StarFunc result for job id Q10589

User Input

>input (180 residues)
MASTSYDYCRVPMEDGDKRCKLLLGIGILVLLIIVILGVPLIIFTIKANSEACRDGLRAV
MECRNVTHLLQQELTEAQKGFQDVEAQAATCNHTVMALMASLDAEKAQGQKKVEELEGEI
TTLNHKLQDASAEVERLRRENQVLSVRIADKKYYPSSQDSSSAAAPQLLIVLLGLSALLQ

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A0A024R7H5	0.794	0.794	2.912E-24	180	1.000	1.000	A0A024R7H5.pdb.gz	A0A024R7H5_HUMAN Bone marrow stromal antigen 2 OS=Homo sapiens OX=9606 GN=BST2 PE=4 SV=1
2	AFDB:Q8R2Q8	0.579	0.603	3.863E-7	172	0.400	0.419	Q8R2Q8.pdb.gz	BST2_MOUSE Bone marrow stromal antigen 2 OS=Mus musculus OX=10090 GN=Bst2 PE=1 SV=1
3	AFDB:Q811A2	0.614	0.639	2.441E-5	172	0.339	0.355	Q811A2.pdb.gz	BST2_RAT Bone marrow stromal antigen 2 OS=Rattus norvegicus OX=10116 GN=Bst2 PE=1 SV=1
4	AFDB:O14148	0.265	0.045	6.888E-1	1604	0.156	0.017	O14148.pdb.gz	INO80_SCHPO Chromatin-remodeling ATPase INO80 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=ino80 PE=1 SV=4
5	AFDB:Q6UXB4	0.544	0.341	1.101	293	0.161	0.099	Q6UXB4.pdb.gz	CLC4G_HUMAN C-type lectin domain family 4 member G OS=Homo sapiens OX=9606 GN=CLEC4G PE=1 SV=1
6	AFDB:Q71F23	0.532	0.247	1.288	418	0.122	0.053	Q71F23.pdb.gz	CENPU_HUMAN Centromere protein U OS=Homo sapiens OX=9606 GN=CENPU PE=1 SV=1
7	AFDB:Q8IYT3	0.403	0.136	1.629	715	0.161	0.041	Q8IYT3.pdb.gz	CC170_HUMAN Coiled-coil domain-containing protein 170 OS=Homo sapiens OX=9606 GN=CCDC170 PE=1 SV=3
8	AFDB:Q38840	0.295	0.245	2.227	227	0.144	0.115	Q38840.pdb.gz	AGL17_ARATH Agamous-like MADS-box protein AGL17 OS=Arabidopsis thaliana OX=3702 GN=AGL17 PE=1 SV=2
9	AFDB:A8JF70	0.566	0.195	2.408	552	0.167	0.054	A8JF70.pdb.gz	ODA1_CHLRE Outer dynein arm protein 1 OS=Chlamydomonas reinhardtii OX=3055 GN=ODA1 PE=1 SV=1
10	AFDB:Q9D495	0.475	0.284	2.408	329	0.167	0.091	Q9D495.pdb.gz	SYCE1_MOUSE Synaptonemal complex central element protein 1 OS=Mus musculus OX=10090 GN=Syce1 PE=1 SV=1
11	PDB:6qlfU	0.269	0.278	3.779	171	0.144	0.152	6qlfU.pdb.gz
12	PDB:3jd5d	0.291	0.297	4.086	176	0.144	0.148	3jd5d.pdb.gz	Cryo-EM structure of the small subunit of the mammalian mitochondrial ribosome.
13	PDB:6cm9T	0.060	0.385	4.419	13	0.067	0.923	6cm9T.pdb.gz	HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation.
14	PDB:7qo4H	0.120	0.057	7.640	391	0.050	0.023	7qo4H.pdb.gz	Allosteric control of Ubp6 and the proteasome via a bidirectional switch.
15	PDB:4gwpA	0.191	0.289	8.262	112	0.106	0.170	4gwpA.pdb.gz
16	PDB:1ezvG	0.196	0.333	8.934	93	0.067	0.129	1ezvG.pdb.gz	Structure at 2.3 A resolution of the cytochrome bc(1) complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment.
