StarFunc result for job id Q07889

User Input

>input (1333 residues)
MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLC
QAQPRSASDVEERVQKSFPHPIDKWAIADAQSAIEKRKRRNPLSLPVEKIHPLLKEVLGY
KIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDV
EDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSAN
DVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYAR
DILRPGFHDRFLSQLSKPGAALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQL
EEKSEDQEDKECLKQAITALLNVQSGMEKICSKSLAKRRLSESACRFYSQQMKGKQLAIK
KMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTRVGAKHERHIFLFDGLMICCKSNHGQPRL
PGASNAEYRLKEKFFMRKVQINDKDDTNEYKHAFEIILKDENSVIFSAKSAEEKNNWMAA
LISLQYRSTLERMLDVTMLQEEKEEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPI
IKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADR
IAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGT
VRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLH
PIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV
ETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKI
LEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSK
RRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRN
PKPLPRFPKKYSYPLKSPGVRPSNPRPGTMRHPTPLQQEPRKISYSRIPESETESTASAP
NSPRTPLTPPPASGASSTTDVCSVFDSDHSSPFHSSNDTVFIQVTLPHGPRSASVSSISL
TKGTDEVPVPPPVPPRRRPESAPAESSPSKIMSKHLDSPPAIPPRQPTSKAYSPRYSISD
RTSISDPPESPPLLPPREPVRTPDVFSSSPLHLQPPPLGKKSDHGNAFFPNSPSPFTPPP
PQTPSPHGTRRHLPSPPLTQEVDLHSIAGPPVPPRQSTSQHIPKLPPKTYKREHTHPSMH
RDGPPLLENAHSS

