StarFunc result for job id Q02750

User Input

>input (393 residues)
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A4QPA9	0.907	0.907	2.291E-66	393	1.000	1.000	A4QPA9.pdb.gz	A4QPA9_HUMAN Mitogen-activated protein kinase kinase 1 OS=Homo sapiens OX=9606 GN=MAP2K1 PE=2 SV=1
2	AFDB:Q63932	0.947	0.929	2.814E-60	401	0.814	0.798	Q63932.pdb.gz	MP2K2_MOUSE Dual specificity mitogen-activated protein kinase kinase 2 OS=Mus musculus OX=10090 GN=Map2k2 PE=1 SV=2
3	PDB:3eqdA	0.790	0.984	2.557E-51	315	0.799	0.997	3eqdA.pdb.gz	Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors.
4	AFDB:Q24324	0.873	0.867	1.320E-48	396	0.621	0.616	Q24324.pdb.gz	DSOR1_DROME Dual specificity mitogen-activated protein kinase kinase dSOR1 OS=Drosophila melanogaster OX=7227 GN=Dsor1 PE=1 SV=2
5	PDB:5eymA	0.736	0.987	2.579E-43	292	0.743	1.000	5eymA.pdb.gz	Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases.
6	AFDB:Q10664	0.811	0.822	2.758E-42	387	0.504	0.512	Q10664.pdb.gz	MEK2_CAEEL Dual specificity mitogen-activated protein kinase kinase mek-2 OS=Caenorhabditis elegans OX=6239 GN=mek-2 PE=1 SV=1
7	AFDB:Q5B7Q8	0.701	0.515	1.343E-32	539	0.402	0.293	Q5B7Q8.pdb.gz	Q5B7Q8_EMENI MAP kinase kinase (Eurofung) OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=ANIA_03422 PE=4 SV=1
8	AFDB:G4NEB8	0.720	0.682	1.661E-32	415	0.394	0.373	G4NEB8.pdb.gz	MST7_MAGO7 Mitogen-activated protein kinase kinae MST7 OS=Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) OX=242507 GN=MST7 PE=1 SV=1
9	AFDB:A9JRD0	0.684	0.599	1.066E-31	450	0.351	0.307	A9JRD0.pdb.gz	A9JRD0_DANRE Dual specificity mitogen-activated protein kinase kinase 5 OS=Danio rerio OX=7955 GN=zgc:172137 PE=2 SV=1
10	AFDB:Q13163	0.691	0.607	1.318E-31	448	0.354	0.310	Q13163.pdb.gz	MP2K5_HUMAN Dual specificity mitogen-activated protein kinase kinase 5 OS=Homo sapiens OX=9606 GN=MAP2K5 PE=1 SV=2
11	AFDB:Q94A06	0.685	0.758	1.163E-30	354	0.305	0.339	Q94A06.pdb.gz	M2K1_ARATH Mitogen-activated protein kinase kinase 1 OS=Arabidopsis thaliana OX=3702 GN=MKK1 PE=1 SV=2
12	AFDB:P10506	0.675	0.777	4.880E-30	340	0.384	0.444	P10506.pdb.gz	BYR1_SCHPO Protein kinase byr1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=byr1 PE=1 SV=1
13	PDB:8a8mB	0.588	0.762	5.382E-20	298	0.295	0.389	8a8mB.pdb.gz	Architecture of the MKK6-p38 alpha complex defines the basis of MAPK specificity and activation.
14	PDB:6s73A	0.589	0.843	1.070E-16	269	0.216	0.316	6s73A.pdb.gz	Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine.
15	PDB:1blxA	0.495	0.624	4.992E-16	305	0.196	0.252	1blxA.pdb.gz	Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d.
16	PDB:4c0tA	0.547	0.719	4.992E-16	291	0.170	0.230	4c0tA.pdb.gz
17	PDB:4eomC	0.514	0.714	6.510E-16	276	0.181	0.257	4eomC.pdb.gz	An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity.
18	PDB:4ek6A	0.517	0.719	1.107E-15	279	0.188	0.265	4ek6A.pdb.gz	Crystal structure of the cdk2 in complex with aminopyrazole inhibitor
19	PDB:4krcA	0.516	0.674	2.456E-15	297	0.214	0.283	4krcA.pdb.gz	New Structural Insights into Phosphorylation-free Mechanism for Full Cyclin-dependent Kinase (CDK)-Cyclin Activity and Substrate Recognition.
20	PDB:1unlA	0.494	0.653	3.961E-15	292	0.178	0.240	1unlA.pdb.gz	Mechanism of Cdk5/P25 Binding by Cdk Inhibitors