17	PDB:5n9jG	0.176	0.194	8.934	163	0.061	0.067	5n9jG.pdb.gz
18	PDB:7rjeF	0.196	0.347	8.934	88	0.044	0.091	7rjeF.pdb.gz	Rieske head domain dynamics and indazole-derivative inhibition of Candida albicans complex III.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A024R7H5	6.46e-131	365	180	1.000	1.000	A0A024R7H5_HUMAN Bone marrow stromal antigen 2 OS=Homo sapiens OX=9606 GN=BST2 PE=4 SV=1
2	Q10589	6.46e-131	365	180	1.000	1.000	BST2_HUMAN Bone marrow stromal antigen 2 OS=Homo sapiens OX=9606 GN=BST2 PE=1 SV=1
3	Q8R2Q8	3.07e-30	110	172	0.339	0.355	BST2_MOUSE Bone marrow stromal antigen 2 OS=Mus musculus OX=10090 GN=Bst2 PE=1 SV=1
4	Q811A2	9.93e-19	80.9	172	0.317	0.331	BST2_RAT Bone marrow stromal antigen 2 OS=Rattus norvegicus OX=10116 GN=Bst2 PE=1 SV=1
5	O60447	0.25	33.9	810	0.094	0.021	EVI5_HUMAN Ecotropic viral integration site 5 protein homolog OS=Homo sapiens OX=9606 GN=EVI5 PE=1 SV=3
6	P10716	0.44	33.1	550	0.156	0.051	CLC4F_RAT C-type lectin domain family 4 member F OS=Rattus norvegicus OX=10116 GN=Clec4f PE=1 SV=1
7	O64631	0.72	32.7	511	0.122	0.043	O64631_ARATH At2g45510 OS=Arabidopsis thaliana OX=3702 GN=CYP704A2 PE=1 SV=1
8	Q5EE04	0.77	32.7	1997	0.117	0.011	TPR_XENLA Nucleoprotein TPR (Fragment) OS=Xenopus laevis OX=8355 GN=tpr PE=1 SV=1
9	H0YJ97	0.78	32.7	1695	0.106	0.011	H0YJ97_HUMAN Thyroid hormone receptor interactor 11 (Fragment) OS=Homo sapiens OX=9606 GN=TRIP11 PE=1 SV=1
10	Q15643	0.78	32.7	1979	0.106	0.010	TRIPB_HUMAN Thyroid receptor-interacting protein 11 OS=Homo sapiens OX=9606 GN=TRIP11 PE=1 SV=3
11	G5EAY1	1.4	32.0	1474	0.150	0.018	G5EAY1_EMENI Uncharacterized protein OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=teaA PE=4 SV=1
12	Q17607	1.4	32.0	623	0.128	0.037	MCE1_CAEEL mRNA-capping enzyme OS=Caenorhabditis elegans OX=6239 GN=cel-1 PE=1 SV=2
13	P02567	1.6	31.6	1938	0.167	0.015	MYO1_CAEEL Myosin-1 OS=Caenorhabditis elegans OX=6239 GN=myo-1 PE=1 SV=3
14	P70336	1.6	31.6	1388	0.156	0.020	ROCK2_MOUSE Rho-associated protein kinase 2 OS=Mus musculus OX=10090 GN=Rock2 PE=1 SV=1
15	Q4U0S2	1.9	31.6	1974	0.122	0.011	Q4U0S2_DANRE Myosin-11 OS=Danio rerio OX=7955 GN=myh11 PE=1 SV=1
16	O95136	2.0	31.2	353	0.083	0.042	S1PR2_HUMAN Sphingosine 1-phosphate receptor 2 OS=Homo sapiens OX=9606 GN=S1PR2 PE=1 SV=2
17	Q6AWQ6	2.0	31.2	535	0.100	0.034	Q6AWQ6_DROME RH06321p (Fragment) OS=Drosophila melanogaster OX=7227 GN=plx PE=2 SV=1
18	Q99JB4	2.1	30.8	223	0.139	0.112	KRBBB_MOUSE Killer cell lectin-like receptor subfamily B member 1B allele B OS=Mus musculus OX=10090 GN=Klrb1b PE=1 SV=1
19	Q9X1X1	2.2	31.2	852	0.083	0.018	RAD50_THEMA Probable DNA double-strand break repair Rad50 ATPase OS=Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) OX=243274 GN=rad50 PE=1 SV=1
20	A0A0B4KGK7	2.6	31.2	1518	0.122	0.014	A0A0B4KGK7_DROME Pollux, isoform E OS=Drosophila melanogaster OX=7227 GN=plx PE=4 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF08614 ATG16	1.2	20.8	Autophagy protein 16 (ATG16)
2	PF16716 BST2	9e-33	124.1	Bone marrow stromal antigen 2
3	PF07888 CALCOCO1	2.3	18.7	Calcium binding and coiled-coil domain (CALCOCO1) like
4	PF08172 CASP_C	2.4e+02	12.5	CASP C terminal
5	PF15188 CCDC-167	5	18.8	Coiled-coil domain-containing protein 167
6	PF10473 CENP-F_leu_zip	46	15.5	Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
7	PF05837 CENP-H	3.8e+02	12.9	Centromere protein H (CENP-H)
