StarFunc result for job id Q01814

User Input

>input (1243 residues)
MGDMTNSDFYSKNQRNESSHGGEFGCTMEELRSLMELRGTEAVVKIKETYGDTEAICRRL
KTSPVEGLPGTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLG
LSFYHPPGEGNEGCATAQGGAEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFR
GLQSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESS
LTGESDQVRKSVDKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAGGEEEEKKD
KKGVKKGDGLQLPAADGAAASNAADSANASLVNGKMQDGNVDASQSKAKQQDGAAAMEMQ
PLKSAEGGDADDRKKASMHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDT
FVVNKKPWLPECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNL
VRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIPDPSSINTKTMELLIN
AIAINSAYTTKILPPEKEGALPRQVGNKTECGLLGFVLDLKQDYEPVRSQMPEEKLYKVY
TFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEMVKKV
IEPMACDGLRTICVAYRDFPSSPEPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKC
QRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEFNRRIRNEKGEIEQERIDK
IWPKLRVLARSSPTDKHTLVKGIIDSTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGIA
GTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACIT
QDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAV
YQLALIFTLLFVGEKMFQIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGER
NVFDGIFRNPIFCTIVLGTFAIQIVIVQFGGKPFSCSPLQLDQWMWCIFIGLGELVWGQV
IATIPTSRLKFLKEAGRLTQKEEIPEEELNEDVEEIDHAERELRRGQILWFRGLNRIQTQ
IRVVKAFRSSLYEGLEKPESRTSIHNFMAHPEFRIEDSQPHIPLIDDTDLEEDAALKQNS
SPPSSLNKNNSAIDSGINLTTDTSKSATSSSPGSPIHSLETSL

