StarFunc result for job id Q01658

User Input

>input (176 residues)
MASSSGNDDDLTIPRAAINKMIKETLPNVRVANDARELVVNCCTEFIHLISSEANEICNK
SEKKTISPEHVIQALESLGFGSYISEVKEVLQECKTVALKRRKASSRLENLGIPEEELLR
QQQELFAKARQQQAELAQQEWLQMQQAAQQAQLAAASASASNQAGSSQDEEDDDDI

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q01658	1.000	1.000	8.754E-26	176	1.000	1.000	Q01658.pdb.gz	NC2B_HUMAN Protein Dr1 OS=Homo sapiens OX=9606 GN=DR1 PE=1 SV=1
2	PDB:1jfiB	0.624	0.803	2.291E-18	135	0.761	0.993	1jfiB.pdb.gz	Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex.
3	AFDB:Q9VJQ5	0.644	0.621	5.420E-16	183	0.585	0.563	Q9VJQ5.pdb.gz	NC2B_DROME Protein Dr1 OS=Drosophila melanogaster OX=7227 GN=NC2beta PE=1 SV=1
4	AFDB:O14348	0.668	0.726	5.508E-12	161	0.364	0.398	O14348.pdb.gz	NC2B_SCHPO Negative cofactor 2 complex subunit beta OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=ncb2 PE=3 SV=1
5	AFDB:Q8W0W9	0.610	0.379	2.983E-11	296	0.352	0.209	Q8W0W9.pdb.gz	Q8W0W9_ORYSA Repressor protein OS=Oryza sativa OX=4530 GN=Dr1 PE=1 SV=1
6	AFDB:P49592	0.594	0.652	5.713E-11	159	0.324	0.358	P49592.pdb.gz	NC2B_ARATH Protein Dr1 homolog OS=Arabidopsis thaliana OX=3702 GN=DR1 PE=1 SV=1
7	AFDB:Q944I5	0.623	0.667	1.094E-10	163	0.330	0.356	Q944I5.pdb.gz	Q944I5_ARATH AT5g08190/T22D6_130 OS=Arabidopsis thaliana OX=3702 GN=NF-YB12 PE=1 SV=1
8	AFDB:Q5A0I6	0.624	0.728	1.168E-10	149	0.318	0.376	Q5A0I6.pdb.gz	Q5A0I6_CANAL Negative cofactor 2 transcription regulator complex subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=NCB2 PE=4 SV=1
9	AFDB:Q92317	0.609	0.720	3.760E-10	146	0.330	0.397	Q92317.pdb.gz	NCB2_YEAST Negative cofactor 2 complex subunit beta OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=NCB2 PE=1 SV=1
10	AFDB:Q75IZ7	0.579	0.469	6.559E-9	219	0.193	0.155	Q75IZ7.pdb.gz	NFYB8_ORYSJ Nuclear transcription factor Y subunit B-8 OS=Oryza sativa subsp. japonica OX=39947 GN=NFYB8 PE=1 SV=1
11	AFDB:Q9FGJ3	0.536	0.499	1.340E-8	190	0.193	0.179	Q9FGJ3.pdb.gz	NFYB2_ARATH Nuclear transcription factor Y subunit B-2 OS=Arabidopsis thaliana OX=3702 GN=NFYB2 PE=1 SV=1
12	PDB:5y27A	0.499	0.862	1.340E-6	98	0.159	0.286	5y27A.pdb.gz
13	PDB:2bykD	0.469	0.873	9.763E-5	92	0.136	0.261	2bykD.pdb.gz
14	PDB:3b0dC	0.366	0.794	4.955E-4	75	0.131	0.307	3b0dC.pdb.gz
15	PDB:6gejG	0.432	0.757	6.857E-4	96	0.091	0.167	6gejG.pdb.gz	Structure and dynamics of the yeast SWR1-nucleosome complex.
16	PDB:6wjv4	0.458	0.720	1.013E-3	107	0.125	0.206	6wjv4.pdb.gz
17	PDB:7r5sW	0.366	0.700	1.081E-3	88	0.102	0.205	7r5sW.pdb.gz	Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome.
18	PDB:7pj1B	0.366	0.500	1.153E-3	122	0.091	0.131	7pj1B.pdb.gz
19	PDB:2rvqD	0.392	0.514	1.817E-3	129	0.074	0.101	2rvqD.pdb.gz
20	PDB:7edxk	0.387	0.673	3.714E-3	98	0.085	0.153	7edxk.pdb.gz	Structural insights into preinitiation complex assembly on core promoters.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q01658	7.44e-127	355	176	1.000	1.000	NC2B_HUMAN Protein Dr1 OS=Homo sapiens OX=9606 GN=DR1 PE=1 SV=1
2	Q658N3	7.44e-127	355	176	1.000	1.000	Q658N3_HUMAN Protein Dr1 OS=Homo sapiens OX=9606 GN=DKFZp666G145 PE=1 SV=1
