StarFunc result for job id Q10472

User Input

>input (559 residues)
MRKFAYCKVVLATSLIWVLLDMFLLLYFSECNKCDEKKERGLPAGDVLEPVQKPHEGPGE
MGKPVVIPKEDQEKMKEMFKINQFNLMASEMIALNRSLPDVRLEGCKTKVYPDNLPTTSV
VIVFHNEAWSTLLRTVHSVINRSPRHMIEEIVLVDDASERDFLKRPLESYVKKLKVPVHV
IRMEQRSGLIRARLKGAAVSKGQVITFLDAHCECTVGWLEPLLARIKHDRRTVVCPIIDV
ISDDTFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPVRTPTMAGGLFSIDR
DYFQEIGTYDAGMDIWGGENLEISFRIWQCGGTLEIVTCSHVGHVFRKATPYTFPGGTGQ
IINKNNRRLAEVWMDEFKNFFYIISPGVTKVDYGDISSRVGLRHKLQCKPFSWYLENIYP
DSQIPRHYFSLGEIRNVETNQCLDNMARKENEKVGIFNCHGMGGNQVFSYTANKEIRTDD
LCLDVSKLNGPVTMLKCHHLKGNQLWEYDPVKLTLQHVNSNQCLDKATEEDSQVPSIRDC
NGSRSQQWLLRNVTLPEIF