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A4QPA9	0.0	810	393	1.000	1.000	A4QPA9_HUMAN Mitogen-activated protein kinase kinase 1 OS=Homo sapiens OX=9606 GN=MAP2K1 PE=2 SV=1
2	P29678	0.0	808	393	0.997	0.997	MP2K1_RABIT Dual specificity mitogen-activated protein kinase kinase 1 OS=Oryctolagus cuniculus OX=9986 GN=MAP2K1 PE=1 SV=2
3	P31938	0.0	805	393	0.990	0.990	MP2K1_MOUSE Dual specificity mitogen-activated protein kinase kinase 1 OS=Mus musculus OX=10090 GN=Map2k1 PE=1 SV=2
4	P36506	0.0	626	400	0.807	0.792	MP2K2_RAT Dual specificity mitogen-activated protein kinase kinase 2 OS=Rattus norvegicus OX=10116 GN=Map2k2 PE=1 SV=1
5	P36507	0.0	630	400	0.812	0.797	MP2K2_HUMAN Dual specificity mitogen-activated protein kinase kinase 2 OS=Homo sapiens OX=9606 GN=MAP2K2 PE=1 SV=1
6	Q01986	0.0	806	393	0.992	0.992	MP2K1_RAT Dual specificity mitogen-activated protein kinase kinase 1 OS=Rattus norvegicus OX=10116 GN=Map2k1 PE=1 SV=2
7	Q02750	0.0	810	393	1.000	1.000	MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 OS=Homo sapiens OX=9606 GN=MAP2K1 PE=1 SV=2
8	Q63932	0.0	628	401	0.799	0.783	MP2K2_MOUSE Dual specificity mitogen-activated protein kinase kinase 2 OS=Mus musculus OX=10090 GN=Map2k2 PE=1 SV=2
9	I3L5D4	1.06e-180	506	302	0.641	0.834	I3L5D4_PIG Mitogen-activated protein kinase kinase 2 OS=Sus scrofa OX=9823 GN=MAP2K2 PE=1 SV=3
10	Q24324	3.93e-176	498	396	0.608	0.604	DSOR1_DROME Dual specificity mitogen-activated protein kinase kinase dSOR1 OS=Drosophila melanogaster OX=7227 GN=Dsor1 PE=1 SV=2
11	Q10664	3.29e-136	396	387	0.501	0.509	MEK2_CAEEL Dual specificity mitogen-activated protein kinase kinase mek-2 OS=Caenorhabditis elegans OX=6239 GN=mek-2 PE=1 SV=1
12	G4NEB8	3.40e-93	287	415	0.377	0.357	MST7_MAGO7 Mitogen-activated protein kinase kinae MST7 OS=Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) OX=242507 GN=MST7 PE=1 SV=1
13	Q5B7Q8	6.84e-91	285	539	0.377	0.275	Q5B7Q8_EMENI MAP kinase kinase (Eurofung) OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=ANIA_03422 PE=4 SV=1
14	Q13163	2.85e-86	271	448	0.356	0.312	MP2K5_HUMAN Dual specificity mitogen-activated protein kinase kinase 5 OS=Homo sapiens OX=9606 GN=MAP2K5 PE=1 SV=2
15	Q62862	1.27e-85	269	448	0.354	0.310	MP2K5_RAT Dual specificity mitogen-activated protein kinase kinase 5 OS=Rattus norvegicus OX=10116 GN=Map2k5 PE=1 SV=1
16	Q9WVS7	1.42e-85	269	448	0.354	0.310	MP2K5_MOUSE Dual specificity mitogen-activated protein kinase kinase 5 OS=Mus musculus OX=10090 GN=Map2k5 PE=1 SV=1
17	P10506	3.26e-85	264	340	0.389	0.450	BYR1_SCHPO Protein kinase byr1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=byr1 PE=1 SV=1
18	B1NA67	3.25e-83	263	449	0.346	0.303	B1NA67_DANRE Dual specificity mitogen-activated protein kinase kinase 5 isoform X1 OS=Danio rerio OX=7955 GN=wu:fb73f02 PE=2 SV=1
19	A9JRD0	5.25e-83	262	450	0.338	0.296	A9JRD0_DANRE Dual specificity mitogen-activated protein kinase kinase 5 OS=Danio rerio OX=7955 GN=zgc:172137 PE=2 SV=1
20	P33886	5.73e-81	261	605	0.346	0.225	WIS1_SCHPO Protein kinase wis1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=wis1 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF03109 ABC1	0.00077	30.2	ABC1 atypical kinase-like domain
2	PF12330 Haspin_kinase	1.1e+02	13.2	Haspin like kinase domain
3	PF14531 Kinase-like	42	14.9	Kinase-like
4	PF08030 NAD_binding_6	6.6e+02	11.8	Ferric reductase NAD binding domain
5	PF00069 Pkinase	5e-59	211.4	Protein kinase domain
6	PF17667 Pkinase_fungal	0.0068	26.9	Fungal protein kinase
7	PF07714 PK_Tyr_Ser-Thr	2.2e-31	120.7	Protein tyrosine and serine/threonine kinase
8	PF07387 Seadorna_VP7	55	14.3	Seadornavirus VP7

