StarFunc result for job id Q02218

User Input

>input (1023 residues)
MFHLRTCAAKLRPLTASQTVKTFSQNRPAAARTFQQIRCYSAPVAAEPFLSGTSSNYVEE
MYCAWLENPKSVHKSWDIFFRNTNAGAPPGTAYQSPLPLSRGSLAAVAHAQSLVEAQPNV
DKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSSVPADIISSTDKLGFYGLDES
DLDKVFHLPTTTFIGGQESALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIRQKFET
PGIMQFTNEEKRTLLARLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTIIDKSSEN
GVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGSGDVKYHLGMYHRRINR
VTDRNITLSLVANPSHLEAADPVVMGKTKAEQFYCGDTEGKKVMSILLHGDAAFAGQGIV
YETFHLSDLPSYTTHGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNSDDP
EAVMYVCKVAAEWRSTFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKQIRKQKPVLQKY
AELLVSQGVVNQPEYEEEISKYDKICEEAFARSKDEKILHIKHWLDSPWPGFFTLDGQPR
SMSCPSTGLTEDILTHIGNVASSVPVENFTIHGGLSRILKTRGEMVKNRTVDWALAEYMA
FGSLLKEGIHIRLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMNHLWPNQAPYTVCNSSL
SEYGVLGFELGFAMASPNALVLWEAQFGDFHNTAQCIIDQFICPGQAKWVRQNGIVLLLP
HGMEGMGPEHSSARPERFLQMCNDDPDVLPDLKEANFDINQLYDCNWVVVNCSTPGNFFH
VLRRQILLPFRKPLIIFTPKSLLRHPEARSSFDEMLPGTHFQRVIPEDGPAAQNPENVKR
LLFCTGKVYYDLTRERKARDMVGQVAITRIEQLSPFPFDLLLKEVQKYPNAELAWCQEEH
KNQGYYDYVKPRLRTTISRAKPVWYAGRDPAAAPATGNKKTHLTELQRLLDTAFDLDVFK
NFS

