StarFunc result for job id Q06124

User Input

>input (593 residues)
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG
DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK
EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD
VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT
DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP
VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV
ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHF
RTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIR
EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGH
EYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A0A2R8QL35	0.937	0.928	0.000	599	0.911	0.902	A0A2R8QL35.pdb.gz
2	PDB:5xzrA	0.858	0.978	2.682E-94	519	0.868	0.992	5xzrA.pdb.gz	Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment.
3	PDB:4gwfA	0.828	0.986	3.054E-91	497	0.835	0.996	4gwfA.pdb.gz
4	AFDB:F1R1Z7	0.569	0.570	5.207E-83	592	0.681	0.682	F1R1Z7.pdb.gz
5	AFDB:P81718	0.559	0.541	4.442E-76	613	0.543	0.525	P81718.pdb.gz	PTN6_RAT Tyrosine-protein phosphatase non-receptor type 6 OS=Rattus norvegicus OX=10116 GN=Ptpn6 PE=1 SV=1
6	AFDB:P29349	0.841	0.595	4.308E-75	845	0.597	0.419	P29349.pdb.gz	CSW_DROME Tyrosine-protein phosphatase corkscrew OS=Drosophila melanogaster OX=7227 GN=csw PE=1 SV=2
7	AFDB:A0A2R8Q2T0	0.536	0.539	5.793E-72	590	0.531	0.534	A0A2R8Q2T0.pdb.gz	A0A2R8Q2T0_DANRE Tyrosine-protein phosphatase non-receptor type OS=Danio rerio OX=7955 GN=Hcph PE=3 SV=1
8	PDB:3ps5A	0.533	0.596	1.465E-67	529	0.521	0.584	3ps5A.pdb.gz	Crystal structure of human protein tyrosine phosphatase SHP-1 in the open conformation.
9	AFDB:G5EC24	0.496	0.443	3.219E-51	668	0.376	0.334	G5EC24.pdb.gz	PTP2_CAEEL Tyrosine-protein phosphatase non-receptor type ptp-2 OS=Caenorhabditis elegans OX=6239 GN=ptp-2 PE=1 SV=1
10	AFDB:B6HY54	0.456	0.169	6.764E-30	1650	0.236	0.085	B6HY54.pdb.gz	B6HY54_DANRE protein-tyrosine-phosphatase OS=Danio rerio OX=7955 GN=dep1a PE=2 SV=1
11	AFDB:A0A0R4ITJ9	0.461	0.150	7.988E-30	1892	0.216	0.068	A0A0R4ITJ9.pdb.gz	A0A0R4ITJ9_DANRE protein-tyrosine-phosphatase OS=Danio rerio OX=7955 GN=R-PTP-beta PE=3 SV=2
12	AFDB:E9Q0N2	0.459	0.283	1.315E-29	971	0.226	0.138	E9Q0N2.pdb.gz	PTPRH_MOUSE Receptor-type tyrosine-protein phosphatase H OS=Mus musculus OX=10090 GN=Ptprh PE=1 SV=1
13	AFDB:P23467	0.479	0.147	3.192E-29	1997	0.211	0.063	P23467.pdb.gz	PTPRB_HUMAN Receptor-type tyrosine-protein phosphatase beta OS=Homo sapiens OX=9606 GN=PTPRB PE=1 SV=3
14	PDB:6krwA	0.447	0.847	1.561E-22	306	0.164	0.317	6krwA.pdb.gz
15	PDB:3m4uA	0.380	0.759	1.534E-16	285	0.140	0.291	3m4uA.pdb.gz
16	PDB:4fl2A	0.197	0.206	1.284E-12	555	0.142	0.151	4fl2A.pdb.gz	Structural and biophysical characterization of the syk activation switch.
17	PDB:4k2rA	0.149	0.160	1.684E-10	551	0.094	0.102	4k2rA.pdb.gz	Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker.
18	PDB:2h8hA	0.165	0.215	4.653E-7	445	0.061	0.081	2h8hA.pdb.gz	N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor.
19	PDB:1k9aB	0.154	0.203	8.560E-7	441	0.093	0.125	1k9aB.pdb.gz
