StarFunc result for job id Q07890

User Input

>input (1332 residues)
MQQAPQPYEFFSEENSPKWRGLLVSALRKVQEQVHPTLSANEESLYYIEELIFQLLNKLC
MAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGY
KVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDD
IGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPSDI
EKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDI
LSPEFHEHFNKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKA
CSEEQEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYSHQLRSKHLAIKKM
NEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHGQTRLPG
YSSAEYRLKEKFVMRKIQICDKEDTCEHKHAFELVSKDENSIIFAAKSAEEKNNWMAALI
SLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIK
GGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTDADKLA
IEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVR
GKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLHPI
EIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEA
ENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILD
EAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRR
KVAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCK
QPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTV
SAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLS
EEPLIPPPLPPRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPVPTGAFDGPL
HSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDSDWLRDISTCPNSPS
TPPSTPSPRVPRRCYVLSSSQNNLAHPPAPPVPPRQNSSPHLPKLPPKTYKRELSHPPLY
RLPLLENAETPQ

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A0A0G2JVU2	0.790	0.886	0.000	1186	0.848	0.953	A0A0G2JVU2.pdb.gz	A0A0G2JVU2_RAT SOS Ras/Rho guanine nucleotide exchange factor 2 OS=Rattus norvegicus OX=10116 GN=Sos2 PE=4 SV=2
2	AFDB:F1MAI3	0.816	0.815	0.000	1333	0.947	0.946	F1MAI3.pdb.gz	F1MAI3_RAT SOS Ras/Rho guanine nucleotide exchange factor 2 OS=Rattus norvegicus OX=10116 GN=Sos2 PE=4 SV=1
3	AFDB:F1R019	0.777	0.772	0.000	1341	0.733	0.728	F1R019.pdb.gz	F1R019_DANRE Son of sevenless homolog 2 OS=Danio rerio OX=7955 GN=si:ch211-67f24.8 PE=1 SV=2
4	AFDB:Q07889	0.781	0.780	0.000	1333	0.699	0.698	Q07889.pdb.gz	SOS1_HUMAN Son of sevenless homolog 1 OS=Homo sapiens OX=9606 GN=SOS1 PE=1 SV=1
5	AFDB:P26675	0.698	0.587	9.788E-91	1596	0.440	0.367	P26675.pdb.gz	SOS_DROME Protein son of sevenless OS=Drosophila melanogaster OX=7227 GN=Sos PE=1 SV=2
6	PDB:7rx9A	0.138	0.359	2.658E-13	432	0.053	0.162	7rx9A.pdb.gz
7	PDB:4mt6A	0.124	0.391	5.040E-13	389	0.059	0.201	4mt6A.pdb.gz
8	AFDB:Q86X27	0.179	0.396	7.989E-12	583	0.071	0.163	Q86X27.pdb.gz	RGPS2_HUMAN Ras-specific guanine nucleotide-releasing factor RalGPS2 OS=Homo sapiens OX=9606 GN=RALGPS2 PE=1 SV=1
9	PDB:2byvE	0.256	0.362	1.846E-11	922	0.087	0.126	2byvE.pdb.gz
10	AFDB:Q0E949	0.178	0.332	3.240E-11	702	0.075	0.142	Q0E949.pdb.gz	Q0E949_DROME Uncharacterized protein, isoform A OS=Drosophila melanogaster OX=7227 GN=RalGPS PE=4 SV=1
11	PDB:4f7zA	0.265	0.367	5.657E-11	946	0.085	0.119	4f7zA.pdb.gz
12	AFDB:Q8N1W1	0.133	0.105	4.706E-8	1705	0.104	0.081	Q8N1W1.pdb.gz	ARG28_HUMAN Rho guanine nucleotide exchange factor 28 OS=Homo sapiens OX=9606 GN=ARHGEF28 PE=1 SV=3
13	PDB:4gouA	0.117	0.259	2.463E-6	507	0.044	0.114	4gouA.pdb.gz
14	PDB:6a7uA	0.109	0.803	1.270E-5	170	0.026	0.206	6a7uA.pdb.gz
15	AFDB:Q54WI0	0.080	0.080	3.750E-5	1333	0.099	0.099	Q54WI0.pdb.gz	Q54WI0_DICDI Ankyrin repeat-containing protein OS=Dictyostelium discoideum OX=44689 GN=DDB_G0279649 PE=4 SV=1
16	PDB:7r04A	0.073	0.055	8.817E-4	2326	0.105	0.060	7r04A.pdb.gz	Structural basis of activation of the tumor suppressor protein neurofibromin.
17	PDB:7r04B	0.078	0.058	1.264E-3	2229	0.098	0.059	7r04B.pdb.gz	Structural basis of activation of the tumor suppressor protein neurofibromin.