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A0A0R4IP01	0.885	0.886	0.000	1022	0.865	0.866	A0A0R4IP01.pdb.gz	A0A0R4IP01_DANRE oxoglutarate dehydrogenase (succinyl-transferring) OS=Danio rerio OX=7955 GN=im:7045267 PE=1 SV=1
2	AFDB:A0A2R8Q9W1	0.844	0.880	0.000	981	0.814	0.849	A0A2R8Q9W1.pdb.gz
3	AFDB:D3ZQD3	0.893	0.904	0.000	1010	0.750	0.759	D3ZQD3.pdb.gz	OGDHL_RAT 2-oxoglutarate dehydrogenase-like, mitochondrial OS=Rattus norvegicus OX=10116 GN=Ogdhl PE=1 SV=2
4	AFDB:E7EZ05	0.886	0.886	0.000	1023	0.845	0.845	E7EZ05.pdb.gz	E7EZ05_DANRE oxoglutarate dehydrogenase (succinyl-transferring) OS=Danio rerio OX=7955 GN=ogdhb PE=1 SV=1
5	AFDB:E9PCR7	0.911	0.898	0.000	1038	0.999	0.985	E9PCR7.pdb.gz	E9PCR7_HUMAN oxoglutarate dehydrogenase (succinyl-transferring) OS=Homo sapiens OX=9606 GN=OGDH PE=1 SV=1
6	AFDB:E9PFG7	0.762	0.892	0.000	873	0.824	0.966	E9PFG7.pdb.gz	E9PFG7_HUMAN oxoglutarate dehydrogenase (succinyl-transferring) OS=Homo sapiens OX=9606 GN=OGDH PE=1 SV=1
7	AFDB:O61199	0.914	0.909	0.000	1029	0.556	0.553	O61199.pdb.gz	ODO1_CAEEL 2-oxoglutarate dehydrogenase, mitochondrial OS=Caenorhabditis elegans OX=6239 GN=ogdh-1 PE=1 SV=2
8	AFDB:O74378	0.901	0.913	0.000	1009	0.458	0.465	O74378.pdb.gz	ODO1_SCHPO 2-oxoglutarate dehydrogenase, mitochondrial OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=kgd1 PE=3 SV=1
9	AFDB:F4IWV2	0.832	0.837	3.524E-103	1017	0.480	0.483	F4IWV2.pdb.gz	F4IWV2_ARATH oxoglutarate dehydrogenase (succinyl-transferring) OS=Arabidopsis thaliana OX=3702 GN=At3g55410 PE=1 SV=1
10	AFDB:P20967	0.881	0.888	4.476E-103	1014	0.449	0.453	P20967.pdb.gz	ODO1_YEAST 2-oxoglutarate dehydrogenase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=KGD1 PE=1 SV=2
11	PDB:6u3jA	0.796	0.926	9.306E-82	876	0.334	0.390	6u3jA.pdb.gz	Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex.
12	PDB:2jgdA	0.743	0.931	2.214E-70	812	0.326	0.410	2jgdA.pdb.gz	Crystal Structure of the E1 Component of the Escherichia Coli 2-Oxoglutarate Dehydrogenase Multienzyme Complex.
13	PDB:6vefA	0.765	0.922	6.751E-66	844	0.350	0.424	6vefA.pdb.gz	Cryo-EM Structure of Escherichia coli 2-oxoglutarate dehydrogenase E1 component sucA
14	PDB:1itzA	0.395	0.578	3.323E-14	666	0.098	0.150	1itzA.pdb.gz	Structure and properties of an engineered transketolase from maize
15	PDB:6rjbB	0.339	0.529	3.627E-13	622	0.074	0.122	6rjbB.pdb.gz	Low-barrier hydrogen bonds in enzyme cooperativity.
16	PDB:1ay0A	0.384	0.546	6.752E-13	678	0.080	0.121	1ay0A.pdb.gz	Identification of catalytically important residues in yeast transketolase.
17	PDB:5hhtB	0.387	0.558	7.730E-12	667	0.095	0.145	5hhtB.pdb.gz	Structural Analysis of an Evolved Transketolase Reveals Divergent Binding Modes.
18	PDB:1umbA	0.260	0.673	5.231E-11	362	0.057	0.160	1umbA.pdb.gz	Ligand-induced Conformational Changes and a Reaction Intermediate in Branched-chain 2-Oxo Acid Dehydrogenase (E1) from Thermus thermophilus HB8, as Revealed by X-ray Crystallography
19	PDB:3exeA	0.248	0.638	2.195E-10	363	0.054	0.152	3exeA.pdb.gz	Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops.
20	PDB:3rimA	0.394	0.550	2.787E-10	694	0.086	0.127	3rimA.pdb.gz	Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	Bit-score	Length	ID1	ID2	Description
1	A0A0R4IP01	1881	1022	0.865	0.866	A0A0R4IP01_DANRE oxoglutarate dehydrogenase (succinyl-transferring) OS=Danio rerio OX=7955 GN=im:7045267 PE=1 SV=1
2	A0A140VJQ5	840	427	0.394	0.944	A0A140VJQ5_HUMAN Testicular tissue protein Li 131 OS=Homo sapiens OX=9606 PE=2 SV=1
3	A2ATU0	589	921	0.350	0.389	DHTK1_MOUSE 2-oxoadipate dehydrogenase complex component E1 OS=Mus musculus OX=10090 GN=Dhtkd1 PE=1 SV=1
4	B8JI08	1884	1022	0.867	0.868	B8JI08_DANRE oxoglutarate dehydrogenase (succinyl-transferring) OS=Danio rerio OX=7955 GN=im:7045267 PE=1 SV=1
5	D3ZQD3	1636	1010	0.751	0.760	OGDHL_RAT 2-oxoglutarate dehydrogenase-like, mitochondrial OS=Rattus norvegicus OX=10116 GN=Ogdhl PE=1 SV=2
6	E7EZ05	1844	1023	0.845	0.845	E7EZ05_DANRE oxoglutarate dehydrogenase (succinyl-transferring) OS=Danio rerio OX=7955 GN=ogdhb PE=1 SV=1
7	E9PCR7	2138	1038	1.000	0.986	E9PCR7_HUMAN oxoglutarate dehydrogenase (succinyl-transferring) OS=Homo sapiens OX=9606 GN=OGDH PE=1 SV=1
8	E9PDF2	2099	1034	0.981	0.971	E9PDF2_HUMAN oxoglutarate dehydrogenase (succinyl-transferring) OS=Homo sapiens OX=9606 GN=OGDH PE=1 SV=1
9	E9PFG7	1607	873	0.746	0.874	E9PFG7_HUMAN oxoglutarate dehydrogenase (succinyl-transferring) OS=Homo sapiens OX=9606 GN=OGDH PE=1 SV=1
10	F1Q5B8	1842	1019	0.850	0.854	F1Q5B8_DANRE oxoglutarate dehydrogenase (succinyl-transferring) OS=Danio rerio OX=7955 GN=im:7045267 PE=1 SV=3
11	F4IWV2	945	1017	0.489	0.492	F4IWV2_ARATH oxoglutarate dehydrogenase (succinyl-transferring) OS=Arabidopsis thaliana OX=3702 GN=At3g55410 PE=1 SV=1
12	O61199	1203	1029	0.562	0.559	ODO1_CAEEL 2-oxoglutarate dehydrogenase, mitochondrial OS=Caenorhabditis elegans OX=6239 GN=ogdh-1 PE=1 SV=2
13	O74378	912	1009	0.464	0.471	ODO1_SCHPO 2-oxoglutarate dehydrogenase, mitochondrial OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=kgd1 PE=3 SV=1
14	P0AFG3	648	933	0.370	0.406	ODO1_ECOLI 2-oxoglutarate dehydrogenase E1 component OS=Escherichia coli (strain K12) OX=83333 GN=sucA PE=1 SV=1
15	P20967	862	1014	0.459	0.464	ODO1_YEAST 2-oxoglutarate dehydrogenase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=KGD1 PE=1 SV=2
16	P9WIS5	664	1231	0.370	0.307	KGD_MYCTU Multifunctional 2-oxoglutarate metabolism enzyme OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=kgd PE=1 SV=1
17	Q02218	2147	1023	1.000	1.000	ODO1_HUMAN 2-oxoglutarate dehydrogenase complex component E1 OS=Homo sapiens OX=9606 GN=OGDH PE=1 SV=3
18	Q383T1	665	1005	0.393	0.400	Q383T1_TRYB2 oxoglutarate dehydrogenase (succinyl-transferring) OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb11.01.1740 PE=3 SV=1
19	Q387A7	610	1008	0.367	0.372	Q387A7_TRYB2 2-oxoglutarate dehydrogenase subunit, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb11.47.0004 PE=3 SV=1
20	Q54VG0	681	900	0.362	0.411	DHTK1_DICDI Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial OS=Dictyostelium discoideum OX=44689 GN=odhA PE=3 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF16078 2-oxogl_dehyd_N	2.7e-15	66.9	2-oxoglutarate dehydrogenase N-terminus
2	PF00676 E1_dh	1.3e-98	341.2	Dehydrogenase E1 component
3	PF18308 GGA_N-GAT	1.5e+02	13.4	N-terminal extension of GAT domain
4	PF16870 OxoGdeHyase_C	1.1e-51	186.0	2-oxoglutarate dehydrogenase C-terminal
5	PF18299 R2K_2	3.2e+02	12.6	ATP-grasp domain, R2K clade family 2
6	PF02779 Transket_pyr	9e-63	222.7	Transketolase, pyrimidine binding domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000222673

