StarFunc result for job id Q05952

User Input

>input (138 residues)
MDTQTHSLPITHTQLHSNSQPQSRTCTRHCQTFSQSCRQSHRGSRSQSSSQSPASHRNPT
GAHSSSGHQSQSPNTSPPPKRHKKTMNSHHSPMRPTILHCRCPKNRKNLEGKLKKKKMAK
RIQQVYKTKTRSSGWKSN

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q05952	1.000	1.000	1.208E-19	138	1.000	1.000	Q05952.pdb.gz	STP2_HUMAN Nuclear transition protein 2 OS=Homo sapiens OX=9606 GN=TNP2 PE=1 SV=1
2	AFDB:Q99373	0.172	0.111	1.984	253	0.152	0.083	Q99373.pdb.gz	PET20_YEAST Protein PET20, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=PET20 PE=4 SV=1
3	AFDB:P29536	0.150	0.048	3.000	600	0.152	0.035	P29536.pdb.gz	LMOD1_HUMAN Leiomodin-1 OS=Homo sapiens OX=9606 GN=LMOD1 PE=1 SV=3
4	AFDB:Q9VWA1	0.163	0.119	3.214	219	0.065	0.041	Q9VWA1.pdb.gz	CLC_DROME Clathrin light chain OS=Drosophila melanogaster OX=7227 GN=Clc PE=1 SV=1
5	AFDB:P21127	0.216	0.045	4.234	795	0.145	0.025	P21127.pdb.gz	CD11B_HUMAN Cyclin-dependent kinase 11B OS=Homo sapiens OX=9606 GN=CDK11B PE=1 SV=4
6	AFDB:A5JYU8	0.198	0.133	4.536	221	0.072	0.045	A5JYU8.pdb.gz	A5JYU8_CAEEL Transient receptor potential channel OS=Caenorhabditis elegans OX=6239 GN=gon-2 PE=4 SV=1
7	AFDB:Q04347	0.176	0.062	5.577	519	0.101	0.027	Q04347.pdb.gz	BUD22_YEAST Bud site selection protein 22 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=BUD22 PE=1 SV=1
8	AFDB:U3KQN1	0.190	0.089	5.577	320	0.232	0.100	U3KQN1.pdb.gz	U3KQN1_HUMAN POU class 2 homeobox 2 (Fragment) OS=Homo sapiens OX=9606 GN=POU2F2 PE=1 SV=2
9	AFDB:A7SXY9	0.123	0.054	5.975	367	0.159	0.060	A7SXY9.pdb.gz	A7SXY9_NEMVE BZIP domain-containing protein OS=Nematostella vectensis OX=45351 GN=NEMVEDRAFT_v1g248021 PE=1 SV=1
10	AFDB:A6MUT2	0.153	0.094	6.402	321	0.080	0.034	A6MUT2.pdb.gz	A6MUT2_GOSHI 26S proteasome regulatory subunit (Fragment) OS=Gossypium hirsutum OX=3635 PE=2 SV=1

