StarFunc result for job id Q00536

User Input

>input (496 residues)
MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSAR
GPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSL
PADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVY
KGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVF
EYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL
KLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRP
LFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGA
DLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS
MPDSGRPAFRVVDTEF

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q07002	0.742	0.776	2.753E-59	474	0.597	0.624	Q07002.pdb.gz	CDK18_HUMAN Cyclin-dependent kinase 18 OS=Homo sapiens OX=9606 GN=CDK18 PE=1 SV=4
2	AFDB:Q7KM03	0.631	0.600	1.233E-41	522	0.446	0.423	Q7KM03.pdb.gz	Q7KM03_DROME Ecdysone-induced protein 63E, isoform G OS=Drosophila melanogaster OX=7227 GN=Eip63E PE=1 SV=1
3	AFDB:O35495	0.621	0.655	9.578E-40	469	0.427	0.452	O35495.pdb.gz	CDK14_MOUSE Cyclin-dependent kinase 14 OS=Mus musculus OX=10090 GN=Cdk14 PE=1 SV=2
4	AFDB:Q96Q40	0.613	0.696	5.173E-39	435	0.395	0.451	Q96Q40.pdb.gz	CDK15_HUMAN Cyclin-dependent kinase 15 OS=Homo sapiens OX=9606 GN=CDK15 PE=1 SV=2
5	AFDB:P34117	0.555	0.932	2.652E-35	292	0.359	0.610	P34117.pdb.gz	CDK5_DICDI Cyclin-dependent kinase 5 homolog OS=Dictyostelium discoideum OX=44689 GN=cdk5 PE=2 SV=2
6	AFDB:A0A1D8PDA6	0.565	0.835	2.214E-34	332	0.347	0.518	A0A1D8PDA6.pdb.gz	A0A1D8PDA6_CANAL Cyclin-dependent serine/threonine-protein kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=PHO85 PE=3 SV=1
7	AFDB:G5EAZ1	0.552	0.742	5.894E-34	366	0.341	0.462	G5EAZ1.pdb.gz	G5EAZ1_EMENI Protein kinase domain-containing protein OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=ANIA_08261 PE=3 SV=1
8	AFDB:O74456	0.544	0.925	9.109E-34	288	0.333	0.573	O74456.pdb.gz	PEF1_SCHPO Serine/threonine-protein kinase pef1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=pef1 PE=3 SV=2
9	AFDB:P23437	0.549	0.904	1.054E-32	297	0.319	0.532	P23437.pdb.gz	CDK2_XENLA Cyclin-dependent kinase 2 OS=Xenopus laevis OX=8355 GN=cdk2 PE=1 SV=3
10	AFDB:P24100	0.549	0.909	1.816E-32	294	0.323	0.544	P24100.pdb.gz	CDKA1_ARATH Cyclin-dependent kinase A-1 OS=Arabidopsis thaliana OX=3702 GN=CDKA-1 PE=1 SV=1
11	PDB:1unlA	0.524	0.873	6.249E-32	292	0.331	0.562	1unlA.pdb.gz	Mechanism of Cdk5/P25 Binding by Cdk Inhibitors
12	PDB:4gcjA	0.535	0.852	4.678E-31	304	0.321	0.523	4gcjA.pdb.gz	Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
13	PDB:4krcA	0.524	0.857	1.549E-30	297	0.321	0.535	4krcA.pdb.gz	New Structural Insights into Phosphorylation-free Mechanism for Full Cyclin-dependent Kinase (CDK)-Cyclin Activity and Substrate Recognition.
14	PDB:4yc3A	0.547	0.902	3.317E-30	295	0.306	0.515	4yc3A.pdb.gz
15	PDB:4ek6A	0.505	0.879	4.354E-30	279	0.298	0.530	4ek6A.pdb.gz	Crystal structure of the cdk2 in complex with aminopyrazole inhibitor
16	PDB:4eomC	0.483	0.852	8.237E-26	276	0.300	0.540	4eomC.pdb.gz	An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity.
17	PDB:1blxA	0.518	0.815	1.251E-24	305	0.254	0.413	1blxA.pdb.gz	Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d.
18	PDB:3mi9A	0.527	0.776	6.060E-24	329	0.248	0.374	3mi9A.pdb.gz	Crystal structure of HIV-1 Tat complexed with human P-TEFb.
19	PDB:6dtlB	0.515	0.703	1.900E-23	357	0.228	0.317	6dtlB.pdb.gz
20	PDB:2zoqA	0.528	0.733	1.674E-22	352	0.216	0.304	2zoqA.pdb.gz	Crystal structure of human mono-phosphorylated ERK1 at Tyr204