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:O08912	0.962	0.962	0.000	559	0.982	0.982	O08912.pdb.gz	GALT1_MOUSE Polypeptide N-acetylgalactosaminyltransferase 1 OS=Mus musculus OX=10090 GN=Galnt1 PE=1 SV=1
2	AFDB:Q8CF93	0.893	0.898	7.256E-103	556	0.839	0.844	Q8CF93.pdb.gz	GLT13_MOUSE Polypeptide N-acetylgalactosaminyltransferase 13 OS=Mus musculus OX=10090 GN=Galnt13 PE=1 SV=1
3	AFDB:Q6WV17	0.882	0.784	8.311E-87	630	0.610	0.541	Q6WV17.pdb.gz	GALT5_DROME Polypeptide N-acetylgalactosaminyltransferase 5 OS=Drosophila melanogaster OX=7227 GN=Pgant5 PE=1 SV=2
4	AFDB:P34678	0.848	0.776	2.681E-76	612	0.501	0.458	P34678.pdb.gz	GALT3_CAEEL Polypeptide N-acetylgalactosaminyltransferase 3 OS=Caenorhabditis elegans OX=6239 GN=gly-3 PE=2 SV=2
5	AFDB:Q95ZJ1	0.818	0.735	8.722E-70	626	0.470	0.420	Q95ZJ1.pdb.gz	GALT5_CAEEL Polypeptide N-acetylgalactosaminyltransferase 5 OS=Caenorhabditis elegans OX=6239 GN=gly-5 PE=2 SV=2
6	AFDB:Q8MRC9	0.831	0.719	1.332E-68	650	0.462	0.397	Q8MRC9.pdb.gz	GALT9_DROME Putative polypeptide N-acetylgalactosaminyltransferase 9 OS=Drosophila melanogaster OX=7227 GN=Pgant9 PE=1 SV=2
7	AFDB:Q9Y117	0.808	0.684	5.659E-67	667	0.449	0.376	Q9Y117.pdb.gz	GALT3_DROME Polypeptide N-acetylgalactosaminyltransferase 3 OS=Drosophila melanogaster OX=7227 GN=Pgant3 PE=1 SV=1
8	AFDB:Q49A17	0.661	0.621	4.629E-66	601	0.390	0.363	Q49A17.pdb.gz	GLTL6_HUMAN Polypeptide N-acetylgalactosaminyltransferase-like 6 OS=Homo sapiens OX=9606 GN=GALNTL6 PE=2 SV=2
9	AFDB:Q8N4A0	0.788	0.763	4.629E-66	578	0.417	0.403	Q8N4A0.pdb.gz	GALT4_HUMAN Polypeptide N-acetylgalactosaminyltransferase 4 OS=Homo sapiens OX=9606 GN=GALNT4 PE=1 SV=2
10	AFDB:B0V0U4	0.657	0.657	4.007E-65	559	0.408	0.408	B0V0U4.pdb.gz	B0V0U4_DANRE Polypeptide N-acetylgalactosaminyltransferase OS=Danio rerio OX=7955 GN=im:7140357 PE=1 SV=1
11	PDB:6pxuB	0.809	0.848	3.508E-62	532	0.413	0.434	6pxuB.pdb.gz	The structure of the colorectal cancer-associated enzyme GalNAc-T12 reveals how nonconserved residues dictate its function.
12	PDB:2d7iA	0.651	0.678	1.371E-61	536	0.395	0.412	2d7iA.pdb.gz	Structural basis of carbohydrate transfer activity by human UDP-GalNAc: polypeptide alpha-N-acetylgalactosaminyltransferase (pp-GalNAc-T10)
13	PDB:4d0tA	0.651	0.729	2.420E-61	496	0.395	0.446	4d0tA.pdb.gz	Substrate-Guided Front-Face Reaction Revealed by Combined Structural Snapshots and Metadynamics for the Polypeptide N-Acetylgalactosaminyltransferase 2.
14	PDB:6h0bB	0.804	0.859	3.215E-61	521	0.411	0.441	6h0bB.pdb.gz	Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4.
15	PDB:6iwqA	0.689	0.703	3.896E-58	546	0.388	0.397	6iwqA.pdb.gz	Structural basis of carbohydrate transfer activity of UDP-GalNAc: Polypeptide N-acetylgalactosaminyltransferase 7.
16	PDB:4d11C	0.614	0.781	1.010E-51	436	0.354	0.454	4d11C.pdb.gz	Substrate-Guided Front-Face Reaction Revealed by Combined Structural Snapshots and Metadynamics for the Polypeptide N- Acetylgalactosaminyltransferase 2.
17	PDB:1vclA	0.198	0.253	3.495E-8	432	0.057	0.074	1vclA.pdb.gz	Crystal Structure of the Hemolytic Lectin CEL-III Isolated from the Marine Invertebrate Cucumaria echinata: IMPLICATIONS OF DOMAIN STRUCTURE FOR ITS MEMBRANE PORE-FORMATION MECHANISM
18	PDB:4fixA	0.357	0.322	5.828E-8	629	0.064	0.057	4fixA.pdb.gz	Tetrameric Structure of the GlfT2 Galactofuranosyltransferase Reveals a Scaffold for the Assembly of Mycobacterial Arabinogalactan.
19	PDB:5mlzA	0.252	0.372	3.390E-7	355	0.102	0.161	5mlzA.pdb.gz	Structural basis for dolichylphosphate mannose biosynthesis.
20	PDB:7msnA	0.232	0.300	7.947E-7	417	0.088	0.118	7msnA.pdb.gz	Structural and mechanistic investigations of protein S-glycosyltransferases.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	O08912	0.0	1155	559	0.984	0.984	GALT1_MOUSE Polypeptide N-acetylgalactosaminyltransferase 1 OS=Mus musculus OX=10090 GN=Galnt1 PE=1 SV=1
2	P34678	0.0	581	612	0.519	0.474	GALT3_CAEEL Polypeptide N-acetylgalactosaminyltransferase 3 OS=Caenorhabditis elegans OX=6239 GN=gly-3 PE=2 SV=2
3	Q07537	0.0	1163	559	0.989	0.989	GALT1_BOVIN Polypeptide N-acetylgalactosaminyltransferase 1 OS=Bos taurus OX=9913 GN=GALNT1 PE=1 SV=1
4	Q10472	0.0	1170	559	1.000	1.000	GALT1_HUMAN Polypeptide N-acetylgalactosaminyltransferase 1 OS=Homo sapiens OX=9606 GN=GALNT1 PE=1 SV=1
5	Q10473	0.0	1159	559	0.989	0.989	GALT1_RAT Polypeptide N-acetylgalactosaminyltransferase 1 OS=Rattus norvegicus OX=10116 GN=Galnt1 PE=1 SV=1
6	Q29121	0.0	1158	559	0.986	0.986	GALT1_PIG Polypeptide N-acetylgalactosaminyltransferase 1 OS=Sus scrofa OX=9823 GN=GALNT1 PE=1 SV=1
7	Q6WV17	0.0	718	630	0.621	0.551	GALT5_DROME Polypeptide N-acetylgalactosaminyltransferase 5 OS=Drosophila melanogaster OX=7227 GN=Pgant5 PE=1 SV=2
8	Q8CF93	0.0	1005	556	0.839	0.844	GLT13_MOUSE Polypeptide N-acetylgalactosaminyltransferase 13 OS=Mus musculus OX=10090 GN=Galnt13 PE=1 SV=1
9	Q8IUC8	0.0	1009	556	0.843	0.847	GLT13_HUMAN Polypeptide N-acetylgalactosaminyltransferase 13 OS=Homo sapiens OX=9606 GN=GALNT13 PE=1 SV=2
10	Q95ZJ1	5.04e-170	498	626	0.449	0.401	GALT5_CAEEL Polypeptide N-acetylgalactosaminyltransferase 5 OS=Caenorhabditis elegans OX=6239 GN=gly-5 PE=2 SV=2
11	Q8MRC9	1.48e-168	494	650	0.465	0.400	GALT9_DROME Putative polypeptide N-acetylgalactosaminyltransferase 9 OS=Drosophila melanogaster OX=7227 GN=Pgant9 PE=1 SV=2
12	Q9Y117	2.35e-157	466	667	0.383	0.321	GALT3_DROME Polypeptide N-acetylgalactosaminyltransferase 3 OS=Drosophila melanogaster OX=7227 GN=Pgant3 PE=1 SV=1
13	A0A1L7NY50	3.56e-153	452	571	0.401	0.392	A0A1L7NY50_HUMAN Polypeptide N-acetylgalactosaminyltransferase OS=Homo sapiens OX=9606 GN=GALNT2 PE=2 SV=1
14	Q10471	3.56e-153	452	571	0.401	0.392	GALT2_HUMAN Polypeptide N-acetylgalactosaminyltransferase 2 OS=Homo sapiens OX=9606 GN=GALNT2 PE=1 SV=1
15	Q6PB93	1.84e-151	448	570	0.401	0.393	GALT2_MOUSE Polypeptide N-acetylgalactosaminyltransferase 2 OS=Mus musculus OX=10090 GN=Galnt2 PE=1 SV=1
16	B0V0U4	2.09e-151	447	559	0.390	0.390	B0V0U4_DANRE Polypeptide N-acetylgalactosaminyltransferase OS=Danio rerio OX=7955 GN=im:7140357 PE=1 SV=1
17	Q6WV19	7.42e-150	446	633	0.410	0.362	GALT2_DROME Polypeptide N-acetylgalactosaminyltransferase 2 OS=Drosophila melanogaster OX=7227 GN=Pgant2 PE=1 SV=2
18	Q8NCL4	1.60e-146	437	622	0.454	0.408	GALT6_HUMAN Polypeptide N-acetylgalactosaminyltransferase 6 OS=Homo sapiens OX=9606 GN=GALNT6 PE=1 SV=2
19	Q6P9S7	1.67e-143	429	603	0.411	0.381	GLT10_MOUSE Polypeptide N-acetylgalactosaminyltransferase 10 OS=Mus musculus OX=10090 GN=Galnt10 PE=2 SV=1
20	Q86SR1	2.16e-143	429	603	0.411	0.381	GLT10_HUMAN Polypeptide N-acetylgalactosaminyltransferase 10 OS=Homo sapiens OX=9606 GN=GALNT10 PE=1 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00535 Glycos_transf_2	1.4e-35	134.1	Glycosyl transferase family 2
2	PF10111 Glyco_tranf_2_2	0.98	20.4	Glycosyltransferase like family 2
3	PF13641 Glyco_tranf_2_3	0.029	25.8	Glycosyltransferase like family 2
4	PF02709 Glyco_transf_7C	0.0086	27.1	N-terminal domain of galactosyltransferase
5	PF14200 RicinB_lectin_2	0.021	26.8	Ricin-type beta-trefoil lectin domain-like
6	PF00652 Ricin_B_lectin	3.1e-26	103.5	Ricin-type beta-trefoil lectin domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 61853.ENSNLEP00000007598

