StarFunc result for job id P86397

User Input

>input (168 residues)
MFPLISSHHLWWGGLRRTVCLNLPVLTLQHFQHMHIKVGDRAELRRAFTQTDVATFSELT
GDVNPLHLNEDFAKHTKFGNTIVHGVLINGLISALLGTKMPGPGCVFLSQEISFPAPLYI
GEVVLASAEVKKLKRFIAIIAVSCSVIESKKTVMEGWVKVMVPEASKS

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:L0R6P0	0.887	0.887	6.441E-31	168	1.000	1.000	L0R6P0.pdb.gz	L0R6P0_HUMAN Alternative protein RPP14 OS=Homo sapiens OX=9606 GN=RPP14 PE=4 SV=1
2	AFDB:C5AZ74	0.757	0.809	3.667E-16	157	0.345	0.369	C5AZ74.pdb.gz	CROR_METEA 3-hydroxybutyryl-CoA dehydratase OS=Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1) OX=272630 GN=croR PE=4 SV=1
3	AFDB:Q2RQ36	0.733	0.853	1.398E-15	144	0.315	0.368	Q2RQ36.pdb.gz	PHAJ_RHORT (R)-specific enoyl-CoA hydratase OS=Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1) OX=269796 GN=phaJ PE=1 SV=1
4	AFDB:Q580H9	0.712	0.737	4.327E-14	162	0.298	0.309	Q580H9.pdb.gz	Q580H9_TRYB2 MaoC-like dehydratase, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb08.29O9.70 PE=4 SV=1
5	AFDB:Q9FJI2	0.719	0.728	1.468E-13	166	0.232	0.235	Q9FJI2.pdb.gz	MTHD_ARATH 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, mitochondrial OS=Arabidopsis thaliana OX=3702 GN=MTHD PE=1 SV=1
6	AFDB:A0A3Q7HWE4	0.710	0.722	3.947E-13	165	0.238	0.242	A0A3Q7HWE4.pdb.gz	FERN_SOLLC 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FERN, mitochondrial OS=Solanum lycopersicum OX=4081 GN=FERN PE=1 SV=1
7	AFDB:P71860	0.669	0.857	7.601E-10	129	0.149	0.194	P71860.pdb.gz	P71860_MYCTO Beta-hydroxyacyl-ACP dehydratase OS=Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) OX=83331 GN=MT3645 PE=4 SV=1
8	AFDB:P96927	0.684	0.800	1.283E-9	142	0.173	0.204	P96927.pdb.gz	P96927_MYCTO MaoC family protein OS=Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) OX=83331 GN=MT0665 PE=1 SV=1
9	AFDB:P77455	0.707	0.187	1.928E-9	681	0.185	0.046	P77455.pdb.gz	PAAZ_ECOLI Bifunctional protein PaaZ OS=Escherichia coli (strain K12) OX=83333 GN=paaZ PE=1 SV=1
10	PDB:2c2iA	0.588	0.654	3.781E-9	149	0.208	0.235	2c2iA.pdb.gz
11	PDB:6jqmA	0.654	0.175	1.619E-8	678	0.185	0.046	6jqmA.pdb.gz	Molecular basis for metabolite channeling in a ring opening enzyme of the phenylacetate degradation pathway.
12	AFDB:P9WNP3	0.602	0.660	1.660E-8	151	0.202	0.225	P9WNP3.pdb.gz	HTDZ_MYCTU 3-hydroxyacyl-thioester dehydratase Z OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=htdZ PE=1 SV=1
13	PDB:7mkuA	0.594	0.348	4.352E-8	302	0.196	0.109	7mkuA.pdb.gz
14	PDB:4rltA	0.567	0.608	1.565E-7	155	0.119	0.129	4rltA.pdb.gz	Molecular basis for the inhibition of beta-hydroxyacyl-ACP dehydratase HadAB complex from Mycobacterium tuberculosis by flavonoid inhibitors.
15	PDB:3p3iA	0.574	0.698	3.746E-7	135	0.131	0.163	3p3iA.pdb.gz	Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity.
16	PDB:5zy8C	0.630	0.757	5.011E-7	137	0.119	0.146	5zy8C.pdb.gz
17	PDB:3omlA	0.583	0.201	1.513E-6	532	0.196	0.062	3omlA.pdb.gz
18	PDB:4e3eA	0.597	0.304	3.417E-6	351	0.137	0.066	4e3eA.pdb.gz
19	PDB:4k00A	0.471	0.564	5.135E-6	137	0.095	0.117	4k00A.pdb.gz
20	PDB:4ordA	0.479	0.572	1.229E-5	138	0.125	0.152	4ordA.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	L0R6P0	2.41e-123	345	168	1.000	1.000	L0R6P0_HUMAN Alternative protein RPP14 OS=Homo sapiens OX=9606 GN=RPP14 PE=4 SV=1