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A0A0G2JVU2	0.757	0.848	0.000	1186	0.648	0.728	A0A0G2JVU2.pdb.gz	A0A0G2JVU2_RAT SOS Ras/Rho guanine nucleotide exchange factor 2 OS=Rattus norvegicus OX=10116 GN=Sos2 PE=4 SV=2
2	AFDB:F1MAI3	0.777	0.777	0.000	1333	0.697	0.697	F1MAI3.pdb.gz	F1MAI3_RAT SOS Ras/Rho guanine nucleotide exchange factor 2 OS=Rattus norvegicus OX=10116 GN=Sos2 PE=4 SV=1
3	AFDB:F1R019	0.762	0.757	0.000	1341	0.642	0.638	F1R019.pdb.gz	F1R019_DANRE Son of sevenless homolog 2 OS=Danio rerio OX=7955 GN=si:ch211-67f24.8 PE=1 SV=2
4	AFDB:Q07889	1.000	1.000	0.000	1333	1.000	1.000	Q07889.pdb.gz	SOS1_HUMAN Son of sevenless homolog 1 OS=Homo sapiens OX=9606 GN=SOS1 PE=1 SV=1
5	AFDB:P26675	0.693	0.585	3.212E-85	1596	0.443	0.370	P26675.pdb.gz	SOS_DROME Protein son of sevenless OS=Drosophila melanogaster OX=7227 GN=Sos PE=1 SV=2
6	PDB:2byvE	0.258	0.366	7.042E-13	922	0.092	0.132	2byvE.pdb.gz
7	PDB:4f7zA	0.260	0.360	1.645E-12	946	0.089	0.125	4f7zA.pdb.gz
8	PDB:4mt6A	0.126	0.395	2.515E-12	389	0.057	0.195	4mt6A.pdb.gz
9	AFDB:Q86X27	0.189	0.420	6.788E-12	583	0.072	0.165	Q86X27.pdb.gz	RGPS2_HUMAN Ras-specific guanine nucleotide-releasing factor RalGPS2 OS=Homo sapiens OX=9606 GN=RALGPS2 PE=1 SV=1
10	PDB:7rx9A	0.126	0.315	1.048E-11	432	0.060	0.185	7rx9A.pdb.gz
11	AFDB:D1MYR8	0.118	0.150	1.254E-8	1007	0.120	0.159	D1MYR8.pdb.gz	D1MYR8_9HYPO Guanine-nucleotide exchange factor Cdc24 OS=Epichloe festucae OX=35717 GN=Cdc24 PE=1 SV=1
12	AFDB:A0A0B4LEF8	0.065	0.072	2.291E-6	1143	0.122	0.142	A0A0B4LEF8.pdb.gz	A0A0B4LEF8_DROME ArfGAP with SH3 domain, ankyrin repeat and PH domain, isoform D OS=Drosophila melanogaster OX=7227 GN=Asap PE=4 SV=1
13	AFDB:Q54YZ6	0.131	0.142	8.838E-6	1218	0.056	0.061	Q54YZ6.pdb.gz	Q54YZ6_DICDI Uncharacterized protein OS=Dictyostelium discoideum OX=44689 GN=gxcA PE=4 SV=1
14	PDB:4gouA	0.139	0.310	8.926E-6	507	0.046	0.120	4gouA.pdb.gz
15	AFDB:Q6REY9	0.064	0.071	1.158E-5	1182	0.118	0.133	Q6REY9.pdb.gz	RHG20_RAT Rho GTPase-activating protein 20 OS=Rattus norvegicus OX=10116 GN=Arhgap20 PE=1 SV=2
16	PDB:6a7uA	0.108	0.797	1.720E-5	170	0.027	0.212	6a7uA.pdb.gz
17	PDB:6xu2A	0.079	0.092	5.822E-3	1091	0.094	0.115	6xu2A.pdb.gz	X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking.
18	PDB:7mp5A	0.060	0.053	6.289E-3	1629	0.095	0.078	7mp5A.pdb.gz
19	PDB:6tgbB	0.074	0.123	7.927E-3	680	0.067	0.131	6tgbB.pdb.gz
20	PDB:7r03B	0.064	0.049	8.238E-3	2246	0.099	0.059	7r03B.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A0G2JVU2	0.0	1667	1300	0.614	0.630	A0A0G2JVU2_RAT SOS Ras/Rho guanine nucleotide exchange factor 2 OS=Rattus norvegicus OX=10116 GN=Sos2 PE=4 SV=2
2	A0A8I6B4D6	0.0	2508	1283	0.915	0.951	A0A8I6B4D6_RAT SOS Ras/Rac guanine nucleotide exchange factor 1 OS=Rattus norvegicus OX=10116 GN=Sos1 PE=1 SV=1
3	D4A3T0	0.0	2649	1319	0.967	0.977	D4A3T0_RAT SOS Ras/Rac guanine nucleotide exchange factor 1 OS=Rattus norvegicus OX=10116 GN=Sos1 PE=1 SV=2
4	F1MAI3	0.0	1741	1333	0.635	0.635	F1MAI3_RAT SOS Ras/Rho guanine nucleotide exchange factor 2 OS=Rattus norvegicus OX=10116 GN=Sos2 PE=4 SV=1
5	F1R019	0.0	1577	1341	0.589	0.585	F1R019_DANRE Son of sevenless homolog 2 OS=Danio rerio OX=7955 GN=si:ch211-67f24.8 PE=1 SV=2
6	G1TRT1	0.0	2669	1304	0.971	0.993	G1TRT1_RABIT SOS Ras/Rac guanine nucleotide exchange factor 1 OS=Oryctolagus cuniculus OX=9986 GN=SOS1 PE=4 SV=2
7	P26675	0.0	1021	1596	0.401	0.335	SOS_DROME Protein son of sevenless OS=Drosophila melanogaster OX=7227 GN=Sos PE=1 SV=2
8	Q02384	0.0	1746	1333	0.635	0.635	SOS2_MOUSE Son of sevenless homolog 2 OS=Mus musculus OX=10090 GN=Sos2 PE=1 SV=2
9	Q07889	0.0	2747	1333	1.000	1.000	SOS1_HUMAN Son of sevenless homolog 1 OS=Homo sapiens OX=9606 GN=SOS1 PE=1 SV=1
10	Q07890	0.0	1758	1332	0.638	0.638	SOS2_HUMAN Son of sevenless homolog 2 OS=Homo sapiens OX=9606 GN=SOS2 PE=1 SV=2
11	Q497A5	0.0	1197	592	0.428	0.963	Q497A5_RAT Sos1 protein (Fragment) OS=Rattus norvegicus OX=10116 GN=Sos1 PE=2 SV=1
12	Q62245	0.0	2649	1319	0.968	0.978	SOS1_MOUSE Son of sevenless homolog 1 OS=Mus musculus OX=10090 GN=Sos1 PE=1 SV=2
13	Q9N5D3	0.0	589	1493	0.299	0.267	SOS_CAEEL Son of sevenless homolog OS=Caenorhabditis elegans OX=6239 GN=sos-1 PE=1 SV=3
14	Q9Z1I1	1.10e-103	329	204	0.120	0.784	Q9Z1I1_RAT Son of sevenless 1 (Fragment) OS=Rattus norvegicus OX=10116 GN=Sos1 PE=2 SV=1
15	Q54PQ4	1.15e-50	192	605	0.098	0.217	GEFA_DICDI Ras guanine nucleotide exchange factor A OS=Dictyostelium discoideum OX=44689 GN=gefA PE=1 SV=1
16	Q8SSQ0	4.23e-43	175	1721	0.092	0.071	GEFR_DICDI Ras guanine nucleotide exchange factor R OS=Dictyostelium discoideum OX=44689 GN=gefR PE=1 SV=1
17	Q8IS18	2.41e-42	171	1037	0.071	0.092	GEFE_DICDI Ras guanine nucleotide exchange factor E OS=Dictyostelium discoideum OX=44689 GN=gefE PE=2 SV=1
18	Q9USU1	6.11e-39	160	987	0.089	0.120	EFC25_SCHPO Ras guanine nucleotide exchange factor efc25 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=efc25 PE=1 SV=1
19	P04821	6.30e-39	161	1589	0.103	0.086	CDC25_YEAST Cell division control protein 25 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=CDC25 PE=1 SV=1
20	Q13972	4.63e-36	151	1273	0.074	0.077	RGRF1_HUMAN Ras-specific guanine nucleotide-releasing factor 1 OS=Homo sapiens OX=9606 GN=RASGRF1 PE=1 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF16453 IQ_SEC7_PH	7.7	17.9	PH domain
2	PF00169 PH	3.6e-08	45.2	PH domain
3	PF15411 PH_10	2	20.1	Pleckstrin homology domain
4	PF19057 PH_19	1.1	20.4	PH domain
5	PF00617 RasGEF	1.9e-46	170.0	RasGEF domain
6	PF00618 RasGEF_N	2.9e-27	106.3	RasGEF N-terminal motif
7	PF00621 RhoGEF	6.6e-13	60.8	RhoGEF domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 61622.XP_010362443.1