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A140VK97	0.0	1017	496	1.000	1.000	A0A140VK97_HUMAN Testis secretory sperm-binding protein Li 224n OS=Homo sapiens OX=9606 PE=2 SV=1
2	E5RGN0	0.0	775	393	0.762	0.962	E5RGN0_HUMAN Cyclin dependent kinase 16 (Fragment) OS=Homo sapiens OX=9606 GN=CDK16 PE=1 SV=1
3	Q00536	0.0	1017	496	1.000	1.000	CDK16_HUMAN Cyclin-dependent kinase 16 OS=Homo sapiens OX=9606 GN=CDK16 PE=1 SV=1
4	Q00537	0.0	714	523	0.718	0.681	CDK17_HUMAN Cyclin-dependent kinase 17 OS=Homo sapiens OX=9606 GN=CDK17 PE=1 SV=2
5	Q04735	0.0	999	496	0.976	0.976	CDK16_MOUSE Cyclin-dependent kinase 16 OS=Mus musculus OX=10090 GN=Cdk16 PE=1 SV=1
6	Q07002	0.0	599	474	0.573	0.599	CDK18_HUMAN Cyclin-dependent kinase 18 OS=Homo sapiens OX=9606 GN=CDK18 PE=1 SV=4
7	Q63686	0.0	961	496	0.956	0.956	CDK16_RAT Cyclin-dependent kinase 16 OS=Rattus norvegicus OX=10116 GN=Cdk16 PE=1 SV=1
8	Q9BRL4	0.0	897	448	0.903	1.000	Q9BRL4_HUMAN PCTK1 protein OS=Homo sapiens OX=9606 GN=PCTK1 PE=1 SV=1
9	Q8I7M8	3.19e-179	520	667	0.530	0.394	CDK17_CAEEL Cyclin-dependent kinase 17 OS=Caenorhabditis elegans OX=6239 GN=pct-1 PE=1 SV=1
10	Q8MZ44	3.31e-134	394	367	0.393	0.531	Q8MZ44_DROME LD27880p OS=Drosophila melanogaster OX=7227 GN=Eip63E PE=2 SV=1
11	Q94888	4.19e-133	397	509	0.395	0.385	Q94888_DROME Serine/threonine protein kinase OS=Drosophila melanogaster OX=7227 GN=Eip63E PE=2 SV=1
12	Q7KM04	6.30e-133	396	501	0.393	0.389	Q7KM04_DROME Ecdysone-induced protein 63E, isoform H OS=Drosophila melanogaster OX=7227 GN=Eip63E PE=2 SV=1
13	Q7KM03	6.89e-133	396	522	0.393	0.374	Q7KM03_DROME Ecdysone-induced protein 63E, isoform G OS=Drosophila melanogaster OX=7227 GN=Eip63E PE=1 SV=1
14	Q9XTK9	8.84e-133	396	522	0.393	0.374	Q9XTK9_DROME Ecdysone-induced protein 63E, isoform D OS=Drosophila melanogaster OX=7227 GN=Eip63E PE=2 SV=2
15	Q7KM08	1.10e-132	395	509	0.393	0.383	Q7KM08_DROME Ecdysone-induced protein 63E, isoform F OS=Drosophila melanogaster OX=7227 GN=Eip63E PE=2 SV=1
16	Q7KM05	1.19e-132	395	509	0.393	0.383	Q7KM05_DROME Ecdysone-induced protein 63E, isoform A OS=Drosophila melanogaster OX=7227 GN=Eip63E PE=2 SV=1
17	M9PE01	1.44e-132	396	538	0.393	0.362	M9PE01_DROME Ecdysone-induced protein 63E, isoform N OS=Drosophila melanogaster OX=7227 GN=Eip63E PE=4 SV=1
18	E5RJM2	2.76e-131	380	189	0.381	1.000	E5RJM2_HUMAN Cyclin dependent kinase 16 (Fragment) OS=Homo sapiens OX=9606 GN=CDK16 PE=1 SV=1
19	O35495	3.45e-128	382	469	0.387	0.409	CDK14_MOUSE Cyclin-dependent kinase 14 OS=Mus musculus OX=10090 GN=Cdk14 PE=1 SV=2
20	O94921	1.52e-127	381	469	0.387	0.409	CDK14_HUMAN Cyclin-dependent kinase 14 OS=Homo sapiens OX=9606 GN=CDK14 PE=1 SV=3

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF03109 ABC1	3.9	18.1	ABC1 atypical kinase-like domain
2	PF01636 APH	2.5e+02	12.9	Phosphotransferase enzyme family
3	PF12330 Haspin_kinase	0.0025	28.5	Haspin like kinase domain
4	PF06293 Kdo	4.3	18.2	Lipopolysaccharide kinase (Kdo/WaaP) family
5	PF14531 Kinase-like	0.088	23.7	Kinase-like
6	PF00069 Pkinase	9.2e-68	240.0	Protein kinase domain
7	PF07714 PK_Tyr_Ser-Thr	1.1e-30	118.3	Protein tyrosine and serine/threonine kinase
8	PF07387 Seadorna_VP7	97	13.5	Seadornavirus VP7

