StarFunc result for job id Q06787

User Input

>input (632 residues)
MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPPPVGYNKDIN
ESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKP
ATKDTFHKIKLDVPEDLRQMCAKEAAHKDFKKAVGAFSVTYDPENYQLVILSINEVTSKR
AHMLIDMHFRSLRTKLSLIMRNEEASKQLESSRQLASRFHEQFIVREDLMGLAIGTHGAN
IQQARKVPGVTAIDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIGKN
GKLIQEIVDKSGVVRVRIEAENEKNVPQEEEIMPPNSLPSNNSRVGPNAPEEKKHLDIKE
NSTHFSQPNSTKVQRVLVASSVVAGESQKPELKAWQGMVPFVFVGTKDSIANATVLLDYH
LNYLKEVDQLRLERLQIDEQLRQIGASSRPPPNRTDKEKSYVTDDGQGMGRGSRPYRNRG
HGRRGPGYTSGTNSEASNASETESDHRDELSDWSLAPTEEERESFLRRGDGRRRGGGGRG
QGGRGRGGGFKGNDDHSRTDNRPRNPREAKGRTTDGSLQIRVDCNNERSVHTKTLQNTSS
EGSRLRTGKDRNQKKEKPDSVDGQQPLVNGVP

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q06787	1.000	1.000	3.483E-104	632	1.000	1.000	Q06787.pdb.gz	FMR1_HUMAN Fragile X messenger ribonucleoprotein 1 OS=Homo sapiens OX=9606 GN=FMR1 PE=1 SV=1
2	AFDB:Q80WE1	0.462	0.489	2.623E-90	593	0.908	0.968	Q80WE1.pdb.gz	FMR1_RAT Fragile X messenger ribonucleoprotein 1 OS=Rattus norvegicus OX=10116 GN=Fmr1 PE=1 SV=2
3	AFDB:Q6GLC9	0.545	0.581	2.449E-80	590	0.786	0.842	Q6GLC9.pdb.gz	FMR1_XENTR Fragile X messenger ribonucleoprotein 1 homolog OS=Xenopus tropicalis OX=8364 GN=fmr1 PE=2 SV=1
4	AFDB:P51113	0.479	0.529	2.890E-80	564	0.778	0.872	P51113.pdb.gz	FMR1A_XENLA Fragile X messenger ribonucleoprotein 1 homolog A OS=Xenopus laevis OX=8355 GN=fmr1-a PE=1 SV=1
5	AFDB:F1R159	0.513	0.562	3.043E-73	569	0.660	0.733	F1R159.pdb.gz
6	AFDB:Q7SYM7	0.488	0.608	7.219E-67	493	0.576	0.738	Q7SYM7.pdb.gz
7	AFDB:P51115	0.409	0.389	3.957E-63	676	0.573	0.536	P51115.pdb.gz	FXR1A_XENLA RNA-binding protein fxr1-A OS=Xenopus laevis OX=8355 GN=fxr1-a PE=1 SV=2
8	AFDB:Q61584	0.404	0.381	4.181E-63	677	0.568	0.530	Q61584.pdb.gz	FXR1_MOUSE RNA-binding protein FXR1 OS=Mus musculus OX=10090 GN=Fxr1 PE=1 SV=2
9	AFDB:P51114	0.405	0.411	2.021E-60	621	0.554	0.564	P51114.pdb.gz	FXR1_HUMAN RNA-binding protein FXR1 OS=Homo sapiens OX=9606 GN=FXR1 PE=1 SV=3
10	AFDB:P51116	0.415	0.394	1.557E-59	673	0.513	0.481	P51116.pdb.gz	FXR2_HUMAN RNA-binding protein FXR2 OS=Homo sapiens OX=9606 GN=FXR2 PE=1 SV=2
11	PDB:7mqaSW	0.094	0.265	2.757E-3	195	0.054	0.174	7mqaSW.pdb.gz	Nucleolar maturation of the human small subunit processome.
12	PDB:2io9B	0.092	0.094	7.868E-3	603	0.032	0.033	2io9B.pdb.gz	Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase
13	PDB:7ajuJJ	0.094	0.257	7.868E-3	199	0.044	0.141	7ajuJJ.pdb.gz	Structure of the Maturing 90S Pre-ribosome in Association with the RNA Exosome.
14	PDB:7abi7	0.077	0.185	1.037E-2	236	0.019	0.051	7abi7.pdb.gz	Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation.