3	Q91WV0	5.25e-126	353	176	0.994	0.994	NC2B_MOUSE Protein Dr1 OS=Mus musculus OX=10090 GN=Dr1 PE=1 SV=1
4	Q9VJQ5	1.74e-64	197	183	0.580	0.557	NC2B_DROME Protein Dr1 OS=Drosophila melanogaster OX=7227 GN=NC2beta PE=1 SV=1
5	O14348	8.02e-39	132	161	0.358	0.391	NC2B_SCHPO Negative cofactor 2 complex subunit beta OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=ncb2 PE=3 SV=1
6	P49592	2.09e-34	120	159	0.335	0.371	NC2B_ARATH Protein Dr1 homolog OS=Arabidopsis thaliana OX=3702 GN=DR1 PE=1 SV=1
7	Q8W0W9	7.93e-33	120	296	0.330	0.196	Q8W0W9_ORYSA Repressor protein OS=Oryza sativa OX=4530 GN=Dr1 PE=1 SV=1
8	Q944I5	3.82e-32	115	163	0.341	0.368	Q944I5_ARATH AT5g08190/T22D6_130 OS=Arabidopsis thaliana OX=3702 GN=NF-YB12 PE=1 SV=1
9	Q5A0I6	2.72e-23	92.0	149	0.318	0.376	Q5A0I6_CANAL Negative cofactor 2 transcription regulator complex subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=NCB2 PE=4 SV=1
10	Q92317	1.72e-19	82.0	146	0.295	0.356	NCB2_YEAST Negative cofactor 2 complex subunit beta OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=NCB2 PE=1 SV=1
11	P63139	4.69e-16	74.3	207	0.205	0.174	NFYB_MOUSE Nuclear transcription factor Y subunit beta OS=Mus musculus OX=10090 GN=Nfyb PE=1 SV=1
12	P63140	4.69e-16	74.3	207	0.205	0.174	NFYB_RAT Nuclear transcription factor Y subunit beta OS=Rattus norvegicus OX=10116 GN=Nfyb PE=1 SV=1
13	P25208	5.27e-16	74.3	207	0.205	0.174	NFYB_HUMAN Nuclear transcription factor Y subunit beta OS=Homo sapiens OX=9606 GN=NFYB PE=1 SV=2
14	F8VSL3	5.71e-16	74.3	208	0.205	0.173	F8VSL3_HUMAN Nuclear transcription factor Y subunit beta OS=Homo sapiens OX=9606 GN=NFYB PE=1 SV=2
15	Q75IZ7	1.44e-15	73.6	219	0.193	0.155	NFYB8_ORYSJ Nuclear transcription factor Y subunit B-8 OS=Oryza sativa subsp. japonica OX=39947 GN=NFYB8 PE=1 SV=1
16	O23310	2.73e-15	71.2	161	0.188	0.205	NFYB3_ARATH Nuclear transcription factor Y subunit B-3 OS=Arabidopsis thaliana OX=3702 GN=NFYB3 PE=1 SV=1
17	Q8VYK4	1.64e-14	69.7	173	0.176	0.179	NFYB8_ARATH Nuclear transcription factor Y subunit B-8 OS=Arabidopsis thaliana OX=3702 GN=NFYB8 PE=1 SV=1
18	Q67XJ2	2.78e-14	68.9	176	0.176	0.176	NFYBA_ARATH Nuclear transcription factor Y subunit B-10 OS=Arabidopsis thaliana OX=3702 GN=NFYB10 PE=1 SV=1
19	Q5QMG3	3.04e-14	68.9	178	0.182	0.180	NFYB2_ORYSJ Nuclear transcription factor Y subunit B-2 OS=Oryza sativa subsp. japonica OX=39947 GN=NFYB2 PE=1 SV=1
20	Q9SLG0	3.36e-14	68.2	141	0.205	0.255	NFYB1_ARATH Nuclear transcription factor Y subunit B-1 OS=Arabidopsis thaliana OX=3702 GN=NFYB1 PE=1 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00808 CBFD_NFYB_HMF	8.3e-20	82.1	Histone-like transcription factor (CBF/NF-Y) and archaeal histone
2	PF15510 CENP-W	32	16.2	CENP-W protein
3	PF00125 Histone	0.067	24.9	Core histone H2A/H2B/H3/H4
4	PF20436 LonB_AAA-LID	9.5	17.6	Archaeal LonB, AAA+ ATPase LID domain
5	PF15969 RexA	1.9e+02	13.0	Intracellular sensor of Lambda phage, Abi component
6	PF04092 SAG	1.3e+02	14.8	SRS domain
7	PF12140 SLED	1.2e+02	14.6	SLED domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 482537.XP_008570265.1