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A0A024RBC7	0.842	0.857	0.000	1220	0.800	0.816	A0A024RBC7.pdb.gz
2	AFDB:B7CED8	0.787	0.836	0.000	1170	0.562	0.597	B7CED8.pdb.gz	B7CED8_CAEEL Calcium-transporting ATPase OS=Caenorhabditis elegans OX=6239 GN=mca-3 PE=1 SV=1
3	AFDB:F6PDY7	0.842	0.852	0.000	1228	0.784	0.794	F6PDY7.pdb.gz	F6PDY7_DANRE Calcium-transporting ATPase OS=Danio rerio OX=7955 GN=pmca1 PE=1 SV=1
4	AFDB:G5EFR6	0.782	0.777	0.000	1252	0.507	0.503	G5EFR6.pdb.gz	MCA1_CAEEL Plasma membrane calcium-transporting ATPase mca-1 OS=Caenorhabditis elegans OX=6239 GN=mca-1 PE=1 SV=1
5	AFDB:P11506	0.941	0.941	0.000	1243	0.983	0.983	P11506.pdb.gz	AT2B2_RAT Plasma membrane calcium-transporting ATPase 2 OS=Rattus norvegicus OX=10116 GN=Atp2b2 PE=1 SV=2
6	AFDB:P23634	0.849	0.850	0.000	1241	0.714	0.716	P23634.pdb.gz	AT2B4_HUMAN Plasma membrane calcium-transporting ATPase 4 OS=Homo sapiens OX=9606 GN=ATP2B4 PE=1 SV=2
7	AFDB:Q59DP9	0.784	0.777	0.000	1255	0.578	0.573	Q59DP9.pdb.gz	Q59DP9_DROME Calcium-transporting ATPase OS=Drosophila melanogaster OX=7227 GN=PMCA PE=1 SV=3
8	AFDB:Q64568	0.838	0.828	0.000	1258	0.813	0.804	Q64568.pdb.gz	AT2B3_RAT Plasma membrane calcium-transporting ATPase 3 OS=Rattus norvegicus OX=10116 GN=Atp2b3 PE=1 SV=2
9	AFDB:Q6Q477	0.860	0.887	0.000	1205	0.705	0.727	Q6Q477.pdb.gz	AT2B4_MOUSE Plasma membrane calcium-transporting ATPase 4 OS=Mus musculus OX=10090 GN=Atp2b4 PE=1 SV=1
10	AFDB:Q95XP5	0.810	0.816	0.000	1234	0.579	0.583	Q95XP5.pdb.gz	Q95XP5_CAEEL Calcium-transporting ATPase OS=Caenorhabditis elegans OX=6239 GN=mca-3 PE=1 SV=1
11	PDB:6a69A	0.681	0.919	1.756E-94	911	0.601	0.820	6a69A.pdb.gz
12	PDB:7e7sA	0.585	0.697	1.274E-53	1020	0.221	0.270	7e7sA.pdb.gz	Cryo-EM analysis provides new mechanistic insight into ATP binding to Ca 2+ -ATPase SERCA2b.
13	PDB:5zmwA	0.587	0.713	6.168E-51	1000	0.220	0.274	5zmwA.pdb.gz	Mechanism of the E2 to E1 transition in Ca2+pump revealed by crystal structures of gating residue mutants.
14	PDB:8d3xA	0.478	0.582	9.722E-47	989	0.212	0.267	8d3xA.pdb.gz	Structural basis for gating mechanism of the human sodium-potassium pump.
15	PDB:7x20A	0.501	0.615	2.322E-46	986	0.201	0.254	7x20A.pdb.gz	Structure and function of H + /K + pump mutants reveal Na + /K + pump mechanisms.
16	PDB:3ixzA	0.491	0.597	1.071E-44	998	0.204	0.255	3ixzA.pdb.gz
17	PDB:3b8eA	0.497	0.604	2.584E-42	998	0.212	0.265	3b8eA.pdb.gz	Crystal structure of the sodium-potassium pump.
18	PDB:7vh5A	0.457	0.668	1.031E-34	804	0.152	0.235	7vh5A.pdb.gz
19	PDB:7vpkA	0.460	0.530	1.413E-32	1055	0.156	0.184	7vpkA.pdb.gz	Cryo-EM reveals mechanistic insights into lipid-facilitated polyamine export by human ATP13A2.
20	PDB:7m5xA	0.421	0.505	4.803E-31	1000	0.151	0.188	7m5xA.pdb.gz	Structural mechanisms for gating and ion selectivity of the human polyamine transporter ATP13A2.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	Bit-score	Length	ID1	ID2	Description
1	B7CED8	1350	1170	0.572	0.608	B7CED8_CAEEL Calcium-transporting ATPase OS=Caenorhabditis elegans OX=6239 GN=mca-3 PE=1 SV=1
2	E6EK15	1383	1194	0.576	0.600	E6EK15_DROME Calcium-transporting ATPase OS=Drosophila melanogaster OX=7227 GN=PMCA PE=1 SV=1
3	E6EK17	1387	1187	0.582	0.609	E6EK17_DROME Calcium-transporting ATPase OS=Drosophila melanogaster OX=7227 GN=PMCA PE=1 SV=1
4	E6EK18	1380	1210	0.577	0.593	E6EK18_DROME Calcium-transporting ATPase OS=Drosophila melanogaster OX=7227 GN=PMCA PE=1 SV=1
5	F6PDY7	1875	1228	0.776	0.785	F6PDY7_DANRE Calcium-transporting ATPase OS=Danio rerio OX=7955 GN=pmca1 PE=1 SV=1
6	F7AAP4	1688	1166	0.677	0.721	F7AAP4_MOUSE Calcium-transporting ATPase OS=Mus musculus OX=10090 GN=Atp2b4 PE=1 SV=1
7	G5E829	1935	1220	0.796	0.811	AT2B1_MOUSE Plasma membrane calcium-transporting ATPase 1 OS=Mus musculus OX=10090 GN=Atp2b1 PE=1 SV=1
8	G5EFR6	915	1252	0.374	0.371	MCA1_CAEEL Plasma membrane calcium-transporting ATPase mca-1 OS=Caenorhabditis elegans OX=6239 GN=mca-1 PE=1 SV=1
9	P11505	1930	1220	0.795	0.810	AT2B1_RAT Plasma membrane calcium-transporting ATPase 1 OS=Rattus norvegicus OX=10116 GN=Atp2b1 PE=1 SV=3
10	P11506	2536	1243	0.983	0.983	AT2B2_RAT Plasma membrane calcium-transporting ATPase 2 OS=Rattus norvegicus OX=10116 GN=Atp2b2 PE=1 SV=2
11	P20020	1913	1220	0.793	0.808	AT2B1_HUMAN Plasma membrane calcium-transporting ATPase 1 OS=Homo sapiens OX=9606 GN=ATP2B1 PE=1 SV=4
12	P23634	1785	1241	0.724	0.725	AT2B4_HUMAN Plasma membrane calcium-transporting ATPase 4 OS=Homo sapiens OX=9606 GN=ATP2B4 PE=1 SV=2
13	P54678	572	1115	0.274	0.306	ATC1_DICDI Calcium-transporting ATPase PAT1 OS=Dictyostelium discoideum OX=44689 GN=patA PE=1 SV=2
14	Q01814	2569	1243	1.000	1.000	AT2B2_HUMAN Plasma membrane calcium-transporting ATPase 2 OS=Homo sapiens OX=9606 GN=ATP2B2 PE=1 SV=2
15	Q16720	2009	1220	0.816	0.831	AT2B3_HUMAN Plasma membrane calcium-transporting ATPase 3 OS=Homo sapiens OX=9606 GN=ATP2B3 PE=1 SV=3
16	Q59DP8	1375	1120	0.575	0.638	Q59DP8_DROME Calcium-transporting ATPase OS=Drosophila melanogaster OX=7227 GN=PMCA PE=1 SV=3
17	Q59DP9	1397	1255	0.585	0.579	Q59DP9_DROME Calcium-transporting ATPase OS=Drosophila melanogaster OX=7227 GN=PMCA PE=1 SV=3
18	Q59DQ0	1393	1183	0.582	0.611	Q59DQ0_DROME Calcium-transporting ATPase OS=Drosophila melanogaster OX=7227 GN=PMCA PE=1 SV=3
19	Q64542	1739	1203	0.700	0.723	AT2B4_RAT Plasma membrane calcium-transporting ATPase 4 OS=Rattus norvegicus OX=10116 GN=Atp2b4 PE=1 SV=1
20	Q64568	2011	1258	0.816	0.806	AT2B3_RAT Plasma membrane calcium-transporting ATPase 3 OS=Rattus norvegicus OX=10116 GN=Atp2b3 PE=1 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF12424 ATP_Ca_trans_C	1.2e-22	91.4	Plasma membrane calcium transporter ATPase C terminal
2	PF13246 Cation_ATPase	1.4e-14	65.2	Cation transport ATPase (P-type)
3	PF00689 Cation_ATPase_C	1.3e-41	153.9	Cation transporting ATPase, C-terminus
4	PF00690 Cation_ATPase_N	9e-11	52.7	Cation transporter/ATPase, N-terminus
5	PF00122 E1-E2_ATPase	1.6e-28	111.0	E1-E2 ATPase
6	PF00702 Hydrolase	4.9e-11	54.9	haloacid dehalogenase-like hydrolase
7	PF08282 Hydrolase_3	0.0046	28.3	haloacid dehalogenase-like hydrolase

