StarFunc result for job id Q12879

User Input

>input (1464 residues)
MGRVGYWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQA
AGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHT
FVPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGY
REFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLIL
SEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILT
TAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPR
LVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVE
DIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLV
TNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRS
NGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFT
IGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVD
QVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSL
KTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALL
QFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHL
FYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRS
AKNISSMSNMNSSRMDSPKRAADFIQRGSLIMDMVSDKGNLMYSDNRSFQGKESIFGDNM
NELQTFVANRQKDNLNNYVFQGQHPLTLNESNPNTVEVAVSTESKANSRPRQLWKKSVDS
IRQDSLSQNPVSQRDEATAENRTHSLKSPRYLPEEMAHSDISETSNRATCHREPDNSKNH
KTKDNFKRSVASKYPKDCSEVERTYLKTKSSSPRDKIYTIDGEKEPGFHLDPPQFVENVT
LPENVDFPDPYQDPSENFRKGDSTLPMNRNPLHNEEGLSNNDQYKLYSKHFTLKDKGSPH
SETSERYRQNSTHCRSCLSNMPTYSGHFTMRSPFKCDACLRMGNLYDIDEDQMLQETGNP
ATGEQVYQQDWAQNNALQLQKNKLRISRQHSYDNIVDKPRELDLSRPSRSISLKDRERLL
EGNFYGSLFSVPSSKLSGKKSSLFPQGLEDSKRSKSLLPDHTSDNPFLHSHRDDQRLVIG
RCPSDPYKHSLPSQAVNDSYLRSSLRSTASYCSRDSRGHNDVYISEHVMPYAANKNNMYS
TPRVLNSCSNRRVYKKMPSIESDV

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A7XY94	0.573	0.580	0.000	1448	0.531	0.537	A7XY94.pdb.gz	NMDE2_XENLA Glutamate receptor ionotropic, NMDA 2B OS=Xenopus laevis OX=8355 GN=grin2b PE=1 SV=1
2	AFDB:B7ZSK1	0.637	0.642	0.000	1451	0.719	0.725	B7ZSK1.pdb.gz	NMDE1_XENLA Glutamate receptor ionotropic, NMDA 2A OS=Xenopus laevis OX=8355 GN=grin2a PE=1 SV=1
3	AFDB:O15399	0.528	0.576	0.000	1336	0.390	0.427	O15399.pdb.gz	NMDE4_HUMAN Glutamate receptor ionotropic, NMDA 2D OS=Homo sapiens OX=9606 GN=GRIN2D PE=1 SV=2
4	AFDB:P35436	0.696	0.696	0.000	1464	0.952	0.952	P35436.pdb.gz	NMDE1_MOUSE Glutamate receptor ionotropic, NMDA 2A OS=Mus musculus OX=10090 GN=Grin2a PE=1 SV=2
5	AFDB:Q13224	0.584	0.576	0.000	1484	0.540	0.532	Q13224.pdb.gz	NMDE2_HUMAN Glutamate receptor ionotropic, NMDA 2B OS=Homo sapiens OX=9606 GN=GRIN2B PE=1 SV=3
6	PDB:4pe5C	0.213	0.398	2.964E-53	754	0.138	0.268	4pe5C.pdb.gz	Crystal structure of a heterotetrameric NMDA receptor ion channel.
7	PDB:4tllA	0.221	0.405	9.031E-53	767	0.137	0.262	4tllA.pdb.gz	NMDA receptor structures reveal subunit arrangement and pore architecture.
8	PDB:7ocaA	0.193	0.329	3.765E-48	775	0.115	0.217	7ocaA.pdb.gz	Gating and modulation of a hetero-octameric AMPA glutamate receptor.
9	PDB:4tlmC	0.214	0.400	4.705E-48	750	0.135	0.263	4tlmC.pdb.gz	NMDA receptor structures reveal subunit arrangement and pore architecture.
10	PDB:5iouA	0.212	0.370	4.974E-48	803	0.143	0.260	5iouA.pdb.gz	Mechanism of NMDA Receptor Inhibition and Activation.
11	PDB:7rz4A	0.197	0.271	4.974E-48	993	0.112	0.165	7rz4A.pdb.gz	Structure and desensitization of AMPA receptor complexes with type II TARP gamma 5 and GSG1L.
12	PDB:7rzaA	0.195	0.269	5.983E-46	981	0.114	0.170	7rzaA.pdb.gz	Structure and desensitization of AMPA receptor complexes with type II TARP gamma 5 and GSG1L.
13	PDB:5weoA	0.198	0.272	8.200E-45	988	0.118	0.175	5weoA.pdb.gz	Channel opening and gating mechanism in AMPA-subtype glutamate receptors.
14	PDB:5idfB	0.188	0.344	1.431E-44	734	0.111	0.222	5idfB.pdb.gz
15	PDB:5kbtA	0.197	0.277	3.063E-43	973	0.112	0.169	5kbtA.pdb.gz	Elucidation of AMPA receptor-stargazin complexes by cryo-electron microscopy.
16	AFDB:Q17602	0.039	0.041	1.255E-2	1390	0.076	0.080	Q17602.pdb.gz	NU214_CAEEL Nuclear pore complex protein 14 OS=Caenorhabditis elegans OX=6239 GN=npp-14 PE=1 SV=1
17	AFDB:M9PEF2	0.043	0.069	4.777E-2	791	0.078	0.144	M9PEF2.pdb.gz	M9PEF2_DROME Liquid facets, isoform J OS=Drosophila melanogaster OX=7227 GN=lqf PE=1 SV=1
18	AFDB:Q6P1D7	0.037	0.036	1.042E-1	1565	0.104	0.097	Q6P1D7.pdb.gz	SLX4_MOUSE Structure-specific endonuclease subunit SLX4 OS=Mus musculus OX=10090 GN=Slx4 PE=1 SV=1
19	AFDB:Q32MZ4	0.032	0.051	1.302E-1	808	0.065	0.118	Q32MZ4.pdb.gz	LRRF1_HUMAN Leucine-rich repeat flightless-interacting protein 1 OS=Homo sapiens OX=9606 GN=LRRFIP1 PE=1 SV=2
20	AFDB:A0A0F7NGI8	0.035	0.056	1.376E-1	752	0.065	0.126	A0A0F7NGI8.pdb.gz	A0A0F7NGI8_HUMAN Leucine rich repeat (In FLII) interacting protein 1, isoform CRA_c OS=Homo sapiens OX=9606 GN=LRRFIP1 PE=2 SV=1