20	PDB:1griA	0.137	0.361	2.077E-6	211	0.073	0.204	1griA.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A2R8Q2T0	0.0	639	590	0.546	0.549	A0A2R8Q2T0_DANRE Tyrosine-protein phosphatase non-receptor type OS=Danio rerio OX=7955 GN=Hcph PE=3 SV=1
2	E7F3D4	0.0	639	589	0.546	0.550	E7F3D4_DANRE Tyrosine-protein phosphatase non-receptor type OS=Danio rerio OX=7955 GN=Hcph PE=2 SV=2
3	F1N339	0.0	1233	593	0.990	0.990	F1N339_BOVIN Tyrosine-protein phosphatase non-receptor type OS=Bos taurus OX=9913 GN=PTPN11 PE=3 SV=3
4	P29350	0.0	667	595	0.540	0.538	PTN6_HUMAN Tyrosine-protein phosphatase non-receptor type 6 OS=Homo sapiens OX=9606 GN=PTPN6 PE=1 SV=1
5	P29351	0.0	671	595	0.551	0.550	PTN6_MOUSE Tyrosine-protein phosphatase non-receptor type 6 OS=Mus musculus OX=10090 GN=Ptpn6 PE=1 SV=2
6	P35235	0.0	1240	593	0.995	0.995	PTN11_MOUSE Tyrosine-protein phosphatase non-receptor type 11 OS=Mus musculus OX=10090 GN=Ptpn11 PE=1 SV=3
7	P41499	0.0	1233	593	0.990	0.990	PTN11_RAT Tyrosine-protein phosphatase non-receptor type 11 OS=Rattus norvegicus OX=10116 GN=Ptpn11 PE=1 SV=5
8	P81718	0.0	671	613	0.551	0.533	PTN6_RAT Tyrosine-protein phosphatase non-receptor type 6 OS=Rattus norvegicus OX=10116 GN=Ptpn6 PE=1 SV=1
9	Q06124	0.0	1245	593	1.000	1.000	PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 OS=Homo sapiens OX=9606 GN=PTPN11 PE=1 SV=3
10	Q53XS4	0.0	671	597	0.543	0.539	Q53XS4_HUMAN Tyrosine-protein phosphatase non-receptor type OS=Homo sapiens OX=9606 GN=PTPN6 PE=2 SV=1
11	Q7SY37	0.0	806	592	0.678	0.679	Q7SY37_DANRE Tyrosine-protein phosphatase non-receptor type OS=Danio rerio OX=7955 GN=zgc:63553 PE=2 SV=1
12	Q7ZW17	0.0	1080	594	0.916	0.914	Q7ZW17_DANRE Tyrosine-protein phosphatase non-receptor type OS=Danio rerio OX=7955 GN=ptpn11 PE=1 SV=1
13	Q803M6	0.0	637	589	0.543	0.547	Q803M6_DANRE Tyrosine-protein phosphatase non-receptor type OS=Danio rerio OX=7955 GN=fj22f05 PE=2 SV=1
14	S6CMQ2	0.0	798	590	0.671	0.675	S6CMQ2_DANRE Tyrosine-protein phosphatase non-receptor type OS=Danio rerio OX=7955 GN=shp3 PE=2 SV=1
15	P29349	5.47e-132	408	845	0.346	0.243	CSW_DROME Tyrosine-protein phosphatase corkscrew OS=Drosophila melanogaster OX=7227 GN=csw PE=1 SV=2
16	G5EC24	7.36e-108	340	668	0.374	0.332	PTP2_CAEEL Tyrosine-protein phosphatase non-receptor type ptp-2 OS=Caenorhabditis elegans OX=6239 GN=ptp-2 PE=1 SV=1
17	A5HV10	1.37e-60	216	709	0.212	0.178	A5HV10_RAT Receptor-like protein tyrosine phosphatase kappa (Fragment) OS=Rattus norvegicus OX=10116 GN=Ptprk PE=2 SV=1
18	F1QE38	1.41e-60	217	831	0.206	0.147	F1QE38_DANRE Receptor-type tyrosine-protein phosphatase alpha OS=Danio rerio OX=7955 GN=RPTP[a] PE=1 SV=1
19	P18433	1.12e-59	214	802	0.206	0.152	PTPRA_HUMAN Receptor-type tyrosine-protein phosphatase alpha OS=Homo sapiens OX=9606 GN=PTPRA PE=1 SV=3
20	Q03348	2.25e-59	213	796	0.204	0.152	PTPRA_RAT Receptor-type tyrosine-protein phosphatase alpha OS=Rattus norvegicus OX=10116 GN=Ptpra PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00782 DSPc	0.12	23.6	Dual specificity phosphatase, catalytic domain
2	PF14566 PTPlike_phytase	43	15.7	Inositol hexakisphosphate
3	PF00017 SH2	3.1e-48	173.1	SH2 domain
4	PF00102 Y_phosphatase	1.6e-76	268.5	Protein-tyrosine phosphatase
5	PF13350 Y_phosphatase3	5.6	18.5	Tyrosine phosphatase family