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000353414

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000269571	0.820	Receptor tyrosine-protein kinase erbB-2
2	9606.ENSP00000264399	0.816	cGMP-dependent protein kinase 2
3	9606.ENSP00000363092	0.812	cGMP-dependent protein kinase 1
4	9606.ENSP00000382428	0.808	Disks large homolog 4
5	9606.ENSP00000381768	0.773	Cadherin-23
6	9606.ENSP00000335153	0.757	Heat shock protein HSP 90-alpha
7	9606.ENSP00000254627	0.739	Otoconin 90
8	9606.ENSP00000262283	0.739	Otoconin-90
9	9606.ENSP00000296358	0.734	Otopetrin-1
10	9606.ENSP00000434364	0.720	Sodium- and chloride-dependent glycine transporter 2
11	9606.ENSP00000236877	0.714	Sodium/calcium exchanger 2
12	9606.ENSP00000408005	0.700	Na(+)/H(+) exchange regulatory cofactor NHE-RF2
13	9606.ENSP00000262613	0.682	Na(+)/H(+) exchange regulatory cofactor NHE-RF1
14	9606.ENSP00000359719	0.673	cAMP-dependent protein kinase catalytic subunit beta
15	9606.ENSP00000363068	0.669	Protocadherin-15
16	9606.ENSP00000365272	0.644	Disks large homolog 2
17	9606.ENSP00000384763	0.640	Sodium/calcium exchanger 1
18	9606.ENSP00000354896	0.637	Metabotropic glutamate receptor 1
19	9606.ENSP00000369981	0.636	Endophilin-A1
20	9606.ENSP00000362566	0.628	Neuron-specific calcium-binding protein hippocalcin

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.998	protein binding
GO:0005388	0.998	P-type calcium transporter activity
GO:0019904	0.747	protein domain specific binding
GO:0030165	0.713	PDZ domain binding
GO:0000166	0.454	nucleotide binding
GO:0030554	0.443	adenyl nucleotide binding
GO:0043167	0.398	ion binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.973	cellular process
GO:0032501	0.970	multicellular organismal process
GO:0051179	0.956	localization
GO:0006811	0.939	monoatomic ion transport
GO:0048731	0.928	system development
GO:0065007	0.911	biological regulation
GO:0050789	0.896	regulation of biological process
GO:0007399	0.854	nervous system development
GO:0006812	0.717	monoatomic cation transport
GO:0030001	0.712	metal ion transport
GO:0050794	0.698	regulation of cellular process
GO:0030182	0.625	neuron differentiation
GO:0048513	0.614	animal organ development
GO:0006873	0.566	intracellular monoatomic ion homeostasis
GO:0030003	0.563	intracellular monoatomic cation homeostasis
GO:0098771	0.559	inorganic ion homeostasis
GO:0007423	0.477	sensory organ development
GO:0006816	0.448	calcium ion transport
GO:0006874	0.433	intracellular calcium ion homeostasis
GO:0060041	0.419	retina development in camera-type eye
GO:0003008	0.364	system process
GO:0003407	0.344	neural retina development
GO:0051480	0.308	regulation of cytosolic calcium ion concentration

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005886	0.999	plasma membrane
GO:0005622	0.780	intracellular anatomical structure
GO:0043226	0.754	organelle
GO:0043229	0.655	intracellular organelle
GO:0043227	0.620	membrane-bounded organelle
GO:0005737	0.569	cytoplasm
GO:0043231	0.504	intracellular membrane-bounded organelle
GO:0045202	0.380	synapse

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:18105	0.998	ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate
EC:7.2.2.10	0.998	P-type Ca(2+) transporter.

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