18	AFDB:Q6TRW4	0.077	0.074	1.487E-3	1447	0.125	0.115	Q6TRW4.pdb.gz	PDS5B_RAT Sister chromatid cohesion protein PDS5 homolog B OS=Rattus norvegicus OX=10116 GN=Pds5b PE=1 SV=2
19	PDB:3pvuA	0.068	0.141	2.703E-3	609	0.058	0.126	3pvuA.pdb.gz	Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors.
20	PDB:4mk0A	0.069	0.138	2.813E-3	631	0.052	0.109	4mk0A.pdb.gz	Structural and functional analysis of g protein-coupled receptor kinase inhibition by paroxetine and a rationally designed analog.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A0G2JVU2	0.0	2331	1300	0.923	0.945	A0A0G2JVU2_RAT SOS Ras/Rho guanine nucleotide exchange factor 2 OS=Rattus norvegicus OX=10116 GN=Sos2 PE=4 SV=2
2	A0A8I6B4D6	0.0	1679	1283	0.642	0.666	A0A8I6B4D6_RAT SOS Ras/Rac guanine nucleotide exchange factor 1 OS=Rattus norvegicus OX=10116 GN=Sos1 PE=1 SV=1
3	D4A3T0	0.0	1785	1319	0.679	0.685	D4A3T0_RAT SOS Ras/Rac guanine nucleotide exchange factor 1 OS=Rattus norvegicus OX=10116 GN=Sos1 PE=1 SV=2
4	F1MAI3	0.0	2417	1333	0.947	0.947	F1MAI3_RAT SOS Ras/Rho guanine nucleotide exchange factor 2 OS=Rattus norvegicus OX=10116 GN=Sos2 PE=4 SV=1
5	F1R019	0.0	1727	1341	0.644	0.640	F1R019_DANRE Son of sevenless homolog 2 OS=Danio rerio OX=7955 GN=si:ch211-67f24.8 PE=1 SV=2
6	G1TRT1	0.0	1788	1304	0.687	0.702	G1TRT1_RABIT SOS Ras/Rac guanine nucleotide exchange factor 1 OS=Oryctolagus cuniculus OX=9986 GN=SOS1 PE=4 SV=2
7	P26675	0.0	1015	1596	0.396	0.331	SOS_DROME Protein son of sevenless OS=Drosophila melanogaster OX=7227 GN=Sos PE=1 SV=2
8	Q02384	0.0	2437	1333	0.950	0.950	SOS2_MOUSE Son of sevenless homolog 2 OS=Mus musculus OX=10090 GN=Sos2 PE=1 SV=2
9	Q07889	0.0	1816	1333	0.695	0.695	SOS1_HUMAN Son of sevenless homolog 1 OS=Homo sapiens OX=9606 GN=SOS1 PE=1 SV=1
10	Q07890	0.0	2735	1332	1.000	1.000	SOS2_HUMAN Son of sevenless homolog 2 OS=Homo sapiens OX=9606 GN=SOS2 PE=1 SV=2
11	Q497A5	0.0	970	592	0.339	0.764	Q497A5_RAT Sos1 protein (Fragment) OS=Rattus norvegicus OX=10116 GN=Sos1 PE=2 SV=1
12	Q62245	0.0	1787	1319	0.689	0.696	SOS1_MOUSE Son of sevenless homolog 1 OS=Mus musculus OX=10090 GN=Sos1 PE=1 SV=2
13	Q9N5D3	3.44e-176	565	1493	0.296	0.264	SOS_CAEEL Son of sevenless homolog OS=Caenorhabditis elegans OX=6239 GN=sos-1 PE=1 SV=3
14	Q9Z1I1	5.69e-129	397	204	0.147	0.961	Q9Z1I1_RAT Son of sevenless 1 (Fragment) OS=Rattus norvegicus OX=10116 GN=Sos1 PE=2 SV=1
15	Q54PQ4	1.56e-51	194	605	0.096	0.212	GEFA_DICDI Ras guanine nucleotide exchange factor A OS=Dictyostelium discoideum OX=44689 GN=gefA PE=1 SV=1
16	Q8IS18	6.17e-42	170	1037	0.069	0.089	GEFE_DICDI Ras guanine nucleotide exchange factor E OS=Dictyostelium discoideum OX=44689 GN=gefE PE=2 SV=1
17	Q8SSQ0	8.76e-41	167	1721	0.086	0.066	GEFR_DICDI Ras guanine nucleotide exchange factor R OS=Dictyostelium discoideum OX=44689 GN=gefR PE=1 SV=1
18	Q9USU1	6.90e-38	157	987	0.092	0.125	EFC25_SCHPO Ras guanine nucleotide exchange factor efc25 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=efc25 PE=1 SV=1
19	Q13972	1.03e-35	150	1273	0.078	0.082	RGRF1_HUMAN Ras-specific guanine nucleotide-releasing factor 1 OS=Homo sapiens OX=9606 GN=RASGRF1 PE=1 SV=2
20	P27671	3.12e-35	149	1262	0.078	0.082	RGRF1_MOUSE Ras-specific guanine nucleotide-releasing factor 1 OS=Mus musculus OX=10090 GN=Rasgrf1 PE=1 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF16453 IQ_SEC7_PH	24	16.3	PH domain
2	PF00169 PH	8.1e-08	44.1	PH domain
3	PF16652 PH_13	90	14.4	Pleckstrin homology domain
4	PF00617 RasGEF	7.5e-45	164.9	RasGEF domain
5	PF00618 RasGEF_N	8.9e-28	108.0	RasGEF N-terminal motif
6	PF00621 RhoGEF	1.7e-15	69.2	RhoGEF domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000216373