Rank	PPI partner	STRING score	Description
1	61622.XP_010385914.1	0.999	Growth factor receptor bound protein 2
2	61622.XP_010352136.1	0.998	GTPase HRas isoform X1
3	61622.XP_010362972.1	0.998	SHC-transforming protein 1 isoform X1
4	61622.XP_010377025.1	0.995	Tyrosine-protein phosphatase non-receptor type 11 isoform X1
5	61622.XP_010378850.1	0.994	Epidermal growth factor receptor isoform X1
6	61622.XP_010371501.1	0.992	KRAS proto-oncogene, GTPase
7	61622.XP_010366777.1	0.990	Epidermal growth factor receptor pathway substrate 8
8	61622.XP_010370267.1	0.986	Neuroblastoma RAS viral oncogene homolog
9	61622.XP_010379741.1	0.977	Abl interactor 1
10	61622.XP_010355029.1	0.976	GRB2 associated binding protein 1
11	61622.XP_010356107.1	0.951	SHC-transforming protein 4
12	61622.XP_010374254.1	0.951	Phospholipase C gamma 1
13	61622.XP_010377602.1	0.950	Erb-b2 receptor tyrosine kinase 2
14	61622.XP_010386688.1	0.947	Related RAS viral (r-ras) oncogene homolog 2
15	61622.XP_010364069.1	0.932	GRB2 associated binding protein 2
16	61622.XP_010351079.1	0.931	HCK proto-oncogene, Src family tyrosine kinase
17	61622.XP_010377977.1	0.926	GRB2-related adapter protein 2 isoform X1
18	61622.XP_010367790.1	0.921	Related RAS viral (r-ras) oncogene homolog
19	61622.XP_010378799.1	0.909	Fibroblast growth factor receptor 2 isoform X1
20	61622.XP_010382646.1	0.909	Fibroblast growth factor receptor 3 isoform X1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.999	protein binding
GO:0005085	0.999	guanyl-nucleotide exchange factor activity
GO:0008047	0.920	enzyme activator activity
GO:0005096	0.892	GTPase activator activity
GO:0019899	0.529	enzyme binding
GO:0005102	0.414	signaling receptor binding
GO:0070851	0.365	growth factor receptor binding
GO:0005154	0.300	epidermal growth factor receptor binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0050794	0.998	regulation of cellular process
GO:0051716	0.995	cellular response to stimulus
GO:0007165	0.994	signal transduction
GO:0048522	0.991	positive regulation of cellular process
GO:0009966	0.990	regulation of signal transduction
GO:1902533	0.981	positive regulation of intracellular signal transduction
GO:0051056	0.976	regulation of small GTPase mediated signal transduction
GO:0007264	0.969	small GTPase mediated signal transduction
GO:0007169	0.959	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0009719	0.958	response to endogenous stimulus
GO:0071495	0.929	cellular response to endogenous stimulus
GO:0071363	0.883	cellular response to growth factor stimulus
GO:0051057	0.816	positive regulation of small GTPase mediated signal transduction
GO:0042058	0.815	regulation of epidermal growth factor receptor signaling pathway
GO:0045742	0.765	positive regulation of epidermal growth factor receptor signaling pathway
GO:0006950	0.729	response to stress
GO:0007265	0.693	Ras protein signal transduction
GO:0019222	0.543	regulation of metabolic process
GO:0032501	0.519	multicellular organismal process
GO:0032502	0.468	developmental process
GO:0042221	0.434	response to chemical
GO:0060255	0.426	regulation of macromolecule metabolic process
GO:0042127	0.407	regulation of cell population proliferation
GO:0031323	0.405	regulation of cellular metabolic process
GO:0051239	0.399	regulation of multicellular organismal process
GO:0048856	0.387	anatomical structure development
GO:0002682	0.342	regulation of immune system process
GO:0051171	0.325	regulation of nitrogen compound metabolic process
GO:0065009	0.311	regulation of molecular function
GO:0070887	0.310	cellular response to chemical stimulus
GO:0071310	0.300	cellular response to organic substance

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005829	0.998	cytosol
GO:0005886	0.997	plasma membrane
GO:0043226	0.995	organelle
GO:0032991	0.939	protein-containing complex
GO:0043227	0.807	membrane-bounded organelle
GO:0030054	0.801	cell junction
GO:0043231	0.796	intracellular membrane-bounded organelle
GO:0045202	0.386	synapse
GO:1902494	0.376	catalytic complex
GO:0098984	0.315	neuron to neuron synapse

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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