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 132908.ENSPVAP00000000060

Rank	PPI partner	STRING score	Description
1	132908.ENSPVAP00000005021	0.959	A-Raf proto-oncogene, serine/threonine kinase
2	132908.ENSPVAP00000009950	0.951	Mitogen-activated protein kinase 3
3	132908.ENSPVAP00000005507	0.949	Raf-1 proto-oncogene, serine/threonine kinase
4	132908.ENSPVAP00000013894	0.927	Kinase suppressor of ras 1
5	132908.ENSPVAP00000009314	0.921	P21 protein (Cdc42/Rac)-activated kinase 2
6	132908.ENSPVAP00000014843	0.916	B-Raf proto-oncogene, serine/threonine kinase
7	132908.ENSPVAP00000012891	0.908	Kirsten rat sarcoma viral oncogene homolog
8	132908.ENSPVAP00000009165	0.904	Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
9	132908.ENSPVAP00000007771	0.901	Neuroblastoma RAS viral (v-ras) oncogene homolog
10	132908.ENSPVAP00000007367	0.885	Mitogen-activated protein kinase kinase kinase 8
11	132908.ENSPVAP00000012944	0.882	P21 protein (Cdc42/Rac)-activated kinase 4
12	132908.ENSPVAP00000012319	0.880	Kinase suppressor of ras 2
13	132908.ENSPVAP00000016672	0.875	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
14	132908.ENSPVAP00000006043	0.869	V-mos Moloney murine sarcoma viral oncogene homolog
15	132908.ENSPVAP00000002648	0.866	Mitogen-activated protein kinase 10
16	132908.ENSPVAP00000012866	0.865	Mitogen-activated protein kinase 1
17	132908.ENSPVAP00000016560	0.865	Protein kinase, cAMP-dependent, catalytic, alpha
18	132908.ENSPVAP00000005409	0.859	Mitogen-activated protein kinase kinase kinase 7
19	132908.ENSPVAP00000001083	0.857	P21 protein (Cdc42/Rac)-activated kinase 1
20	132908.ENSPVAP00000014118	0.855	Mitogen-activated protein kinase 13