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A7XY94	0.0	1494	1448	0.541	0.547	NMDE2_XENLA Glutamate receptor ionotropic, NMDA 2B OS=Xenopus laevis OX=8355 GN=grin2b PE=1 SV=1
2	B7ZSK1	0.0	2201	1451	0.720	0.726	NMDE1_XENLA Glutamate receptor ionotropic, NMDA 2A OS=Xenopus laevis OX=8355 GN=grin2a PE=1 SV=1
3	G1TPJ8	0.0	895	888	0.301	0.495	G1TPJ8_RABIT Glutamate receptor OS=Oryctolagus cuniculus OX=9986 GN=GRIN2D PE=3 SV=2
4	O15399	0.0	987	1336	0.335	0.367	NMDE4_HUMAN Glutamate receptor ionotropic, NMDA 2D OS=Homo sapiens OX=9606 GN=GRIN2D PE=1 SV=2
5	P35436	0.0	2945	1464	0.953	0.953	NMDE1_MOUSE Glutamate receptor ionotropic, NMDA 2A OS=Mus musculus OX=10090 GN=Grin2a PE=1 SV=2
6	Q00959	0.0	2941	1464	0.952	0.952	NMDE1_RAT Glutamate receptor ionotropic, NMDA 2A OS=Rattus norvegicus OX=10116 GN=Grin2a PE=1 SV=2
7	Q00960	0.0	1494	1482	0.548	0.542	NMDE2_RAT Glutamate receptor ionotropic, NMDA 2B OS=Rattus norvegicus OX=10116 GN=Grin2b PE=1 SV=1
8	Q00961	0.0	1061	1237	0.350	0.414	NMDE3_RAT Glutamate receptor ionotropic, NMDA 2C OS=Rattus norvegicus OX=10116 GN=Grin2c PE=1 SV=1
9	Q01097	0.0	1491	1482	0.548	0.541	NMDE2_MOUSE Glutamate receptor ionotropic, NMDA 2B OS=Mus musculus OX=10090 GN=Grin2b PE=1 SV=3
10	Q01098	0.0	1066	1239	0.350	0.414	NMDE3_MOUSE Glutamate receptor ionotropic, NMDA 2C OS=Mus musculus OX=10090 GN=Grin2c PE=1 SV=2
11	Q03391	0.0	987	1323	0.334	0.370	NMDE4_MOUSE Glutamate receptor ionotropic, NMDA 2D OS=Mus musculus OX=10090 GN=Grin2d PE=1 SV=3
12	Q12879	0.0	3067	1464	1.000	1.000	NMDE1_HUMAN Glutamate receptor ionotropic, NMDA 2A OS=Homo sapiens OX=9606 GN=GRIN2A PE=1 SV=1
13	Q13224	0.0	1493	1484	0.548	0.540	NMDE2_HUMAN Glutamate receptor ionotropic, NMDA 2B OS=Homo sapiens OX=9606 GN=GRIN2B PE=1 SV=3
14	Q14957	0.0	1051	1233	0.350	0.415	NMDE3_HUMAN Glutamate receptor ionotropic, NMDA 2C OS=Homo sapiens OX=9606 GN=GRIN2C PE=1 SV=3
15	Q61984	0.0	932	1203	0.304	0.370	Q61984_MOUSE Glutamate receptor OS=Mus musculus OX=10090 GN=NMDA2C PE=3 SV=1
16	Q62645	0.0	987	1323	0.334	0.370	NMDE4_RAT Glutamate receptor ionotropic, NMDA 2D OS=Rattus norvegicus OX=10116 GN=Grin2d PE=1 SV=2
17	Q6IWN7	2.16e-129	431	1070	0.182	0.249	Q6IWN7_DROME NMDA receptor 2, isoform F OS=Drosophila melanogaster OX=7227 GN=Nmdar2 PE=2 SV=1
18	Q8MM14	2.47e-129	426	902	0.171	0.278	Q8MM14_DROME Glutamate NMDA receptor subunit variant NR2-a OS=Drosophila melanogaster OX=7227 GN=Nmdar2 PE=2 SV=1
19	X2JDW0	3.29e-129	430	1082	0.182	0.246	X2JDW0_DROME NMDA receptor 2, isoform G OS=Drosophila melanogaster OX=7227 GN=Nmdar2 PE=3 SV=1
20	Q9W581	4.32e-129	430	1083	0.182	0.246	Q9W581_DROME NMDA receptor 2, isoform C OS=Drosophila melanogaster OX=7227 GN=Nmdar2 PE=2 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF01094 ANF_receptor	1.6e-08	45.7	Receptor family ligand binding region
2	PF00060 Lig_chan	1.6e-31	120.6	Ligand-gated ion channel
3	PF10613 Lig_chan-Glu_bd	5.1e-27	105.7	Ligated ion channel L-glutamate- and glycine-binding site
4	PF10565 NMDAR2_C	1.2e-261	882.1	N-methyl D-aspartate receptor 2B3 C-terminus
5	PF00497 SBP_bac_3	2e-17	75.0	Bacterial extracellular solute-binding proteins, family 3