15	PDB:7okyZ	0.079	0.130	1.612E-2	374	0.025	0.043	7okyZ.pdb.gz	Allosteric transcription stimulation by RNA polymerase II super elongation complex.
16	PDB:6ke6RC	0.124	0.244	2.649E-2	278	0.059	0.133	6ke6RC.pdb.gz	3.4 angstrom cryo-EM structure of yeast 90S small subunit preribosome
17	PDB:6tedZ	0.078	0.095	3.491E-2	510	0.028	0.035	6tedZ.pdb.gz	Structure of complete Pol II-DSIF-PAF-SPT6 transcription complex reveals RTF1 allosteric activation.
18	PDB:5wq8A	0.075	0.093	3.899E-2	496	0.051	0.065	5wq8A.pdb.gz
19	PDB:7r1dC	0.082	0.251	5.137E-2	192	0.013	0.042	7r1dC.pdb.gz
20	PDB:5wq7A	0.079	0.099	5.737E-2	472	0.055	0.074	5wq7A.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A8MQB8	0.0	1179	582	0.921	1.000	A8MQB8_HUMAN Fragile X messenger ribonucleoprotein 1 OS=Homo sapiens OX=9606 GN=FMR1 PE=1 SV=1
2	G3V0J0	0.0	1202	592	0.937	1.000	G3V0J0_HUMAN Fragile X mental retardation 1, isoform CRA_e OS=Homo sapiens OX=9606 GN=FMR1 PE=1 SV=1
3	P35922	0.0	1218	614	0.940	0.967	FMR1_MOUSE Fragile X messenger ribonucleoprotein 1 OS=Mus musculus OX=10090 GN=Fmr1 PE=1 SV=1
4	P51113	0.0	647	564	0.481	0.539	FMR1A_XENLA Fragile X messenger ribonucleoprotein 1 homolog A OS=Xenopus laevis OX=8355 GN=fmr1-a PE=1 SV=1
5	P51114	0.0	528	621	0.391	0.398	FXR1_HUMAN RNA-binding protein FXR1 OS=Homo sapiens OX=9606 GN=FXR1 PE=1 SV=3
6	Q06787	0.0	1311	632	1.000	1.000	FMR1_HUMAN Fragile X messenger ribonucleoprotein 1 OS=Homo sapiens OX=9606 GN=FMR1 PE=1 SV=1
7	Q6GLC9	0.0	650	590	0.484	0.519	FMR1_XENTR Fragile X messenger ribonucleoprotein 1 homolog OS=Xenopus tropicalis OX=8364 GN=fmr1 PE=2 SV=1
8	Q80WE1	0.0	1173	593	0.913	0.973	FMR1_RAT Fragile X messenger ribonucleoprotein 1 OS=Rattus norvegicus OX=10116 GN=Fmr1 PE=1 SV=2
9	Q8IXW7	0.0	621	297	0.465	0.990	Q8IXW7_HUMAN FMR1 protein OS=Homo sapiens OX=9606 GN=FMR1 PE=1 SV=1
10	Q9DF20	0.0	578	569	0.424	0.471	Q9DF20_DANRE KH domain containing RNA-binding protein FMR1 OS=Danio rerio OX=7955 GN=zFMR1 PE=1 SV=1
11	Q61584	1.43e-179	526	677	0.389	0.363	FXR1_MOUSE RNA-binding protein FXR1 OS=Mus musculus OX=10090 GN=Fxr1 PE=1 SV=2
12	P51115	1.46e-174	514	676	0.381	0.357	FXR1A_XENLA RNA-binding protein fxr1-A OS=Xenopus laevis OX=8355 GN=fxr1-a PE=1 SV=2
13	Q5BJ56	7.31e-173	509	674	0.378	0.355	FXR1_XENTR RNA-binding protein fxr1 OS=Xenopus tropicalis OX=8364 GN=fxr1 PE=2 SV=2
14	P51116	6.51e-172	507	673	0.375	0.352	FXR2_HUMAN RNA-binding protein FXR2 OS=Homo sapiens OX=9606 GN=FXR2 PE=1 SV=2
15	B4DXZ6	3.41e-169	498	608	0.367	0.382	B4DXZ6_HUMAN FMR1 autosomal homolog 1 OS=Homo sapiens OX=9606 GN=FXR1 PE=1 SV=1
16	Q9WVR4	2.94e-164	487	673	0.362	0.340	FXR2_MOUSE RNA-binding protein FXR2 OS=Mus musculus OX=10090 GN=Fxr2 PE=1 SV=1
17	F1QLR3	3.55e-164	485	622	0.358	0.363	FXR1_DANRE RNA-binding protein FXR1 OS=Danio rerio OX=7955 GN=fxr1 PE=1 SV=1
18	E9PFF5	1.19e-143	428	490	0.339	0.437	E9PFF5_HUMAN FMR1 autosomal homolog 1 OS=Homo sapiens OX=9606 GN=FXR1 PE=1 SV=1
19	E7EU85	4.01e-126	382	454	0.290	0.403	E7EU85_HUMAN FMR1 autosomal homolog 1 OS=Homo sapiens OX=9606 GN=FXR1 PE=1 SV=1
20	Q9NFU0	3.30e-95	309	684	0.255	0.235	FMR1_DROME Fragile X messenger ribonucleoprotein 1 homolog OS=Drosophila melanogaster OX=7227 GN=Fmr1 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF05641 Agenet	1.8e-07	42.8	Agenet domain
2	PF12235 FXMRP1_C_core	3.3e-43	158.9	Fragile X-related 1 protein core C terminal
3	PF16098 FXMR_C2	6.8e-36	133.9	Fragile X-related mental retardation protein C-terminal region 2