2	P86397	2.41e-123	345	168	1.000	1.000	HTD2_HUMAN Hydroxyacyl-thioester dehydratase type 2, mitochondrial OS=Homo sapiens OX=9606 GN=HTD2 PE=1 SV=1
3	C5AZ74	4.18e-33	117	157	0.369	0.395	CROR_METEA 3-hydroxybutyryl-CoA dehydratase OS=Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1) OX=272630 GN=croR PE=4 SV=1
4	Q2RQ36	4.75e-28	103	144	0.345	0.403	PHAJ_RHORT (R)-specific enoyl-CoA hydratase OS=Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1) OX=269796 GN=phaJ PE=1 SV=1
5	Q580H9	9.02e-26	98.2	162	0.298	0.309	Q580H9_TRYB2 MaoC-like dehydratase, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb08.29O9.70 PE=4 SV=1
6	Q9FJI2	4.70e-17	75.9	166	0.220	0.223	MTHD_ARATH 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, mitochondrial OS=Arabidopsis thaliana OX=3702 GN=MTHD PE=1 SV=1
7	A0A3Q7HWE4	2.82e-16	73.9	165	0.232	0.236	FERN_SOLLC 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FERN, mitochondrial OS=Solanum lycopersicum OX=4081 GN=FERN PE=1 SV=1
8	P96927	6.92e-06	45.8	142	0.143	0.169	P96927_MYCTO MaoC family protein OS=Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) OX=83331 GN=MT0665 PE=1 SV=1
9	Q8AYH1	1.33e-05	46.6	725	0.208	0.048	Q8AYH1_DANRE 17-beta-hydroxysteroid dehydrogenase type 4 OS=Danio rerio OX=7955 GN=Dbp PE=1 SV=1
10	A0A1D8PJ13	1.37e-05	46.6	906	0.125	0.023	A0A1D8PJ13_CANAL Bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=FOX2 PE=3 SV=1
11	Q8VYI3	3.19e-05	45.1	309	0.214	0.117	ECH2_ARATH Enoyl-CoA hydratase 2, peroxisomal OS=Arabidopsis thaliana OX=3702 GN=ECH2 PE=1 SV=1
12	Q02207	9.43e-05	43.9	900	0.161	0.030	FOX2_YEAST Peroxisomal hydratase-dehydrogenase-epimerase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=FOX2 PE=2 SV=1
13	P9WNP3	0.002	38.9	151	0.155	0.172	HTDZ_MYCTU 3-hydroxyacyl-thioester dehydratase Z OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=htdZ PE=1 SV=1
14	P51660	0.003	39.7	735	0.143	0.033	DHB4_MOUSE Peroxisomal multifunctional enzyme type 2 OS=Mus musculus OX=10090 GN=Hsd17b4 PE=1 SV=3
15	P07149	0.012	37.7	2051	0.083	0.007	FAS1_YEAST Fatty acid synthase subunit beta OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=FAS1 PE=1 SV=2
16	P97852	0.018	37.4	735	0.137	0.031	DHB4_RAT Peroxisomal multifunctional enzyme type 2 OS=Rattus norvegicus OX=10116 GN=Hsd17b4 PE=1 SV=3
17	Q19058	0.018	37.0	298	0.179	0.101	Q19058_CAEEL MaoC-like domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=maoc-1 PE=1 SV=1
18	Q5AQM2	0.034	36.6	2093	0.077	0.006	Q5AQM2_EMENI Fatty acid synthase, beta subunit OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=ANIA_09408 PE=3 SV=1
19	Q9VXJ0	0.034	36.6	598	0.131	0.037	DHB4_DROME Peroxisomal multifunctional enzyme type 2 OS=Drosophila melanogaster OX=7227 GN=Mfe2 PE=1 SV=1
20	P77455	0.036	36.2	681	0.107	0.026	PAAZ_ECOLI Bifunctional protein PaaZ OS=Escherichia coli (strain K12) OX=83333 GN=paaZ PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF03061 4HBT	1.9e+02	13.8	Thioesterase superfamily
2	PF01575 MaoC_dehydratas	1.4e-14	65.2	MaoC like domain
3	PF13452 MaoC_dehydrat_N	15	17.2	N-terminal half of MaoC dehydratase