8	PF10234 Cluap1	6.1e+02	11.2	Clusterin-associated protein-1
9	PF07889 DUF1664	4.2e+02	12.4	Protein of unknown function (DUF1664)
10	PF10224 DUF2205	9.8e+02	11.3	Short coiled-coil protein
11	PF11932 DUF3450	26	15.6	Protein of unknown function (DUF3450)
12	PF14739 DUF4472	3.4e+02	13.3	Domain of unknown function (DUF4472)
13	PF15397 DUF4618	15	16.5	Domain of unknown function (DUF4618)
14	PF01105 EMP24_GP25L	2.1e+02	13.3	emp24/gp25L/p24 family/GOLD
15	PF20492 ERM_helical	8e+02	11.5	Ezrin/radixin/moesin, alpha-helical domain
16	PF00038 Filament	68	14.5	Intermediate filament protein
17	PF05377 FlaC_arch	69	15.3	Flagella accessory protein C (FlaC)
18	PF02050 FliJ	88	14.7	Flagellar FliJ protein
19	PF13851 GAS	3.5e+02	11.9	Growth-arrest specific micro-tubule binding
20	PF01025 GrpE	2.7e+02	12.6	GrpE

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000252593

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000291759	0.993	Leukocyte immunoglobulin-like receptor subfamily A member 4
2	9606.ENSP00000368699	0.985	Ubiquitin-like protein ISG15
3	9606.ENSP00000262878	0.981	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
4	9606.ENSP00000381601	0.977	Interferon-induced GTP-binding protein Mx1
5	9606.ENSP00000333657	0.976	Interferon-induced GTP-binding protein Mx2
6	9606.ENSP00000371471	0.976	Radical S-adenosyl methionine domain-containing protein 2
7	9606.ENSP00000388001	0.972	2'-5'-oligoadenylate synthase 1
8	9606.ENSP00000380697	0.971	Interferon regulatory factor 7
9	9606.ENSP00000395590	0.969	Interferon-induced 35 kDa protein
10	9606.ENSP00000342278	0.966	2'-5'-oligoadenylate synthase 2
11	9606.ENSP00000386187	0.966	Interferon-induced transmembrane protein 1
12	9606.ENSP00000360869	0.963	Interferon-induced protein with tetratricopeptide repeats 1
13	9606.ENSP00000360883	0.963	Interferon-induced protein with tetratricopeptide repeats 3
14	9606.ENSP00000342513	0.961	Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis . However, it has also been shown to have a pro-apoptotic activity . Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, which activation is required for entry of the virus into cells . ECO:0000269\|PubMed:17823654, ECO:0000269\|PubMed:25757571,
15	9606.ENSP00000382707	0.961	Interferon-induced transmembrane protein 3
16	9606.ENSP00000354394	0.960	Signal transducer and activator of transcription 1-alpha/beta
17	9606.ENSP00000380073	0.953	Interferon regulatory factor 9
18	9606.ENSP00000228928	0.952	2'-5'-oligoadenylate synthase 3
19	9606.ENSP00000257570	0.951	2'-5'-oligoadenylate synthase-like protein
20	9606.ENSP00000315768	0.951	Signal transducer and activator of transcription 2

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.999	protein binding
GO:0003676	0.819	nucleic acid binding
GO:0042802	0.786	identical protein binding
GO:0003723	0.707	RNA binding
GO:0098772	0.382	molecular function regulator activity
GO:0008191	0.364	metalloendopeptidase inhibitor activity
GO:0046983	0.356	protein dimerization activity
GO:0042803	0.346	protein homodimerization activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0065007	0.996	biological regulation
GO:0050896	0.989	response to stimulus
GO:0048583	0.988	regulation of response to stimulus
GO:0050794	0.986	regulation of cellular process
GO:0019222	0.986	regulation of metabolic process
GO:0060255	0.983	regulation of macromolecule metabolic process