4	PF00013 KH_1	2.1e-12	58.0	KH domain
5	PF07650 KH_2	8.5	17.6	KH domain
6	PF13083 KH_4	2.6e+02	12.9	KH domain
7	PF17904 KH_9	8.8e-34	127.2	FMRP KH0 domain
8	PF18336 Tudor_FRX1	7.5e-27	104.4	Fragile X mental retardation Tudor domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000359506

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000481038	0.999	Cytoplasmic FMR1-interacting protein 1
2	9606.ENSP00000220592	0.997	Protein argonaute-2
3	9606.ENSP00000425561	0.995	Eukaryotic translation initiation factor 4E
4	9606.ENSP00000440190	0.986	Tudor domain-containing protein 3
5	9606.ENSP00000444645	0.983	Cytoplasmic FMR1-interacting protein 2
6	9606.ENSP00000340329	0.980	Caprin-1
7	9606.ENSP00000250113	0.979	Fragile X mental retardation syndrome-related protein 2
8	9606.ENSP00000437256	0.979	Endoribonuclease Dicer
9	9606.ENSP00000350170	0.976	Fragile X mental retardation syndrome-related protein 1
10	9606.ENSP00000225388	0.973	Nuclear fragile X mental retardation-interacting protein 2
11	9606.ENSP00000362300	0.951	Protein argonaute-1
12	9606.ENSP00000368459	0.938	Nuclear fragile X mental retardation-interacting protein 1
13	9606.ENSP00000338173	0.930	Pumilio homolog 2
14	9606.ENSP00000240185	0.924	TAR DNA-binding protein 43
15	9606.ENSP00000332706	0.895	Transcriptional activator protein Pur-alpha
16	9606.ENSP00000377681	0.883	Ras GTPase-activating protein-binding protein 1
17	9606.ENSP00000361626	0.882	Nuclease-sensitive element-binding protein 1
18	9606.ENSP00000296755	0.879	Microtubule-associated protein 1B
19	9606.ENSP00000477715	0.877	Cytoplasmic polyadenylation element-binding protein 1
20	9606.ENSP00000446271	0.855	Protein LSM14 homolog A

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.999	protein binding
GO:0003723	0.999	RNA binding
GO:0045182	0.998	translation regulator activity
GO:0003729	0.971	mRNA binding
GO:0030371	0.900	translation repressor activity
GO:0042802	0.860	identical protein binding
GO:0003730	0.766	mRNA 3'-UTR binding
GO:0046982	0.733	protein heterodimerization activity
GO:0042803	0.733	protein homodimerization activity
GO:0044877	0.699	protein-containing complex binding
GO:0003727	0.549	single-stranded RNA binding
GO:0061980	0.478	regulatory RNA binding
GO:0140666	0.444	annealing activity
GO:0035198	0.379	miRNA binding
GO:0003677	0.310	DNA binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0050794	0.995	regulation of cellular process
GO:0060255	0.993	regulation of macromolecule metabolic process
GO:0051171	0.992	regulation of nitrogen compound metabolic process
GO:0009987	0.990	cellular process
GO:0080090	0.990	regulation of primary metabolic process
GO:0031323	0.990	regulation of cellular metabolic process
GO:0048518	0.989	positive regulation of biological process
GO:0010468	0.984	regulation of gene expression
GO:0051246	0.965	regulation of protein metabolic process
GO:0034248	0.957	regulation of amide metabolic process
GO:0010608	0.953	post-transcriptional regulation of gene expression
GO:0032501	0.949	multicellular organismal process
GO:2000112	0.948	regulation of cellular macromolecule biosynthetic process
GO:0048519	0.947	negative regulation of biological process
GO:0006417	0.943	regulation of translation
GO:0009893	0.940	positive regulation of metabolic process
GO:0010604	0.934	positive regulation of macromolecule metabolic process
GO:0048522	0.921	positive regulation of cellular process
GO:0010628	0.920	positive regulation of gene expression