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.999	protein binding
GO:0004712	0.999	protein serine/threonine/tyrosine kinase activity
GO:0004708	0.988	MAP kinase kinase activity
GO:0004674	0.929	protein serine/threonine kinase activity
GO:0098772	0.739	molecular function regulator activity
GO:0030234	0.678	enzyme regulator activity
GO:0008047	0.413	enzyme activator activity
GO:0019207	0.408	kinase regulator activity
GO:0019899	0.389	enzyme binding
GO:0019209	0.381	kinase activator activity
GO:0019887	0.361	protein kinase regulator activity
GO:0030295	0.320	protein kinase activator activity
GO:0060090	0.317	molecular adaptor activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0009987	0.996	cellular process
GO:0050794	0.996	regulation of cellular process
GO:0050896	0.991	response to stimulus
GO:0048583	0.989	regulation of response to stimulus
GO:0023052	0.988	signaling
GO:0048518	0.987	positive regulation of biological process
GO:0044237	0.987	cellular metabolic process
GO:0071704	0.985	organic substance metabolic process
GO:0043170	0.982	macromolecule metabolic process
GO:1903649	0.978	regulation of cytoplasmic transport
GO:0007165	0.978	signal transduction
GO:0006468	0.973	protein phosphorylation
GO:0070302	0.969	regulation of stress-activated protein kinase signaling cascade
GO:0035556	0.942	intracellular signal transduction
GO:0048522	0.923	positive regulation of cellular process
GO:0043408	0.904	regulation of MAPK cascade
GO:0032872	0.821	regulation of stress-activated MAPK cascade
GO:0019222	0.769	regulation of metabolic process
GO:0060255	0.691	regulation of macromolecule metabolic process
GO:0031323	0.633	regulation of cellular metabolic process
GO:0080090	0.613	regulation of primary metabolic process
GO:0051171	0.578	regulation of nitrogen compound metabolic process
GO:0032501	0.497	multicellular organismal process
GO:0032502	0.490	developmental process
GO:0048856	0.483	anatomical structure development
GO:0048584	0.445	positive regulation of response to stimulus
GO:0048519	0.440	negative regulation of biological process
GO:0009893	0.411	positive regulation of metabolic process
GO:0010604	0.404	positive regulation of macromolecule metabolic process
GO:0010468	0.387	regulation of gene expression
GO:0031325	0.380	positive regulation of cellular metabolic process
GO:0051173	0.374	positive regulation of nitrogen compound metabolic process
GO:0065009	0.371	regulation of molecular function
GO:0051246	0.365	regulation of protein metabolic process
GO:0048523	0.354	negative regulation of cellular process
GO:0051128	0.322	regulation of cellular component organization
GO:0006950	0.321	response to stress
GO:1902533	0.304	positive regulation of intracellular signal transduction

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0012505	1.000	endomembrane system
GO:0005829	1.000	cytosol
GO:0043231	1.000	intracellular membrane-bounded organelle
GO:0005634	0.994	nucleus
GO:0005886	0.991	plasma membrane
GO:0031410	0.989	cytoplasmic vesicle
GO:0030054	0.948	cell junction
GO:0070161	0.868	anchoring junction
GO:0005768	0.859	endosome
GO:0005769	0.838	early endosome
GO:0030055	0.823	cell-substrate junction
GO:0005794	0.822	Golgi apparatus
GO:0005925	0.809	focal adhesion
GO:0005770	0.803	late endosome
GO:0005739	0.772	mitochondrion
GO:0070013	0.660	intracellular organelle lumen
GO:0031981	0.431	nuclear lumen
GO:0043232	0.318	intracellular non-membrane-bounded organelle

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:2.7.12.1	0.999	dual-specificity kinase.
EC:2.7.12.2	0.988	mitogen-activated protein kinase kinase.

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