa GTPase regulator
6	9606.ENSP00000230381	0.753	Peripherin-2
7	9606.ENSP00000399709	0.752	Bestrophin-1
8	9606.ENSP00000386331	0.737	Unconventional myosin-VIIa
9	9606.ENSP00000296271	0.726	Rhodopsin
10	9606.ENSP00000316605	0.721	Cyclic nucleotide-gated cation channel beta-3
11	9606.ENSP00000356370	0.720	Protein crumbs homolog 1
12	9606.ENSP00000341159	0.715	Ceramide kinase-like protein
13	9606.ENSP00000449079	0.714	Retinol dehydrogenase 12
14	9606.ENSP00000251102	0.712	Cyclic nucleotide-gated cation channel beta-1
15	9606.ENSP00000254854	0.703	Retinal guanylyl cyclase 1
16	9606.ENSP00000424243	0.703	Protein eyes shut homolog
17	9606.ENSP00000448012	0.701	Centrosomal protein of 290 kDa
18	9606.ENSP00000302478	0.695	DNA-directed RNA polymerases I and III subunit RPAC2
19	9606.ENSP00000255266	0.693	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
20	9606.ENSP00000221996	0.681	Cone-rod homeobox protein

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0003824	1.000	catalytic activity
GO:0042626	1.000	ATPase-coupled transmembrane transporter activity
GO:0140333	0.999	glycerophospholipid flippase activity
GO:0008289	0.998	lipid binding
GO:0005524	0.997	ATP binding
GO:0016462	0.989	pyrophosphatase activity
GO:0005501	0.979	retinoid binding
GO:0017111	0.979	ribonucleoside triphosphate phosphatase activity
GO:0090482	0.978	vitamin transmembrane transporter activity
GO:0005515	0.973	protein binding
GO:1901618	0.972	organic hydroxy compound transmembrane transporter activity
GO:0016887	0.826	ATP hydrolysis activity
GO:0016918	0.710	retinal binding
GO:0015665	0.493	alcohol transmembrane transporter activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.993	cellular process
GO:0032501	0.978	multicellular organismal process
GO:0071704	0.925	organic substance metabolic process
GO:0015748	0.906	organophosphate ester transport
GO:0044238	0.896	primary metabolic process
GO:0044237	0.890	cellular metabolic process
GO:0010876	0.889	lipid localization
GO:0007601	0.886	visual perception
GO:0006869	0.874	lipid transport
GO:0065007	0.844	biological regulation
GO:0050896	0.825	response to stimulus
GO:0050789	0.794	regulation of biological process
GO:0015914	0.734	phospholipid transport
GO:0071840	0.689	cellular component organization or biogenesis
GO:0016043	0.683	cellular component organization
GO:0001523	0.674	retinoid metabolic process
GO:0050794	0.630	regulation of cellular process
GO:0120254	0.566	olefinic compound metabolic process
GO:0042574	0.538	retinal metabolic process
GO:0051716	0.483	cellular response to stimulus
GO:0061024	0.429	membrane organization

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0016020	1.000	membrane
GO:0097730	0.998	non-motile cilium
GO:0097733	0.986	photoreceptor cell cilium
GO:0001750	0.983	photoreceptor outer segment
GO:0005622	0.975	intracellular anatomical structure
GO:0012505	0.973	endomembrane system
GO:0043231	0.971	intracellular membrane-bounded organelle
GO:0005737	0.963	cytoplasm
GO:0071944	0.960	cell periphery
GO:0005886	0.952	plasma membrane
GO:0031090	0.911	organelle membrane
GO:0031982	0.824	vesicle
GO:0031410	0.754	cytoplasmic vesicle
GO:0097381	0.415	photoreceptor disc membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:7.-.-.-	1.000	Translocases.
EC:7.6.2.1	1.000	P-type phospholipid transporter.
EC:3.6.1.-	0.989	In phosphorus-containing anhydrides.
RHEA:23680	0.979	a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H(+) + phosphate
EC:3.6.1.15	0.979	nucleoside-triphosphate phosphatase.
RHEA:13065	0.826	ATP + H2O = ADP + H(+) + phosphate

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