StarFunc result for job id P81534

User Input

>input (67 residues)
MRIHYLLFALLFLFLVPVPGHGGIINTLQKYYCRVRGGRCAVLSCLPKEEQIGKCSTRGR
KCCRRKK

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:P81534	1.000	1.000	2.494E-12	67	1.000	1.000	P81534.pdb.gz	D103A_HUMAN Beta-defensin 103 OS=Homo sapiens OX=9606 GN=DEFB103A PE=1 SV=2
2	AFDB:P83943	0.706	0.706	6.883E-11	67	0.776	0.776	P83943.pdb.gz	DEFB1_CHILA Beta-defensin 1 OS=Chinchilla lanigera OX=34839 GN=DEFB1 PE=1 SV=1
3	AFDB:Q7TNV9	0.685	0.685	2.169E-9	67	0.687	0.687	Q7TNV9.pdb.gz	DFB14_MOUSE Beta-defensin 14 OS=Mus musculus OX=10090 GN=Defb14 PE=3 SV=1
4	PDB:1kj6A	0.471	0.660	1.938E-5	45	0.672	1.000	1kj6A.pdb.gz
5	AFDB:O15263	0.542	0.566	3.339E-4	64	0.403	0.422	O15263.pdb.gz	DFB4A_HUMAN Defensin beta 4A OS=Homo sapiens OX=9606 GN=DEFB4A PE=1 SV=1
6	AFDB:P0DP74	0.596	0.526	7.403E-4	79	0.313	0.266	P0DP74.pdb.gz	D130A_HUMAN Beta-defensin 130A OS=Homo sapiens OX=9606 GN=DEFB130A PE=2 SV=1
7	AFDB:Q6IV18	0.622	0.479	1.259E-3	89	0.284	0.213	Q6IV18.pdb.gz	GLL13_CHICK Gallinacin-13 OS=Gallus gallus OX=9031 GN=GAL13 PE=2 SV=1
8	AFDB:O89117	0.518	0.505	1.536E-3	69	0.313	0.304	O89117.pdb.gz	DEFB1_RAT Beta-defensin 1 OS=Rattus norvegicus OX=10116 GN=Defb1 PE=2 SV=1
9	AFDB:Q9WTL0	0.517	0.548	1.641E-3	63	0.433	0.460	Q9WTL0.pdb.gz	DEFB3_MOUSE Beta-defensin 3 OS=Mus musculus OX=10090 GN=Defb3 PE=2 SV=1
10	AFDB:P82020	0.675	0.645	2.003E-3	71	0.299	0.282	P82020.pdb.gz	DEFB2_MOUSE Beta-defensin 2 OS=Mus musculus OX=10090 GN=Defb2 PE=2 SV=1
11	AFDB:P46158	0.452	0.471	2.287E-3	64	0.343	0.359	P46158.pdb.gz	GLL2_CHICK Gallinacin-2 OS=Gallus gallus OX=9031 GN=GAL2 PE=1 SV=2
12	PDB:6cs9A	0.500	0.785	8.684E-3	41	0.179	0.293	6cs9A.pdb.gz	Human beta-defensin 2 killsCandida albicansthrough phosphatidylinositol 4,5-bisphosphate-mediated membrane permeabilization.
13	PDB:1bnbA	0.411	0.669	1.155E-1	38	0.209	0.368	1bnbA.pdb.gz
14	PDB:2lwlA	0.413	0.577	2.737E-1	45	0.179	0.267	2lwlA.pdb.gz
15	PDB:1e4rA	0.351	0.558	3.814E-1	35	0.164	0.314	1e4rA.pdb.gz
16	PDB:5lcsA	0.375	0.506	6.930E-1	47	0.194	0.277	5lcsA.pdb.gz
17	PDB:1f1hA	0.299	0.060	1.875	468	0.090	0.013	1f1hA.pdb.gz	The crystal structure of phosphinothricin in the active site of glutamine synthetase illuminates the mechanism of enzymatic inhibition.
18	PDB:7o9mf	0.249	0.135	2.983	130	0.045	0.023	7o9mf.pdb.gz	Structural basis for late maturation steps of the human mitoribosomal large subunit.
19	PDB:5azfA	0.265	0.181	5.073	119	0.060	0.034	5azfA.pdb.gz	Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy.