Rank	PPI partner	STRING score	Description
1	482537.XP_008588463.1	0.998	Dr1-associated corepressor
2	482537.XP_008577259.1	0.989	SAGA-associated factor 29 homolog
3	482537.XP_008583441.1	0.988	Cysteine-rich protein 2-binding protein isoform X1
4	482537.XP_008572389.1	0.986	WD repeat-containing protein 5 isoform X1
5	482537.XP_008566962.1	0.984	DNA polymerase epsilon subunit 3
6	482537.XP_008566281.1	0.983	Transcriptional adapter 2-alpha isoform X1
7	482537.XP_008566570.1	0.977	Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 3 mRNAs, 6 Proteins, and 99% coverage of the annotated genomic feature by RNAseq alignments
8	482537.XP_008588206.1	0.977	The sequence of the model RefSeq protein was modified relative to its source genomic sequence to represent the inferred CDS: inserted 1 base in 1 codon
9	482537.XP_008575703.1	0.971	Transcriptional adapter 3
10	482537.XP_008571744.1	0.962	Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 1 mRNA, 8 Proteins, and 97% coverage of the annotated genomic feature by RNAseq alignments, including 2 samples with support for all annotated introns
11	482537.XP_008563538.1	0.956	YEATS domain-containing protein 2-like
12	482537.XP_008572434.1	0.956	YEATS domain-containing protein 2
13	482537.XP_008576951.1	0.951	Histone acetyltransferase KAT2A isoform X1
14	482537.XP_008591743.1	0.948	Histone acetyltransferase KAT2B
15	482537.XP_008573452.1	0.931	YEATS domain-containing protein 4
16	482537.XP_008571339.1	0.916	Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 1 mRNA, 9 Proteins, and 91% coverage of the annotated genomic feature by RNAseq alignments, including 2 samples with support for all annotated introns
17	482537.XP_008565563.1	0.906	Inhibitor of growth protein 3
18	482537.XP_008578667.1	0.894	Chromatin modification-related protein MEAF6
19	482537.XP_008580551.1	0.893	ruvB-like 1
20	482537.XP_008589482.1	0.893	Mortality factor 4-like protein 1 isoform X1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0008134	0.886	transcription factor binding
GO:1901363	0.848	heterocyclic compound binding
GO:0097159	0.848	organic cyclic compound binding
GO:0003676	0.822	nucleic acid binding
GO:0003677	0.759	DNA binding
GO:0043565	0.365	sequence-specific DNA binding
GO:0003690	0.342	double-stranded DNA binding
GO:0140296	0.334	general transcription initiation factor binding
GO:0016251	0.329	RNA polymerase II general transcription initiation factor activity
GO:0017025	0.323	TBP-class protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0051726	0.995	regulation of cell cycle
GO:0051302	0.995	regulation of cell division
GO:0060255	0.990	regulation of macromolecule metabolic process
GO:0080090	0.988	regulation of primary metabolic process
GO:0051171	0.988	regulation of nitrogen compound metabolic process
GO:0031323	0.987	regulation of cellular metabolic process
GO:0071704	0.986	organic substance metabolic process
GO:0044238	0.985	primary metabolic process
GO:0009889	0.978	regulation of biosynthetic process
GO:0006807	0.973	nitrogen compound metabolic process
GO:0043170	0.961	macromolecule metabolic process
GO:0031326	0.961	regulation of cellular biosynthetic process
GO:0019219	0.948	regulation of nucleobase-containing compound metabolic process
GO:0019538	0.946	protein metabolic process
GO:0010556	0.935	regulation of macromolecule biosynthetic process
GO:0016573	0.932	histone acetylation
GO:0010468	0.912	regulation of gene expression
GO:0006355	0.890	regulation of DNA-templated transcription
GO:0043966	0.839	histone H3 acetylation
GO:0031056	0.818	regulation of histone modification
GO:0009987	0.799	cellular process
GO:0048519	0.799	negative regulation of biological process
GO:0090311	0.742	regulation of protein deacetylation
GO:0048523	0.741	negative regulation of cellular process
GO:0045995	0.730	regulation of embryonic development
GO:0006357	0.698	regulation of transcription by RNA polymerase II
GO:0009892	0.623	negative regulation of metabolic process
GO:0031063	0.494	regulation of histone deacetylation
GO:0031324	0.459	negative regulation of cellular metabolic process
GO:0009890	0.458	negative regulation of biosynthetic process
GO:0051172	0.425	negative regulation of nitrogen compound metabolic process
GO:0010605	0.388	negative regulation of macromolecule metabolic process
GO:0051253	0.372	negative regulation of RNA metabolic process
GO:0048518	0.347	positive regulation of biological process
GO:0010558	0.343	negative regulation of macromolecule biosynthetic process
GO:0031327	0.341	negative regulation of cellular biosynthetic process
GO:0044237	0.322	cellular metabolic process
GO:0048522	0.319	positive regulation of cellular process
GO:0045892	0.308	negative regulation of DNA-templated transcription
GO:0009893	0.304	positive regulation of metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0043232	0.999	intracellular non-membrane-bounded organelle
GO:0005654	0.999	nucleoplasm
GO:0032991	0.998	protein-containing complex
GO:0005694	0.992	chromosome
GO:1902494	0.989	catalytic complex
GO:0000785	0.983	chromatin
GO:0140535	0.967	intracellular protein-containing complex
GO:1990234	0.967	transferase complex
GO:1902493	0.928	acetyltransferase complex
GO:0140513	0.838	nuclear protein-containing complex
GO:0031248	0.836	protein acetyltransferase complex
GO:0000123	0.834	histone acetyltransferase complex
GO:0140672	0.794	ATAC complex
GO:0005737	0.623	cytoplasm

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

[back to server]