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q05952	3.13e-95	272	138	1.000	1.000	STP2_HUMAN Nuclear transition protein 2 OS=Homo sapiens OX=9606 GN=TNP2 PE=1 SV=1
2	Q4VB56	3.13e-95	272	138	1.000	1.000	Q4VB56_HUMAN Nuclear transition protein 2 OS=Homo sapiens OX=9606 GN=TNP2 PE=1 SV=1
3	P29258	2.92e-23	90.1	137	0.572	0.577	STP2_PIG Nuclear transition protein 2 OS=Sus scrofa OX=9823 GN=TNP2 PE=2 SV=1
4	P11101	2.56e-06	45.4	114	0.384	0.465	STP2_RAT Nuclear transition protein 2 OS=Rattus norvegicus OX=10116 GN=Tnp2 PE=1 SV=2
5	P11378	5.77e-05	42.0	117	0.370	0.436	STP2_MOUSE Nuclear transition protein 2 OS=Mus musculus OX=10090 GN=Tnp2 PE=2 SV=3
6	A0A452E9Y6	1.1	31.2	712	0.094	0.018	PERL_CAPHI Lactoperoxidase OS=Capra hircus OX=9925 GN=LPO PE=1 SV=1
7	P35000	1.5	30.8	437	0.130	0.041	VIPR2_RAT Vasoactive intestinal polypeptide receptor 2 OS=Rattus norvegicus OX=10116 GN=Vipr2 PE=2 SV=1
8	A5JUY8	2.3	30.4	712	0.094	0.018	PERL_BUBBU Lactoperoxidase OS=Bubalus bubalis OX=89462 GN=LPO PE=1 SV=1
9	P80025	2.5	30.0	712	0.094	0.018	PERL_BOVIN Lactoperoxidase OS=Bos taurus OX=9913 GN=LPO PE=1 SV=1
10	O15354	3.2	30.0	613	0.130	0.029	GPR37_HUMAN Prosaposin receptor GPR37 OS=Homo sapiens OX=9606 GN=GPR37 PE=1 SV=2
11	P22455	4.8	29.3	802	0.138	0.024	FGFR4_HUMAN Fibroblast growth factor receptor 4 OS=Homo sapiens OX=9606 GN=FGFR4 PE=1 SV=2
12	Q384C3	6.8	28.9	397	0.109	0.038	Q384C3_TRYB2 P21-C-terminal region-binding protein OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb11.01.0790 PE=3 SV=1
13	G3V9E7	7.4	28.9	402	0.138	0.047	G3V9E7_RAT LIM homeobox 3 OS=Rattus norvegicus OX=10116 GN=Lhx3 PE=4 SV=1
14	Q9UBR4	8.1	28.5	397	0.138	0.048	LHX3_HUMAN LIM/homeobox protein Lhx3 OS=Homo sapiens OX=9606 GN=LHX3 PE=1 SV=2
15	G3V8E3	8.6	28.5	400	0.138	0.048	G3V8E3_RAT LIM homeobox 3 OS=Rattus norvegicus OX=10116 GN=Lhx3 PE=4 SV=1
16	Q20060	8.6	28.9	1549	0.181	0.016	SMC4_CAEEL Structural maintenance of chromosomes protein 4 OS=Caenorhabditis elegans OX=6239 GN=smc-4 PE=1 SV=1
17	A2ALD8	8.8	28.5	402	0.138	0.047	A2ALD8_MOUSE LIM homeobox protein 3 OS=Mus musculus OX=10090 GN=Lhx3 PE=2 SV=1
18	Q9LFM6	9.9	28.5	602	0.123	0.028	PP375_ARATH Pentatricopeptide repeat-containing protein At5g11310, mitochondrial OS=Arabidopsis thaliana OX=3702 GN=At5g11310 PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF16038 TMIE	2.5e+02	12.9	TMIE protein
2	PF01254 TP2	1e-55	199.5	Nuclear transition protein 2

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000325738

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000236979	0.969	Spermatid nuclear transition protein 1
2	9606.ENSP00000403681	0.913	Protamine-2
3	9606.ENSP00000325638	0.832	Protamine-3
4	9606.ENSP00000310515	0.817	Sperm protamine P1
5	9606.ENSP00000244537	0.783	Histone cluster 1 H4 family member f
6	9606.ENSP00000347168	0.783	Histone cluster 1 H4 family member j
7	9606.ENSP00000366956	0.783	Histone cluster 1 H4 family member h
8	9606.ENSP00000366974	0.783	Histone cluster 1 H4 family member b
9	9606.ENSP00000367034	0.783	Histone cluster 1 H4 family member c
10	9606.ENSP00000443017	0.783	Histone cluster 4, H4
11	9606.ENSP00000462355	0.783	Histone cluster 2 H4 family member b
12	9606.ENSP00000462667	0.783	Histone cluster 2 H4 family member a
13	9606.ENSP00000479106	0.783	Histone cluster 1 H4 family member a
14	9606.ENSP00000479461	0.783	Histone cluster 1 H4 family member d
15	9606.ENSP00000479794	0.783	Histone cluster 1 H4 family member k
16	9606.ENSP00000480960	0.783	Histone cluster 1 H4 family member l
17	9606.ENSP00000481486	0.783	Histone cluster 1 H4 family member i
18	9606.ENSP00000484789	0.783	Histone H4
19	9606.ENSP00000355657	0.782	Histone H3.1t
20	9606.ENSP00000484261	0.769	Histone H2A-Bbd type 1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.985	cellular process
GO:0050789	0.978	regulation of biological process
GO:0032501	0.970	multicellular organismal process
GO:0022414	0.862	reproductive process
GO:0019953	0.852	sexual reproduction
GO:0048609	0.769	multicellular organismal reproductive process
GO:0019222	0.653	regulation of metabolic process
GO:0032502	0.651	developmental process
GO:0048232	0.628	male gamete generation
GO:0071840	0.623	cellular component organization or biogenesis
GO:0016043	0.602	cellular component organization
GO:0007283	0.588	spermatogenesis
GO:0051171	0.526	regulation of nitrogen compound metabolic process
GO:0060255	0.524	regulation of macromolecule metabolic process
GO:0080090	0.519	regulation of primary metabolic process
GO:0050794	0.497	regulation of cellular process
GO:0048518	0.409	positive regulation of biological process
GO:0010468	0.371	regulation of gene expression
GO:0006996	0.318	organelle organization
GO:0051173	0.303	positive regulation of nitrogen compound metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005634	1.000	nucleus
GO:0070013	0.433	intracellular organelle lumen
GO:0031981	0.392	nuclear lumen

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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