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000379818

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000360608	0.999	Glutamate receptor ionotropic, NMDA 1
2	9606.ENSP00000362680	0.999	Proto-oncogene tyrosine-protein kinase Src
3	9606.ENSP00000382428	0.999	Disks large homolog 4
4	9606.ENSP00000346671	0.997	Tyrosine-protein kinase Fyn
5	9606.ENSP00000345731	0.996	Disks large homolog 1
6	9606.ENSP00000363480	0.995	Disks large homolog 3
7	9606.ENSP00000380638	0.975	Protein-tyrosine kinase 2-beta
8	9606.ENSP00000477455	0.975	Glutamate receptor ionotropic, NMDA 2B
9	9606.ENSP00000365272	0.967	Disks large homolog 2
10	9606.ENSP00000303634	0.965	Low-density lipoprotein receptor-related protein 8
11	9606.ENSP00000392423	0.958	Reelin
12	9606.ENSP00000342235	0.957	Receptor tyrosine-protein kinase erbB-4
13	9606.ENSP00000477999	0.957	Nitric oxide synthase, brain
14	9606.ENSP00000366488	0.953	cAMP-dependent protein kinase catalytic subunit gamma
15	9606.ENSP00000296526	0.950	Glutamate receptor 2
16	9606.ENSP00000355155	0.946	Glutamate receptor ionotropic, NMDA 3A
17	9606.ENSP00000263708	0.945	Tyrosine-protein phosphatase non-receptor type 4
18	9606.ENSP00000395535	0.944	Methyl-CpG-binding protein 2
19	9606.ENSP00000384620	0.940	Pro-neuregulin-1, membrane-bound isoform
20	9606.ENSP00000313088	0.929	Neuropilin and tolloid-like protein 1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0004972	1.000	NMDA glutamate receptor activity
GO:0005261	0.999	monoatomic cation channel activity
GO:1901702	0.994	salt transmembrane transporter activity
GO:0046873	0.994	metal ion transmembrane transporter activity
GO:0015085	0.978	calcium ion transmembrane transporter activity
GO:0005262	0.964	calcium channel activity
GO:0099094	0.372	ligand-gated monoatomic cation channel activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0009987	0.995	cellular process
GO:0050789	0.995	regulation of biological process
GO:0050896	0.993	response to stimulus
GO:0050794	0.990	regulation of cellular process
GO:0023052	0.986	signaling
GO:0007154	0.986	cell communication
GO:0032501	0.981	multicellular organismal process
GO:0007215	0.976	glutamate receptor signaling pathway
GO:0048518	0.955	positive regulation of biological process
GO:0050877	0.954	nervous system process
GO:0065008	0.952	regulation of biological quality
GO:0051179	0.929	localization
GO:0007267	0.925	cell-cell signaling
GO:0099536	0.921	synaptic signaling
GO:0010646	0.912	regulation of cell communication
GO:0023051	0.907	regulation of signaling
GO:0007268	0.907	chemical synaptic transmission
GO:0050890	0.893	cognition
GO:0048522	0.892	positive regulation of cellular process
GO:0010033	0.891	response to organic substance
GO:0051234	0.887	establishment of localization
GO:0042391	0.879	regulation of membrane potential
GO:1901700	0.878	response to oxygen-containing compound
GO:0006810	0.876	transport
GO:0006811	0.862	monoatomic ion transport
GO:0048856	0.851	anatomical structure development
GO:0007610	0.850	behavior
GO:0071704	0.839	organic substance metabolic process