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9593.ENSGGOP00000002459

Rank	PPI partner	STRING score	Description
1	9593.ENSGGOP00000004320	0.900	Cyclin Y
2	9593.ENSGGOP00000015116	0.862	Cell division control protein
3	9593.ENSGGOP00000007479	0.841	Cyclin B2
4	9593.ENSGGOP00000021956	0.841	Uncharacterized protein
5	9593.ENSGGOP00000027066	0.841	Cyclin B1
6	9593.ENSGGOP00000001670	0.840	Proliferating cell nuclear antigen
7	9593.ENSGGOP00000017490	0.840	Proliferating cell nuclear antigen
8	9593.ENSGGOP00000013726	0.831	Origin recognition complex, subunit 2
9	9593.ENSGGOP00000018002	0.830	Cyclin B3
10	9593.ENSGGOP00000005067	0.819	Cyclin H
11	9593.ENSGGOP00000004909	0.801	DNA helicase
12	9593.ENSGGOP00000005036	0.801	Protein kinase, membrane associated tyrosine/threonine 1
13	9593.ENSGGOP00000024568	0.788	Kinesin family member 11
14	9593.ENSGGOP00000027926	0.780	Chromatin licensing and DNA replication factor 1
15	9593.ENSGGOP00000009443	0.774	DNA helicase
16	9593.ENSGGOP00000003862	0.768	Origin recognition complex, subunit 1
17	9593.ENSGGOP00000002165	0.763	Fizzy/cell division cycle 20 related 1 (Drosophila)
18	9593.ENSGGOP00000008259	0.763	Cyclin E1
19	9593.ENSGGOP00000010165	0.763	Cell division cycle 20
20	9593.ENSGGOP00000014576	0.763	Cyclin E2

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.999	protein binding
GO:0004674	0.999	protein serine/threonine kinase activity
GO:0004693	0.773	cyclin-dependent protein serine/threonine kinase activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0065007	0.998	biological regulation
GO:0009987	0.993	cellular process
GO:0050794	0.991	regulation of cellular process
GO:0044237	0.976	cellular metabolic process
GO:0071704	0.974	organic substance metabolic process
GO:0044238	0.972	primary metabolic process
GO:0006807	0.967	nitrogen compound metabolic process
GO:0043170	0.963	macromolecule metabolic process
GO:0031323	0.851	regulation of cellular metabolic process
GO:0065008	0.821	regulation of biological quality
GO:0016310	0.729	phosphorylation
GO:1901564	0.716	organonitrogen compound metabolic process
GO:0006468	0.699	protein phosphorylation
GO:0048518	0.691	positive regulation of biological process
GO:0023051	0.669	regulation of signaling
GO:0048522	0.668	positive regulation of cellular process
GO:0010646	0.624	regulation of cell communication
GO:0007049	0.561	cell cycle
GO:0060255	0.557	regulation of macromolecule metabolic process
GO:0080090	0.535	regulation of primary metabolic process
GO:0051171	0.535	regulation of nitrogen compound metabolic process
GO:0009893	0.506	positive regulation of metabolic process
GO:0022402	0.459	cell cycle process
GO:0031325	0.445	positive regulation of cellular metabolic process
GO:0000278	0.438	mitotic cell cycle
GO:0071840	0.413	cellular component organization or biogenesis
GO:1903047	0.402	mitotic cell cycle process
GO:0016043	0.389	cellular component organization
GO:0032501	0.358	multicellular organismal process
GO:0050896	0.344	response to stimulus
GO:0051246	0.331	regulation of protein metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005737	0.999	cytoplasm
GO:0043232	0.998	intracellular non-membrane-bounded organelle
GO:0016020	0.985	membrane
GO:0005829	0.971	cytosol
GO:0005856	0.970	cytoskeleton
GO:0015630	0.961	microtubule cytoskeleton
GO:0043227	0.957	membrane-bounded organelle
GO:0043231	0.953	intracellular membrane-bounded organelle
GO:0032991	0.948	protein-containing complex
GO:0071944	0.871	cell periphery
GO:0005886	0.843	plasma membrane
GO:0005634	0.709	nucleus
GO:0070013	0.417	intracellular organelle lumen
GO:0031981	0.414	nuclear lumen
GO:0005654	0.377	nucleoplasm
GO:0012505	0.348	endomembrane system

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:2.7.1.-	0.999	Phosphotransferases with an alcohol group as acceptor.
EC:2.7.11.22	0.773	cyclin-dependent kinase.

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