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000481593

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000360569	0.931	Non-specific lipid-transfer protein
2	9606.ENSP00000303525	0.917	Carbonyl reductase family member 4
3	9606.ENSP00000363794	0.917	Estradiol 17-beta-dehydrogenase 8
4	9606.ENSP00000263702	0.914	Enoyl-[acyl-carrier-protein] reductase, mitochondrial
5	9606.ENSP00000304592	0.911	Fatty acid synthase
6	9606.ENSP00000315013	0.799	Carnitine O-acetyltransferase
7	9606.ENSP00000337103	0.799	Choline O-acetyltransferase
8	9606.ENSP00000333664	0.787	3-ketoacyl-CoA thiolase, peroxisomal
9	9606.ENSP00000412894	0.783	Ribonuclease P protein subunit p14
10	9606.ENSP00000359211	0.711	Dihydropyrimidine dehydrogenase [NADP(+)]
11	9606.ENSP00000369461	0.690	Enoyl-CoA delta isomerase 2, mitochondrial
12	9606.ENSP00000356563	0.660	Peroxisomal biogenesis factor 3
13	9606.ENSP00000389813	0.654	Acyl-CoA dehydrogenase family member 10
14	9606.ENSP00000450353	0.645	Uncharacterized protein
15	9606.ENSP00000391601	0.641	Peroxisomal targeting signal 1 receptor
16	9606.ENSP00000419975	0.641	PEX5-related protein
17	9606.ENSP00000348775	0.636	Peroxisomal acyl-coenzyme A oxidase 3
18	9606.ENSP00000407761	0.636	Acyl-coenzyme A oxidase-like protein
19	9606.ENSP00000218104	0.623	ATP-binding cassette sub-family D member 1
20	9606.ENSP00000310688	0.623	ATP-binding cassette sub-family D member 2

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0016836	1.000	hydro-lyase activity
GO:0005515	0.969	protein binding
GO:0042802	0.379	identical protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0009987	0.996	cellular process
GO:0044238	0.993	primary metabolic process
GO:0044237	0.992	cellular metabolic process
GO:0044281	0.985	small molecule metabolic process
GO:1901564	0.985	organonitrogen compound metabolic process
GO:0035337	0.978	fatty-acyl-CoA metabolic process
GO:1901570	0.976	fatty acid derivative biosynthetic process
GO:0071616	0.976	acyl-CoA biosynthetic process
GO:0006082	0.599	organic acid metabolic process
GO:0019752	0.471	carboxylic acid metabolic process
GO:0006631	0.335	fatty acid metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005739	1.000	mitochondrion
GO:0005730	1.000	nucleolus
GO:0005759	0.969	mitochondrial matrix
GO:0016020	0.333	membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:4.2.1.-	1.000	Hydro-lyases.

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