GO:0002682	0.980	regulation of immune system process
GO:0009615	0.977	response to virus
GO:0051239	0.976	regulation of multicellular organismal process
GO:0048518	0.976	positive regulation of biological process
GO:0045087	0.973	innate immune response
GO:0048523	0.963	negative regulation of cellular process
GO:0010468	0.961	regulation of gene expression
GO:0048525	0.951	negative regulation of viral process
GO:0045071	0.944	negative regulation of viral genome replication
GO:0048522	0.939	positive regulation of cellular process
GO:1903901	0.931	negative regulation of viral life cycle
GO:0140546	0.909	defense response to symbiont
GO:0001817	0.899	regulation of cytokine production
GO:0023051	0.893	regulation of signaling
GO:0051128	0.869	regulation of cellular component organization
GO:0051607	0.848	defense response to virus
GO:0010646	0.837	regulation of cell communication
GO:0009966	0.832	regulation of signal transduction
GO:0048584	0.820	positive regulation of response to stimulus
GO:0002700	0.788	regulation of production of molecular mediator of immune response
GO:0002683	0.780	negative regulation of immune system process
GO:0010605	0.775	negative regulation of macromolecule metabolic process
GO:0002698	0.758	negative regulation of immune effector process
GO:0002718	0.754	regulation of cytokine production involved in immune response
GO:0042127	0.699	regulation of cell population proliferation
GO:0010629	0.697	negative regulation of gene expression
GO:0070663	0.669	regulation of leukocyte proliferation
GO:0043123	0.668	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0002703	0.667	regulation of leukocyte mediated immunity
GO:0001818	0.661	negative regulation of cytokine production
GO:0009987	0.660	cellular process
GO:0030334	0.654	regulation of cell migration
GO:0008284	0.635	positive regulation of cell population proliferation
GO:0030308	0.585	negative regulation of cell growth
GO:0030336	0.584	negative regulation of cell migration
GO:0002701	0.577	negative regulation of production of molecular mediator of immune response
GO:0002704	0.568	negative regulation of leukocyte mediated immunity
GO:0070665	0.511	positive regulation of leukocyte proliferation
GO:0051716	0.454	cellular response to stimulus
GO:0007165	0.426	signal transduction
GO:0042221	0.383	response to chemical
GO:0034097	0.369	response to cytokine
GO:0009893	0.338	positive regulation of metabolic process
GO:0031323	0.330	regulation of cellular metabolic process
GO:0010604	0.326	positive regulation of macromolecule metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005794	0.995	Golgi apparatus
GO:0016020	0.993	membrane
GO:0005886	0.979	plasma membrane
GO:0031090	0.957	organelle membrane
GO:0031982	0.946	vesicle
GO:0097708	0.905	intracellular vesicle
GO:0031410	0.869	cytoplasmic vesicle
GO:0005576	0.826	extracellular region
GO:0098588	0.804	bounding membrane of organelle
GO:0005829	0.733	cytosol
GO:0030659	0.700	cytoplasmic vesicle membrane
GO:0005773	0.617	vacuole
GO:0099503	0.607	secretory vesicle
GO:0005764	0.585	lysosome
GO:0030141	0.577	secretory granule
GO:0009986	0.536	cell surface
GO:0070062	0.534	extracellular exosome
GO:0005768	0.514	endosome
GO:0030667	0.455	secretory granule membrane
GO:0005765	0.386	lysosomal membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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