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000335304	0.999	Dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
2	9606.ENSP00000205402	0.998	Dihydrolipoyl dehydrogenase, mitochondrial
3	9606.ENSP00000280346	0.992	Dihydrolipoamide S-acetyltransferase
4	9606.ENSP00000299518	0.988	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
5	9606.ENSP00000377446	0.985	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
6	9606.ENSP00000370223	0.982	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
7	9606.ENSP00000217901	0.981	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
8	9606.ENSP00000227868	0.978	Pyruvate dehydrogenase protein X component, mitochondrial
9	9606.ENSP00000331897	0.974	Isocitrate dehydrogenase [NADP], mitochondrial
10	9606.ENSP00000390265	0.970	Isocitrate dehydrogenase 1, cytosolic
11	9606.ENSP00000369134	0.966	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
12	9606.ENSP00000359151	0.963	Dihydrolipoamide branched chain transacylase E2
13	9606.ENSP00000264932	0.960	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
14	9606.ENSP00000355518	0.958	Fumarate hydratase, mitochondrial
15	9606.ENSP00000307241	0.957	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
16	9606.ENSP00000367923	0.957	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
17	9606.ENSP00000216254	0.944	Aconitate hydratase, mitochondrial
18	9606.ENSP00000277865	0.933	Glutamate dehydrogenase 1, mitochondrial
19	9606.ENSP00000342056	0.931	Citrate synthase, mitochondrial
20	9606.ENSP00000364649	0.929	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0016903	1.000	oxidoreductase activity, acting on the aldehyde or oxo group of donors
GO:0016624	0.992	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0043167	0.946	ion binding
GO:0043169	0.920	cation binding
GO:0004591	0.800	oxoglutarate dehydrogenase (succinyl-transferring) activity
GO:1901363	0.402	heterocyclic compound binding
GO:0046872	0.369	metal ion binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.969	cellular process
GO:0044237	0.937	cellular metabolic process
GO:0071704	0.932	organic substance metabolic process
GO:0044238	0.905	primary metabolic process
GO:0032501	0.809	multicellular organismal process
GO:0044281	0.782	small molecule metabolic process
GO:0006807	0.700	nitrogen compound metabolic process
GO:1901564	0.602	organonitrogen compound metabolic process
GO:0019752	0.475	carboxylic acid metabolic process
GO:0006091	0.464	generation of precursor metabolites and energy
GO:0015980	0.345	energy derivation by oxidation of organic compounds
GO:1901360	0.330	organic cyclic compound metabolic process
GO:0043648	0.308	dicarboxylic acid metabolic process
GO:0046483	0.304	heterocycle metabolic process
GO:0034641	0.304	cellular nitrogen compound metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005739	0.999	mitochondrion
GO:0032991	0.990	protein-containing complex
GO:0070013	0.969	intracellular organelle lumen
GO:1902494	0.875	catalytic complex
GO:1990204	0.817	oxidoreductase complex
GO:0005759	0.536	mitochondrial matrix
GO:1990234	0.442	transferase complex
GO:0045239	0.413	tricarboxylic acid cycle enzyme complex
GO:0045240	0.369	dihydrolipoyl dehydrogenase complex

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:1.2.-.-	1.000	Acting on the aldehyde or oxo group of donors.
EC:1.2.4.-	0.992	With a disulfide as acceptor.
RHEA:12188	0.800	(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2
EC:1.2.4.2	0.800	oxoglutarate dehydrogenase (succinyl-transferring).

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