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 1026970.XP_008845726.1

Rank	PPI partner	STRING score	Description
1	1026970.XP_008824062.1	0.999	Insulin receptor substrate 1
2	1026970.XP_008841666.1	0.999	GRB2-associated-binding protein 1 isoform X1
3	1026970.XP_008844787.1	0.998	Platelet endothelial cell adhesion molecule isoform X1
4	1026970.XP_008837055.1	0.997	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
5	1026970.XP_008842419.1	0.997	GRB2-associated-binding protein 2
6	1026970.XP_008821920.1	0.995	Fibroblast growth factor receptor substrate 2
7	1026970.XP_008829634.1	0.995	Growth factor receptor bound protein 2
8	1026970.XP_008847605.1	0.995	Platelet-derived growth factor receptor beta
9	1026970.XP_008827587.1	0.992	Myelin protein zero-like protein 1 isoform X1
10	1026970.XP_008839879.1	0.992	Tyrosine-protein kinase JAK2 isoform X1
11	1026970.XP_008843731.1	0.992	SOS Ras/Rac guanine nucleotide exchange factor 1
12	1026970.XP_008842781.1	0.991	Insulin receptor
13	1026970.XP_008829286.1	0.987	Tyrosine-protein kinase JAK1 isoform X1
14	1026970.XP_008822143.1	0.986	Mitogen-activated protein kinase 3
15	1026970.XP_008828076.1	0.985	SOS Ras/Rho guanine nucleotide exchange factor 2
16	1026970.XP_008849862.1	0.985	Epidermal growth factor receptor
17	1026970.XP_008840426.1	0.982	Mitogen-activated protein kinase 1
18	1026970.XP_008822806.1	0.980	Tyrosine-protein kinase JAK3
19	1026970.XP_008827391.1	0.980	Programmed cell death 1
20	1026970.XP_008831541.1	0.977	KIT proto-oncogene receptor tyrosine kinase

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.998	protein binding
GO:0004725	0.998	protein tyrosine phosphatase activity
GO:0005102	0.821	signaling receptor binding
GO:0019899	0.783	enzyme binding
GO:0001784	0.762	phosphotyrosine residue binding
GO:1990782	0.734	protein tyrosine kinase binding
GO:0004726	0.427	non-membrane spanning protein tyrosine phosphatase activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0050794	0.994	regulation of cellular process
GO:0023052	0.992	signaling
GO:0007154	0.992	cell communication
GO:0051716	0.991	cellular response to stimulus
GO:0007165	0.983	signal transduction
GO:0032501	0.937	multicellular organismal process
GO:0048856	0.930	anatomical structure development
GO:0007275	0.887	multicellular organism development
GO:0048518	0.833	positive regulation of biological process
GO:0035556	0.827	intracellular signal transduction
GO:0048731	0.820	system development
GO:0048522	0.783	positive regulation of cellular process
GO:0048513	0.771	animal organ development
GO:0009653	0.748	anatomical structure morphogenesis
GO:0048519	0.744	negative regulation of biological process
GO:0048583	0.634	regulation of response to stimulus
GO:0000165	0.630	MAPK cascade
GO:0044237	0.587	cellular metabolic process
GO:0048523	0.556	negative regulation of cellular process
GO:0071704	0.549	organic substance metabolic process
GO:0006807	0.546	nitrogen compound metabolic process
GO:0044238	0.522	primary metabolic process
GO:0019222	0.499	regulation of metabolic process
GO:0048701	0.476	embryonic cranial skeleton morphogenesis
GO:0048589	0.460	developmental growth
GO:0048703	0.456	embryonic viscerocranium morphogenesis
GO:0060255	0.419	regulation of macromolecule metabolic process
GO:0007166	0.415	cell surface receptor signaling pathway
GO:0009966	0.409	regulation of signal transduction
GO:0042221	0.406	response to chemical
GO:0007507	0.404	heart development
GO:0043170	0.403	macromolecule metabolic process
GO:0010941	0.399	regulation of cell death
GO:0008283	0.389	cell population proliferation
GO:0006796	0.363	phosphate-containing compound metabolic process
GO:0051239	0.358	regulation of multicellular organismal process
GO:0070887	0.348	cellular response to chemical stimulus
GO:1901564	0.334	organonitrogen compound metabolic process
GO:0048584	0.313	positive regulation of response to stimulus
GO:0031323	0.311	regulation of cellular metabolic process
GO:0080090	0.302	regulation of primary metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0043231	0.999	intracellular membrane-bounded organelle
GO:0005829	0.998	cytosol
GO:0032991	0.988	protein-containing complex
GO:0031974	0.988	membrane-enclosed lumen
GO:0016020	0.988	membrane
GO:0071944	0.986	cell periphery
GO:0005886	0.975	plasma membrane
GO:0005654	0.975	nucleoplasm

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:10684	0.998	H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate
EC:3.1.3.48	0.998	protein-tyrosine-phosphatase.

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