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000376345	0.999	Growth factor receptor-bound protein 2
2	9606.ENSP00000407586	0.989	GTPase HRas
3	9606.ENSP00000275493	0.980	Epidermal growth factor receptor
4	9606.ENSP00000256078	0.962	GTPase KRas
5	9606.ENSP00000401303	0.962	SHC-transforming protein 1
6	9606.ENSP00000340944	0.955	Tyrosine-protein phosphatase non-receptor type 11
7	9606.ENSP00000358548	0.951	GTPase NRas
8	9606.ENSP00000348461	0.936	Ras-related C3 botulinum toxin substrate 1
9	9606.ENSP00000264554	0.866	SHC-transforming protein 2
10	9606.ENSP00000256196	0.865	Ras-related protein R-Ras2
11	9606.ENSP00000289104	0.861	Ras-related protein M-Ras
12	9606.ENSP00000329668	0.861	SHC-transforming protein 4
13	9606.ENSP00000364995	0.850	SHC-transforming protein 3
14	9606.ENSP00000310244	0.849	RAS guanyl-releasing protein 1
15	9606.ENSP00000262995	0.847	GRB2-associated-binding protein 1
16	9606.ENSP00000365312	0.839	Abl interactor 1
17	9606.ENSP00000384192	0.837	Ras guanyl-releasing protein 3
18	9606.ENSP00000408695	0.834	Protein kinase C alpha type
19	9606.ENSP00000246792	0.827	Ras-related protein R-Ras
20	9606.ENSP00000387784	0.813	Son of sevenless homolog 1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0005085	1.000	guanyl-nucleotide exchange factor activity
GO:0008047	0.972	enzyme activator activity
GO:0005096	0.705	GTPase activator activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0050794	0.997	regulation of cellular process
GO:0050896	0.995	response to stimulus
GO:0009987	0.995	cellular process
GO:0035556	0.985	intracellular signal transduction
GO:0048583	0.984	regulation of response to stimulus
GO:0048522	0.981	positive regulation of cellular process
GO:0007264	0.981	small GTPase mediated signal transduction
GO:0007169	0.978	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0010646	0.966	regulation of cell communication
GO:0009966	0.962	regulation of signal transduction
GO:0051056	0.953	regulation of small GTPase mediated signal transduction
GO:1902533	0.915	positive regulation of intracellular signal transduction
GO:0071363	0.906	cellular response to growth factor stimulus
GO:0007265	0.898	Ras protein signal transduction
GO:0051057	0.793	positive regulation of small GTPase mediated signal transduction
GO:0006950	0.749	response to stress
GO:0042058	0.636	regulation of epidermal growth factor receptor signaling pathway
GO:0032501	0.406	multicellular organismal process
GO:0019222	0.405	regulation of metabolic process
GO:0031323	0.350	regulation of cellular metabolic process
GO:0032502	0.347	developmental process
GO:0042221	0.311	response to chemical

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005829	0.999	cytosol
GO:0043226	0.996	organelle
GO:0005886	0.995	plasma membrane
GO:0032991	0.909	protein-containing complex
GO:0030054	0.866	cell junction
GO:0043227	0.809	membrane-bounded organelle
GO:0043231	0.797	intracellular membrane-bounded organelle
GO:1902494	0.443	catalytic complex

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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