20	PDB:5u4jv	0.230	0.148	5.073	132	0.104	0.053	5u4jv.pdb.gz	Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	P81534	2.27e-43	135	67	1.000	1.000	D103A_HUMAN Beta-defensin 103 OS=Homo sapiens OX=9606 GN=DEFB103A PE=1 SV=2
2	P83943	2.77e-27	95.1	67	0.776	0.776	DEFB1_CHILA Beta-defensin 1 OS=Chinchilla lanigera OX=34839 GN=DEFB1 PE=1 SV=1
3	Q7TNV9	9.07e-22	81.3	67	0.687	0.687	DFB14_MOUSE Beta-defensin 14 OS=Mus musculus OX=10090 GN=Defb14 PE=3 SV=1
4	Q91VD6	1.86e-04	37.4	63	0.373	0.397	DEFB6_MOUSE Beta-defensin 6 OS=Mus musculus OX=10090 GN=Defb6 PE=2 SV=1
5	A0A0N9WLX3	0.002	35.0	67	0.284	0.284	A0A0N9WLX3_CHICK Beta-defensin 9 OS=Gallus gallus gallus OX=208526 GN=BD-9 PE=2 SV=1
6	Q6QLR1	0.002	35.0	67	0.284	0.284	GLL9_CHICK Gallinacin-9 OS=Gallus gallus OX=9031 GN=GAL9 PE=2 SV=1
7	P56386	0.024	32.3	69	0.343	0.333	DEFB1_MOUSE Beta-defensin 1 OS=Mus musculus OX=10090 GN=Defb1 PE=2 SV=1
8	Q30KQ6	0.024	32.0	69	0.343	0.333	DB114_HUMAN Beta-defensin 114 OS=Homo sapiens OX=9606 GN=DEFB114 PE=1 SV=1
9	Q9WTL0	0.046	31.2	63	0.433	0.460	DEFB3_MOUSE Beta-defensin 3 OS=Mus musculus OX=10090 GN=Defb3 PE=2 SV=1
10	P0DP74	0.064	31.2	79	0.343	0.291	D130A_HUMAN Beta-defensin 130A OS=Homo sapiens OX=9606 GN=DEFB130A PE=2 SV=1
11	O15263	0.64	28.5	64	0.418	0.438	DFB4A_HUMAN Defensin beta 4A OS=Homo sapiens OX=9606 GN=DEFB4A PE=1 SV=1
12	Q8NET1	0.67	28.5	73	0.313	0.288	D108B_HUMAN Beta-defensin 108B OS=Homo sapiens OX=9606 GN=DEFB108B PE=1 SV=3
13	Q6IV18	1.3	28.1	89	0.358	0.270	GLL13_CHICK Gallinacin-13 OS=Gallus gallus OX=9031 GN=GAL13 PE=2 SV=1
14	P35995	3.4	27.3	705	0.194	0.018	YKW2_YEAST Uncharacterized transcriptional regulatory protein YKL222C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=YKL222C PE=4 SV=1
15	Q386V9	4.0	27.3	550	0.179	0.022	Q386V9_TRYB2 JmjC domain-containing protein OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb11.46.0007 PE=4 SV=1
16	O60462	6.2	26.9	931	0.254	0.018	NRP2_HUMAN Neuropilin-2 OS=Homo sapiens OX=9606 GN=NRP2 PE=1 SV=3
17	Q57WU1	6.3	26.6	1541	0.209	0.009	Q57WU1_TRYB2 RING-type domain-containing protein OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb07.27M11.170 PE=4 SV=1
18	P97846	8.5	26.6	1381	0.239	0.012	CNTP1_RAT Contactin-associated protein 1 OS=Rattus norvegicus OX=10116 GN=Cntnap1 PE=1 SV=1
19	P86194	9.4	25.0	42	0.224	0.357	MYXC3_CRODM Crotamine-IV-3 OS=Crotalus durissus cumanensis OX=184542 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00711 Defensin_beta	7.6e-08	43.6	Beta defensin
2	PF13841 Defensin_beta_2	22	16.9	Beta defensin