GO:0050896	0.907	response to stimulus
GO:0051252	0.903	regulation of RNA metabolic process
GO:0048523	0.897	negative regulation of cellular process
GO:0010605	0.889	negative regulation of macromolecule metabolic process
GO:0010646	0.879	regulation of cell communication
GO:0051173	0.875	positive regulation of nitrogen compound metabolic process
GO:1903311	0.875	regulation of mRNA metabolic process
GO:0051172	0.871	negative regulation of nitrogen compound metabolic process
GO:0065008	0.849	regulation of biological quality
GO:0031325	0.846	positive regulation of cellular metabolic process
GO:0051716	0.839	cellular response to stimulus
GO:0010629	0.823	negative regulation of gene expression
GO:0009894	0.809	regulation of catabolic process
GO:0051128	0.805	regulation of cellular component organization
GO:0023051	0.794	regulation of signaling
GO:0051247	0.791	positive regulation of protein metabolic process
GO:0032502	0.771	developmental process
GO:0031324	0.725	negative regulation of cellular metabolic process
GO:0071840	0.703	cellular component organization or biogenesis
GO:0045727	0.689	positive regulation of translation
GO:0071704	0.688	organic substance metabolic process
GO:0043484	0.644	regulation of RNA splicing
GO:0003008	0.613	system process
GO:0032879	0.613	regulation of localization
GO:0060964	0.602	regulation of miRNA-mediated gene silencing
GO:0044237	0.589	cellular metabolic process
GO:0044238	0.581	primary metabolic process
GO:0044087	0.579	regulation of cellular component biogenesis
GO:0050877	0.553	nervous system process
GO:0048856	0.551	anatomical structure development
GO:0006807	0.547	nitrogen compound metabolic process
GO:0016043	0.541	cellular component organization
GO:0043170	0.498	macromolecule metabolic process
GO:0048259	0.486	regulation of receptor-mediated endocytosis
GO:0031329	0.462	regulation of cellular catabolic process
GO:0007154	0.434	cell communication
GO:0023052	0.433	signaling
GO:0006950	0.426	response to stress
GO:0007215	0.408	glutamate receptor signaling pathway
GO:0007275	0.407	multicellular organism development
GO:0065009	0.371	regulation of molecular function
GO:0048731	0.342	system development
GO:0034641	0.337	cellular nitrogen compound metabolic process
GO:0006139	0.331	nucleobase-containing compound metabolic process
GO:0090304	0.306	nucleic acid metabolic process
GO:0045934	0.305	negative regulation of nucleobase-containing compound metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005829	1.000	cytosol
GO:0070013	0.965	intracellular organelle lumen
GO:0032991	0.920	protein-containing complex
GO:0005634	0.912	nucleus
GO:0016020	0.846	membrane
GO:0043232	0.812	intracellular non-membrane-bounded organelle
GO:0031981	0.749	nuclear lumen
GO:1990904	0.708	ribonucleoprotein complex
GO:0120025	0.671	plasma membrane bounded cell projection
GO:0099080	0.664	supramolecular complex
GO:0036464	0.652	cytoplasmic ribonucleoprotein granule
GO:0005654	0.587	nucleoplasm
GO:0043005	0.570	neuron projection
GO:0036477	0.464	somatodendritic compartment
GO:0030424	0.433	axon
GO:0044297	0.417	cell body
GO:0048471	0.408	perinuclear region of cytoplasm
GO:0043025	0.407	neuronal cell body
GO:0005844	0.355	polysome
GO:0043204	0.339	perikaryon
GO:0030427	0.337	site of polarized growth
GO:0150034	0.335	distal axon
GO:0030426	0.320	growth cone

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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