Rank	PPI partner	STRING score	Description
1	61853.ENSNLEP00000019501	0.972	Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
2	61853.ENSNLEP00000018266	0.830	C1GALT1-specific chaperone 1
3	61853.ENSNLEP00000021677	0.792	Mucin 15, cell surface associated
4	61853.ENSNLEP00000009960	0.745	Uncharacterized protein
5	61853.ENSNLEP00000002480	0.733	Glucosaminyl (N-acetyl) transferase 1, core 2
6	61853.ENSNLEP00000018323	0.697	Golgi brefeldin A resistant guanine nucleotide exchange factor 1
7	61853.ENSNLEP00000020950	0.697	beta-1,4-N-acetyl-galactosaminyl transferase 1
8	61853.ENSNLEP00000021729	0.695	Elongator acetyltransferase complex subunit 4
9	61853.ENSNLEP00000023742	0.695	TBC/LysM-associated domain containing 1
10	61853.ENSNLEP00000020286	0.692	C1GALT1-specific chaperone 1 like
11	61853.ENSNLEP00000014308	0.682	Mucin 1, cell surface associated
12	61853.ENSNLEP00000020384	0.682	Hexosyltransferase
13	61853.ENSNLEP00000010793	0.654	annotation not available
14	61853.ENSNLEP00000010764	0.634	Mucin 6, oligomeric mucus/gel-forming
15	61853.ENSNLEP00000010211	0.633	Uncharacterized protein
16	61853.ENSNLEP00000017367	0.630	Polypeptide N-acetylgalactosaminyltransferase 2
17	61853.ENSNLEP00000009352	0.621	Uncharacterized protein
18	61853.ENSNLEP00000020617	0.621	RAB18, member RAS oncogene family
19	61853.ENSNLEP00000009441	0.615	Uncharacterized protein
20	61853.ENSNLEP00000000830	0.612	Mucin 13, cell surface associated

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0004653	0.998	polypeptide N-acetylgalactosaminyltransferase activity
GO:0005488	0.797	binding
GO:0005515	0.570	protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0009987	0.998	cellular process
GO:0044238	0.997	primary metabolic process
GO:1901576	0.996	organic substance biosynthetic process
GO:0006486	0.988	protein glycosylation
GO:0006493	0.982	protein O-linked glycosylation

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0000139	0.997	Golgi membrane
GO:0031984	0.478	organelle subcompartment
GO:0005783	0.445	endoplasmic reticulum
GO:0042175	0.437	nuclear outer membrane-endoplasmic reticulum membrane network
GO:0070062	0.426	extracellular exosome
GO:0048471	0.403	perinuclear region of cytoplasm
GO:0098827	0.396	endoplasmic reticulum subcompartment
GO:0005789	0.393	endoplasmic reticulum membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:2.4.1.41	0.998	polypeptide N-acetylgalactosaminyltransferase.

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