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 61853.ENSNLEP00000002199

Rank	PPI partner	STRING score	Description
1	61853.ENSNLEP00000018165	0.966	Defensin, beta 1
2	61853.ENSNLEP00000018166	0.848	Defensin, alpha 6, Paneth cell-specific
3	61853.ENSNLEP00000018168	0.848	Defensin, alpha 4, corticostatin
4	61853.ENSNLEP00000018169	0.848	Uncharacterized protein
5	61853.ENSNLEP00000018170	0.848	Defensin, alpha 5, Paneth cell-specific
6	61853.ENSNLEP00000018375	0.843	Uncharacterized protein
7	61853.ENSNLEP00000011652	0.758	Belongs to the beta-defensin family.
8	61853.ENSNLEP00000014147	0.753	Belongs to the G-protein coupled receptor 1 family.
9	61853.ENSNLEP00000011640	0.743	Belongs to the beta-defensin family.
10	61853.ENSNLEP00000016023	0.732	Chemokine (C-C motif) receptor 2
11	61853.ENSNLEP00000022789	0.695	Toll-like receptor 2
12	61853.ENSNLEP00000011647	0.637	Belongs to the beta-defensin family.
13	61853.ENSNLEP00000020714	0.595	Belongs to the Toll-like receptor family.
14	61853.ENSNLEP00000018348	0.579	Uncharacterized protein
15	61853.ENSNLEP00000022888	0.559	Proline rich 23C
16	61853.ENSNLEP00000000470	0.554	Belongs to the beta-defensin family.
17	61853.ENSNLEP00000007795	0.553	Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity
18	61853.ENSNLEP00000016712	0.550	Methyl CpG binding protein 2
19	61853.ENSNLEP00000000466	0.547	Belongs to the beta-defensin family.
20	61853.ENSNLEP00000000476	0.547	Belongs to the beta-defensin family.

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0005102	0.689	signaling receptor binding
GO:0098772	0.305	molecular function regulator activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0006950	0.995	response to stress
GO:0098542	0.991	defense response to other organism
GO:0009987	0.981	cellular process
GO:0009617	0.963	response to bacterium
GO:0051702	0.951	biological process involved in interaction with symbiont
GO:0042742	0.945	defense response to bacterium
GO:0051873	0.939	killing by host of symbiont cells
GO:0002376	0.920	immune system process
GO:0006955	0.893	immune response
GO:0050829	0.808	defense response to Gram-negative bacterium
GO:0050830	0.747	defense response to Gram-positive bacterium
GO:0019730	0.747	antimicrobial humoral response
GO:0061844	0.719	antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0051716	0.431	cellular response to stimulus
GO:0042221	0.376	response to chemical
GO:0031640	0.376	killing of cells of another organism

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005737	1.000	cytoplasm
GO:0043231	1.000	intracellular membrane-bounded organelle
GO:0012505	0.999	endomembrane system
GO:0005615	0.999	extracellular space
GO:0070013	0.998	intracellular organelle lumen
GO:0005794	0.985	Golgi apparatus
GO:0005796	0.915	Golgi lumen
GO:0016020	0.886	membrane
GO:0031982	0.758	vesicle
GO:0031410	0.379	cytoplasmic vesicle
GO:0030141	0.369	secretory granule
GO:0031981	0.312	nuclear lumen

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

[back to server]