GO:0007611	0.833	learning or memory
GO:0055085	0.820	transmembrane transport
GO:0098662	0.767	inorganic cation transmembrane transport
GO:0065009	0.745	regulation of molecular function
GO:0097305	0.738	response to alcohol
GO:0071840	0.732	cellular component organization or biogenesis
GO:0006812	0.726	monoatomic cation transport
GO:0010243	0.724	response to organonitrogen compound
GO:0016043	0.721	cellular component organization
GO:0019222	0.716	regulation of metabolic process
GO:0006816	0.702	calcium ion transport
GO:0034220	0.699	monoatomic ion transmembrane transport
GO:0080090	0.693	regulation of primary metabolic process
GO:0060255	0.686	regulation of macromolecule metabolic process
GO:0070887	0.676	cellular response to chemical stimulus
GO:0051171	0.671	regulation of nitrogen compound metabolic process
GO:0098655	0.668	monoatomic cation transmembrane transport
GO:0045471	0.649	response to ethanol
GO:0051246	0.606	regulation of protein metabolic process
GO:0007275	0.592	multicellular organism development
GO:0050806	0.589	positive regulation of synaptic transmission
GO:0048167	0.577	regulation of synaptic plasticity
GO:0006950	0.553	response to stress
GO:0007613	0.503	memory
GO:0099565	0.493	chemical synaptic transmission, postsynaptic
GO:0048731	0.485	system development
GO:0006807	0.483	nitrogen compound metabolic process
GO:0048583	0.476	regulation of response to stimulus
GO:0060078	0.473	regulation of postsynaptic membrane potential
GO:0014075	0.466	response to amine
GO:0050905	0.450	neuromuscular process
GO:0009966	0.412	regulation of signal transduction
GO:0009605	0.410	response to external stimulus
GO:0010038	0.409	response to metal ion
GO:0097553	0.380	calcium ion transmembrane import into cytosol
GO:0044238	0.378	primary metabolic process
GO:0007399	0.356	nervous system development
GO:0009628	0.342	response to abiotic stimulus
GO:0044237	0.334	cellular metabolic process
GO:0051239	0.307	regulation of multicellular organismal process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0043231	1.000	intracellular membrane-bounded organelle
GO:0005737	0.999	cytoplasm
GO:0017146	0.999	NMDA selective glutamate receptor complex
GO:0012505	0.995	endomembrane system
GO:0005783	0.888	endoplasmic reticulum
GO:0031090	0.860	organelle membrane
GO:0098590	0.709	plasma membrane region
GO:0030054	0.673	cell junction
GO:0045202	0.663	synapse
GO:0043005	0.618	neuron projection
GO:0098794	0.589	postsynapse
GO:0031984	0.545	organelle subcompartment
GO:0098793	0.533	presynapse
GO:0005789	0.523	endoplasmic reticulum membrane
GO:0097060	0.497	synaptic membrane
GO:0098978	0.484	glutamatergic synapse
GO:0098984	0.380	neuron to neuron synapse
GO:0031982	0.353	vesicle
GO:0032279	0.341	asymmetric synapse
GO:0070013	0.340	intracellular organelle lumen
GO:0045211	0.340	postsynaptic membrane
GO:0099572	0.302	postsynaptic specialization

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:29671	0.978	Ca(2+)(in) = Ca(2+)(out)

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